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a. a.tificia. intelligence fra.ework for expla.na.le drift detection in energy foreca.ting

Energy a.d a. 2024年第3期17卷 368-379页

作者： Cha.od Sa.a.a.eewa.Da.win De silva Milos Ma.ic Nisha. Mills Ha.sha.Mora.iya.e Da.minda.a.a.a.oon a.drew Jennings Centre for Da.a.a.a.ytics a.d Cognition La Trobe UniversityAustralia Depa.tment of Computer Science Virginia Commonwealth UniversityRichmondUSA

a.cura.e energy consumption foreca.ting is crucia. for reducing opera.iona. costs, a.hieving net-zero ca.bon emissions, a.d ensuring susta.na.le buildings a.d cities of the future. Despite the frequent use of a.tificia. Intelligence (a.) a.gorithms for lea.ning energy consumption pa.terns a.d predictions in Building Science, relying solely on these techniques for energy dema.d prediction a.dresses only a.fra.tion of the cha.lenge. a.drift in energy usa.e ca. lea. to ina.cura.ies in these a. models a.d subsequently to poor decision-ma.ing a.d interventions. While drift detection techniques ha.e been reported, a.relia.le a.d robust a.proa.h ca.a.le of expla.ning identified discrepa.cies with a.tiona.le insights ha. not been discussed in exta.t litera.ure. Hence, this pa.er presents a. a.tificia. Intelligence fra.ework for energy consumption foreca.ting with expla.na.le drift detection, a.med a. a.dressing these cha.lenges. The proposed fra.ework is composed of energy embeddings, a. optimized dimensiona. model integra.ed within a.da.a.wa.ehouse, a.d sca.a.le cloud implementa.ion for effective drift detection with expla.na.ility ca.a.ility. The fra.ework is empirica.ly eva.ua.ed in the rea.-world setting of a.multi-ca.pus, mixed-use tertia.y educa.ion setting in Victoria. a.stra.ia. The results of these experiments highlight its ca.a.ilities in detecting concept drift, a.a.ting foreca.t predictions, a.d providing a. interpreta.ion of the cha.ges using energy embeddings.

关键词： Building energy consumption foreca.ting Expla.na.le drift detection Energy embedding Dimensiona. modeling

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Pla.t community on a.volca.o mounta.ntop revea.s unique high-a.titude vegeta.ion in southea.tern Bra.il

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Journa. of Mounta.n Science 2024年第9期21卷 3018-3030页

作者： Igor Musa.er KESSOUS Ruy JoséVa.ka.a.VES Nílber Gonça.ves da.silva a.ilca. Wa.ter Sa.ORETTI JUNIOR Biodiversity La.ora.ory Federal Institute of EducationScience and Technology of Southern Minas Gerais(IFSULDEMINAS)Av.Dirce Pereira Rosa300-Jardim Esperança37713-100Poços de CaldasMGBrazil Depa.tment of Bota.y National MuseumFederal University of Rio de JaneiroQuinta da Boa Vista s.n.São Cristóvão20949-040Rio de JaneiroRJBrazil Gothenburg Globa. Biodiversity Centre Carl Skottsbergs Gata 22BSE 41319GothenburgSweden

Mounta.ns exhibit a.high degree of endemism a.d diversity,however,qua.tifying their biodiversity ca. be *** to isla.ds,species isola.ion in mounta.nous regions results in compa.a.le pa.terns of evolution a.d extinction,rendering their biodiversity unique a.d highly susceptible to a.thropogenic *** topogra.hic relief in mounta.ns pla.s a.crucia. role in crea.ing ha.ita. complexity,which in turn contribute to high pla.t ***,we investiga.ed pla.t diversity in the volca.o mounta.ntop vegeta.ion on the Poços de Ca.da. Pla.ea.,a.region situa.ed in the ecotone between the a.la.tic Forest a.d Cerra.o,cha.a.terized by na.ura. ra.ia.ion a.d significa.t a.thropogenic *** employed a. a.toma.ed a.proa.h through the filtering of georeferenced a.d non-georeferenced da.a.to obta.n a.list of pla.t species in the ***,we sta.istica.ly investiga.ed the simila.ity a.ong different high-a.titude vegeta.ions belonging to the ca.pos de a.titude from the a.la.tic Forest a.d ca.pos rupestres from the *** pla.ea. exhibits high pla.t diversity,including 1,659 specific a.d infra.pecific ta.a.especia.ly belonging to a.tera.ea. a.d *** a.a.yses suggest tha. geogra.hica. dista.ce is a.strong predictor of dissimila.ity a.d tha. the Poços de Ca.da. Pla.ea. is more floristica.ly rela.ed to the ca.pos rupestres,despite being a.socia.ed with ca.pos de *** region possesses a.unique set of biodiversity,indica.ing tha. it ma. be a.distinct ***,we hypothesize tha. Pleistocene events likely influenced the conforma.ion of the current floristic composition in the region through species intercha.ge between the Cerra.o a.d a.la.tic *** study a.so highlights the few ta.a.a.sessed for conserva.ion sta.us a.d a.thropogenic threa.s tha. this ha.ita. is fa.ing.

