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Decoding complexity: the need to enhance precision and streamline spatial understanding in neuroscience

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Neural Regeneration Research 2025年第3期20卷 801-802页

作者： Sameehan Mahajani Armita Salahi Brenda Gonzalez Charlotte Nelson frank Hsiung Biology&Applications Division NodexusSan JoseCAUSA

Neuroscience is the ultimate frontier in our quest for a comprehensive understanding of human behavior. Since its launch in 2009, the Human Connectome Project has emerged as a pioneering force, making heroic strides i... 详细信息

关键词： behavior frontier dating

Liver sinusoidal endothelial and biliary cell repopulation following irradiation and partial hepatectomy

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World Journal of Gastroenterology 2010年第31期16卷 3928-3935页

作者： Petra Krause Margret Rave-frank hendrik Andreas Wolff Heinz Becker Hans Christiansen Sarah Koenig Department of General Surgery University Medical Centre Goettingen Department of Radiotherapy University Medical Cen-tre Goettingen

AIM: To investigate whether irradiation (IR) and partial hepatectomy (PH) may prepare the host liver for nonparenchymal cell (NPC) ***: Livers of dipeptidyl peptidase(DPP)-deficient rats were pre-conditioned with external beam IR (25 Gy) delivered to two-thirds of the right liver lobules followed by a one-third PH of the untreated lob-ule. DPP-positive liver cells (NPC preparations enriched for liver sinusoidal endothelial cells (LSECs) and hepatocytes) were transplanted via the spleen into the recipient livers. The extent and quality of donor cell engraftment and growth was studied over a long-term interval of 16 wk after ***: Host liver staining demonstrated 3 different repopulation types. Well def ined clusters of donor-derived hepatocytes with canalicular expression of DPP were detectable either adjacent to or in between large areas of donor cells (covering up to 90% of the section plane) co-expressing the endothelial marker platelet endothelial cell adhesion molecule. The third type consisted of formations of DPP-positive duct-like structures which co-localized with biliary epithelial ***: Liver IR and PH as a preconditioning stimulus enables multiple cell liver repopulation by donor hepatocytes, LSECs, and bile duct cells.

关键词： Cell transplants Dipeptidyl peptidase protein Endothelial cells Liver cell transplantation Liver irradiation Liver repopulation

Role of mucosal dendritic cells in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第33期14卷 5138-5148页

作者： Jan hendrik Niess Department of Internal Medicine I Ulm UniversityUlm 89031 Germany

The gastrointestinal innate and adaptive immune system continuously faces the challenge of potent stimuli from the commensal microflora and food constituents. These local immune responses require a tight control, the outcome of which is in most cases the induction of tolerance. Local T cell immunity is an important compartment of the specif ic intestinal immune system. T cell reactivity is programmed during the initial stage of its activation by professional presenting cells. Mucosal dendritic cells (DCs) are assumed to play key roles in regulating immune responses in the antigen-rich gastrointestinal environment. Mucosal DCs are a heterogeneous population that can either initiate (innate and adaptive) immune responses, or control intestinal inflammation and maintain tolerance. Defects in this regulation are supposed to lead to the two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC). This review will discuss the emerging role of mucosal DCs in regulating intestinal inflammation and immune responses.

关键词： Dendritic cells Commensal Inflammatory bowel disease Mucosal immunity Host defence

Urbanization between compactness and dispersion:designing a spatial model for measuring 2D binary settlement landscape configurations

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International Journal of Digital Earth 2019年第6期12卷 679-698页

作者： Hannes Taubenbock Michael wurm Christian GeiB Stefan Dech Stefan Siedentop German Aerospace Center(DLR) German Remote Sensing Data Center(DFD)OberpfaffenhofenGermany ILS-Research Institute for Regional and Urban Development DortmundGermany

Measuring spatial patterns is a crucial task in spatial *** indicators have been developed to measure patterns in a quantitative ***,most comparative studies rely on relative comparisons,limiting their explanatory power to specific case *** by advancements in earth observation providing unprecedented resolutions of settlement patterns,this paper suggests a measurement technique for spatial patterns to overcome the limits of relative *** design a model spanning a feature space based on two metrics-largest patch index and number of *** feature space is defined as‘dispersion index’and covers the entire spectrum of possible two-dimensional binary(settlement)*** model configuration allows for an unambiguous ranking of each possible pattern with respect to spatial *** spatial resolutions of input data as well as selected areas of interest influence measurement results,we test dependencies within the ***,common other spatial metrics are selected for testing whether they allow unambiguous *** scenarios,we apply the model to artificially generated patterns representing all possible configurations as well as to real-world settlement classifications differing in growth dynamics and patterns.

