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Intensified intravitreal bevacizumab treatment regime for type 1 and 2 idiopathic macular telangiectasia

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International Journal of Ophthalmology(English edition) 2016年第7期9卷 1076-1078页

作者： Christos Chryssafis Aljoscha Steffen neubauer Efstathios Papadopoulos Kai Januschowski Karl Thomas Boden Peter Szurman Knappschafts Eye Clinic Sulzbach 66280 Saar Germany Eye Clinic Ludwig Maximilians University Munich 80336Germany Department of Experimental Ophthalmosurgery Eye Clinic Eberhard-Karls University Ttibingen 72074 Germany

Dear Sir,I am *** Chryssafis,from the Knappschafts Eye Clinic,Sulzbach,Saar,Germany.I write to present the results of our study about an intensified intravitreal bevacizumab（IVB）injections regime for type 1 and 2idi... 详细信息

关键词： IMT type

EFFECTS OF LEUKOTRIENE D4 AND ITS SPECIFIC ANTAGONIST L-660, 711 ON ISOLATED RAT HEART WITH CHRONIC MYOCAROIAL INFARCTION

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Chinese Medical Journal 1995年第3期 72-73页

作者： H Han S neubauer P Gaudron K Hu G Ertl Medizinische Universitats Klinik. Wurzburg Medizinische Universitats Klinik. WurzburgMedizinische Universitats Klinik. WurzburgMedizinische Universitats Klinik. WurzburgMedizinische Universitats Klinik. Wurzburg

Coronary reserve is reduced in residual myocardium after myocardial infarction and endogenous vasoconstrictors

关键词： LTD ON ISOLATED RAT HEART WITH CHRONIC MYOCAROIAL INFARCTION EFFECTS OF LEUKOTRIENE D4 AND ITS SPECIFIC ANTAGONIST L-660

Open Space Technology as a Method for Strategic Planning

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Open Space Technology as a Method for Strategic Planning

BlackBerry Enterprise Server 4.0

北京论坛（2006）文明的和谐与共同繁荣—对人类文明方式的思考

作者： Deane neubauer Professor Emeritus University of Hawai’iManoa Senior AdvisorEast-West Center

A typical problem of higher education strategic planning is the absence of"buy-in"throughout the *** planning processes are typically representative in that they employ representatives from major institutional players,but in the nature of the process,plans are often developed by relatively small groups of *** the plan moves toward adoption and subsequent implementation,it is not uncommon for numerous groups in the institution to argue that they have"not really been included."This perception of exclusion can then have the effect of creating a climate of artificiality when budgets are developed in alignment with strategic planning goals.

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Windows IT Pro Magazine（国际中文版） 2005年第11期 73-75,79页

作者： Joseph neubauer 沈重威(译者) HP公司高级技术顾问不详

本文介绍了BlackBerry Enterprise Server 4.0在架构方面的8个主要服务以及一系列的新特性。通过阅读本文，您将掌握BlackBerry Enterprise 4.0的主要功能、配置注意事项和手持设备的升级方法。

关键词： BlackBerry Enterprise Server 4.0 服务器存储能力路由协议调度服务

Probe manipulators for Wendelstein 7-X and their interaction with the magnetic topology

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Plasma Science and Technology 2018年第5期20卷 6-17页

作者： M RACK D HOSCHEN D REITER B UNTERBERG J W COENEN S BREZINSEK O neubauer S BOZHENKOV G CZYMEK Y LIANG M HUBENY Ch LINSMEIER the Wendelstein 7-X Team Forschungszentrum Julich GmbH Institut für Energie- und Klimaforschung-Plasmaphysik Partner of the Trilateral Euregio Cluster (TEC) D-52425 Julich Germany JARA-HPC D-52425 Julich Germany Max-Planck-Institut für Plasmaphysik D-17491 Greifswald/D-85748 Garching Germany

Probe manipulators are a versatile addition to typical plasma edge *** with material samples they allow for detailed investigation of plasma–wall interaction processes,such as material erosion,deposition or impurity transport *** combined with electrical probes,a study of scrape-off layer and plasma edge density,temperature and flow profiles as well as magnetic topologies is possible.A mid-plane manipulator is already in operation on Wendelstein 7-X.A system in the divertor region is currently under *** the present paper we discuss the critical issue of heat and power loads,power redistribution and experimental access to the complex magnetic topology of Wendelstein *** the aforementioned aspects are of relevance for the design and operation of a probe manipulator in a device like Wendelstein？7-X.A focus is put on the topological region that is accessible for the different coil current configurations at Wendelstein 7-X and the power load on the manipulator with respect to the resulting different magnetic *** analysis of power loads on plasma-facing components is performed using a numerical tracer particle diffusion tool provided via the Wendelstein 7-X Webservices.

关键词： stellarators Wendelstein 7-X manipulator divertor power load

利用GC-ICP-MS分析生物组织中的汞形态

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环境化学 2017年第10期36卷 2295-2296页

作者： Joaudimir Castro Kenneth neubauer 张桢 Universitéde Pau et des Pays de l'Adour Avenue de l'Université 64012PauFrance PerkinElmer Inc.SheltonCT USA 珀金埃尔默企业管理(上海)有限公司上海201203

汞的形态对于其对生物的毒性具有非常重要的影响.本文利用气相色谱仪与ICP-MS进行联用,对海产品中的汞形态进行精确分离和定量,并给出了优化后的接口条件、色谱条件等仪器参数.

