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Adjuvant therapy for hepatocellular carcinoma:Dilemmas at the start of a new era

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World Journal of Gastroenterology 2024年第8期30卷 806-810页

作者： Jian-hong Zhong Department of Hepatobiliary Surgery Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina

Approximately 50%-70%of patients with hepatocellular carcinoma experience recurrence within five years after curative hepatic resection or *** a result,many patients receive adjuvant therapy after curative resection or ablation in order to prolong recurrence-free *** therapy recommended by national guidelines can differ,and guidelines do not specify when to initiate adjuvant therapy or how long to continue *** and other unanswered questions around adjuvant therapies make it difficult to optimize them and determine which may be more appropriate for a given type of *** questions need to be addressed by clinicians and researchers.

关键词： Adjuvant therapy Hepatocellular carcinoma Tumor recurrence unanswered questions

Review on synergistic damage effect of irradiation and corrosion on reactor structural alloys

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Nuclear Science and Techniques 2024年第3期35卷 109-141页

作者： Hui Liu Guan-hong Lei He-Fei Huang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

The synergistic damage effect of irradiation and corrosion of reactor structural materials has been a prominent research *** paper provides a comprehensive review of the synergistic effects on the third-and fourth-generation fission nuclear energy structural materials used in pressurized water reactors and molten salt *** competitive mechanisms of multiple influencing factors,such as the irradiation dose,corrosion type,and environmental temperature,are summarized in this *** approaches are proposed to alleviate the synergistic damage caused by irradiation and corrosion,thereby promoting in-depth research in the future and solving this key challenge for the structural materials used in reactors.

关键词： Irradiation and corrosion Synergistic effect Austenitic stainless steels Nickel-based alloys Reactors

Optimized the vanadium electrolyte with sulfate-phosphoric mixed acids to enhance the stable operation at high-temperature

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Frontiers of Chemical Science and Engineering 2024年第2期18卷 13-26页

作者： Ling Ge Tao Liu Yimin Zhang hong Liu School of Resource and Environmental Engineering Wuhan University of Science and TechnologyWuhan 430081China State Environmental Protection Key Laboratory of Mineral Metallurgical Resources Utilization and Pollution Control Wuhan University of Science and TechnologyWuhan 430081China Hubei Collaborative Innovation Center for High Efficient Utilization of Vanadium Resources Wuhan University of Science and TechnologyWuhan 430081China Hubei Provincial Engineering Technology Research Center of High Efficient Cleaning Utilization for Shale Vanadium Resource Wuhan University of Science and TechnologyWuhan 430081China School of Resource and Environmental Engineering Wuhan University of TechnologyWuhan 430070China

Herein, the influence of the concentration design and comprehensive performance of the sulfate-phosphoric mixed acid system electrolyte is investigated to realize an electrolyte that maintains high energy density and stable operation at high temperatures. Static stability tests have shown that VOPO4 precipitation occurs only with vanadium(V) electrolyte. The concentration of vanadium ion of 2.0–2.2 mol·L^(–1), phosphoric acid of 0.10–0.15 mol·L^(–1), and sulfuric acid of 2.5–3.0 mol·L^(–1) are suitable for a vanadium redox flow battery in the temperature range from –20 to 50 ℃. The equations for predicting the viscosity and conductivity of electrolytes are obtained by the response surface method. The optimized electrolyte overcomes precipitation generation. It has 2.8 times higher energy density than the non-phosphate electrolyte, and a coulomb efficiency of 94.0% at 50 ℃. The sulfate-phosphoric mixed acid system electrolyte promotes the electrode reaction process, increases the current density, and reduces the resistance. This work systematically optimizes the concentrations of composition of positive and negative vanadium electrolytes with mixed sulfate-phosphoric acid. It provides a basis for the different valence states and comprehensive properties of sulfate-phosphoric mixed acid system vanadium electrolytes under extreme environments, guiding engineering applications.

关键词： all vanadium redox flow battery mixed-acid vanadium electrolyte concentration optimization response surface methodology high-temperature stability

Exogeneous metal ions as therapeutic agents in cardiovascular disease and their delivery strategies

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Regenerative Biomaterials 2024年第2期3卷 1-16页

