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At the dawn of a new revolution in life sciences

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World Journal of Biological Chemistry 2013年第2期4卷 13-15页

作者： frantiek baluka Guenther Witzany IZMB University of Bonn Telos-Philosophische Praxis

In a recently published article Sydney Brenner argued that the most relevant scientific revolution in biology at his time was the breakthrough of the role of "information" in *** fundamental concept that integrates this new biological "information" with matter and energy is the universal Turing machine and von Neumann's self-reproducing *** this article we demonstrate that in contrast to Turing/von Neumann machines living cells can really reproduce *** current knowledge on the roles of noncoding RNAs indicates a radical violation of the central dogma of molecular biology and opens the way to a new revolution in life sciences.

关键词： History of science Paradigm shift Information Non-coding RNAs

Disruption of Actin Filaments by Latrunculin B Affects Cell Wall Construction in Picea meyeri Pollen Tube Via Vesicle Trafficking Disturbance

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Disruption of Actin Filaments by Latrunculin B Affects Cell ...

The Subcellular Localization and Blue Light-induced Dynamic Relocalization of Phototropin 1 in Root and Shoot Cells of Arabidopsis thaliana

The Second International Symposium on Plant Neurobiology

作者： Jozef Samaj frantiek baluka Institute of Cellular and Molecular Botany University of Bonn Kirschallee 1D-53115 BonnGermany Institute of Plant Genetics and BiotechnologySlovak Academy of SciencesAkademicka 2SK-95007NitraSlovak Republic Institute of Cellular and Molecular Botany University of Bonn Kirschallee 1D-53115 BonnGermany Institute of BotanySlovak Academy of SciencesDubravska 14SK-84223BratislavaSlovak Republic

＜正＞The involvement of actin filaments （AFs） in vesicle trafficking, cell wall construction and tip growth were investigated during pollen tube development of Picea meyeri. Pollen germination and tube elongation were inhibited in a dose-dependent manner by the latrunculin B treatment. The fine actin filaments （AFs） were broken down into disorganized fragments showing a tendency of aggregation. FM4-64 labelling revealed that the dynamic balance of vesicle trafficking was

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The Subcellular Localization and Blue Light-induced Dynamic ...

Dynamic spatial reorganization of BSK1 complexes in the plasma membrane underpins signal-specific activation for growth and immunity

The Second International Symposium on Plant Neurobiology

作者： William R Eisinger Weronika Krzeszowiec Halina Gabrys frantiek baluka David W.Ehrhardt Winslow R Briggs Santa Clara University 500 El Camino Real CA 95053 Santa ClaraUSA The Jan Zurzycki Institute of Molecular Biology Jagiellonian University Krakow.Poland The Jan Zurzycki Institute of Molecular Biology Jagiellonian University Krakow.Poland Institute of Cellular and Molecular Botany University of Bonn Kieschallee 1.D-53115 BonnGermany Carnegie Institution Department of Plant Biology 260 Panama Street CA94305 StanfordUSA Carnegie Institution Department of Plant Biology 260 Panama Street CA94305 StanfordUSA

＜正＞The blue light receptor phototropin 1 （phot1） is a flavin-binding light-activated protein kinase. It serves as the major photoreceptor for phototropism in both roots and shoots. Although the activation of the C-terminal kinase domain has been characterized, the signal transduction pathway between perception of blue light by photl and phototropic responses remains unresolved. In continuation of our previous study with phot1-GFP-transformed Arabidopsis plants lacking photl （Sakamoto et al., 2002）, here we have investigated patterns of subcellular localizations of phot1-GFP in

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Molecular Plant 2021年第4期14卷 588-603页

作者： Bodan Su Xi Zhang Li Li Sammar Abbas Meng Yu Yaning Cui frantisek baluska Inhwan Hwang Xiaoyi Shan Jinxing Lin Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry UniversityBeijing 100083China College of Biological Sciences&Biotechnology Beijing Forestry UniversityBeijing 100083China lnstitute of Cellular and Molecular Botany University of BonnBonn53115Germany 々Division of Integrative Biosciences and Biotechnology Pohang University of Science and TechnologyPohang37673Korea Present address:School of Life Sciences Tsinghua UniversityBeijing 100084China

