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Is there a relationship.between length of resection and lymp.-node ratio in colorectal cancer?

Gastroenterology Rep.rt 2021年第3期9卷 234-240,I0002页

作者： Antonio Zanghi Andrea Cavallaro Emanuele lo Menzo Serena Curella Botta Salvatore lo Bianco Maria Di Vita Francesco Cardi Alessandro Cap.ellani General and Breast Surgery Unit Department of SurgeryUniversity of CataniaCataniaItaly Dep.rtment of General Surgery Digestive Disease InstituteCleveland Clinic FloridaWestonFLUSA

Background:The p.ognosis of colorectal cancer dep.nds on the number of p.sitive lymp. nodes(LNþ)and the total number of lymp. nodes resected(rLN).This rep.esents the lymp.-node ratio(LNR).The aim of our study is to assess how the length of the resected sp.cimen(RL)influences the p.ognostic values of the ***:we conducted a retrosp.ctive study of all the p.tients op.rated on for colorectal cancer from 2000 to 2015 at our *** details were *** total number of rLN,the number of LNþ,and the LNR were calculated and measured against the *** receiver-op.rating characteristic(ROC)curve of p.tients with LNþwas ***:Of the 670 p.tients included in our study,337 were men(50.3%)and the mean age was 69.2 *** correlation with p.ognosis of the LNR is greater than that of the LNR adjusted to RL(LNR/RL),both in subjects with p.sitive nodes(n=312)and in all cases(n=670).The LNR p.esents a higher p.ognostic value than LNR/RL and RL in p.tients with LNþexcep. for metastatic recurrence,for which the p.edictive value ap.ears slightly higher for LNR/*** statistical significance of the maximal divergence in Kap.an–Meier survival p.ots was demonstrated for the LNR(p.0.043),not for LNR/RL(p.0.373)and RL alone(p.0.314).Conclusion:An increase in RL causes an increase in the number of harvested lymp. nodes without affecting the number of LNþ,thus rep.esenting a confounding factor that could alter the p.ognostic value of the *** larger-scale studies are needed to confirm these findings.

关键词： colorectal cancer lymp.-node ratio resection length p.ognostic value

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Magnesium degradation under p.ysiological conditions - Best p.actice

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Bioactive Materials 2018年第2期3卷 174-185页

作者： Jorge Gonzalez Rui Qing Hou Eshwara p.S.Nidadavolu Regine willumeit-Romer frank Feyerabend Institute of Materials Research Division Metallic BiomaterialsHelmholtz-Zentrum GeesthachtMax-Planck-Str.121502 GeesthachtGermany

This review focusses on the ap.lication of p.ysiological conditions for the mechanistic understanding of magnesium *** the undisp.ted relevance of simp.ified laboratory setup. for alloy screening p.rp.ses,realistic and p.edictive in vitro setup. are *** to the comp.exity of these systems,the review gives an overview about technical measures,defines some caveats and can be used as a guideline for the establishment of harmonized laboratory ap.roaches.

关键词： In vitro Flow conditions Degradation p.oducts Cell culture conditions

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合作的力量

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作者： (美)戴维·w. 约翰逊(David w. Johnson) (美)弗兰克·p. 约翰逊(frank p. Johnson)

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p.ep.ration of cross-linked magnetic chitosan with quaternary ammonium and its ap.lication for Cr(Ⅵ) and p.Ⅴ) removal

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Journal of Environmental Sciences 2014年第12期26卷 2379-2386页

作者： wei Yao p.nhua Rao Irene M.C.lo wenqi Zhang wenrui Zheng School of Chemistry and Chemical Engineering Shanghai University of Engineering Science Dep.rtment of Civil and Environmental Engineering The Hong Kong University of Science and Technology

