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At the dawn of a new revolution in life sciences

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World Journal of Biological Chemistry 2013年第2期4卷 13-15页

作者： frantiek baluka Guenther Witzany IZMB University of Bonn Telos-Philosophische Praxis

In a recently published article Sydney Brenner argued that the most relevant scientific revolution in biology at his time was the breakthrough of the role of "information" in *** fundamental concept that integrates this new biological "information" with matter and energy is the universal Turing machine and von Neumann's self-reproducing *** this article we demonstrate that in contrast to Turing/von Neumann machines living cells can really reproduce *** current knowledge on the roles of noncoding RNAs indicates a radical violation of the central dogma of molecular biology and opens the way to a new revolution in life sciences.

关键词： History of science Paradigm shift Information Non-coding RNAs

Disruption of Actin Filaments by Latrunculin B Affects Cell Wall Construction in Picea meyeri Pollen Tube Via Vesicle Trafficking Disturbance

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Disruption of Actin Filaments by Latrunculin B Affects Cell ...

The Subcellular Localization and Blue Light-induced Dynamic Relocalization of Phototropin 1 in Root and Shoot Cells of Arabidopsis thaliana

The Second International Symposium on Plant Neurobiology

作者： Jozef Samaj frantiek baluka Institute of Cellular and Molecular Botany University of Bonn Kirschallee 1D-53115 BonnGermany Institute of Plant Genetics and BiotechnologySlovak Academy of SciencesAkademicka 2SK-95007NitraSlovak Republic Institute of Cellular and Molecular Botany University of Bonn Kirschallee 1D-53115 BonnGermany Institute of BotanySlovak Academy of SciencesDubravska 14SK-84223BratislavaSlovak Republic

＜正＞The involvement of actin filaments （AFs） in vesicle trafficking, cell wall construction and tip growth were investigated during pollen tube development of Picea meyeri. Pollen germination and tube elongation were inhibited in a dose-dependent manner by the latrunculin B treatment. The fine actin filaments （AFs） were broken down into disorganized fragments showing a tendency of aggregation. FM4-64 labelling revealed that the dynamic balance of vesicle trafficking was

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The Subcellular Localization and Blue Light-induced Dynamic ...

Dynamic spatial reorganization of BSK1 complexes in the plasma membrane underpins signal-specific activation for growth and immunity

The Second International Symposium on Plant Neurobiology

作者： William R Eisinger Weronika Krzeszowiec Halina Gabrys frantiek baluka David W.Ehrhardt Winslow R Briggs Santa Clara University 500 El Camino Real CA 95053 Santa ClaraUSA The Jan Zurzycki Institute of Molecular Biology Jagiellonian University Krakow.Poland The Jan Zurzycki Institute of Molecular Biology Jagiellonian University Krakow.Poland Institute of Cellular and Molecular Botany University of Bonn Kieschallee 1.D-53115 BonnGermany Carnegie Institution Department of Plant Biology 260 Panama Street CA94305 StanfordUSA Carnegie Institution Department of Plant Biology 260 Panama Street CA94305 StanfordUSA

＜正＞The blue light receptor phototropin 1 （phot1） is a flavin-binding light-activated protein kinase. It serves as the major photoreceptor for phototropism in both roots and shoots. Although the activation of the C-terminal kinase domain has been characterized, the signal transduction pathway between perception of blue light by photl and phototropic responses remains unresolved. In continuation of our previous study with phot1-GFP-transformed Arabidopsis plants lacking photl （Sakamoto et al., 2002）, here we have investigated patterns of subcellular localizations of phot1-GFP in

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Molecular Plant 2021年第4期14卷 588-603页

作者： Bodan Su Xi Zhang Li Li Sammar Abbas Meng Yu Yaning Cui frantisek baluska Inhwan Hwang Xiaoyi Shan Jinxing Lin Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry UniversityBeijing 100083China College of Biological Sciences&Biotechnology Beijing Forestry UniversityBeijing 100083China lnstitute of Cellular and Molecular Botany University of BonnBonn53115Germany 々Division of Integrative Biosciences and Biotechnology Pohang University of Science and TechnologyPohang37673Korea Present address:School of Life Sciences Tsinghua UniversityBeijing 100084China

