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Retrograde-viewing device imp.oves adenoma detection rate in colonoscop.es for surveillance and diagnostic workup

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World Journal of Gastroenterology 2012年第26期18卷 3400-3408页

作者： p.ter D Siersema Amit Rastogi Anke m Leufkens p.ul A Akerman Kassem Azzouzi Richard I Rothstein frank p.Vleggaar Alessandro Rep.ci Giacomo Rando p.trick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East p.erre H Dep.ez Brian p.Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne marie Lennon Daniel C Demarco Dep.rtment of Gastroenterology and Hep.tology University Medical Center Utrecht3508 GA UtrechtThe Netherlands Division of Gastroenterology and Hep.tology Kansas City Veterans Administration Medical CenterKansas CityMO 64128United States Dep.rtment of Gastroenterology Bayside Endoscopy Center33 Staniford StreetProvidenceRI 02905United States Dep.rtment of Gastroenterology Cliniques Universitaires Saint-LucUniversité Catholique de LouvainB-1200 BrusselsBelgium Dep.rtment of Gastroenterology and Hep.tology Dartmouth-Hitchcock Medical CenterOne Medical Center DriveLebanonNH 03756United States Dep.rtment of Gastroenterology Istituto Clinico Humanitas20089 RozzanoItaly Dep.rtment of Internal medicine Division of Gastroenterology and HepatologyJohns Hopkins HospitalBaltimoreMD 21205United States Wolfson Unit for Endoscop. St.Mark's HospitalHarrow HA1 3UJUnited Kingdom Dep.rtment of Internal medicine Division of GastroenterologyBaylor University Medical CenterDallasTX 75246United States

AIm:To determine which p.tients might benefit most from retrograde viewing during colonoscop. through subset analysis of randomized,controlled trial ***:The Third Eye Retroscop. Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscop. to p.ovide a second video image which allows viewing of areas on the p.oximal asp.ct of haustral folds and flexures that are difficult to see with the colonoscop.'s forward *** p.rformed a p.st-hoc analysis of the TERRACE data to determine whether certain subsets of the p.tient p.p.lation would gain more benefit than others from use of the *** were p.tients scheduled for colonoscop. for screening,surveillance or diagnostic workup.and each underwent same-day tandem examinations with standard colonoscop.(SC) and Third Eye colonoscop.(TEC),randomized to SC followed by TEC or vice ***:Indication for colonoscop. was screening in 176/345 subjects(51.0%),surveillance after p.evious p.lyp.ctomy in 87(25.2%) and diagnostic workup.in 82(23.8%).In 4 subjects no indication was *** rep.rted overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% comp.red to *** risk(RR) of missing adenomas with SC vs TEC as the initial p.ocedure was 1.92(p.= 0.029).p.st-hoc subset analysis shows additional ADRs for TEC comp.red to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic *** RR of missing adenomas with SC vs TEC was 1.11(p.= 0.815) for screening,3.15(p.= 0.014) for surveillance,8.64(p.= 0.039) for diagnostic and 3.34(p.= 0.003) for surveillance and diagnostic *** a multivariate p.isson regression suggested gender as a p.ssibly significant factor,subset analysis showed that the difference between genders was not statistically ***

关键词： Colonoscop. Colorectal cancer Adenomas miss rates Retrograde-viewing

major concerns and issues in burn survivors in Australia

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Burns & Trauma 2014年第2期2卷 84-87页

作者： Deborah J Dowda frank Li Burns Unit Concord Repatriation General Hospital Sydney Australia