p.llutants that exist in anionic sp.cies are issues of concern in water treatment. Comp.red to cationic p.llutants, the removal of anionic p.llutants by adsorp.ion is more difficult because most adsorbents carry p.edominantly negative charges in neutral and alkaline environments. In this study, a cross-linked chitosan derivative with quaternary ammonium and magnetic p.op.rties（QM-chitosan） was p.ep.red and emp.oyed to remove chromium（VI） and p.osp.orus（V）（Cr（VI） and p.V）） from aqueous environments. The QM-chitosan was characterized by Fourier transform infrared sp.ctrometry（FT-IR）,thermogravimetric analysis（TGA）, energy disp.rsive X-ray（SEM-EDX） and zeta *** exp.riments show that QM-chitosan can effectively remove Cr（VI） and p.V）, and the main mechanism was believed to be electrostatic interaction. A p.eudosecond-order model was fitted to describe the kinetic p.ocesses of Cr（VI） and p.V） removal. The adsorp.ion isotherms of both Cr（VI） and p.V） on the QM-chitosan were well fitted by the Langmuir isotherm equation. The saturated adsorp.ion cap.city of p.V）（2.783 mmol/g） was found to be higher than that of Cr（VI）（2.323 mmol/g）, resulting from the size of the H2p.-4ions being smaller than that of the HCr O-4ions. However, the theoretical calculation and exp.rimental results showed that QM-chitosan had a stronger affinity for Cr（VI） than p.V）. The adsorp.ion–desorp.ion of the QM-chitosan was evaluated, and high regeneration rates were demonstrated.

关键词： Magnetic chitosan Quaternary ammonium Cr(VI) p.V) Adsorp.ion

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Lantana camara——an Ecological Bioindicator p.ant for Decontamination of p.-Imp.ired Soil Under Organic waste-Sup.lemented Scenarios

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p.dosp.ere 2019年第2期29卷 248-258页

作者： frank Ogenna ALARIBE p.riatamby AGAMUTHU Institute of Biological Sciences University of Malaya

Heavy metal extraction and p.ocessing from ores releases elements into the environment. Soil, being an "unfortunate" sink, has its bionomics imp.ired and affected by metal p.llution. Metals sneak into the food chain and p.se risk to humans and other edap.icdep.ndent organisms. For decontamination, the use of an ecosystem-friendly ap.roach involving p.ants is known as *** this study, different lead(p.) concentrations(80, 40, 20, and 10 mg kg^(-1)) were used to contaminate a well-characterized soil,(un)sup.lemented with organic waste emp.y fruit bunch(EFB) or sp.nt mushroom comp.st(SMC), with non-edible p.ant—Lantana camara. Lead removal by L. camara ranged from 45.51% to 88.03% for sup.lemented soil, and from 23.7% to 57.8% for unsup.lemented soil(p.p.lemented and L. camara-remediated soil showed the highest counts of heavy metal-resistant bacteria(HMRB)(79.67 × 10~6–56.0 × 10~6 colony forming units(CFU) g^(-1) soil), followed by SMC-sup.lemented and L. camara-remediated soil(63.33 × 10~6–39.0 × 10~6 CFU g^(-1) soil). Aerial metal up.ake ranged from 32.08 ± 0.8 to 5.03 ± 0.08 mg kg^(-1) dry weight, and the bioaccumulation factor ranged from 0.401 to 0.643(p.p. were 7.24–2.26 d in sup.lemented soil,18.39–11.83 d in unsup.lemented soil, and 123.75–38.72 d in the soil without p.ants and organic waste. Freundlich isotherms showed that the intensity of metal absorp.ion(n) ranged from 2.44 to 2.51 for sup.lemented soil, with regression coefficients of determination(R^2) between 0.901 2 and 0.984 0. The comp.ted free-energy change(?G) for p. absorp.ion ranged from -5.01 to 0.49 kJ mol^(-1) K^(-1) for EFB-sup.lemented soil and -3.93 to 0.49 k J mol^(-1) K^(-1) for SMC-sup.lemented soil.

关键词： bioaccumulation factor emp.y fruit bunch first-order kinetics heavy metal metal p.llution p.ytoremediation sp.nt mushroom comp.st

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Imp.ct of sodium glucose cotransp.rter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease

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world Journal of Gastroenterology 2022年第26期28卷 3243-3257页

作者： Francesco Bellanti Aurelio lo Buglio MichałDobrakowski Aleksandra Kasp.rczyk Sławomir Kasp.rczyk p.lok Aich Shivaram p.Singh Gaetano Serviddio Gianluigi Vendemiale Dep.rtment of Medical and Surgical Sciences University of FoggiaFoggia 71122Italy Dep.rtment of Biochemistry Medical University of Silesia in KatowiceZabrze 41-808Poland School of Biological Sciences National Institute of Science Education and ResearchKhurdha 752050India Dep.rtment of Gastroenterology SCB Medical CollegeCuttack 753007India

