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近海应用中土壤-结构界面的亚塑性模型（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第8期19卷 624-637页

作者： Hans henning STUTZ frank WUTTKE Department of Engineering Aarhus University Institute of Geo-Science Kiel University

目的:研究一种使用连续的土壤模型模拟土壤-结构界面的新方法,并阐述这些模型增强土壤-结构相互作用的建模方法。创新点:1.基于先前的亚塑性模型,通过将晶粒间应变的概念融入模型公式来模拟循环载荷。2.整体性较好的模型具有更好、更精... 详细信息

目的:研究一种使用连续的土壤模型模拟土壤-结构界面的新方法,并阐述这些模型增强土壤-结构相互作用的建模方法。创新点:1.基于先前的亚塑性模型,通过将晶粒间应变的概念融入模型公式来模拟循环载荷。2.整体性较好的模型具有更好、更精确的模拟结果。方法:1.采用一种砂浆接触的力学方法,其中一个表面作为主面,另一个表面作为从属面。2.采用砂浆接触的力学方法并结合用户定义的子程序,对土壤-结构界面进行建模。3.基于先前的亚塑性模型,将晶粒间应变的概念融入模型公式来模拟循环载荷。结论:1.整体性较好的模型具有更好、更精确的模拟结果。2.本文提出的土壤-结构界面建模方法不仅提高了模拟结果,且在某些模拟中提高了数值收敛性。

关键词：亚塑性接触面循环荷载细颗粒和粗粒土

Spatial H202 Signaling Specificity： H202 from Chloroplasts and Peroxisomes Modulates the Plant Transcriptome Differentially

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Molecular Plant 2014年第7期7卷 1191-1210页

作者： Nasser Sewelam Nils Jaspert Katrien Van Der Kelen Vanesa B. Tognetti Jessica Schmitz henning Frerigmann Elia Stahl frank Van Breusegem Veronica G. Maurino Institut of Developmental and Molecular Biology of Plants Plant Molecular Physiology and Biotechnology Group Heinrich-Heine-Universit~t Universit~tsstraBe 1 40225 D~sseldorf Germany Botany Department Faculty of Science Tanta University 31527 Tanta Egypt Department of Plant Systems Biology VIB and Department of Plant Biotechnology and Bioinformatics Ghent UniversityTechnologiepark 927 B-9052 Gent Belgium Present address: Mendel Centre for Plant Genomics and Proteomics CEITEC--Central European Institute of Technology MasarykUniversity Kamenice 5 CZ-62500 Brno Czech Republic Botanical Institute Cologne Biocenter University of Cologne 50674 Cologne Germany Cluster of Excellence on Plant Sciences (CEPLAS) 40225 Dusseldorf and 50674 Cologne Germany Molecular Ecophysiology of Plants Heinrich-Heine-Universitat Universitatsstraf3e 1 40225 D~sseldorf Germany

Hydrogen peroxide （H2O2） operates as a signaling molecule in eukaryotes, but the specificity of its signal- ing capacities remains largely unrevealed. Here, we analyzed whether a moderate production of H2O2 from two different plant cellular compartments has divergent effects on the plant transcriptome. Arabidopsis thaliana overexpressing glycolate oxidase in the chloroplast （Fahnenstich et al., 2008; Balazadeh et al., 2012） and plants deficient in peroxisomal catalase （Queval et al., 2007; Inze et al., 2012） were grown under non-photorespiratory conditions and then transferred to photorespiratory conditions to foster the production of H202 in both organelles. We show that H202 originating in a specific organelle induces two types of responses： one that integrates signals independently from the subcellular site of H202 production and another that is dependent on the H2O2 production site. H2O2 produced in peroxisomes induces transcripts involved in protein repair responses, while H2O2 produced in chloroplasts induces early signaling responses, including transcription factors and biosynthetic genes involved in production of secondary signaling messengers. There is a significant bias towards the induction of genes involved in responses to wounding and pathogen attack by chloroplas- tic-produced H202, including indolic glucosinolates-, camalexin-, and stigmasterol-biosynthetic genes. These transcriptional responses were accompanied by the accumulation of 4-methoxy-indol-3-ylmethyl glucosinolate and stigmasterol.

关键词： hydrogen peroxide reactive oxygen species glycolate oxidase catalase photorespiration oxidative signaling.

Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis

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World Journal of Hepatology 2018年第1期10卷 8-21页

作者： David Haldrup Sara Heeboll Karen Louise Thomsen Kasper Jarlhelt Andersen Michelle Meier frank Viborg Mortensen Jens Randel Nyengaard Stephen Hamilton-Dutoit henning Gronbaek Department of Hepatology and Gastroenterology Aarhus University HospitalAarhus C DK-8000Denmark Department of Internal Medicine Randers Regional HospitalRanders NO DK-8930Denmark Department of Surgical Gastroenterology Aarhus University HospitalAarhus C DK-8000Denmark Stereology and Electron Microscopy Laboratory Centre for Stochastic Geometry and Advanced BioimagingAarhus University HospitalAarhus C DK-8000Denmark Institute of Pathology Aarhus University HospitalAarhus C DK-8000Denmark

