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A SYNDROmE OF SEVERE HYPOGLYCEmIA AND ACIDOSIS IN YOUNG ImmUNOSUPPRESSED DIABETIC mONKEYS - ASSOCIATION WITH SEPSIS

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A SYNDROME OF SEVERE HYPOGLYCEMIA AND ACIDOSIS IN YOUNG IMMU...

2012中国器官移植大会

作者： Dirk J.van der Windt Eefje m.Dons Gabriel J. Echeverri Noriko murase Rita Bottino martin Wijkstrom Robert Wagner David K.C.Cooper thomas E.Starzl Transplantation Institute Department of SurgeryUniversity of Pittsburgh Medical CenterPittsburghPAUSA Division of Immunogenetics Department of PediatricsChildren's Hospital of PittsburghPittsburghPAUSA

Large animals treated with immunosuppressive drug regimens for preclinical experiments of transplantation have increased risks of infection,as do individuals with *** we report our experience with severe sepsis in two young cynomolgus monkeys that were subjected to diabetes induction +/- islet *** both monkeys,infection was associated with a syndrome of profound hypoglycemia accompanied by severe *** the discussion of these cases we include information on five immunosuppressed pigs that also experienced severe hypoglycemic episodes after diabetes induction and islet

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斯科茨大楼,新加坡

世界建筑 2020年第10期 70-75,136页

作者： Ben van Berkel Astrid Piber with Ger Gijzen Konstantinos Chrysos Luis Etchegorry Cynthia markhoff Elisabeth Brauner Shany Barath thomas van Bekhoven Iris Pastor Rodrigo Canizares Albert Gnodde mo Ching Ying Lai Grete Veskivali Philipp Weisz Samuel Bernier Lavigne Lukasz Walczak Alicja Chola Cheng Gong Darren Soh(摄影) EdmonLeong(摄影) UN Studio 不详

斯科茨大楼SOHO公寓位于新加坡的黄金地段,靠近乌节路豪华购物区,眺望邻近公园和新加坡城市全景。该塔楼拥有18,500m12、共231个居住单位,包含一至三居室的公寓、四居室的楼顶公寓、宽敞的绿植园林、空中花园、楼顶公寓顶层花园以及各... 详细信息

斯科茨大楼SOHO公寓位于新加坡的黄金地段,靠近乌节路豪华购物区,眺望邻近公园和新加坡城市全景。该塔楼拥有18,500m12、共231个居住单位,包含一至三居室的公寓、四居室的楼顶公寓、宽敞的绿植园林、空中花园、楼顶公寓顶层花园以及各种娱乐设备。UN Studio创始人及首席建筑师本·范·贝克尔表示:“这个大楼是新加坡城市的一个趣味点,跳出了一般的惯常设计手法,我们创造了一个空中的街区,一个每个区域都拥有独特功效的垂直城市。”

关键词：空中花园设计手法垂直城市娱乐设备贝克尔新加坡城市独特功效科茨

模拟日光射线对接触性过敏反应诱发阶段的影响在多形性日光疹患者和对照无区别

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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 7-8页

作者： Palmer R.A. Hawk J.L.m. Young A.R. Walker S.L. 刘安 Dr. Photobiology Unit St. John's Institute of Dermatology St. Thomas'Hospital London SE1 7EH United Kingdom

It has been suggested that polymorphic light eruption (PLE) is characterized by a failure of ultraviolet radiation (UVR)-induced immunosuppression, resulting in a type-IV hypersensitivity response to photoinduced antigens. We measured the effect of solar-simulated radiation (SSR) on the elicitation phase of contact hypersensitivity to 2,4-dinitrochlorobenzene (DNCB), in ten PLE patients and 11 controls. Subjects were given a sensitizing dose of DNCB, and 3 wk later were exposed to 0.75 and 2 minimum erythema doses (mED) of SSR on the upper inner arm. Immediately and 24 h later these sites, and a non-irradiated control site, were challenged with DNCB. The resulting increase in skin thickness was measured with high-frequency ultrasound. Overall, 2 mED caused 17%-20%suppression of elicitation responses (compared with 93%suppression of sensitization reported previously), but the effect of SSR varied greatly between subjects, with some subjects showing potentiated responses, which may be of relevance to false-positive reactions in photopatch testing. In a repeated measures general linear model, SSR overall caused significant suppression of responses (p matched normal controls. These results contrast with our previous finding of a resistance to UVR-induced suppression of sensitization toDNCB in PLE. This difference may reflect the greater importance of Langerhans cells in the sensitization phase, and is consistent with the hypothesis that PLE arises from impaired suppression of Langerhans cell activation or migration.

