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Fruit intake associated with urinary estrogen metabolites in healthy premenopausal women

Open Journal of Preventive Medicine 2012年第1期2卷 1-8页

作者： Kerryn W. Reding Charlotte Atkinson Kim C. Westerlind frank stanczyk Erin J. Aiello Bowles Mellissa Yong Katherine M. Newton Johanna W. Lampe Center for Observational Research Amgen Inc. Thousand Oaks USA Division of Endocrinology Metabolism and Diabetes University of Colorado Health Sciences Center Denver USA Group Health Research Institute Seattle USA Keck School of Medicine University of Southern California Los Angeles USA Lifecourse Epidemiology & Population Oral Health Research University of Bristol Bristol UK Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle USA School of Nursing University of Washington Seattle USA

Urinary concentrations of 2:16-hydroxyestrone (2:16-OHE1) approximate concentrations of 2-OHE1 and 16α-OHE1 in breast tissue. As estrogens are purported to be involved in breast cancer development, the 2:16-OHE1 ratio can provide an indication of estrogen metabolite exposure in the breast. With prior studies observing associations between urinary estrogen metabolites and dietary intakeof fruits, vegetables, and fiberascertained from food questionnaires, we examined associations between dietary factors ascertained through 3-day food records and urinary 2:16-OHE1 in191 pre-menopausal healthy women. Fruit consumption was positively associated with 2:16-OHE1 after adjustment for total energy, ethnicity, body mass index, parity, smoking history, and serum estradiol (p = 0.003). Fruit consumption was positively associated with 2-OHE1 concentrations (p = 0.006), but was not associated with 16α-OHE1 (p = 0.92). The Musaceae botanical grouping (comprised primarily of bananas) was positively associated with the 2:16-OHE1 ratio, and Rosaceae (comprised of citrus fruits) and Musaceae botanical groupings were positively associated with 2-OHE1 (but not 16α-OHE1) concentrations, after adjustment for confounders. Our data suggest that dietary fruit intakeis associated with urinary 2-OHE1 and the 2:16-OHE1 ratio and that breast tissue exposure to estrogen metabolites may thus be influenced-by diet.

关键词： Estrogen Metabolism Diet Botanical Groupings

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