Growth and immunity are opposing processes that compete for cellular resources,and proper resource allocation is crucial for plant ***1 plays a key role in the regulation of both growth and immunity by associating with BRI1 and FLS2,***,it remains unclear how two antagonistic signals co-opt BSK1 to induce signal-specific *** we show that the dynamic spatial reorganiization of BSK1 within the plasma membrane underlies the mechanism of signal-specific activation for growth or *** BSK1 localizes to membrane rafts as *** BSK1-associated FLS2 and BRI1,flg22 or exogenous brassinosteroid(BR)treatment did not decrease BSK1 levels at the plasma membrane(PM)but rather induced BSK1 multimerization and dissociation from FLS2/BSK1 or BRI1/BSK1,***,flg22-activated BSK1 translocated from membrane rafts to non-membrane-raft regions,whereas BR-activated BSK1 remained in membrane *** applied together with flg22,BR suppressed various flg22-induced BSK1 activities such as BSK1 dissociation from FLS2/BSK1,BSK1 interaction with MAPKKK5,and BSK translocation together with *** together,this study provides a unique insight into how the precise control of BSK1 spatiotemporal organization regulates the signaling specificity to balance plant growth and immunity.

关键词： BSK1 dynamic spatiotemporal organization membrane rafts growth and immunity

Introducing a New Tool for Studying Unstable Systems

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International Journal of Automation and computing 2014年第6期11卷 580-587页

作者： frantiek Gazdo Tomas Bata University in Zlín Faculty of Applied Informatics nam.T.G.Masaryka 5555760 01 Zlin Czech Republic

This paper presents the starting project of a web site focussed on unstable systems. It is a web-based database in a bilingual version(English/Czech), which can be used as an information database for models of unstable processes. The web site contains the mathematical models of such systems, including their simulation files together with basic information about the stability of dynamic systems. The paper outlines the motivation for the development of this database, presents its basic structure, and discusses several models from the site. The areas of prospective usage are also suggested together with the possible directions of further development of this project. The contribution ends with a case study using the database for control system analysis and design of the Amira inverted pendulum. The systematic polynomial approach is fruitfully utilised for the task together with some useful tools from the robust control theory.

关键词： Unstable systems stability modelling simulation database robust control polynomial approach

Effects of no mating on the female adults and embryonic development of Schistocerca gregaria (Orthoptera: Acrididae)

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Chinese Science Bulletin 2013年第26期58卷 3244-3247页

作者： WANG FangHai SEHNAL frantiek Institute of Entomology & State Key Laboratory for Biocontrol Sun Yat-sen University Institute of Entomology Academy of SciencesBranisovská 31 370 11 eské Budějovice Czech Republic

The newly emerged adult females of Schistocerca gregaria were separated and kept in the rearing conditions without males to examine the detailed developmental characteristic of the no mating females and carefully observed the developmental progress of non-fertilised eggs laid by virgin females. The results showed that the females kept without males survived in average 43 d, i.e. 58% of the life span of mated controls, and laid correspondingly fewer egg pods. The size of egg batches, the weight of eggs, and their content of ecdysteroids were normal but the hatch rate was reduced to 18.27%. Blocks of early embryogenesis (58.43%) and hatching failures (23.29%) were the major causes of death. Moreover, most of the hatched insects died during the postembryonic development and only a few females reached the adult stage. All insects that developed until the penultimate or last larval instar or reached the adult stage were females.

关键词：胚胎发育女性交配沙漠直翅目孵化率降低蝗科成人

Nomore blind dates with calcite: Fluid-flow vs. fault-slip along the Očkov thrust, Prague Basin

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Geoscience Frontiers 2021年第4期12卷 163-174页

作者： Nick M.W.Roberts JiříŽák františek Vacek JiříSláma Geochronology and Tracers Facility British Geological SurveyEnvironmental Science CentreNottingham NG125GGUK Institute of Geology and Paleontology Faculty of ScienceCharles UniversityAlbertov 6Prague 12843Czech Republic Department of Mineralogy and Petrology National MuseumVáclavskénáměstí68Prague 11579Czech Republic Institute of Geology Czech Academy of Sciencesv.v.i.Rozvojová269Prague 16500Czech Republic

Dating of fracture-filling calcitewith U-Pb geochronology is becoming a rapidly adopted technique for determining the absolute timing of brittle deformation in the upper *** calcite is a desirable target,as it precipitates between individual fault slip displacement events,and provides additional kinematic *** we present a case study of slickenfibres formed on the Očkov thrust in the Lower Palaezoic Prague Basin,Bohemian Massif,utilising a combination of petrographic and in situ *** demonstrate that slickenfibre external textures can be preserved,whilst internally primary textures are removed by fluid infiltration and recrystallization,leading to variable U and Pb *** slickenfibre yielded a date of ca.250 Ma,which we interpret as recording fault slip along the Očkov *** cross-cutting slickenfibre yielded more scattered U-Pb data,with an imprecise apparent age around ca.95 *** slickenfibre is recrystallised,destroying the primary textures,and exhibits element *** meaning of this younger apparent age is therefore questionable;whereas it likely reflects Cretaceous U and Pb mobility assisted by fluid-flow along the fault plane,it may not reflect a period of fault *** results demonstrate that slickenfibre-based U-Pb dates do not unequivocally relate to fault motion,and that petrographic and elemental analyses are important requirements for interpreting calcite U-Pb data.