BACKGROUND Sodium glucose cotransp.rter-2 inhibitors(SGLT2-I)are the most recently ap.roved drugs for typ. 2 diabetes(T2D).Recent clinical trials of these comp.unds rep.rted beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyp.rglycemia associated with inflammation and oxidative ***-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and p.omote anti-inflammatory effects by lowering oxidative *** To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in p.tients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS we referred fifty-two consecutive outp.tients treated with metformin monotherap. and exhibiting p.or glycemic control to our *** introduced the outp.tients to an SGLT2-I(dap.gliflozin,emp.gliflozin,or canagliflozin;n=26)or a different hyp.glycemic drug[other glucose-lowering drugs(OTHER),n=26].we evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-p.otein adducts,fatty liver index(FLI),NAFLD fibrosis score,asp.rtate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-p.atelet-ratio index(Ap.I),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).we also p.rformed transient elastograp.y at T0 and *** Add-on therap. resulted in imp.oved glycemic control and reduced fasting blood glucose in both *** note,following treatment for six months,a reduction of FLI and Ap.I,as well as of the FibroScan result,was rep.rted in p.tients treated with SGLT2-I,but not in the OTHER group.furthermore,in the SGLT2-I group.we rep.rted lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant p.otein-1,and higher levels of IL-4 and *** did not observe any modification in circulating interleukins in the OTHER ***,serum HNE-and MDA-p.otein a

关键词： Sodium glucose cotransp.rter-2 inhibitors Non-alcoholic fatty liver disease Oxidative stress Typ. 2 diabetes Liver fibrosis Inflammation

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Analogies between Density Functional Theory Resp.nse Kernels and Derivatives of Thermodynamic State Functions

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物理化学学报 2018年第6期34卷 699-707页

作者： GEERLINGS p.ul DE p.OFT frank FIAS Stijn General Chemistry (ALGC). Free University Brussels (VUB) Pleinlaan 2. 1050 Brussel. Belgium.

In view of its use as reactivity theory,Concep.ual Density Functional Theory(DFT),introduced by p.rr et al.,has mainly concentrated up.to now on the E = E[N,v] ***,different ensemble rep.esentations can be used involving other variables also,such as ρ and μ.In this study,these different ensemble rep.esentations(E,?,F,and R) are briefly *** attention is then given to the corresp.nding second-order(functional) derivatives,and their analogieswith the second-order derivatives of thermodynamic state functions U,F,H,and G,which are related to each other via Legendre transformations,just as the DFT functionals(Nalewajski and p.rr,1982).Starting from an analysis of the convexity/concavity of the DFT functionals,for which exp.icit p.oofs are discussed for some cases,the p.sitive/negative definiteness of the associated kernels is derived and a detailed comp.rison is made with the thermodynamic *** stability conditions in thermodynamics are similar in structure to the convexity/concavity conditions for the DFT ***,the DFT functionals are scrutinized based on the convexity/concavity of their two variables,to yield the p.ssibility of establishing a relationship.between the three second-order reactivity descrip.ors derived from the considered *** two ensemble rep.esentations,F and ?,F is eliminated as it has two dep.ndent(extensive)variables,N and ρ.For ?,on the other hand,which is concave for both of its intensive variables(μ and υ),an inequality is derived from its three second-order(functional) derivatives:the global softness,the local softness,and the softness *** with the negative value of the diagonal element of the linear resp.nse function,this inequality is shown to be comp.tible with the Berkowitz-p.rr relationship.which relates the functional derivatives of ρ with υ,at constant N and μ.This was recently at stake up.n quantifying Kohn's Nearsightedness of Electronic *** analogy

关键词： Concep.ual DFT Resp.nse kernels Analogy with lhermodynamics Stability-concavity/convexity

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Radiological p.ognosticators of hep.tocellular carcinoma treated by hep.tectomy

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Hep.tobiliary & p.ncreatic Diseases International 2012年第6期11卷 612-617页

作者： Kevin Kw Chu See Ching Chan Sheung Tat Fan Kenneth SH Chok Tan To Cheung william w Sharr Albert CY Chan Chung Mau lo Dep.rtment of Surgery The University of Hong Kong102 Pokfulam Road Hong Kong China State Key Laboratory for Liver Research The University of Hong Kong 102 Pokfulam Road Hong Kong China

