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Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms

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World Journal of Gastrointestinal Oncology 2016年第8期8卷 615-622页

作者： Vivian Weiss Julie Dueber Jesse P Wright Justin Cates frank revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi Department of Pathology Microbiology and Immunology Vanderbilt University Medical Center Department of Surgery Surgical Oncology Vanderbilt University Medical Center Department of Surgery Surgical Oncology University of Miami Hospital

AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC.

关键词： β-catenin Familial adenomatous polyposis Pancreatic neuroendocrine neoplasm Adenomatous polyposis coli E-cadherin

Decoding complexity: the need to enhance precision and streamline spatial understanding in neuroscience

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Neural Regeneration Research 2025年第3期20卷 801-802页

作者： Sameehan Mahajani Armita Salahi Brenda Gonzalez Charlotte Nelson frank Hsiung Biology&Applications Division NodexusSan JoseCAUSA

Neuroscience is the ultimate frontier in our quest for a comprehensive understanding of human behavior. Since its launch in 2009, the Human Connectome Project has emerged as a pioneering force, making heroic strides i... 详细信息

关键词： behavior frontier dating

From basic properties to the Mott design of correlated delafossites

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npj Computational Materials 2021年第1期7卷 1084-1100页

作者： frank Lechermann European XFEL SchenefeldGermany Center for Computational Quantum Physics Flatiron InstituteNew YorkNYUSA

The natural-heterostructure concept realized in delafossites highlights these layered *** metallic,band-or Mott-insulating character may be associated with individual layers,inter-layer coupling still plays a decisive *** review the correlated electronic structure of PdCoO_(2),PdCrO_(2),and AgCrO_(2),showing that layer-entangled electronic states can deviate from standard classifications of interacting *** finding opens up possibilities for materials design in a subtle Mott-critical *** Hidden-Mott physics,correlation-induced semimetallicity,or Dirac/flat-band dispersions in a Mott background are emerging *** with achievements in the experimental preparation,this inaugurates an exciting research field in the arena of correlated materials.

关键词： materials metallic showing

Magnesium research in Canada:Highlights of the last two decades

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Journal of Magnesium and Alloys 2023年第10期11卷 3484-3510页

作者： frank Czerwinski Natural Resources Canada CanmetMATERIALSHamiltonONCanada

The highlights of major Canadian research projects of last two decades that aimed at advancing applications of magnesium and its alloys,being at the heart of lightweighting and ecological sustainability, are outlined. The research at universities, government laboratories, and other dedicated institutions, funded primarily through federal programs, was accompanied by strong activities of the industrial sector involved in designing and building the machinery for magnesium processing and production of components from magnesium alloys. The overall research directions matched the global trends of overcoming the key challenges that prevent magnesium alloys to play the major role in large-scale applications. Among industrially oriented projects the processing technologies in liquid, semisolid and solid states such as casting, twin roll casting, injection molding, rolling, extrusion, forging, and joining techniques were frequently pursued. Although the fundamental research aimed at understanding of a variety of magnesium behaviors and structural peculiarities up to nano and atomic levels, its essence spread around the inherently poor formability and high reactivity at room and elevated temperatures, including the ignition/flammability *** recent years, a shift in research interests was observed and novel directions emerged such as magnesium air batteries, biodegradable alloys, additive manufacturing, and magnesium-rich high entropy alloys. The volume of data gathered in this report may constitute a base for specifically oriented assessments, analyses, and drawing conclusions.

关键词： Magnesium Magnesium alloys Processing technologies Canadian research projects

Ultra-broadband access enabled by fiber optics(Invited Paper)

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Chinese Optics Letters 2016年第12期14卷 17-20页

作者： frank Effenberger Futurewei Technologies Bridgewater NJ 08807 USA

The advent of low loss optical fiber has consistently led us to the ultra-broadband era, where bandwidths exceeding 1 Gb/s are commonplace. This Review reviews the early history of fiber access, pointing out some of the lasting design choices and signature features of fiber access. The progress of the various passive optical network technologies is also reviewed, and some views regarding the future trends of fiber in the access.