Growth and immunity are opposing processes that compete for cellular resources,and proper resource allocation is crucial for plant ***1 plays a key role in the regulation of both growth and immunity by associating with BRI1 and FLS2,***,it remains unclear how two antagonistic signals co-opt BSK1 to induce signal-specific *** we show that the dynamic spatial reorganiization of BSK1 within the plasma membrane underlies the mechanism of signal-specific activation for growth or *** BSK1 localizes to membrane rafts as *** BSK1-associated FLS2 and BRI1,flg22 or exogenous brassinosteroid(BR)treatment did not decrease BSK1 levels at the plasma membrane(PM)but rather induced BSK1 multimerization and dissociation from FLS2/BSK1 or BRI1/BSK1,***,flg22-activated BSK1 translocated from membrane rafts to non-membrane-raft regions,whereas BR-activated BSK1 remained in membrane *** applied together with flg22,BR suppressed various flg22-induced BSK1 activities such as BSK1 dissociation from FLS2/BSK1,BSK1 interaction with MAPKKK5,and BSK translocation together with *** together,this study provides a unique insight into how the precise control of BSK1 spatiotemporal organization regulates the signaling specificity to balance plant growth and immunity.

关键词： BSK1 dynamic spatiotemporal organization membrane rafts growth and immunity

Sex differences in the risk of retinopathy of prematurity:a systematic review,frequentist and Bayesian meta‑analysis,and meta‑regression

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World Journal of Pediatrics 2024年第4期20卷 340-352页

作者： Tamara M.Hundscheid Silvia Gulden Mohamad F.Almutairi františek Bartoš Giacomo Cavallaro Eduardo Villamor Division of Neonatology Department of PediatricsMosaKids Children’s HospitalMaastricht University Medical Center(MUMC+)School for Oncology and Reproduction(GROW)Maastricht UniversityP.Debyelaan 25.P.O.Box 58006202 AZ MaastrichtThe Netherlands Neonatal Intensive Care Unit Sant’Anna HospitalComoItaly Department of Psychology University of Amsterdam1001 NK AmsterdamThe Netherlands Neonatal Intensive Care Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly

Background Retinopathy of prematurity(ROP)is generally considered to be more frequent in males than in ***,it is not known whether sex differences in ROP affect all degrees of the condition,are global and have changed as neonatology has *** aimed to conduct a systematic review and meta-analysis of studies addressing sex differences in the risk of developing *** PubMed/MEDLINE and Embase databases were *** frequentist,random-effects risk ratio(RR)and 95%confidence interval(CI)were *** model averaged(BMA)meta-analysis was used to calculate the Bayes factors(BFs).The BF10 is the ratio of the probability of the data under the alternative hypothesis(H1)over the probability of the data under the null hypothesis(H0).Results We included 205 studies(867,252 infants).Frequentist meta-analysis showed a positive association between male sex and severe ROP(113 studies,RR=1.14,95%CI=1.07–1.22)but no association with any ROP(144 studies,RR=1.00,95%CI=0.96–1.03).BMA showed extreme evidence in favor of H1 for severe ROP(BF10=71,174)and strong evidence in favor of H0 for any ROP(BF10=0.05).The association between male sex and severe ROP remained stable over time and was present only in cohorts from countries with a high or high-middle sociodemographic *** Our study confirms the presence of a male disadvantage in severe ROP but not in less severe forms of the *** are variations in the sex differences in ROP,depending on geographical location and sociodemographic level of the countries.

关键词： Oxidative stress Retinopathy of prematurity Sex characteristics

Colon Structure of Associated Primes of Monomial Ideals

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Algebra Colloquium 2024年第3期31卷 441-450页

作者： Siddhi balu Ambhore Indranath Sengupta Discipline of Mathematics IIT GandhinagarPalajGandhinagarGujarat 382355India

We find an explicit expression of the associated primes of monomial ideals as a colon by an element,using the unique irredundant irreducible decomposition whose irreducible components are monomial *** algorithm to compute is given using *** squarefree monomial ideals the problem is related to the combinatorics of the underlying clutter or *** ideals of Borel type,the monomial u takes a simpler form,and we classify when is unique.

