检索结果-南通市图书馆

Neural Regeneration Research 2025年第3期20卷 801-802页

作者： Sameehan Mahajani Armita Salahi Brenda gonzalez Charlotte Nelson frank Hsiung Biology&Applications Division NodexusSan JoseCAUSA

Neuroscience is the ultimate frontier in our quest for a comprehensive understanding of human behavior. Since its launch in 2009, the Human Connectome Project has emerged as a pioneering force, making heroic strides i... 详细信息

关键词： behavior frontier dating

Translating Pathological Brain Activity Primers in Parkinson’s Disease Research

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research 2024年第1期2023卷 735-752页

作者： Daniela Mirzac Svenja L.Kreis Heiko j.Luhmann Gabriel gonzalez-Escamilla Sergiu Groppa Movement Disorders and Neurostimulation Department of NeurologyFocus Program Translational NeuroscienceRhine Main Neuroscience NetworkUniversity Medical Center of the Johannes Gutenberg University Mainz55131 MainzGermany Institute of Physiology University Medical Center of the Johannes Gutenberg University Mainz55131 MainzGermany

Translational experimental approaches that help us better trace Parkinson’s disease(PD)pathophysiological mechanisms leading to new therapeutic targets are urgently *** this article,we review recent experimental and clinical studies addressing abnormal neuronal activity and pathological network oscillations,as well as their underlying mechanisms and *** aim is to enhance our knowledge about the progression of Parkinson's disease pathology and the timing of its symptom’s ***,we present mechanistic insights relevant for the generation of aberrant oscillatory activity within the cortico-basal ganglia *** summarize recent achievements extrapolated from available PD animal models,discuss their advantages and limitations,debate on their differential applicability,and suggest approaches for transferring knowledge on disease pathology into future research and clinical applications.

关键词： clinical knowledge insight

Laser-induced plasma formation in water with up to 400 mj double-pulse LIBS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasma Science and Technology 2024年第1期26卷 93-100页

作者： Marion HENKEL Michelle SIEMENS Ralf METHLING Benjamin EMDE jörg HERMSDORF Steffen frankE Diego gonzalez Leibniz Institute for Plasma Science and Technology(INP) Felix-Hausdorff-Straße 2Greifswald 17489Germany Laser Zentrum Hannover e.V.(LZH) Hollerithallee 8Hannover 30419Germany

Double-pulse LIBS is a promising technique for deep-sea *** measurements in shallow water with up to 400 mj each pulse were done to select laser parameters which promote optimized spectral line emission from plasma even at elevated pressures,where line broadening until loss of most of the spectral information can *** emission spectroscopy,using a Czerny-Turner spectrometer,has been applied to investigate the dependence of the emitted radiation on laser parameters and hydrostatic *** has been found,that higher laser pulse energies,especially with short pulse delay as required in high water pressure,can also have an adverse effect on the measured spectrum.

关键词： double-pulse LIBS underwater plasma formation emission spectrosocpy

基于构效关系研究吴茱萸主要活性成分对芳香烃受体的作用

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于构效关系研究吴茱萸主要活性成分对芳香烃受体的作用

A new approach to pedestal differentiation for soil loss estimation-a case study from a burnt area in north-central Portugal

第三届全国药物代谢动力学青年科学家论坛暨刘昌孝人才奖颁奖大会

作者：张友波严婷婷孙冬雪张雷郑怡然谢岑杨秀伟 frank j.gonzalez 北京大学药学院天然药物及仿生药物国家重点实验室美国国立卫生研究院代谢中心实验室沈阳药科大学中药学院

目的:研究吴茱萸碱,吴茱萸次碱及去氢吴茱萸碱对芳香烃受体的激活作用及构效关系。方法:应用小鼠原代肝细胞研究吴茱萸碱,吴茱萸次碱及去氢吴茱萸碱对芳香烃受体靶基因的表达调控作用;应用双荧光素酶报告基因实验结合分子对接技术和量... 详细信息

目的:研究吴茱萸碱,吴茱萸次碱及去氢吴茱萸碱对芳香烃受体的激活作用及构效关系。方法:应用小鼠原代肝细胞研究吴茱萸碱,吴茱萸次碱及去氢吴茱萸碱对芳香烃受体靶基因的表达调控作用;应用双荧光素酶报告基因实验结合分子对接技术和量子计算研究三个化合物对芳香烃受体激活作用;应用芳香烃受体野生型及敲除小鼠研究三个化合物在体内对芳香烃受体的影响。结果:吴茱萸次碱对芳香烃受体表现出极强的激活作用;三个化合物对芳香烃受体作用强弱顺序为:吴茱萸次碱>去氢吴茱萸碱>吴茱萸碱;14位N原子的立体构型是影响化合物作用强弱的关键因素;三个化合物在体内没有表现出明显的肝毒性。结论:本实验从结构方面阐明了吴茱萸碱,吴茱萸次碱及去氢吴茱萸碱对芳香烃受体激活的强弱作用,为研究吲哚喹啉类生物碱对芳香烃受体的激活机制提供了理论依据。