关键词： a.la.tic Forest Biogeogra.hy Cerra.o Community ecology Gra.sla.d

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Supplementa.ion of vita.in E or a.bota.ica. extra.t a. a.tioxida.ts to improve growth performa.ce a.d hea.th of growing pigs housed under thermoneutra. or hea.-stressed conditions

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Journa. of a.ima. Science a.d Biotechnology 2024年第3期15卷 1101-1118页

作者： Ysenia.V.silva‑Guillen Consuelo a.ella.o Jeffrey Wiegert R.Dea. Boyd Ga.riela.E.Ma.tinez Eric va. Heugten Depa.tment of a.ima. Science North Carolina State UniversityRaleighNC 27695USA Depa.tment of Sta.istics North Carolina State UniversityRaleighNC 27695USA Depa.tment of a.ima. Science Texas A&M UniversityCollege StationTX 77843USA a.ima. Nutrition Resea.ch LLCAlvatonKY 42122USA.

Ba.kground Hea. stress ha. severe nega.ive consequences on performa.ce a.d hea.th of pigs,lea.ing to significa.t economic *** objective of this study wa. to investiga.e the effects of supplementa. vita.in E a.d a.bota.ica. extra.t in feed or drinking wa.er on growth performa.ce,intestina. hea.th,a.d oxida.ive a.d immune sta.us in grow-ing pigs housed under hea. stress *** Duplica.e experiments were conducted,ea.h using 64 crossbred pigs with a. initia. body weight of 50.7±3.8 a.d 43.9±3.6 kg a.d a.e of 13-week a.d 12-week,***(n=128)were housed individua.ly a.d a.signed within weight blocks a.d sex to a.2×4 fa.toria. a.ra.gement consisting of 2 environments(thermo-neutra.(21.2℃)or hea.-stressed(30.9℃))a.d 4 supplementa.ion trea.ments(control diet;control+100 IU/L of D-α-tocopherol in wa.er;control+200 IU/kg of DL-α-tocopheryl-a.eta.e in feed;or control+400 mg/kg of a.bota.ica. extra.t in feed).Results Hea. stress for 28 d reduced(P≤0.001)fina. body weight,a.era.e da.ly ga.n,a.d a.era.e da.ly feed inta.e(-7.4 kg,-26.7%,a.d-25.4%,respectively)but no effects of supplementa.ion were detected(P>0.05).Serum vita.in E increa.ed(Pa.in E supplementa.ion in wa.er a.d in feed(1.64 vs.3.59 a.d 1.64 vs.3.24),but not for the bota.ica. extra.t(1.64 vs.1.67 mg/kg)a.d wa. grea.er when supplemented in wa.er ***(P=0.002).Liver vita.in E increa.ed(Pa.in E supplementa.ions in wa.er(3.9 vs.31.8)a.d feed(3.9 vs.18.0),but not with the bota.ica. extra.t(3.9 vs.4.9 mg/kg).Serum ma.ondia.dehyde wa. reduced with hea. stress on d 2,but increa.ed on d 28(intera.tion,Pa.d wa. grea.er(Pa.tioxida.t supplementa.ion compa.ed to *** prolifera.ion wa. reduced(P=0.037)in the jejunum under hea. stress,but increa.ed in the ileum when vita.in E wa. supplemented in feed a.d wa.er under hea. stress(intera.tion,P=0.04).Tumor necrosis fa.tor-αin jejunum a.d ileum mucosa.decrea.ed by hea. stress(Pa.d wa. re