关键词： monomial ideals associated primes colon ideals

Extension of Distribution Transformer Life in the Presence of Smart Inverter-based Distributed Solar Photovoltaic Systems

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 88-95页

作者： kanhaiya Kumar Saran Satsangi Ganesh balu Kumbhar Department of Electrical and Electronics Engineering Motihari College of EngineeringMotihariBiharIndia Department of Electrical Engineering National Institute of Technology(NIT)PatnaPatnaBiharIndia Department of Electrical Engineering Indian Institute of Technology(IIT)RoorkeeRoorkeeUttarakhandIndia

A transformer is an essential but expensive power delivery equipment for a distribution *** many distribution utilities worldwide,a sizable percentage of transformers are near the end of their designed *** the same time,distribution utilities are adopting smart inverter-based distributed solar photovoltaic(SPV)systems to maximize renewable *** central objective of this paper is to propose a methodology to quantify the effect of smart inverter-based distributed SPV systems on the aging of distribution *** proposed method is first tested on a modified IEEE-123 node distribution *** that,the procedure is applied to a practical distribution system,i.e.,the Indian Institute of Technology(IIT)Roorkee campus,*** transformer aging models,alongside advanced control functionalities of grid-tied smart inverter-based SPV systems,are implemented in *** open-source simulation tool(OpenDSS)is used to model distribution *** analyze effectiveness of various inverter functionalities,time-series simulations are performed using exponential load models,considering daily load curves from multiple seasons,load types,current harmonics,*** show replacing a traditional inverter with a smart inverter-based SPV system can enable local reactive power generation and may extend the life of a distribution *** results demonstrate,simply by incorporating smart inverter-based SPV systems,transformer aging is reduced by 15%to 22%in comparison to SPV systems operating with traditional inverters.

关键词： Distribution transformer loss of life smart inverter functions solar photovoltaic systems thermal models Volt-VAr control

Liquid superlubricity of lubricants containing hydroxyl groups and their aqueous solution under rolling/sliding conditions

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Friction 2024年第1期12卷 164-173页

作者： Tomáš POLÁČek Petr ŠPERka Ivan KŘUPka Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic

Macroscale rolling/sliding conditions are in the superlubricity,a little-studied topic so *** purpose of this paper is to examine the formation of elastohydrodynamic lubrication(EHL)films by water-based lubricants(glycerol and polyethylene glycol(PEG)),providing superlubricous *** were carried out on an optical ball-on-disc tribometer under rolling/sliding *** film thickness was measured by the thin film colorimetric interferometry,and the viscosity of liquids was measured by rotational and high-pressure falling body *** results show that tribochemical reactions are not the mandatory reason for friction to reach the superlubricity level when using the water-based *** studied liquids themselves are almost *** the addition of water,the signs of shear thinning behavior disappear even *** conditions for this type of lubricant can be predicted using the known Hamrock–Dowson *** anomaly in the thickness of the lubricants was observed as an abrupt change at certain *** more PEG there is in the lubricant,the higher the thickness at the beginning of the jump.

关键词： macroscale superlubricity super low traction water-based lubricants elastohydrodynamic lubrication(EHL) film thickness

High-resolution multi-scale air pollution system:Evaluation of modelling performance and emission control strategies

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Journal of Environmental Sciences 2024年第3期137卷 65-81页

作者： Diogo Lopes Joana Ferreira Sandra Rafael ka In Hoi Xin Li Yuan Liu ka-Veng Yuen kai Meng Mok Ana Isabel Miranda Department of Environment and Planning&CESAM University of AveiroAveiroPortugal Department of Civil&Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao SARChina

A high percentage of the world's population lives in areas where air pollutant concentrations exceed the World Health Organization *** work aims to develop and test,a high-resolution multi-scale air pollution modelling system by integrating a set of adequate *** system is able to provide detailed air pollutant concentrations in urban areas and support air quality management strategies through a better identification of different atmospheric *** also allows furthering the design and assessment of air pollution control measures for a specific *** evaluate its performance and suitability,the system was applied to the Macao Special Administrative Region(SAR),China,one of the most densely populated areas on earth,during a winter period when this area is affected by high levels of Particulate Matter(PM).Although the developed system tends to underestimate the PM concentrations,it revealed a good performance in reproducing the temporal and spatial air pollution *** exceedances of the Chinese air quality standards were calculated and high population exposure to PM pollution was *** tested urban atmospheric emission reduction scenarios have shown air quality improvements,indicating that emission reduction measures at urban level should focus on the domestic ***,it is crucial to implement joint pollution prevention strategies with neighbouring regions to improve the air quality in Macao *** approach developed in this work can support policymakers in defining new strategies to reduce atmospheric pollution in urban areas.

关键词： Urban areas High-resolution emission inventory Particulate matter Population exposure