检索结果-南通市图书馆

Caffeic acid phenethyl ester protects against oxidative stress and dampens inflammation via heme oxygenase 1

International Journal of Oral Science 2019年第1期11卷 50-57页

作者： Alexandra St?hli Ceeneena Ubaidha Maheen franz josef strauss Sigrun Eick Anton Sculean Reinhard Gruber Department of Oral Biology School of Dentistry Medical University of Vienna Department of Periodontology School of Dental MedicineUniversity of Bern Department of Conservative Dentistry School of Dentistry University of Chile Austrian Cluster for Tissue Regeneration

Periodontal disease is associated with chronic oxidative stress and inflammation. Caffeic acid phenethyl ester(CAPE), which is a potent inducer of heme oxygenase 1(HO1), is a central active component of propolis, and the application of propolis improves periodontal status in diabetic patients. Here, primary murine macrophages were exposed to CAPE. Target gene expression was assessed by whole-genome microarray, RT-PCR and Western blotting. The antioxidative and anti-inflammatory activities of CAPE were examined by exposure of the cells to hydrogen peroxide, saliva and periodontal pathogens. The involvement of HO1 was investigated with the HO1 inhibitor tin protoporphyrin(SnPP) and knockout mice for Nrf2, which is a transcription factor for detoxifying enzymes. CAPE increased HO1 and other heat shock proteins in murine macrophages. A p38 MAPK inhibitor and Nrf2 knockout attenuated CAPE-induced HO1 expression in macrophages. CAPE exerted strong antioxidative activity. Additionally, CAPE reduced the inflammatory response to saliva and periodontal pathogens. Blocking HO1 decreased the antioxidative activity and attenuated the anti-inflammatory activity of CAPE. In conclusion, CAPE exerted its antioxidative effects through the Nrf2-mediated HO1 pathway and its anti-inflammatory effects through NF-κB inhibition. However, preclinical models evaluating the use of CAPE in periodontal inflammation are necessary in future studies.

关键词： Caffeic acid phenethyl ester(CAPE) inflammatory response

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SHui, an EU-Chinese cooperative project to optimize soil and water management in agricultural areas in the ⅩⅪ century

引用

International Soil and Water Conservation Research 2020年第1期8卷 1-14页

作者： José A.Gómez Alon Ben-Gal Juan J.Alarcón Gabrielle De Lannoy Shannon de Roos Tomá(s)Dostál Elias Fereres Diego S.Intrigliolo josef Krása Andreas Klik Gunther Liebhard Reinhard Nolz Aviva Peeters Elke Plaas John N.Quinton Rui Miao Peter strauss Weifeng Xu Zhiqiang Zhang Funing Zhong David Zumr Ian C.Dodd Institute for Sustainable Agriculture IASCSICAvda Menendez Pidal S/NCordobaSpain Agricultural Research Organization Gilat Research CenterIsrael Centro de Edafología y Biología Aplicada Del Segura(CSIC) Dept.RiegoMurciaSpain Department of Earth and Environmental Sciences KU LeuvenHeverleeBelgium Czech Technical University in Prague Faculty of Civil Engineering.CVUTPragueCzech Republic Agronomy Department University of CordobaCordobaSpain University of Agricultural Sciences Vienna(BOKU) ViennaAustria TerraVision Lab Midreshet Ben-GurionIsrael Georg-August-Universitat Gottingen Germany Centre for Sustainable Agriculture Lancaster Environment CentreLancaster UniversityUK Center for Plant Water-Use and Nutrition Regulation and College of Life Sciences Joint International Research Laboratory of Water and Nutrient in CropsFujian Agriculture and Forestry UniversityFuzhouChina Institute for Land and Water Management Research Federal Agency for Water ManagementPetzenkirchenAustria College of Soil and Water Conservation Beijing Forestry UniversityBeijingChina College of Economics and Management Nanjing Agricultural UniversityNAUNanjingChina

This article outlines the major scientific objectives of the SHui project that seeks to optimize soil and water use in agricultural systems in the EU and China,by considering major current scientific challenges in this ***(for Soil Hydrology research platform underpinning innovation to manage water scarcity in European and Chinese cropping systems)is large cooperative project that aims to provide significant advances through transdisciplinary research at multiple scales(plot,field,catchment and region).This paper explains our research platform of long-term experiments established at plot scale,approaches taken to integrate crop and hydrological models at field scale;coupled crop models and satellite-based observations at regional scales;decision support systems for specific farming situations;and the integration of these technologies to provide policy recommendations through socio-economic analysis of the impact of soil and water saving *** also outlines the training of stake-holders to develop a basic common curriculum despite the subject being distributed across different disciplines and *** such,this article provides a review of major challenges for improving soil and water use in EU and China as well as information about the potential to access information made available by SHui,and to allow others to engage with the project.

关键词： Yield Sustainability Cropping Cooperation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

5-Fluorouracil-related enhancement of adenoviral infection is Coxsackievirus-adenovirus receptor independent and associated with morphological changes in lipid membranes

引用

World Journal of Gastroenterology 2006年第32期12卷 5168-5174页

作者： Chiara Cabrele Mandy Vogel Pompiliu Piso Markus Rentsch josef Schroder Karl W Jauch Hans J Schlitt Alexander Beham Department of Surgery Clinic of the Regensburg University Franz-Josef-Strauss-Allee 11D-93053RegensburgGermany

AIM： To evaluate the mechanism underlying the effects of 5-Fluorouracil （5-FU） on adenoviral infection. METHODS： Low and high Coxsackievirus-Adenovirus Receptor （CAR） expressing human colon carcinoma cell lines were treated with 5-FU and two El-deleted adenoviral constructs, one transferring GFP （Ad/CMV- GFP） the other bax （Ad/CEA-bax）. The number of infected cells were monitored by GFP expression. To evaluate the effects of 5-FU in a receptor free system, Ad/GFP were encapsulated in liposomes and treated with 5-FU. Ad/GFP release was estimated with PCR and infection of 293 cells with the supernatant. Electron microscopy of the Ad5-GFP-liposome complex was made to investigate morphological changes of the liposomes after 5-FU. RESULTS： Infection rates of all cell lines increased from 50% to 98% with emerging 5-FU concentrations. The enhanced viral uptake was independent of the CAR expression. Additionally, 5-FU treated liposomes released 2-2.5 times more adenoviruses. Furthermore, 5-FU- treated liposomes appeared irregular and porous-like. CONCLUSION： adenoviral uptake is enhanced in the presence of 5-FU irrespective of CAR and is associated with morphological changes in membranes making the combination of both a promising option in gene therapy.

关键词： 5-Fluorouracil Coxsackievirus-adenovirusreceptor Adenoviral infection Gene therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：