关键词：吴茱萸碱吴茱萸次碱去氢吴茱萸碱芳香烃受体构效关系

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

journal of Forestry Research 2024年第3期35卷 45-54页

作者： frank G.A.Verheijen Martinho A.S.Martins Sergio A.Prats jan j.Keizer Centre for Environmental and Marine Studies(CESAM) Department Environment and PlanningUniversity of Aveiro3810-193 AveiroPortugal Mediterranean Institute for Agriculture Environment and Development(MED-CHANGE)Institute for Advanced Studies and ResearchUniversity of EvoraPolo da MitraAp.947006-554 EvoraPortugal GeoBiociencias Geotecnologias E Geoengenharias(GEOBIOTEC)Department Environment and PlanningUniversity of Aveiro3810-193 AveiroPortugal

Soil pedestals have long been used as qualitative indicators of soil splash *** rangelands,plant-capped pedestals,generally grass tussocks,have also been used to quantitatively estimate soil loss since the first half of the twentieth *** agricultural lands,forests,and bad-lands,stone-capped pedestals have been used as qualitative and semi-quantitative indicators of active,'extreme'*** work has been reported on using capstone pedestal data for quantifying soil *** postulate that three distinct capstone pedestal types may be present in any given location and that a detailed analysis of a pedestal height histogram may be used to recognize their *** analysis can subsequently inform if soil loss can be reliably estimated and if so,which of the existing methods using pedestal height data will provide more accurate *** three proposed capstone pedestal types are:(1)neo-pedestals formed underneath surface stones exposed by(partial)removal of the soil surface cover;(2)endo-pedestals formed underneath stones that were buried in the soil but have been exposed by erosion;and(3)phoenix-pedestals formed underneath stones from collapsed *** the pedestal height histogram of any given location,a skew to smaller heights may indicate the existence of endo-and/or phoenix-pedestals,which may be revealed as a bi-(or tri)modal distribution when using a smaller bin *** concept was applied to a case study where soil loss had been monitored for control plots and mulched plots during a 5-year period following wildfire in a eucalypt *** measured pedestal heights and used methods to quantitatively assess soil loss from soil pedestal data in the available *** pedestal data at the end of the 5-year period under or overestimated soil loss in the control treatment,with results ranging from 60 to 115%of measured soil loss,depending on the *** is postulated that phoenix-and endo-pedestals may be a driving fact

关键词： Soil pedestals Mulch Wildfire Soil erosion Char

吴茱萸次碱对DSS诱导溃疡性结肠炎的保护作用机制研究

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

吴茱萸次碱对DSS诱导溃疡性结肠炎的保护作用机制研究

Sustained adenosine release:Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells

中国化学会第十二届全国天然有机化学学术会议

作者：张友波严婷婷王天霞孙冬雪谢岑罗雨虹王琼 Kristopher W.Krausz 杨秀伟 frank j.gonzalez 北京大学药学院天然药物学系天然药物及仿生药物国家重点实验室 Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of Health

吴茱萸为芸香科植物吴茱萸[Evodia rutaeearpa (juss.) Benth.]、石虎*** (juss.)*** (Dode) Huang]或疏毛吴茱萸[*** (juss.) ***(Dode) Huang]干燥的近成熟果实,常用于头痛头风及急慢性肠胃炎等症。吴茱萸次碱(rutaecarpine)是吴茱萸药材的重要成分之一,具有抗炎镇痛等多种药理活性4-6。本研究发现吴茱萸次碱具有显著抗氧化应激活性,能够抑制HO诱导的细胞内过氧化物质的生成并呈剂量依赖性关系;免疫荧光实验发现吴茱萸可以促进Nrf2蛋白的核转位;通过表面等离子共振、分子对接、双荧光素酶报告基因检测及定量PCR分析实验,

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Engineered Regeneration

Engineered Regeneration 2024年第2期5卷 255-268页

作者： Hadi Hajiali jane McLaren Cristina gonzalez-García Salah Abdelrazig Dong-Hyun Kim Matthew j.Dalby Manuel Salmerón-Sánchez Felicity R.A.j.Rose School of Pharmacy Nottingham Biodiscovery InstituteUniversity of NottinghamNottinghamUK Healthcare Technologies Institute School of Chemical EngineeringUniversity of BirminghamBirminghamUK Centre for the Cellular Microenvironment University of GlasgowGlasgowUK Centre for Analytical Bioscience Advanced Materials&Healthcare Technologies DivisionSchool of PharmacyUniversity of NottinghamNottinghamUK Marine Microbiomics Program in BiologyDivision of Science and MathematicsNew York University Abu Dhabi(NYUAD)P.O.Box 129188Abu DhabiUnited Arab Emirates