关键词：多形性日光疹接触性过敏反应 Ⅳ型过敏反应 DNCB 红斑剂量朗格汉斯细胞反应抑制假阳性反应二硝基苯免疫抑制

Fungal diversity notes 1036-1150:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2019年第3期96卷 1-242页

作者： Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama Bhat Sajeewa S.N.maharachchikumbura Walter Rossi marco Leonardi Hyang Burm Lee Hye Yeon mun Jos Houbraken Thuong T.T.Nguyen Sun Jeong Jeon Jens Christian Frisvad Dhanushka N.Wanasinghe Robert Lucking Andre Aptroot marcela E.S.Caceres Samantha C.Karunarathna Sinang Hongsanan Rungtiwa Phookamsak Nimali Ide Silva Kasun m.Thambugala Ruvishika S.Jayawardena Indunil C.Senanayake Saranyaphat Boonmee Jie Chen Zong-Long Luo Chayanard Phukhamsakda Olinto L.Pereira Vanessa P.Abreu Andre Wilson Campos Rosado Buyck Bart Emile Randrianjohany Vale rie Hofstetter Tatiana B.Gibertoni Adriene mayrada Silva Soares Helio Longoni Plautz Jr Helen maria Pontes Sotao William Kalhy Silva Xavier Jadson Diogo Pereira Bezerra Thays Gabrielle Linsde Oliveira Cristina mariade Souza-motta Oliane maria Correia magalhaes Digvijayini Bundhun Dulanjalee Harishchandra Ishara S.manawasinghe Wei Dong Sheng-Nan Zhang Dan-Feng Bao milan C.Samarakoon Dhandevi Pem Anuruddha Karunarathna Chuan-Gen Lin Jing Yang Rekhani H.Perera Vinit Kumar Shi-Ke Huang monika C.Dayarathne Anusha H.Ekanayaka Subashini C.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula Niskanen Kare Liimatainen Yu-Cheng Dai Xiao-Hong Ji Xue-mei Tian Armin mesic Sanjay K.Singh Kunthida Phutthacharoen Lei Cai Touny Sorvongxay Vinodhini Thiyagaraja Chada Norphanphoun Napalai Chaiwan Yong-Zhong Lu Hong-Bo Jiang Jin-Feng Zhang Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahmanage ming Zeng Thilini Chethana Deping Wei martina Reblova Jacques Fournier Jana Nekvindova Renan do Nascimento Barbosa Jose Ewerton Felintodos Santos Neiva Tintide Oliveira Guo-Jie Li Damien Ertz Qiu-Ju Shang Alan J.L.Phillips Chang-Hsin Kuo Erio Camporesi Timur S.Bulgakov Saisamorn Lumyong E.B.Gareth Jones Putarak Chomnunti Eleni Gentekaki frank Bungartz Xiang-Yu Zeng Sally Fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-Chi Wen Paras Nath Singh Yusufjon Gafforov Itthayakorn Promputtha Erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao Paul m Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Plant medicine National Chiayi University300 Syuefu RoadChiayi City 60004TaiwanPeople’s Republic of China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Formerly Department of Botany Goa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Sect.Environmental Sciences Dept.MeSVAUniversity of L’Aquila67100 CoppitoAQItaly Division of Food Technology Biotechnology&AgrochemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186Korea Fungal Resources Research Division NNIBRSangju-si 37242Korea Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Biotechnology and Biomedicine DTUBioengineeringTechnical University of Denmark2800 Kongens LyngbyDenmark Botanischer Garten und Botanisches museum Berlin Freie Universitat BerlinKonigin-Luise-StraßBe 6-814195 BerlinGermany Laboratorio de Botanica/Liquenologia Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitarioCampo GrandeMatto Grosso do Sul CEP 79070-900Brazil Departamento de Biociencias Universidade Federal de SergipeItabaianaSergipe CEP:49500-000Brazil Shenzhen Key Laboratory of microbial