AIM To evaluate the liver regeneration capacity(LRC) after partial hepatectomy(PH) in experimental non-alcoholic steatohepatitis(NASH).METHODS Fifty-four female rats were fed a high-fat, high-cholesterol diet(HFCD, 65% fat, 1% cholesterol) or standard diet(STD) for 16 wk. A 70% PH was performed and the animals were euthanised before PH or 2 or 5 d postPH. LRC was evaluated using: The total number of Ki-67 positive hepatocytes in the caudate lobe, N(Ki-67, lobe) evaluated in a stereology-based design, the regenerated protein ratio(RPR), prothrombin-proconvertin ratio(PP), and m RNA expression of genes related to *** The HFCD NASH model showed significant steatosis with ballooning and inflammation, while no fibrosis was present. Mortality was similar in HFCD and STD animals following PH. HFCD groups were compared to respective STD groups and HFCD animals had a significantly elevated alanine transaminase at baseline(P < 0.001), as well as a significantly elevated bilirubin at day 2 after PH(P < 0.05). HFCD animals had a higher N(Ki-67, lobe) at baseline,(P < 0.0001), day 2 after PH(P = 0.06) and day 5 after PH(P < 0.025). We found no significant difference in RPR or PP neither 2 or 5 d post-PH. Expression of liver regeneration genes(e.g., hepatic growth factor) was higher at both day 2 and 5 post-PH in HFCD groups(P < 0.05).CONCLUSION NASH rats had a preserved LRC after hepatectomy when compared to STD rats. The methods and models of NASH are essential in understanding and evaluating LRC.

关键词： Rat Non-alcoholic fatty liver Non-alcoholic steatohepatitis Liver regeneration Hepatectomy Ki-67 Gene expression

Genetics of hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第16期13卷 2271-2282页

作者： Andreas Teufel frank Staib Stephan Kanzler Arndt Weinmann henning Schulze-Bergkamen Peter R Galle Department of Medicine Johannes Gutenberg University Mainz Germany

The completely assembled human genome has made it possible for modern medicine to step into an era rich in genetic information and high-throughput genomic analysis. These novel and readily available genetic resources and analytical tools may be the key to unravel the molecular basis of hepatocellular carcinoma (HCC). Moreover, since an efficient treatment for this disease is lacking, further understanding of the genetic background of HCC will be crucial in order to develop new therapies aimed at selected targets. We report on the current status and recent developments in HCC genetics. Special emphasis is given to the genetics and regulation of major signalling pathways involved in HCC such as p53, Wnt- signalling, TGFβ, Ras, and Rb pathways. Furthermore, we describe the influence of chromosomal aberrations as well as of DNA methylation. Finally, we report on the rapidly developing field of genomic expression profiling in HCC, mainly by microarray analysis.

关键词：肝细胞癌遗传学基因组学染色体突变

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亚洲土壤对酸化的敏感性:现状与展望

AMBIO－人类环境杂志 2008年第4期37卷 281-289页

作者： W. Kevin Hicks Johan C. I. Kuylenstierna Anne Owen frank Dentener Hans-Martin Seip henning Rodhe 马泽清（译）哈艳梅（译）斯德哥尔摩环境研究所欧洲委员会联合研究中心奥斯陆大学不详

一直以来,研究者发现在中国南方及东南亚地区存在土壤酸化超出标准稳定状态的临界载荷的现象,但尚无证据能够说明土壤酸化在中国境外的影响。本研究介绍了一种在硫(S)、氮(N)和钙(Ca)的未来潜在排放情景下,亚洲土壤敏感性对酸沉降的时... 详细信息

一直以来,研究者发现在中国南方及东南亚地区存在土壤酸化超出标准稳定状态的临界载荷的现象,但尚无证据能够说明土壤酸化在中国境外的影响。本研究介绍了一种在硫(S)、氮(N)和钙(Ca)的未来潜在排放情景下,亚洲土壤敏感性对酸沉降的时间效应的计算方法。这种方法通过对亚洲可用性数据的匹配,制作了区域尺度图,估算了在相应的酸沉降条件下,土壤盐基饱和度需要多少时间(年)能达到20%的临界上限。研究结果表明,南亚、东南亚和东亚的土壤类型敏感地区,包括中国南部部分地区,以及缅甸、海南、老挝、泰国、越南和印度西高止山脉等,达到显著酸化的程度可能需要0～50年(尺度),这主要取决于当地的管理水平、生物和非生物的因素等。为了更明确地评估风险,需要贯穿亚洲代表不同植被和土壤类型及管理制度的典型区域的定点观测数据,如土壤化学、沉降(尤其是相应的阳离子沉降)、土壤和生态系统中硫、氮含量、可收获的生物量及风化速率等。本文介绍的国家和区域评估土壤的简单方法,可以对土壤酸化相关的影响时间尺度进行正确评价,有助于下一步研究,通过相关措施可降低酸化的风险。

关键词：土壤敏感性土壤酸化亚洲东南亚地区展望临界载荷中国南方时间效应