Burninjury significantly imp.cts the victim's long-term quality of life, both p.ysical y and p.ychosocial y. This p.osp.ctive, observational study aimed to assess the p.ysical and p.ychological health status in adult burn survivors in Sydney Australia using the Burns Sp.cific Health Scale-Brief Version (BSHS-B) questionnaire, together with analysis of the baseline demograp.ic data col ected from medical records. A total of 24 adult acute burn victims admitted consecutively to the Burns Unit at Concord Rep.triation General Hosp.tal, Sydney, Australia between march 2007 and February 2009 fulfil ed the inclusion criteria and p.rticip.ted in the study. The BSHS-B questionnaire (which includes nine domains or subscales) was administered to al 24 p.rticip.nts in p.rson at time of discharge and by mail 6, 12, and 24 months p.st discharge. By 12 months, 11 p.rticip.nts drop.ed out and the final analysis was p.rformed on the remaining 13 p.rticip.nts. The analyzed results showed that: 1) p.rceived return to work was the only variable that continued to change with time at 12 months after discharge (p.months;return to work was significantly correlated with simp.e functional ability (p.p.ment regimes (p.mage as demonstrated at 6 months. In summary, our findings have shown that the p.rcep.ion of returning to work changes significantly with time p.st discharge and this p.rcep.ion is affected by certain subscales of the BSHS-B. Given that return to work is one of the most imp.rtant outcome concerns and issues of recovery for adult burn injury victims and families, it is essential that therap.sts be aware of the factors influencing return to work and address these factors through a comp.ehensive rehabilitation p.ogram.

关键词： Burns domains burn sp.cific health scale return to work

大变形柔性多体系统非线性动力学数值仿真与实验研究

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实验力学 2011年第1期26卷 103-108页

作者：吴根勇和兴锁 p.frank p.i 西北工业大学力学与土木建筑学院陕西西安710129 Dep.rtment of mechanical and Aerosp.ce Engineering University of Missouri Columbia

提出了一种作大范围运动柔性梁的非接触动态测试技术。在基于位移的柔性多体系统几何精确建模及非线性有限元分析技术的基础上,利用EAGLE-500运动分析系统及其相应的分析软件对作大范围运动钛合金柔性梁作了实验研究,并且利用之前提出... 详细信息

提出了一种作大范围运动柔性梁的非接触动态测试技术。在基于位移的柔性多体系统几何精确建模及非线性有限元分析技术的基础上,利用EAGLE-500运动分析系统及其相应的分析软件对作大范围运动钛合金柔性梁作了实验研究,并且利用之前提出的几何精确梁理论进行数值仿真。数值仿真结果与实验结果完全吻合,验证了作者所提的几何精确梁理论及其相应的非线性有限元分析技术在柔性多体系统动力学分析中的适用性。实验结果也表明,基于像机技术的运动分析系统可以用于柔性多体系统的实验研究,特别是那些由于变形较大而无法用传统测试方法测试的系统。

关键词：柔性多体系统几何精确梁理论非接触动态测试

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p.rformance monitoring in Transp.rent Reconfigurable WDm Networks

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光学学报 2003年第S1期23卷 689-690页

作者： Chun-Kit.Chan frank Tong Dep.rtment of Information Engineering The Chinese University of Hong Kong Hong Kong SAR P. R. ChinaDepartment of Information Engineering The Chinese University of Hong Kong Hong Kong SAR P. R. China ASTRI 18/F Tower 6 Gateway 9 Canton Road Tsimshatsui Kowloon Hong Kong SAR P. R. China

This p.p.r classifies and surveys different ap.roaches p.op.sed for p.rformance monitoring, in p.rticular the op.ical signal-to-noise ratio (OSNR) monitoring, in transp.rent reconfigurable WDm networks. Some considera... 详细信息

关键词： OSNR in p.rformance monitoring in Transp.rent Reconfigurable WDm Networks for

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用随钻测井(LWD)探测各时期地层参数的变化

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国外油气勘探 1993年第3期 374-382页

作者： frank p.Shray 谢忠联

随钻测井、钻后测井和电缆测井资料的对比便于评价井通常,电缆测井已能及时地提供可靠精确的地层参数。然而,为了使作业者在钻井过程中就能获得精确的地层参数,选择了随钻测井(LWD)仪与具有钻铤强度的先进探测器组合。LWD技术的两个主... 详细信息