This article is the tenth series of the Fungal Diversity Notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and *** described in the present study include one new family(*** in Dothideomycetes),five new genera(Caatingomyces,Cryptoschizotrema,Neoacladium,Paramassaria and Trochilispora)and 71 new species,(*** thailandica,Amniculicola aquatica,***,Angustimassarina sylvatica,Blackwellomyces lateris,Boubovia gelatinosa,Buellia viridula,Caatingomyces brasiliensis,Calophoma humuli,Camarosporidiella mori,Canalisporium dehongense,Cantharellus brunneopallidus,***,Castanediella meliponae,Coprinopsis psammophila,Cordyceps succavus,Cortinarius minusculus,***,Diaporthe italiana,***,Diatrypella delonicis,Dictyocheirospora aquadulcis,***,Digitodesmium chiangmaiense,Distoseptispora dehongensis,***,Dothiorella styphnolobii,Ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,***,Grammothele aurantiaca,***,Hermatomyces bauhiniae,Jahnula queenslandica,Kamalomyces mangrovei,Lecidella yunnanensis,micarea squamulosa,muriphaeosphaeria angustifoliae,Neoacladium indicum,Neodidymelliopsis sambuci,Neosetophoma miscanthi,***,Nodulosphaeria aquilegiae,***,Paramassaria samaneae,Penicillium circulare,***,***-pumilae,***,***,Phaeoisaria siamensis,Phaeopoacea asparagicola,Phaeosphaeria penniseti,Plectocarpon galapagoense,Porina sorediata,Pseudoberkleasmium chiangmaiense,Pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,Stigmatomyces chamaemyiae,***,***,***,***,Thysanorea uniseptata,Torula breviconidiophora,***,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(*** cryptotrema,Prolixandromyces australi,***,***,***,P.

关键词： 71 new taxa Ascomycota Basidiomycota Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes Pezizomycetes Phylogeny Taxonomy

动脉瘤性蛛网膜下腔出血患者的重症监护处理：神经危重症监护学会多学科共识会议的推荐意见

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国际脑血管病杂志 2013年第5期21卷 324-347页

作者： michael N. Diringer thomas P. Bleck J. Claude Hemphill David menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez miriam Tresgiari ming-Yuan Tseng mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿英英(译) From the Neurology/Neurosurgery Intensive Care Unit Washingion University St. Louis MO USA Rush medical College Chicago IL USA University of California at San Francisco San Francisco CA USA University of Cambridge Cambridge UK University of Cincinnati Cincinnati OH USA University of California at Los Angeles LOs Angeles CA USA Universit6 de la m.diterranae Marsedle France Columbia University New York NY USA San Gerardo Hospital Monza Italy University of Virginia Charlottesville VA USA Heinrich-Heine University Dttsseldorf Germany University of Florida Gainesville FL USA mayo Clinic Rochester MN USA University of Pennsylvania Philadelphia PA USA University Hospital Innsbruck lnnsbruck Austria Fondazione IRCCS Ch Granda- Ospedale Policlinico Milan University Milan Italy University of Washington St. Louis MO USA Baylor College of medicine Houston TX USA Nottingham University Hospitals Nottingham UK University of Utrecht Utrecht The Netherlands Freie Universitit Berlin Berlin Germany Washington University St. Louis MO USA 首都医科大学宣武医院神经内科北京100053

蛛网膜下腔出血（subarachnoidhemorrhage，SAH）是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏，使得治疗方法... 详细信息