作者： Xiaoqian hong Geer Tian Yang Zhu Tanchen Ren Department of Cardiology of the Second Affliated Hospital and State Key Laboratory of Transvascular Implantation Devices Cardiovascular Key Laboratory of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310o09China Binjiang Institute of Zhejiang university Hangzhou 310053China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Metal ions participate in many metabolic processes in the human body,and their homeostasis is crucial for *** cardiovascular diseases(CVDs),the equilibriums of metal ions are frequently interrupted,which are related to a variety of disturbances of physiological processes leading to abnormal cardiac *** supplement of metal ions has the potential to work as therapeutic strategies for the treatment of *** with other therapeutic drugs,metal ions possess broad availability,good stability and safety and diverse drug delivery *** delivery strategies of metal ions are important to exert their ther-apeutic effects and reduce the potential toxic side effects for cardiovascular applications,which are also receiving increasing *** local delivery strategies for metal ions based on various biomaterials are constantly being *** this review,we comprehensively summarized the positive roles of metal ions in the treatment of cVDs from three aspects:protecting cells from oxidative stress,inducing angiogenesis,and adjusting the functions of ion *** addition,we introduced the transferability of metal ions in vascular reconstruction and cardiac tissue repair,as well as the currently available engineered strategies for the precise delivery of metal ions,such as integrated with nanoparticles,hydrogels and scaffolds.

关键词： metal ions cardiovascular disease tissue engineering oxidative stress angiogenesis ion channel

An innovative heterogeneous transfer learning framework to enhance the scalability of deep reinforcement learning controllers in buildings with integrated energy systems

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Building Simulation 2024年第5期17卷 739-770页

作者： Davide Coraci Silvio Brandi Tianzhen hong Alfonso Capozzoli Politecnico di Torino Department of EnergyTEBE research groupBAEDA Lab.Corso Duca degli Abruzzi 24Torino10129Italy Building Technology and Urban Systems Division Lawrence Berkeley National LaboratoryOne Cyclotron RoadBerkeleyCA 94720USA

Deep Reinforcement Learning(DRL)-based control shows enhanced performance in the management of integrated energy systems when compared with Rule-Based Controllers(RBCs),but it still lacks scalability and generalisation due to the necessity of using tailored models for the training *** Learning(TL)is a potential solution to address this ***,existing TL applications in building control have been mostly tested among buildings with similar features,not addressing the need to scale up advanced control in real-world scenarios with diverse energy *** paper assesses the performance of an online heterogeneous TL strategy,comparing it with RBC and offline and online DRL controllers in a simulation setup using EnergyPlus and *** study tests the transfer in both transductive and inductive settings of a DRL policy designed to manage a chiller coupled with a Thermal Energy Storage(TES).The control policy is pre-trained on a source building and transferred to various target buildings characterised by an integrated energy system including photovoltaic and battery energy storage systems,different building envelope features,occupancy schedule and boundary conditions(e.g.,weather and price signal).The TL approach incorporates model slicing,imitation learning and fine-tuning to handle diverse state spaces and reward functions between source and target *** show that the proposed methodology leads to a reduction of 10% in electricity cost and between 10% and 40% in the mean value of the daily average temperature violation rate compared to RBC and online DRL ***,online TL maximises self-sufficiency and self-consumption by 9% and 11% with respect to ***,online TL achieves worse performance compared to offline DRL in either transductive or inductive ***,offline Deep Reinforcement Learning(DRL)agents should be trained at least for 15 episodes to reach the same level of performance as the online

关键词： transfer learning reinforcement learning building control building energy management

Advanced Design of Soft Robots with Artificial Intelligence

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Nano-Micro Letters 2024年第10期16卷 474-521页

作者： Ying Cao Bingang Xu Bin Li hong Fu Nanotechnology Center School of Fashion and TextilesThe Hong Kong Polytechnic UniversityHong Kong 999077People's Republic of China Department of Mathematics and Information Technology The Education University of Hong KongHong Kong 999077People's Republic of China Bioinspired Engineering and Biomechanics Center Xi'an Jiaotong UniversityXi'an 710049People's Republic of China

In recent years,breakthrough has been made in the field of artificial intelligence(AI),which has also revolutionized the industry of *** robots featured with high-level safety,less weight,lower power consumption have always been one of the research ***,multifunctional sensors for perception of soft robotics have been rapidly developed,while more algorithms and models of machine learning with high accuracy have been optimized and *** of soft robots with AI have also been advanced ranging from multimodal sensing,human-machine interaction to effective actuation in robotic ***-less,comprehensive reviews concerning the new developments and strategies for the ingenious design of the soft robotic systems equipped with AI are ***,the new development is systematically reviewed in the field of soft robots with ***,background and mechanisms of soft robotic systems are briefed,after which development focused on how to endow the soft robots with AI,including the aspects of feeling,thought and reaction,is ***,applications of soft robots with AI are systematically summarized and discussed together with advanced strategies proposed for performance *** thoughts for future intelligent soft robotics are pointed ***,some perspectives are put forward.