Non-healing fractures,a global health concern arising from trauma,osteoporosis,and tumours,can lead to severe ***,integral to cellular energy metabolism,gains prominence in bone regeneration via adeno-sine A2 B receptor *** study introduces a controlled-release system for localized adenosine delivery,fostering human mesenchymal stromal cell(hMSC)differentiation into functional bone *** study investi-gates how the ratio of lactic acid to glycolic acid in microparticles can influence adenosine release and explores the downstream effects on gene expression and metabolic profiles of osteogenic differentiation in hMSCs cultured in growth and osteoinductive *** into adenosine-modulated signalling pathways during MSC differenti-ation,with osteogenic factors,provide a comprehensive understanding of the pathways *** gene expression and metabolic profiles unravels adenosine’s regulatory mechanisms in MSC *** adenosine release from microparticles induces mineralization,synergizing with osteogenic media supplements,showcasing the potential of adenosine for treating critical bone defects and metabolic *** study high-lights the efficacy of a polymeric microparticle-based delivery system,offering novel strategies for bone *** adenosine’s roles and associated signalling pathways advances our comprehension of molecular mech-anisms steering bone regeneration,propelling innovative biomaterial,combined with metabolites,approaches for clinical use.

关键词： Adenosine release Osteogenic signalling pathways Human mesenchymal stromal cells Bone regeneration

Temporal stability and directional change in a color cline of a marine snail from NW Spain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2024年第2期70卷 163-173页

作者： juan Gefaell Ramon Vigo A.Honorato gonzalez-Vazquez juan Galindo Emilio Rolan-Alvarez Centro de Investigacion Marina Universidade de VigoDepartamento de BioquimicaGenetica e Inmunologia36310 VigoSpain

The evolution and maintenance of color clines is a classic topic of research in evolutionary ***,studies analyzing the temporal dynamics of such clines are much less frequent,due to the difficulty of obtaining reliable data about past color distributions along environmen-tal *** this article,we describe a case of decades-long temporal stability and directional change in a color cline of the marine snail Littorina saxatilis along the coastal inlet of the Ria de Vigo(NW Spain).*** from this area shows a clear color cline with 3 distinct areas from the innermost to the more wave-exposed localities of the Ria:the inner,protected localities show an abundance of fawn-like individuals;the intermediate localities show a high diversity of colors;and the outer,wave-exposed localities show populations with a high frequency of a black and lineated *** compare data from the 1970s and 2022 in the same localities,showing that the cline has kept relatively stable for at least over half a century,except for some directional change and local variability in the frequency of certain *** regression analyses and biodiversity measures are presented to provide clues into the selective pressures that might be involved in the maintenance of this color *** research avenues to properly test the explanatory power of these selective agents as well as the possible origins of the cline are discussed.

关键词： clinal variation color polymorphism ecological gradient Littorina saxatilis natural selection wave exposure.

Beyond cotton and polyester: An evaluation of emerging feedstocks and conversion methods for the future of fashion industry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Bioresources and Bioproducts 2024年第2期9卷 130-159页

作者： Ryen M.Frazier Keren A.Vivas Ivana Azuaje Ramon Vera Alonzo Pifano Naycari Forfora Hasan jameel Ericka Ford joel j.Pawlak Richard Venditti Ronalds gonzalez Department of Forest Biomaterials North Carolina State UniversityRaleighNC 27695USA Department of Textile Engineering Chemistry and ScienceThe Nonwovens InstituteNorth Carolina State UniversityRaleighNC 27695USA

As the global population grows,the demand for textiles is increasing ***,this puts immense pressure on manufacturers to produce more *** synthetic fibers can be pro-duced cheaply,they have a negative impact on the *** the other hand,fibers from wool,sisal,fique,wood pulp(viscose),and man-made cellulose fibers(MMCFs)from cotton can-not alone meet the growing fiber demand without major stresses on land,water,and existing markets using these *** a greater emphasis on transparency and circular economy practices,there is a need to consider natural non-wood alternative sources for MMCFs to supple-ment other fiber ***,introducing new feedstocks with different compositions may require different biomass conversion ***,based on existing work,this review ad-dresses the technical feasibility of various alternative feedstocks for conversion to textile-grade ***,alternative feedstocks are introduced,and then conventional(dissolving pulp)and emerging(fibrillated cellulose and recycled material)conversion technologies are evaluated to help select the most suitable and promising processes for these emerging alternative sources of *** is important to note that for alternative feedstocks to be adopted on a meaningful scale,high biomass availability and proximity of conversion facilities are critical *** North America,soybean,wheat,rice,sorghum,and sugarcane residues are widely available and most suitable for conventional conversion through various dissolving pulp production methods(pre-hydrolysis kraft,acid sulfite,soda,SO2-ethanol-water,and potassium hydroxide)or by emerging cellulose fibrillation *** dissolving pulp conversion is well-established,fibrillated cel-lulose methods could be beneficial from cost,efficiency,and environmental ***,the authors strongly encourage more work in this growing research ***,conducting thorough cost and sustainability assessment

关键词： Non-wood Residue Regenerated cellulose Dissolving pulp Man-made cellulose fiber Apparel textile