关键词：汞形态 ICP-MS 联用技术

Accumulation of amino acids deriving from pyruvate in <i>Escherichia coli</i>W3110 during fed-batch cultivation in a two-compartment scale-down bioreactor

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Advances in Bioscience and Biotechnology 2011年第5期2卷 336-339页

作者： Jaakko Soini Kaisa Ukkonen Peter neubauer 不详

Bioprocess scale-down simulators are used to investigate the phenomena occurring in industrial scale cultivations. The aim is to simulate the large-scale conditions, characterized by long mixing times introducing local gradients into the bioreactor, in laboratory scale bioreactor. We have expanded the current physiological knowledge about the consequences of such cultivation conditions from well-known mixed-acid fermentation to amino acid metabolism. Several interesting deviations were observed for amino acids derived from pyruvate when a STR-PFR scale-down simulator and a regular STR fed-batch cultivation were compared. In this article we show that the cultivation of Escherichia coli K-12 substrain W3110 in a scale-down two-compartment bioreactor has consequences on the free amino acid pools. Repeated occurrence of high glucose zones affects the biosynthesis of amino acids derived from pyruvate. This is interesting since the pyruvate based amino acids are precursors of the branched chain amino acid pathway, which is further disturbed by an unbalanced regulation caused by a frameshift mutation in the ilvG gene of E. coli K-12 strains. As a consequence the formation of non-typical amino acid norvaline was detected in the two compartment bioreactor cultivation.

关键词： E.coli Fermentation Scale-Down Amino Acid

Treatment of genotype 2 and 3 chronic hepatitis C virus-infected patients

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World Journal of Gastroenterology 2005年第39期11卷 6188-6192页

作者： Perdita Wietzke-Braun Volker Meier Katrin neubauer-Saile Sabine Mihm Giuliano Ramadori Abteilung für Gastroenterologie und Endokrinologie Georg-August-Universitt Gttingen Germany

AIM： Before pegylated interferon alpha （IFN） was introduced for the therapy of chronic hepatitis C virus （HCV）-induced hepatitis, conventional thrice weekly IFN therapy was supplemented by ribavirin. Also, at that time, higher and more frequent doses of IFN were expected to be more effective than the standard regimen of 3 MU thrice weekly. As ribavirin significantly increases side effects and negatively influences the quality of life particularly in young patients, we started a prospective non-randomized study with a daily IFN-2a monotherapy as an initial treatment for chronic hepatitis C. METHODS： Forty-six consecutive chronic HCV-infected patients received 3 MU IFN-2a per day as an initial treatment. Patients with genotype 2 or 3 （n = 12） were treated for 24 wk, and patients with genotypes other than 2 or 3 （n = 34） for 48 wk. Treatment outcome was followed up for 48 wk after the end of treatment （EOT）. Virological response was defined as the absence of detectable serum HCV-RNA. Patients without virological response at 12 wk after the start of treatment received low-dose ribavirin （10 mg（kg·d）） additionally. RESULTS： During treatment, three genotype 3 patients were excluded from the study due to incompliance. The remaining patients （n = 9） infected with genotype 2 or 3 showed an initial virological response rate of 100%. Six patients （66.7%） were still found to be virus-free at the end of follow-up period. In these patients, initial virological response was evident already after 2 wk of treatment. In contrast, initial virological response occurred first after 4 wk of treatment in the three patients who relapsed （33.3%）. In comparison, patients infected with genotypes other than 2 or 3 （n = 34） showed an initial virological response rate of only 23.5% （n = 8）, and even in combination with ribavirin a sustained virological response （SVR） rate of only 11.8% （n = 4） could be achieved. CONCLUSION： In chronic HCV-infected patients with genotype 2 or 3, a SVR can be expe

关键词： Chronic hepatitis C virus infection Genotype 2 and 3 Alpha interferon Daily dose interferon therapy

Risk of Pacemaker Patients by TASER X26 Contact Mode Application

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Journal of Electromagnetic Analysis and Applications 2012年第2期4卷 96-100页

作者： Norbert Leitgeb Florian Niedermayr Robert neubauer Gerhard Loos Institute of Health Care Engineering with European Notified Body of Medical Devices Graz University of Technology Graz Austria

The prevalence of pacemaker patients among the general population and of conducted energy devices (CED) for law enforcement and self-defence is increasing. Consequently, the question whether cardiac pacemaker (CPM) patients are on particular risk becomes increasingly important. The risk of Taser X26 electric interference with implanted CPM has been investigated by numerical simulation at MRI-based anatomical models of CPM patients with devices implanted at conventional sites (left pectoral, right pectoral and abdominal) and with the monopolar CPM electrode placed at the ventricular apex. In spite of 10fold higher peak voltages the different coupling conditions make Taser-induced CPM interference voltages lower than those caused by external cardiac defibrillators. It is shown that electric interference considerably depends on ECD electrode orientation. The most unfavourable conditions are encountered with ECD electrodes aligned with the line from the CPM electrode tip to CPM can (EPC line). It could be shown that worst case interference voltages of monopolar pacemakers of any kind of implantation remain below the pulse immunity level as defined in safety standards of implantable cardiac pacemakers and of cardioverter defibrillators. However, interference voltages exceed CPM sensing thresholds. Therefore, capturing should be expected at Taser X26 contact mode application at any position at the upper part of the body including the abdomen, both at frontal and dorsal positions.

关键词： Conducted Energy Numerical Simulation Anatomical Model Health Risk Electromagnetic Compatibility