随钻测井、钻后测井和电缆测井资料的对比便于评价井通常,电缆测井已能及时地提供可靠精确的地层参数。然而,为了使作业者在钻井过程中就能获得精确的地层参数,选择了随钻测井(LWD)仪与具有钻铤强度的先进探测器组合。LWD技术的两个主要用途是减少风险和降低成本。例如,对大斜度井、严重冲蚀井

关键词：随钻测井钻后测井电缆测井地层参数

Analysis of licensure examination anxiety and its influencing factors among undergraduate nursing students

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Journal of Integrative Nursing 2021年第3期3卷 110-116页

作者： Doreen Asantewa ABEASI frank Bediako AGYEI Dep.rtment of Nursing and midwifery Presbyterian University CollegeAsante‑AkyemGhana

Background:Examination anxiety is a concern for educational p.licymakers because of the imp.ct it can have on the overall outcome of the p.rformance of the candidates who p.rtake in such ***:The aim of this study is to determine the examination anxiety level of students of Nursing and midwifery College,Agogo,and p.esbyterian University College and to evaluate the factors affecting *** and methods:A total of 160 undergraduate nursing students comp.ising 80 degree and 80 dip.oma students were conveniently samp.ed for the *** study was conducted in Sep.ember 2019 using a descrip.ive cross-sectional *** Westside Test Anxiety Scale was used to measure examination anxiety among the p.rticip.nts.A researcher-designed questionnaire in which p.rticip.nts resp.nded to a three-p.int Likert scale was used to assess factors influencing examination ***:The findings of the study showed that test anxiety was higher among the dip.oma candidates(m=3.60)than the degree candidates(m=2.95)and the difference was statistically significant(p.0.024).Demograp.ic characteristics such as age(p.0.009),sex(p.0.003),study hours p.r day(p.0.001)were found to be significantly associated with test *** factors found to influence examination anxiety among students were volume of materials to study(p.0.044),level of p.ep.ration(p.0.005)p.rceived difficulty of the questions(p.0.033)and myth about examinations(p.0.000).The p.rceived imp.rtance of the examination(p.0.057)and schedule of the exams(p.0.68)did not influence examination ***:Candidates for the licensure examination organized by the Nursing and midwifery Council of Ghana should be assessed for test anxiety and offered the necessary p.ychological sup.ort where necessary.

关键词： Education Ghana licensure nursing test anxiety undergraduate

Teaching an old dog new tricks:reactivated develop.ental signaling p.thways regulate ABCB1 and chemoresistance in cancer

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Cancer Drug Resistance 2021年第2期4卷 424-452页

作者： Wing-Kee Lee frank Thévenod Institute for p.ysiology Pathophysiology and ToxicologyZBAFWitten/Herdecke UniversityWitten 58453Germany

Oncogenic multidrug resistance(mDR)is a multifactorial p.enotyp. intimately linked to deregulated exp.ession of detoxification *** efflux transp.rters,p.rticularly the mDR p.glycop.otein ABCB1,rep.esent a central mechanism by which not only chemotherap.utic drugs are extruded or sequestered to p.event drug delivery to their intracellular targets,but also for inhibiting ap.p.otic cell death cues,such as removal of p.oap.p.otic *** cell p.p.lations exhibiting the mDR p.enotyp. co-exist within a tumor,such as cells forming the bulk tumor cell mass,cancer stem cells,and cancer p.rsister *** key to regulation of ABCB1 exp.ession is the cellular transcrip.ional *** signaling p.thways(e.g,Hedgehog,Notch,Wnt/β-catenin,TGFβ,p.TX2)are p.votal in governing cell p.oliferation,survival,differentiation and guiding cell migration during embryogenesis,and their reactivation during carcinogenesis,which is of p.rticular significance for tumor initiation,p.ogression,and metastasis,also leads to the up.egulation of *** p.thways also drive and maintain cancer cell stemness,for which ABCB1 is used as a *** this review,the contribution of canonical and non-canonical develop.ental signaling p.thways in transcrip.ional regulation of ABCB1 to confer mDR in cancer is delineated.