关键词： broadband consistently optics pointing signature lasting exceeding deployment bandwidth enabled

Asymptotics and Blow-up for Mass Critical Nonlinear Dispersive Equations(Dedicated to Professor Ham Brezis on the occasion of his 70th birthday)

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Chinese Annals of Mathematics,Series B 2017年第2期38卷 579-590页

作者： frank MERLE Universitéde Cergy-pontoise MathématiquesCNRSCNRSF-95000 Cergy-PontoiseFrance Institut des HautesEtudes Scientifiques 35 Route de Chartres91440 Bures-sur-YvetteFrance

The author considers mass critical nonlinear Schrdinger and Korteweg-de Vries equations. A review on results related to the blow-up of solution of these equations is given.

关键词： Dispersive nonlinear PDE, Criticality, Asymptotics, Blow-up, Globalsolution, Soliton

Constructing parametric triangular patches with boundary conditions

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Progress in Natural Science:Materials International 2008年第3期18卷 315-322页

作者： frank Cheng Department of Computer Science University of Kentucky Lexington KY 40506 USA

The problem of constructing a parametric triangular patch to smoothly connect three surface patches is studied. Usually, these surface patches are defined on different parameter spaces. Therefore, it is necessary to define interpolation conditions, with values from the given surface patches, on the boundary of the triangular patch that can ensure smooth transition between different parameter spaces. In this paper we present a new method to define boundary conditions. Boundary conditions defined by the new method have the same param- eter space if the three given surface patches can be converted into the same form through affine transformation. Consequently, any of the classic methods for constructing functional triangular patches can be used directly to construct a parametric triangular patch to connect given surface patches with G1 continuity. The resulting parametric triangular patch preserves precision of the applied classic method.

关键词： Triangular patch Parametric interpolation Determination of interpolation conditions

Poly(ethylene glycol) conjugated nano-graphene oxide for photodynamic therapy

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Science China Chemistry 2010年第11期53卷 2265-2271页

作者： Pilger frank Institute for Advanced Materials and Nano Biomedicine(iNANO) Tongji University

A novel methoxy-poly(ethylene glycol) modified nano-graphene oxide(NGO-mPEG) was designed and synthesized as a photosensitizer(PS) carrier for photodynamic therapy of *** with a size below 200 nm was prepared using a modified Hummers' *** was observed by AFM to exhibit a structure with single-layer graphene oxide sheets down to a few nanometers in *** mPEG conjugation of NGO(NGO-mPEG) was found to enhance solubility in cell culture *** apparent cytotoxicity of the NGO-mPEG was observed towards MCF-7 carcinoma cell *** phthalocyanine(ZnPc),a photosensitizer for photodynamic therapy,was loaded in the NGO-PEG through π-π stacking and hydrophobic interactions,with the drug loading efficiency up to 14 wt%.Hydrophobic ZnPc was internalized in MCF-7 cells,exhibiting a pronounced phototoxicity in the cells under Xe light *** results indicate a great potential of NGO-mPEG for photodynamic therapy of cancer.

关键词： nano-graphene oxide photodynamic therapy photosensitizer drug delivery biomedical application

Progress in twin roll casting of magnesium alloys: A review

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Journal of Magnesium and Alloys 2021年第2期9卷 362-391页

作者： Amjad Javaid frank Czerwinski CanmetMATERIALS Natural Resources CanadaHamiltonOntarioL8P 0A5Canada

Twin roll casting was commercialized for a strip production from ferrous and non-ferrous alloys in the 1950 s;however,its application to magnesium has proven difficult and still creates major *** report describes global efforts in expanding manufacturing capabilities of magnesium sheet through twin roll casting path,offering many benefits,including a reduction in number of processing steps and energy *** addition to hardware design,alloy transformation during processing,product microstructure and properties,examples of successful solutions along with present technology and knowledge limitations are discussed.A particular attention is paid to developments at Canmet MATERIALS,having the only in North America pilot scale twin roll casting facility,devoted to *** are described that aim at design of new magnesium alloys,which could take advantage of unique processing conditions during twin roll casting and contribute to the overall progress in magnesium sheet manufacturing.

关键词： Twin roll casting Magnesium alloys Solidification Magnesium sheet