关键词： Soft robotic systems Artificial intelligence Design tactics Review and perspective

Multi-Objective Optimization of VBHF in Deep Drawing Based on the Improved QO-Jaya Algorithm

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 189-202页

作者： Xiangyu Jiang Zhaoxi hong Yixiong Feng Jianrong Tan State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province Zhejiang UniversityHangzhou 310027China Ningbo Innovation Center Zhejiang UniversityNingbo 315100China

Blank holder force(BHF)is a crucial parameter in deep drawing,having close relation with the forming quality of sheet ***,there are different BHFs maintaining the best forming effect in different stages of deep *** variable blank holder force(VBHF)varying with the drawing stage can overcome this problem at an *** optimization of VBHF is to determine the optimal BHF in every deep drawing *** this paper,a new heuristic optimization algorithm named Jaya is introduced to solve the optimization *** improved“Quasi-oppositional”strategy is added to Jaya algorithm for improving population ***,an innovated stop criterion is added for better ***,the quality evaluation criteria for wrinkling and tearing are ***,the Kriging models are developed to approximate and quantify the relation between VBHF and forming defects under random ***,the optimization models are established and solved by the improved QO-Jaya algorithm.A VBHF optimization example of component with complicated shape and thin wall is studied to prove the effectiveness of the improved Jaya *** optimization results are compared with that obtained by other algorithms based on the TOPSIS method.

关键词： Variable blank holder force Multi-objective optimization QO-Jaya algorithm Algorithm stop criterion

Reynolds-number scaling analysis on lift generation of a flapping and passive rotating wing with an inhomogeneous mass distribution

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Chinese Journal of Aeronautics 2024年第2期37卷 259-269页

作者： Suyang QIN Haotian HANG Yang XIANG hong LIU J.C.Wu center for aerodynamics school of aeronautics and astronauticsshanghai jiao tong universityshanghai 200240china

Insects usually fly by passively rotating wings,which has been applied to the design of flapping-wing Micro-Air Vehicles(MAVs)to reduce mechanical *** this paper,a robotic passive rotating-wing model is designed to investigate wing kinematics and lift generation,which are measured by a high-speed camera and a force transducer,*** addition,flow fields are measured using the Particle Image Velocimetry(PIV).Experimental results demonstrate that passive rotating motion has a coordinative relationship with actively stroking *** the stroke amplitude or frequency increases,the rotating amplitude is *** characterize the active stroking motion,a driving Reynolds number Redrivingis defined,which varies from 68 to 366 in this *** the gravity center of the wing towards trailing ed ge induces the increase of additional torque M,which decreases the wing rotating amplitude and promotes the advance of wing *** find that the timing of wing rotation is gradually delayed and the mean lift coefficient C^(-)_(L)monotonously decreases as *** increasing the additional torque M,C^(-)_(L)is slightly improved and approaches to the lift coefficient of a real fruit fly at driving Re approximately equal to *** instantaneous lifts combined with the vortical structures further demonstrate that the lift generation associated with wing rotation is mainly attributed to the growth of the LeadingEdge Vortex(LEV)and the passive wake capture *** wake capture is influenced by LEV,reversal stroke motion and wing additional torque together,which can only maintain the lift at a high level for a considerable *** high-lift generation mechanisms of flapping and passive rotating flight could shed light on the simplified design of MAVs and the improvement of their aerodynamic performance.

关键词： Flapping flight unsteady lift Passive rotation Vortex flow Leading-edge vortex

A Bio-Inspired Integration Model of Basal Ganglia and Cerebellum for Motion Learning of a Musculoskeletal Robot

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Journal of Systems Science & Complexity 2024年第1期37卷 82-113页

作者： ZHANG Jinhan CHEN Jiahao Zhong Shanlin QIAO hong State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China.

It is a significant research direction for highly complex musculoskeletal robots that how to develop the ability of motion learning and *** cooperations of multiple brain regions are crucial to improving motion *** by the neural mechanisms of structures,functions,and interconnections of basal ganglia and cerebellum,a biologically inspired integration model for motor learning of musculoskeletal robots is *** on the neural characteristics of the basal ganglia,the basal ganglia actor network,which mainly simulates the dorsal striatum,outputs motion commands,and the basal ganglia critic network,which simulates the ventral striatum,estimates actionstate *** network parameters are updated using the soft actor-critic *** on the sensorimotor prediction mechanism of the cerebellum,the cerebellum network evaluates the state feature extraction quality of the basal ganglia actor network and then updates the weights of its feature *** learning method is proven to converge to the optimal ***,drawing on the mechanism of dopaminergic dynamic regulation in the basal ganglia,the adaptive adjustment of target entropy and the dopaminergic experience replay are proposed to further improve the integration model,which contributes to the exploration-exploitation trade-off of motor *** bio-inspired integration model is validated on a musculoskeletal *** results indicate that this model can effectively control the musculoskeletal robot to accomplish the motion task from random starting locations to random target positions with high precision and robustness.

关键词： Basal ganglia and cerebellum bio-inspired integration model motion learning musculoskeletal robot reinforcement learning.