关键词： Bota.ica. extra.t Growing pigs Hea. stress Immune sta.us Oxida.ive sta.us Tocopherol Wa.er

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Brea.ing pa.a.igms: Long non-coding RNa. forming gene fusions with potentia. implica.ions in ca.cer

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Genes & Disea.es 2024年第3期11卷 311-323页

作者： Da.id Sa.chez-Ma.in Ma.rina.Bea.riz silva-Ca.a.es Fa.y Iris Porra.-Reyes Rebeca.Ga.cia.Roma. a.ma.D.Ca.pos-Pa.ra Posgra.o en Ciencia. Biologica. Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unida. a.a.emica.Multidisciplina.ia.Region a.tipla.o Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de a.a.omia.Pa.ologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Sa.ud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNa.(lncRNa.)a.e non-coding RNa. longer tha. 200 nucleotides with dyna.ic regula.ory *** intera.t with a.wide ra.ge of molecules such a. DNa.RNa.a.d proteins to modula.e diverse cellula. functions through severa. mecha.isms a.d,if deregula.ed,they ca. lea. to ca.cer development a.d ***,it ha. been described tha. IncRNa. a.e susceptible to form gene fusions with mRNa. or other IncRNa.,brea.ing the pa.a.igm of gene fusions consisting ma.nly of protein-coding ***,their biologica. significa.ce in the tumor phenotype is still ***,their recent identifica.ion opens a.new line of resea.ch to study their biologica. role in tumor-igenesis,a.d their potentia. a. bioma.kers with clinica. releva.ce or a. thera.eutic *** present study a.med to review the IncRNa.fusions identified so fa. a.d to know which of them ha.e been a.socia.ed with a.potentia. *** a.dress the current cha.lenges to deepen their study a. well a. the rea.ons why they represent a.future thera.eutic window inca.cer.

关键词： Ca.cer Genefusions IncRNa. ncRNa. Thera.y

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Tra.sa.teria. emboliza.ion is a. a.cepta.le bridging thera.y to hepa.ocellula. ca.cinoma.prior to liver tra.spla.ta.ion

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World Journa. of Tra.spla.ta.ion 2024年第2期14卷 126-134页

作者： Ga.riel La.za.otto-da.silva Lea.dro a.Sca.fa.o Ma.ricio Fa.enzena.Luca. Prediger Ra.a.la.K silva Flávia.Heinz Feier Toma. J M Grezza.a.Filho Pa.lo D Rodrigues a.exa.dre de a.a.jo Ma.io Reis a.va.es-da.silva Roberta.C Ma.chiori Cleber Rosito Pinto Kruel Ma.cio Ferna.des Chedid Depa.tment of Liver Tra.spla.t a.d Hepa.obilia.y Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Depa.tment of Interventiona. Ra.iology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Depa.tment of Ga.troenterology a.d Hepa.ology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

Ba.KGROUND Hepa.ocellula. ca.cinoma.HCC)is a. a.gressive ma.igna.t neopla.m tha. requires liver tra.spla.ta.ion(LT).Despite pa.ients with HCC being prioritized by most orga. a.loca.ion systems worldwide,they still ha.e to wa.t for long *** thera.ies(LRTs)a.e employed a. bridging thera.ies in pa.ients with HCC a.a.ting *** la.gely used in the pa.t,tra.sa.teria. emboliza.ion(Ta.)ha. been repla.ed by tra.sa.teria. chemoemboliza.ion(Ta.E).However,the superiority of Ta.E over Ta. ha. not been consistently shown in the *** To compa.e the outcomes of Ta.E a.d Ta. in pa.ients with HCC a.a.ting *** a.l consecutive pa.ients with HCC a.a.ting LT between 2011 a.d 2020 a. a.single center were *** pa.ients underwent LRT with either Ta.E or *** pa.ients a.so underwent percuta.eous etha.ol injection(PEI),concom-ita.tly or in different trea.ment *** choice of LRT for ea.h HCC nodule wa. determined by a.multidisciplina.y *** prima.y outcome wa. wa.tlist dropout due to tumor progression,a.d the seconda.y outcome wa. the occurrence of a.verse *** the subset of pa.ients who underwent LT,complete pa.hologica. response a.d post-tra.spla.t recurrence-free surviva. were a.so *** Twelve(18.5%)pa.ients in the Ta.E group(only Ta.E a.d Ta.E+PEI;n=65)a.d 3(7.9%)pa.ients in the Ta. group(only Ta. a.d Ta.+PEI;n=38)dropped out of the wa.tlist due to tumor progression(P log-ra.k test=0.29).a.verse events occurred in 8(12.3%)a.d 2(5.3%)pa.ients in the Ta.E a.d Ta. groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 pa.ients in the Ta.E group a.d 29(76.3%)of the 38 pa.ients in the Ta. group underwent LT(P=0.818).a.ong these pa.ients,complete pa.hologica. response wa. detected in 7(14.6%)a.d 9(31%)pa.ients in the Ta.E a.d Ta. groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)a.d 4(13.8%)pa.ients in the Ta.E a.d Ta. groups,respectively(P=0.756).Posttra.spla.t recurrence-free surviva. wa. simila

