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Engineering 2023年第7期26卷 108-118,I0005页

作者： Julija Juric Hongli Peng Manshu Song frano vuckovic JelenaŠimunovic Irena TrbojevicAkmacic Youxin Wang Jiaonan Liu Qing Gao Hao Wang Qiaoyun Chu Marija Pezer Wei Wang Gordan Lauc Genos Glycoscience Research Laboratory Zagreb 10000Croatia Hospital of Traditional Chinese Medicine Fengtai DistrictBeijing 100076China Beijing Municipal Key Laboratory of Clinical Epidemiology School of Public HealthCapital Medical UniversityBeijing 100069China Centre for Precision Health Edith Cowan UniversityPerthWA 6027Australia School of Basic Medical Sciences Capital Medical UniversityBeijing 100069China Department of Biochemistry and Molecular Biology Faculty of Pharmacy and Biochemistry at University of ZagrebZagreb 10000Croatia

Immunoglobulin G(IgG)is the most abundant plasma glycoprotein and a prominent humoral immune *** composition affects the affinity of IgG to ligands and consequent immune *** modification of IgG N-glycosylation is considered to be one of the various mechanisms by which sex hormones modulate the immune *** the menstrual cycle is the central sex hormonerelated physiological process in most women of reproductive age,IgG N-glycosylation dynamics during the menstrual cycle have not yet been *** fill this gap,we profiled the plasma IgG Nglycans of 70 healthy premenopausal women at 12 time points during their menstrual cycles(every 7 days for 3 months)using hydrophilic interaction ultra-performance liquid chromatography(HILIC-UPLC).We observed cyclic periodic changes in the N-glycosylation of IgG in association with the menstrual cycle phase and sex hormone concentration in *** the integrated cohort level,the modeled average menstrual cycle effect on the abundance of IgG N-glycosylation traits was low for each trait,with the highest being 1.1%for agalactosylated ***,intrapersonal changes were relatively high in some cases;for example,the largest difference between the minimum and maximum values during the menstrual cycle was up to 21%for sialylated *** all measurements,the menstrual cycle phase could explain up to 0.72%of the variation in the abundance of a single IgG glycosylation trait of *** contrast,up to 99%of the variation in the abundance of digalactosylation could be attributed to interpersonal differences in IgG *** conclusion,the average extent of changes in the IgG N-glycopattern that occur during the menstrual cycle is small;thus,the IgG N-glycoprofiling of women in large sample-size studies can be performed regardless of menstrual cycle phase.

关键词： N-glycosylation Immunoglobulin G Menstrual cycle Female sex hormones Estrogen Progesterone Testosterone Women

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流感与COVID-19患者的免疫球蛋白G糖基化差异

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Engineering 2023年第7期26卷 54-62,I0003页

作者： Marina Kljakovic-Gašpic Batinjan Tea Petrovic frano vuckovic Irzal Hadz ibegovic Barbara Radovani Ivana Jurin LovorkaÐerek Eva Huljev Alemka Markotic Ivica Lukšic Irena Trbojevic´-Akmacic Gordan Lauc Ivan Gudelj Rok Civljak University Hospital Centre Zagreb Zagreb 10000Croatia Genos Glycoscience Research Laboratory Zagreb 10000Croatia Department of Cardiology University Hospital DubravaZagreb 10000Croatia Faculty of Dental Medicine and Health Josip Juraj Strossmayer UniversityOsijek 31000Croatia Department of Biotechnology University of RijekaRijeka 51000Croatia Department for Laboratory Diagnostics University Hospital DubravaZagreb 10000Croatia Department for Acute Respiratory Infections University Hospital for Infectious Diseases“Dr.Fran Mihaljevic”Zagreb 10000Croatia Department for Urogenital Infections University Hospital for Infectious Diseases“Dr.Fran Mihaljevic”Zagreb 10000Croatia Department for Infectious Diseases School of MedicineCatholic University of Croatia10000 ZagrebCroatia Postdoctoral Study Faculty of MedicineUniversity of RijekaRijeka 51000Croatia Department of Maxillofacial Surgery University of Zagreb School of MedicineDubrava University HospitalZagreb 10000Croatia Faculty of Pharmacy and Biochemistry University of ZagrebZagreb 10000Croatia Department of Infectious Diseases University of Zagreb School of MedicineZagreb 10000Croatia

The essential role of immunoglobulin G(IgG)in immune system regulation and combatting infectious diseases cannot be fully recognized without an understanding of the changes in its N-glycans attached to the asparagine 297 of the fragment crystallizable(Fc)domain that occur under such *** glycans impact the antibody stability,half-life,secretion,immunogenicity,and effector ***,in this study,we analyzed and compared the total IgG glycome—at the level of individual glycan structures and derived glycosylation traits(sialylation,galactosylation,fucosylation,and bisecting Nacetylglucosamine(GlcNAc))—of 64 patients with influenza,77 patients with coronavirus disease 2019(COVID-19),and 56 healthy *** study revealed a significant decrease in IgG galactosylation,sialylation,and bisecting GlcNAc(where the latter shows the most significant decrease)in deceased COVID19 patients,whereas IgG fucosylation was *** the other hand,IgG galactosylation remained stable in influenza patients and COVID-19 *** glycosylation in influenza patients was more time-dependent:In the first seven days of the disease,sialylation increased and fucosylation and bisecting GlcNAc decreased;in the next 21 days,sialylation decreased and fucosylation increased(while bisecting GlcNAc remained stable).The similarity of IgG glycosylation changes in COVID-19 survivors and influenza patients may be the consequence of an adequate immune response to enveloped viruses,while the observed changes in deceased COVID-19 patients may indicate its deviation.

关键词： Influenza COVID-19 Viral infection Glycosylation Immunoglobulin G Pneumonia

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