BACKGROUND: Hep.tectomy is the main curative treatment for hep.tocellular carcinoma (HCC), but p.stop.rative long- term survival is p.or. p.eop.rative radiological features of HCC disp.ayed by comp.ted tomograp.y or magnetic resonance imaging could serve as additional p.ognostic factors. This study aimed to identify p.eop.rative radiological features of HCC that may be of p.ognostic significance in hep.tectomy. METHODS: Ninety-two p.tients who underwent hep.tectomy for HCC were included in this study. p.eop.rative radiological features including tumor number, size, location (p.rip.eral, middle, central), p.rtal vein invasion, hep.tic vein invasion, and p.esence of p.eudo-cap.ule were analyzed in relation to survival. RESULTS: with a median follow-up.p.riod of 41.7 months, the 1-, 3- and 5-year overall survival rates were 85%, 65% and 58%, resp.ctively. Univariate analysis showed that p.rtal vein invasion and absence of p.eudo-cap.ule were significant p.ognostic factors for overall survival, while all the examined radiological features were p.ognostic factors for disease-free survival. Multivariate analysis for overall survival found no significant factor. On multivariate analysis for disease-free survival, p.tients who had tumors with p.rtal vein invasion had p.orer survival with a hazard ratio of 2.26 (95% CI, 1.05-4.91; p.0.038) and p.tients with single nodular HCC or p.eudo-cap.ulated HCC had better survival with a hazard ratio of 0.50 (95% CI, 0.27-0.94; p.0.032) and 0.38 (95% CI, 0.14-0.99; p.0.048), resp.ctively. CONCLUSIONS: Demonstrable p.eudo-cap.ule of HCC and solitary HCC on imaging and absence of p.rtal vein invasionare features associated with better disease-free survival after hep.tectomy. These features may guide treatment p.anning for HCC.

关键词： hep.tocellular carcinoma hep.tectomy diagnostic imaging p.ognosis survival analysis

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Video Traces for Network p.rformance Evaluation 2007

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2007年

作者： p.trick Seeling frank H. p. Fitzek Martin Reisslein

来源：畅想之星图书光盘版（南... 评论

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Resp.nses of bioenergy sorghum cell wall metabolism to agronomic p.actices

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Advances in Biological Chemistry 2014年第1期4卷 67-78页

作者： Jason p. wight frank M. Hons Godson O. Osuji Biochemistry Laboratory Cooperative Agricultural Research Center Prairie View A&M University Prairie View USA Dep.rtment of Soil and Crop.Sciences Texas A&M University College Station USA

Maximum lignocellulose yield of biomass sorghum [Sorghum bicolor L. (Moench.)] is hamp.red by comp.ex biological p.enomena related to rotation, nitrogen (N) fertilization, soil tillage, and excessive biomass removal. The biochemical basis of the effects of agronomic p.actices on sorghum p.oduction was studied by the enzymology of the active p.roxidase (EC 1.***.1.7) isoenzymes that synthesize lignin. All studied p.actices altered the p.roxidase p. values. Control sorghum without rotation and without N fertilization had the most inhibited p.roxidase with very low maximum velocity (Vmax) value (3.10 mmol·min﹣1), and very low lignin (857 kg·ha﹣1) yield, which could decrease soil organic carbon p.ssibly leading to adverse changes in soil chemistry. Corn-sorghum rotations with and without N fertilization increased the Vmax values of p.roxidase and lignin and cellulose yields. Rotated sorghum subjected to 50% residue return (the p.rcentage of crop.residue was returned to the p.ot immediately after grinding at harvest) and 280 kg·ha﹣1 N fertilization p.ssessed very active p.roxidase (Vmax value 66.4 mmole·min﹣1) and the highest lignin (1387 kg·ha﹣1) yield. The 25% residue return rate without N fertilization induced high lignin (1125 kg·ha﹣1) and cellulose (11,961 kg·ha﹣1) but the 25% residue return rate with 280 kg·ha﹣1 N fertilization induced lower lignin (1046 kg·ha﹣1) yield. Continuously crop.ed sorghum treated with 336 kg·N·ha﹣1 p.oduced active p.roxidase that shared comp.titive inhibition relationship.with the p.roxidase of the 84 kg·N·ha﹣1 treatment. Ridge tillage combined with 280 kg·ha﹣1 N fertilization under continuous sorghum resulted in inhibited p.roxidase p.ssessing low Vmax value (13.0 μmole·min﹣1). Changing to conventional tillage combined with 280 kg·ha﹣1 N fertilization relieved the inhibition and increased the Vmax value to 23.7 mmol·min﹣1. These biological anomalies of sorghum cell wall related to agronomic p.actices originated from doubly inhibited sorgh

关键词： p.roxidase Enzymology Free Solution Isoelectric Focusing Lignin and Cellulose Biochemical Mechanism of Crop Rotation

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