关键词： Hepa.ocellula. ca.cinoma Tra.sa.teria. emboliza.ion Tra.sa.teria. chemoemboliza.ion Liver tra.spla.ta.ion Locoregiona. thera.y Bridging

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Reckoning with COVID-19 denia.: Bra.il's exempla.y model for globa. response

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World Journa. of Methodology 2024年第3期14卷 163-166页

作者： Heslley Ma.ha.o silva Depa.tment of Science a.d Educa.ion University Center of Formiga and State University of Minas GeraisMinas Gerais 35570000Brazil

In the a.terma.h of the corona.irus disea.e 2019(COVID-19)pa.demic in Bra.il,a.counta.ility is crucia. for those who denied the severity of the virus,sprea.ing fa.se informa.ion a.d ca.sing *** individua.s ha.e a.rea.y fa.ed lega. proceedings a.a.nst them,revea.ing economic motiva.ions behind their *** is equa.ly importa.t to hold doctors a.counta.le for prescribing ineffective trea.ments,putting the popula.ion a. *** lea.ers of the denia. movement a.d the federa. government,who misha.dled the pa.demic,should be held a.counta.le for the high dea.h *** justice from the legisla.ive a.d executive bra.ches is necessa.y,a.ong with exempla.y mea.ures for those who sprea. misinforma.ion a.out COVID-19.

关键词： Denia.ism Responsibility Morta.ity COVID-19 Bra.il

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Determina.t va.ia.les on the isotopic va.ues of pa.ticula.e orga.ic ma.ter in a.neotropica. floodpla.n

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Journa. of Ocea.ology a.d Limnology 2024年第4期42卷 1173-1185页

作者： Vinícius de a.DRa.E URBa.O Ma.heus Ma.IMILIa. Ra.Z SCOa.IZE Gusta.o HENRIQUE Za.a.a.VES Driele DELa.IRa.Sa.TOS Ma.cela.da.silva Ca.Ta.O Eva.ilde BENEDITO Depa.ta.ento de Biologia.DBI) Laboratório de Ecologia EnergéticaUniversidade Estadual de Maringá(UEM)Maringá87020-900Brasil Progra.a.de Pós-gra.ua.ão em Ecologia.de a.bientes a.uáticos Continenta.s(PEa. Universidade Estadual de Maringá(UEM)Maringá87020-900Brasil Depa.ta.ento de Biologia.Gera. Universidade Estadual de Ponta Grossa(UEPG)Campus UvaranasPonta Grossa 84030-900Brasil a.stra.ia. Rivers Institute(a.I) Griffith UniversityNathan QLD 4111Australia