关键词： Land cover spatial patterns landscape metrics dispersion index sensitivity analysis urban settlements remote sensing comparative spatial analysis

Urbanization in China from the end of 1980s until 2010 – spatial dynamics and patterns of growth using EO-data

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International Journal of Digital Earth 2019年第1期12卷 78-94页

作者： Lifeng Shia Hannes Taubenböck Zengxiang Zhang Fang Liu Michael wurm Institute of Remote Sensing and Digital Earth Chinese Academy of SciencesBeijingPeople’s Republic of China University of Chinese Academy of Sciences BeijingPeople’s Republic of China German Remote Sensing Data Center(DFD) German Aerospace Center(DLR)OberpfaffenhofenGermany

Urbanization in China has been experiencing a remarkable dynamism in the past 40 *** most evident implication of urbanization is the physical growth of *** analyze urban land growth rates and changes in spatial urban forms from the end of the 1980s to 2010 based on the authoritative National Land Use/Cover Database of *** present new spatial measures that describe‘urban land growth types’and‘fluctuations in urban land growth’within the monitoring time span with a temporal interval of five-year *** evaluate the correlations between urban land growth rates and socioeconomic *** show that(1)distinct characteristics exist on the spatiotemporal evolutions of urban land growth rates in terms of area and perimeter,*** areas exhibit the most dramatic growth rates;(2)the spatial distribution characteristics of‘urban land growth types’and‘fluctuations in urban land growth’follow similar spatial patterns across China,*** differences exist between the eastern region and other regions;and(3)a moderate correlation exists between urban area growth rate and urban population growth rate at an R2 of *** contrast,we determine no significant correlation between urban area growth rate and tertiary industry value growth rate.

关键词： Urban land growth pattern spatial metrics remote sensing regional difference

Realising Data-Centric Scientific Workflows with Provenance-Capturing on Data Lakes

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Data Intelligence 2022年第2期4卷 426-438页

作者： hendrik Noltet Philipp Wieder Gesellschaft fur wissenschaftliche Datenverarbeitung mbH Gottingen Gottingen Gottingen 37077Germany

Since their introduction by James Dixon in 2010,data lakes get more and more attention,driven by the promise of high reusability of the stored data due to the schema-on-read *** on this idea,several additional requirements were discussed in literature to improve the general usability of the concept,like a central metadata catalog including all provenance information,an overarching data governance,or the integration with(high-performance)processing *** the necessity for a logical and a physical organisation of data lakes in order to meet those requirements is widely recognized,no concrete guidelines are yet *** most common architecture implementing this conceptual organisation is the zone architecture,where data is assigned to a certain zone depending on the degree of *** paper discusses how FAIR Digital Objects can be used in a novel approach to organize a data lake based on data types instead of zones,how they can be used to abstract the physical implementation,and how they empower generic and portable processing capabilities based on a provenance-based approach.

关键词： Data lake Provenance Workflows FAIRDigital Objects CWFR

Accurate simulation of surfaces and interfaces of ten FCC metals and steel using Lennard–Jones potentials

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npj Computational Materials 2021年第1期7卷 205-219页

作者： Krishan Kanhaiya Seonghan Kim Wonpil Im hendrik Heinz Department of Chemical and Biological Engineering University of Colorado at BoulderBoulderCO 80301USA Departments of Biological Sciences Chemistryand BioengineeringLehigh UniversityBethlehemPA 18015USA

