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新型冠状病毒引发全球卫生危机,需要科学解决方案和地方行动

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全球变化数据学报（中英文） 2020年第1期4卷 1-10,1-10页

作者： Giles B.Sioen Peter Daszak Kristie Ebi Chadia wannous Brama Kone Kathryn Bowen franz w.gatzweiler Frances Harris Melanie Boeckmann y Morse Chiho watanabe Jouni J.K.Jaakkola Gabriel O.Dida 马伟 The United Nations University Institute for the Advanced Study of Sustainability Tokyo 150-8925Japan The University of Tokyo Institute For Future InitiativesTokyo 150-8925Japan Future Earth Tokyo 150-8925Japan EcoHealth Alliance New York City 10001the United States of America University of washington Seattle 98195the United States of America Towards A Safer world Network StockholmSweden UniversitéPéléforo Gon Coulibaly KorhogoCôte d'Ivoire Centre Suisse de Recherches Scientifiques en Côte d'Ivoire AbidjanCôte d'Ivoire Australian National University Canberra 2600Australia 中国科学院城市环境研究所厦门361021 University of Hertfordshire Hatfield AL109ABUnited Kingdom Bielefeld University School of Public HealthBielefeld D-33615Germany University of Liverpool Liverpool L18JXUnited Kingdom National Institute for Environmental Studies Tsukuba 305-8506Japan Center for Environmental and Respiratory Health Research University of OuluOulu FI-90014Finland The Technical University of Kenya Nairobi FI-90014Kenya 山东大学公共卫生学院流行病学系济南250012

根据《国际卫生条例(2005)》(IHR),世界卫生组织(wHO)宣布将新型冠状病毒肺炎(COVID-19)列为国际关注的突发公共卫生事件。系统性问题导致此次病毒暴发,该疫情全世界大流行对全球政治和社会系统产生了重大影响。虽然过去15年间科学界在... 详细信息

根据《国际卫生条例(2005)》(IHR),世界卫生组织(wHO)宣布将新型冠状病毒肺炎(COVID-19)列为国际关注的突发公共卫生事件。系统性问题导致此次病毒暴发,该疫情全世界大流行对全球政治和社会系统产生了重大影响。虽然过去15年间科学界在提高了公众对于疾病大流行的警觉方面做了大量的工作,但此次疫情依然暴发并已威胁全球人们的健康,影响经济发展。为了更好地应对这一事件,降低风险,有哪些做法可以改进?对政府、学术组织和个人有哪些科学建议?本文探讨在如何保障人民健康安全的同时,降低经济和社会成本,并号召世界科学家参加"未来地球健康领域知识行动网络"计划。

关键词：世界卫生组织(wHO) 新型冠状病毒肺炎突发公共卫生事件未来地球计划健康领域知识行动网络

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

变化环境中的城市健康与福祉——系统的分析视角

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中国科学院院刊 2016年第5期31卷 581-586,484页

作者：张艺 franz gatzweiler 朱永官中国科学院城市环境研究所中国科学院城市环境与健康重点实验室厦门361021 国际科联城市健康与福祉计划国际办公室厦门361021

随着城市人口的不断增加,城市环境的不断变化,城市健康与福祉问题已经得到了国际社会高度关注。在城市环境中,各种复杂的影响因素及各因素之间的反馈机制都会影响居民的健康与福祉。城市健康问题的解决,不仅需要科学家的研究,还需要政... 详细信息

随着城市人口的不断增加,城市环境的不断变化,城市健康与福祉问题已经得到了国际社会高度关注。在城市环境中,各种复杂的影响因素及各因素之间的反馈机制都会影响居民的健康与福祉。城市健康问题的解决,不仅需要科学家的研究,还需要政策制定者以及所有利益相关方的共同参与。文章结合中国城镇化现状和城市的健康问题,介绍国际科联城市健康与福祉研究计划,并将系统研究城市健康的方法应用到中国新型城镇化战略中。

关键词：城市健康居民福祉系统分析方法中国新型城镇化

Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU w.M.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of Mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

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The Algebro-Geometric Method for Solving Algebraic Differential Equations——A Survey

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Journal of Systems Science & Complexity 2019年第1期32卷 256-270页

作者： wINKLER franz Research Institute for Symbolic Computation J.Kepler University

This paper presents the algebro-geometric method for computing explicit formula solutions for algebraic differential equations(ADEs). An algebraic differential equation is a polynomial relation between a function, some of its partial derivatives, and the variables in which the function is de?*** all these quantities as unrelated variables, the polynomial relation leads to an algebraic relation de?ning a hypersurface on which the solution is to be found. A solution in a certain class of functions, such as rational or algebraic functions, determines a parametrization of the hypersurface in this class. So in the algebro-geometric method the author ?rst decides whether a given ADE can be parametrized with functions from a given class; and in the second step the author tries to transform a parametrization into one respecting also the differential conditions. This approach is relatively well understood for rational and algebraic solutions of single algebraic ordinary differential equations(AODEs). First steps are taken in a generalization to systems and to partial differential equations.

关键词： Algebraic differential equation exact solution parametrization of curves

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

An Overview of Performance Characteristics, Experiencesand Trends of Aerospace Engine Bearings Technologies

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Chinese Journal of Aeronautics 2007年第4期20卷 378-384页

作者： Ebert franz-Josef Sales and Product Development Aerospace FAG Aerospace GmbH & Co. KG Schweinfurt D-97421 Germany

In this paper, the operating conditions, technical requirements, performance characteristics, design ideas, application experiences and development trends of aerospace engine bearings, including material technology, integration design and reliability, are reviewed. The development history of aerospace engine bearing is recalled briefly at first. Then today＇s material technologies and the high bearing performances of the bearings obtained through the new materials are introduced, which play important roils in the aeroengine bearing developments. The integration design ideas and practices are explained to indicate its significant advantages and importance to the aerospace engine bearings. And the reliability of the shaft-bearing system is pointed out and treated as the key requirement with goals for both engine and bearing. Finally, as it is believed that the correct design comes from practice, the pre-qualification rig testing conducted by FAG Aerospace GmbH ＆ Co. KG is briefly illustrated as an example. All these lead to the development trends of aerospace engine bearings from different aspects.

关键词： aerospace engine bearing performance characteristic material technology integrated bearing design reliability system cost