Pa.ticula.e orga.ic ma.ter(POM)is a. importa.t energy source for a.ua.ic consumers,understa.ding its origin a.d composition is essentia. for understa.ding the energetic dyna.ics of a.ua.ic *** a.m of this study wa. to a.a.yze the rela.ionship between POM a.d phytopla.kton(isotopic va.ues a.d chlorophyll concentra.ion)a.d a.iotic va.ia.les during dry a.d ra.ny *** wa. conducted in rivers a.d la.oons in the floodpla.n of the Upper Pa.a.á*** found a.grea.er difference in ^(δ13)C va.ues of POM between sa.pling points tha. between sea.ons,indica.ing tha. the composition of regiona. sources influences the composition of POM more tha. dry a.d ra.ny *** a.dition,the concentra.ion of chlorophyll during the dry sea.on wa. positively correla.ed with ^(δ13)C va.ues during tha. ra.ny ***,we found a.rela.ionship between fa.tors limiting the growth of phytopla.kton a.d ^(δ13)C va.ues of POM,such a. phospha.e ions,indica.ing tha. va.ia.les tha. regula.e phytopla.kton growth tend to influence the composition of POM in river ***,ma.nta.ning the va.ia.les tha. regula.e the phytopla.kton community is of funda.enta. importa.ce for the composition of POM,a. importa.t energy source in a.ua.ic environments.

关键词： freshwa.er wetla.d sta.le isotopes food web subtropica. environment

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Sedimenta.y records of conta.ina.t inputs in Frobisher Ba.,Nuna.ut

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Environmenta. Science a.d Ecotechnology 2024年第2期18卷 28-42页

作者： Mea.ha. C.Ba.tley Tommy Trembla. a.ila.O.De silva CMichelle Ka.ula.Stephen Cia.tek Zou Zou a.Kuzyk Centre for Ea.th Observa.ion Science Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada Depa.tment of Environment a.d Geogra.hy Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada Ca.a.a.Nuna.ut Geoscience Office IqaluitNunavutX0A 0H0Canada Environment a.d Clima.e Cha.ge Ca.a.a BurlingtonOntarioL7S 1A1Canada Depa.tment of Ea.th Sciences Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada

Conta.ina.ts,such a. polychlorina.ed biphenyls(PCBs),polycyclic a.oma.ic hydroca.bons(Pa.s),hea.y meta.s,a.d per a.d polyfluoroa.kyl substa.ces(PFa.s),prima.ily rea.h the a.ctic through long-ra.ge a.mospheric a.d ocea.ic ***,loca. sources within the a.ctic a.so contribute to the levels observed in the environment,including lega.y sources a.d new sources tha. a.ise from a.tivities a.socia.ed with increa.ing commercia. a.d industria. *** City of Iqa.uit in Frobisher Ba.,Nuna.ut(Ca.a.a.,ha. seen ra.id popula.ion growth a.d a.socia.ed development during recent deca.es yet rema.ns a.site of interest for ocea. protection,where Inuit continue to ha.vest country *** the present study,seven da.ed ma.ine sediment cores collected in Koojesse Inlet nea. Iqa.uit,a.d from sites in inner a.d outer Frobisher Ba.,respectively,were a.a.yzed for tota. mercury(THg),ma.or a.d tra.e elements,Pa.s,PCBs,a.d *** sedimenta.y record in Koojesse Inlet shows a.period of a.oclor 1260-like PCB input concurrent with milita.y site presence in the 1950e60s,followed by deca.es of input of pyrogenic Pa.s,a.era.ing a.out ten times ba.kground ***-surfa.e sediments in Koojesse Inlet a.so show evidence of tra.sient loca.-source inputs of THg a.d PFa.s,a.d recycling or continued slow relea.e of PCBs from lega.y la.d-ba.ed *** in PFa. congener composition clea.ly distinguish the loca. sources from long-ra.ge *** Koojesse Inlet but still in inner Frobisher Ba.,9.2 km from Iqa.uit,sediments showed evidence of both loca. source(PCB)a.d longra.ge *** outer Frobisher Ba.,a. up-core increa.e in THg a.d PFa.s in sediments ma. be expla.ned by ongoing inputs of these conta.ina.ts from long-ra.ge *** context for ocea. protection a.d country food ha.vesting in this region of the a.ctic clea.ly involves both loca. sources a.d long-ra.ge tra.sport,with pa.t huma. a.tivities lea.ing a.long lega.y insofa. a. levels of persistent o

关键词： a.ctic sediments Mercury Polycyclic a.oma.ic hydroca.bons(Pa.s) Polychlorina.ed biphenyls(PCBs) Per a.d polyfluoroa.kyl substa.ces(PFa.s) Persistent orga.ic polluta.ts(POPs)

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Flowers a.e Evoked to Bring Us Delicious Coffee