关键词： U-Pb geochronology Calcite Fault dating Fluid-flow Prague Basin LA-ICP-MS

Advancing drug safety and mitigating health concerns:High-resolution mass spectrometry in the levothyroxine case study

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Journal of Pharmaceutical Analysis 2024年第9期14卷 1361-1371页

作者： Hana Chmelařová Maria Carmen Catapano Jean-Christophe Garrigues františekŠvec Lucie Nováková Department of Analytical Chemistry Faculty of Pharmacy in Hradec KrálovéCharles UniversityAkademika Heyrovského 120350005Hradec KrálovéCzech Republic Laboratoire SOFTMAT(IMRCP) Universitéde ToulouseCNRS UMR 5623UniversitéPaul Sabatier118 route de Narbonne31062 Toulouse Cedex 9France

Levothyroxine is a drug with a narrow therapeutic *** the drug formulation composition or switching between pharmaceutical brands can alter the bioavailability,which can result in major health ***,the increased adverse drug reactions have not been fully explained scientifically yet and a thorough investigation of the formulations is *** this study,we used a non-targeted analytical approach to examine the various levothyroxine formulations in detail and to reveal possible chemical ***-high-performance liquid chromatography coupled with a data-independent acquisition high-resolution mass spectrometry(UHPLC-DIA-HRMS)was ***-DIA-HRMS allowed not only the detection of levothyroxine degradation products,but also the presence of non-expected components in the *** these,we identified compounds resulting from reactions between mannitol and other excipients,such as citric acid,stearate,and palmitate,or from reactions between an excipient and an active pharmaceutical ingredient,such as levothyroxine-lactose *** addition to these compounds,undeclared phospholipids were also found in three *** non-targeted approach is not common in pharmaceutical quality control *** the presence of unexpected compounds in drug formulations proved that the current control mechanisms do not have to cover the full complexity of pharmaceutical formulations necessarily.

关键词： Levothyroxine Excipients Impurities UHPLC-DIA-HRMS Drug safety

From individual elements to macroscopic materials: in search of new superconductors via machine learning

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npj Computational Materials 2023年第1期9卷 1640-1648页

作者： Claudio Pereti Kevin Bernot Thierry Guizouarn františek Laufek Anna Vymazalová Luca Bindi Roberta Sessoli Duccio Fanelli Dipartimento di Fisica e Astronomia Universitàdi FirenzeINFN and CSDCVia Sansone 150019 Sesto FiorentinoFirenzeItaly Univ.Rennes Universitéde Rennes 1INSA RennesCNRSISCR(Institut des Sciences Chimiques de Rennes)UMR 6226F-35000 RennesFrance Institut Universitaire de France 1 rue DescartesParisFrance Czech Geological Survey Geologická615200 Praha 5Czech Republic Dipartimento di Science della Terra Universitàdi FirenzeVia G.La Pira450121 FirenzeItaly Dipartimento di Chimica U.Schiff-DICUS and INSTM Research Unit Universitàdi FirenzeVia della Lastruccia 3-13Sesto Fiorentino 50019 FirenzeItaly

An approach to supervised classification and regression of superconductive materials is proposed which builds on the DeepSet *** enables us to provide the chemical constituents of the examined compounds as an input to the algorithm,while avoiding artefacts that could originate from the chosen ordering in the *** performance of the method are successfully challenged for both classification(tag a given material as superconducting)and regression(quantifying the associated critical temperature).We then searched through the International Mineralogical Association list with the trained neural *** the obtained superconducting candidates,three materials were selected to undergo a thorough experimental *** has been indeed confirmed for the synthetic analogue of michenerite,PdBiTe,and observed for the first time in monchetundraite,Pd2NiTe2,at critical temperatures in good agreement with the theory *** latter is the first certified superconducting material to be identified by artificial intelligence methodologies.

关键词： artificial Deep neural