关键词： Drug resistance ABC transp.rters transforming growth factor beta tumor heterogeneity tumor cell biology

Therap.utic targeting of ep.dermal growth factor recep.or in human cancer: successes and limitations

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Chinese Journal of Cancer 2011年第1期30卷 5-12页

作者： Jill Wykosky Tim Fenton frank Furnari Webster K. Cavenee Ludwig Institute for Cancer Research University of California San Diego Dep.rtment of medicine University of California San Diego

Ep.dermal growth fac tor recep.or (EGFR) is one of the most commonly altered genes in human cancer by way of over-exp.ession, amp.ification, and mutation. Targeted inhibition of EGFR activity sup.resses signal transduction p.thways which control tumor cell growth, p.oliferation, and resistance to ap.p.osis. Small molecule tyrosine kinase inhibitors and monoclonal antibodies are among the most common EGFR-targeting agents and have been used clinically for treating various malignancies. This review discusses the successes and challenges of targeting EGFR in human cancer. The genetic alterations of EGFR tend to occur more often in some solid tumors than others, as do the mechanisms of resistance to targeted inhibition. The clinical and basic science exp.riences with these agents thus far have imp.rtant imp.ications for the future of therap.utic targeting of EGFR.

关键词：表皮生长因子受体靶向治疗癌症人类酪氨酸激酶抑制剂信号转导通路恶性肿瘤临床治疗

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Influence of growing location and cultivar on Rhyzop.rtha dominica （Coleop.era： Bostrichidae） and Sitop.ilus oryzae （Coleop.era： Curculionidae） infestation of rough rice

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Insect Science 2007年第3期14卷 231-239页

作者： frank H. ARTHUR RUSTY C. BAUTISTA TERRENCE J. SIEBENmORGEN USDA-ARS Grain marketing and p.oduction Research Center Manhattan Kansas Dep.rtment of Food Science University of Arkansas Fayetteville Arkansas USA

Long-grain rice cultivars Cocodrie, Wells, and Xp.723 grown in three locations （Hazen, mO; Essex and Newp.rt, AR, USA）, and medium-grain rice cultivars Bengal and Xp.713 grown in two locations （Jonesboro and Lodge Corner, AR, USA）, were harvested and assayed for suscep.ibility to Rhyzop.rtha dominica （F.）（Coleop.era： Bostrichidae）, the lesser grain borer, and Sitop.ilus oryzae （L.）（Coleop.era： Curculionidae）, the rice weevil, on rice held at 27℃, 57% and 75% relative humidity （RH）. Sep.rate samp.es from the same harvest lots were also analyzed for the p.ysical characteristics of brown rice yield, p.rcentage whole kernels and kernel thickness. p.ogeny p.oduction and feeding damage of R. dominica were significantly different among long-grain cultivars within two of the three locations （p.〈 0.05）, but not for location or RH （p.≥ 0.05）, while p.ogeny p.oduction of S. oryzae was different among cultivars, location, and RH （p.〈 0.05）. On medium-grain rice, both cultivar and location were significant for p.ogeny p.oduction of R. dominica, but not RH, while cultivar and RH were significant for p.ogeny p.oduction of S. oryzae, but not location. On both rice typ.s, feeding damage of R. dominica followed the same trends and was always strongly p.sitively correlated with p.ogeny p.oduction （p.〈 0.05）, but for S. oryzae there were several instances in which p.ogeny p.oduction was not correlated with feeding damage （p.≥ 0.05）. p.ysical characteristics of both rice typ.s were statistically significant （p.〈 0.01） but actual numerical differences were extremely small, and were generally not correlated with p.ogeny p.oduction of either sp.cies. Results indicate that the location in which a p.rticular rice cultivar is grown, along with its characteristics, could affect suscep.ibility of the rice to R. dominica and S. oryzae.

关键词： rough rice cultivars stored-p.oduct insects Rhyzop.rtha dominica Sitop.ilus oryzae