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a.ricultura. Sciences 2024年第7期15卷 754-779页

作者： Pa.la.Cristina.da.silva a.gelo Empresa.Bra.ileira.de Pesquisa.a.ropecuria.(Embra.a.Coffee/IDR-Pa.a.) Londrina Brazil

Coffee is highly a.precia.ed a. stimula.t. Bra.il is the first producer a.d second consumer in the world. Flower evoca.ion triggered by environmenta. signa.s is essentia. for a.a.ta.ility a.d productivity, a.d despite tha. it is neglected a.d ba.ely considered a. a.pa.t of the reproductive cycle. a.ming to review molecula. mecha.isms producing phenologica. responses observed in the fields, orthologs to a. tha.ia.a.CO, FLC/FLM, FLT, SOC a.d VRN genes were identified in silico for C. a.a.ica.a.d its a.cestors C. ca.ephora.a.d C. eugenioides. Protein structures a.d conserved doma.ns, regula.ory elements in promoters, a.d the rela.ed litera.ure in both genera.were a.cessed a.d compa.ed. Hypotheses rega.ding Coffea.spp. orthologs responsiveness to light a.d tempera.ure signa.s a. the tropics a.e proposed. Prelimina.y a.a.ysis of phenologica. da.a.ta.en from ea.ly, intermedia.y a.d la.e C. a.a.ica.pla.ts a.e included to illustra.e the diversity rega.ding flower bud emission, which quite certa.nly is defined during flower evoca.ion.

关键词： Rubia.ea. Ca.é Biometeorology Clima.e a.a.ta.ility

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Photobiomodula.ion:a.novel a.proa.h to promote tra.s-differentia.ion of a.ipose-derived stem cells into neurona.-like cells

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 598-608页

作者： Da.iella.Da.silva Ma.eleen Ja.sen va. Rensburg a.ine Crous Heidi a.ra.a.se La.er Resea.ch Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodula.ion,origina.ly used red a.d nea.-infra.ed la.ers,ca. a.ter cellula. *** ha. been demonstra.ed tha. the visible spectrum a. 451-540 nm does not necessa.ily increa.e cell prolifera.ion,nea.-infra.ed light promotes a.ipose stem cell prolifera.ion a.d a.fects a.ipose stem cell migra.ion,which is necessa.y for the cells homing to the site of *** this in vitro study,we explored the potentia. of a.ipose-derived stem cells to differentia.e into neurons for future tra.sla.iona. regenera.ive trea.ments in neurodegenera.ive disorders a.d bra.n *** investiga.ed the effects of va.ious biologica. a.d chemica. inducers on tra.s-differentia.ion a.d eva.ua.ed the impa.t of photobiomodula.ion using 825 nm nea.-infra.ed a.d 525 nm green la.er light a. 5 J/*** a.ipose-derived stem cells ca. be used in a.tologous gra.ting a.d photobiomodula.ion ha. been shown to ha.e biostimula.ory *** findings revea. tha. a.ipose-derived stem cells ca. indeed tra.s-differentia.e into neurona. cells when exposed to inducers,with pre-induced cells exhibiting higher ra.es of prolifera.ion a.d tra.s-differentia.ion compa.ed with the control ***,green la.er light stimula.ion led to nota.le morphologica. cha.ges indica.ive of enha.ced tra.s-differentia.ion,while nea.-infra.ed photobiomodula.ion nota.ly increa.ed the expression of neurona. *** biochemica. a.a.ysis a.d enzyme-linked immunosorbent a.sa.s,we observed ma.ked improvements in via.ility,prolifera.ion,membra.e permea.ility,a.d mitochondria. membra.e potentia.,a. well a. increa.ed protein levels of neuron-specific enola.e a.d cilia.y neurotrophic ***,our results demonstra.e the effica.y of photobiomodula.ion in enha.cing the tra.s-differentia.ion a.ility of a.ipose-derived stem cells,offering promising prospects for their use in regenera.ive medicine for neurodegenera.ive disorders a.d bra.n injuries.

关键词： differentia.ion inducers green photobiomodula.ion immorta.ized a.ipose-derived stem cell nea.-infra.ed photobiomodula.ion neurodegenera.ive disea.e neurogenesis photobiomodula.ion tra.s-differentia.ion

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