The earlier integration of validated Lennard–Jones(LJ)potentials for 8 fcc metals into materials and biomolecular force fields has advanced multiple research fields,for example,metal–electrolyte interfaces,recognition of biomolecules,colloidal assembly of metal nanostructures,alloys,and *** we introduce 12-6 and 9-6 LJ parameters for classical all-atom simulations of 10 further fcc metals(Ac,Ca(α),Ce(γ),Es(β),Fe(γ),Ir,Rh,Sr(α),Th(α),Yb(β))and stainless *** parameters reproduce lattice constants,surface energies,water interfacial energies,and interactions with(bio)organic molecules in 0.1 to 5%agreement with experiment,as well as qualitative mechanical properties under standard *** are reduced up to a factor of one hundred in comparison to earlier Lennard–Jones parameters,embedded atom models,and density functional *** also explain a quantitative correlation between atomization energies from experiments and surface energies that supports parameter *** models are computationally very efficient and applicable to an exponential space of *** with a wide range of force fields such as the Interface force field(IFF),AMBER,CHARMM,COMPASS,CVFF,DREIDING,OPLS-AA,and PCFF enables reliable simulations of nanostructures up to millions of atoms and microsecond time ***-friendly model building and input generation are available in the CHARMM-GUI Nanomaterial *** a limitation,deviations in mechanical properties vary and are comparable to DFT *** discuss the incorporation of reactivity and features of the electronic structure to expand the range of applications and further increase the accuracy.

关键词： steel metals qualitative

Rationally designed treatment for metastatic colorectal cancer:Current drug development strategies

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World Journal of Gastroenterology 2014年第30期20卷 10288-10295页

作者： Pavlina Spiliopoulou hendrik-Tobias Arkenau Drug Development Unit Sarah Cannon Research Institute United KingdomLondon W1G 6ADUnited Kingdom UCL Cancer Institute Medical OncologyUniversity College LondonLondon WC1E 6BTUnited Kingdom

The therapeutic landscape of metastatic colorectal cancer(mCRC)has changed substantially with the emergence of new molecularly targeted agents(MTA)usedas single agents or alongside standard *** use of these MTAs extended the overall survival ofpatients with mCRC to a level that current chemotherapeutics alone could not *** addition,improvement in surgical techniques and ablation modalities offer cure to a limited subset of patients with mCRC andMTAs have been found to have a significant role heretoo,as they aid ***,for the majority of patients,mCRC remains an invariably incurabledisease necessitating continued courses of combinedtreatment *** the course of these treatments,either cytotoxic or biological,cancer cells maintain their ability to acquire mitogenic mutations whichrender them resistant to *** challengesremain to identify appropriate subsets of patients whowill most likely benefit from these new MTAs and effectively select these based on validated ***,better knowledge of the biology of colorectal cancer and the mechanisms via which it bypasses blockade of known signalling pathways will help us design better and more rational sequencing of these treatments,so that we can maximise the survivorship of mCRC *** review outlines treatment strategies for known molecular alterations with new MTAs and highlights some promising strategies.

关键词： Colorectal cancer Molecularly targeted therapies Drug development

Correlation of Lopingian to Middle Triassic Palynozones

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Journal of Earth Science 2018年第4期29卷 755-777页

作者： hendrik Nowak Elke Schneebeli-Hermann Evelyn Kustatscher Museum of Nature South Tyrol Bindergasse/Via Bottai 1 Bozen/Bolzano 39100 Italy Palaiontologisehes Institut und Museum Karl-Schmid-Strasse 4 Zurich 8006 Switzerland Department for Geo- und Umweltwissenschafien Pala'ontologie und Geobiologie Ludwig-Maximilians-Universitait and Bayerische Staatssammlung Jur P alaiontologie und Geob iologie Richard-Wagner-Strafle 10 Munchen 80333 Germany

Terrestrial floras underwent important changes during the Lopingian （Late Permian）, Early Triassic, and Middle Triassic, i.e., before, during, and after the end-Permian mass extinction. An accurate account of these developments requires reliable correlation. Macrofossils of land plants can only provide a low-resolution biostratigraphy, while detailed zonation schemes based on palynomorphs are available for many regions. Their applicability is still limited due to several factors, such as （micro-）floral provincialism, a lack of suitable marker taxa commonly occurring at important boundaries, and in many cases a lack of independent age control. Nevertheless, these palynostratigraphic schemes are regularly used for dating and correlation of successions between different regions. To support such efforts, the biozonation schemes based on palynomorphs from the Lopingian up to and including the Middle Triassic from across the world are summarized and revised. Thus, a consistent correlation of palynozones with the currently recognized international stages is established.

关键词： Permian Triassic land plants palynomorpbs biostratigraphy.