蛛网膜下腔出血（subarachnoidhemorrhage，SAH）是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏，使得治疗方法各异，可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防，很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域，此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验，选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价（GradesofRecommendationsAssessment，DevelopmentandEvaluation，GRADE）系统进行文献回顾，结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见，其制定原则不仅强调研究资料的质量，而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见，即使缺乏高质量的证据。

关键词：蛛网膜下腔出血重症监护动脉瘤血管痉挛抗惊厥药低钠血症血管内发热

临床试验数据共享声明国际医学期刊编辑委员会统一要求

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英国医学杂志中文版 2017年第16期20卷 365-366页

作者： Darren B Taichman Peush Sahni Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee frank A Frizelle Fernando Florenzano Jeffrey m Drazen Howard Bauchner Christopher Baethge Deutsches Arzteblatt Joyce Backus 季媛媛不详中华医学杂志英文版编辑部

国际医学期刊编辑委员会（ICmJE）认为，由于临床试验参与者处于研究风险之中，我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月，ICmJE发表了1项关于临床试验数据共享的提案，旨在帮助创造共享去标识个体患者数... 详细信息

国际医学期刊编辑委员会（ICmJE）认为，由于临床试验参与者处于研究风险之中，我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月，ICmJE发表了1项关于临床试验数据共享的提案，旨在帮助创造共享去标识个体患者数据的常态化环境。迄今，应我们的反馈要求，ICmJE收到了很多来自个人和团体的意见。

关键词：临床试验数据数据共享期刊编辑工作

Distribution of High-Risk Human Papillomavirus Genotypes in Precancerous Cervical Lesions in Ouagadougou, Burkina Faso

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Open Journal of Obstetrics and Gynecology 2016年第4期6卷 196-204页

作者： Charlemagne Ouédraogo Théodora mahoukèdè Zohoncon Esther m. A. Traoré Souleymane Ouattara Prosper Bado Clarisse T. Ouedraogo Florencia W. Djigma Djénéba Ouermi Dorcas Obiri-Yeboah Olga Lompo Simon A. Akpona Jacques Simpore Pietro Annigoni Biomolecular Research Center (CERBA) Ouagadougou Burkina Faso UFR/SDS University of Ouagadougou Ouagadougou Burkina Faso Laboratory of molecular Biology and Genetics (LABIOGENE) University of Ouagadougou Ouagadougo Burkina Faso Teaching and Research Unit in Biochemistry and molecular Biology Faculty of Medicine University of Parakou Parakou Republic of Benin Faculty of medicine Université Saint Thomas d’Aquin Ouagadougou Burkina Faso University of Cape Coast School of Medical Sciences Microbiology Department University Post Office Cape Coast Ghana Yalgado Ouédraogo University Hospital (CHU/YO) Ouagadougou Burkina Faso

Aims: We aimed at identifying the high-risk HPV genotypes associated with high-grade dysplastic cervical lesions in Burkina Faso. The available vaccines to Burkina Faso only protect against two high risk HPV genotypes: HPV 16 and 18. Are the genotypes identified in the high-grade precan-cerous lesions in this survey covered by the available vaccines? methods: The detection and genotyping of high-risk HPV have been conducted based on 118 formalin-fixed and paraffin-embedded archived tissues using the “HPV Genotypes 14 Real-Tm Quant” (Sacace biotechnologies®, Italy) kit allowing for the detection of fourteen high-risk HPV genotypes: HPV 16, 31, 18, 39, 45, 59, 33, 35, 56, 68, 51, 52, 58 and 66. Results: The prevalence of high-risk HPV infections was 48.8% based on the appropriate PCR results (21/43). The most common HPV genotypes were HPV 39 (21.7%), HPV 35 (13.0%) and HPV 45 (13.0%). Two cases of multiple infections between HPV 39 - 45 and HPV 39 - 59 have been observed. HPV 16 was not detected in this study. Conclusions: We noted a high prevalence rate for HPV 39, HPV 35 and HPV 45, which are not covered by the commercial vaccines. We also found that the prevalence of HPV 18 was very low in this study and HPV 16 was not detected.

关键词： HPV Cancer CIN Cervix Burkina Faso

乙基纤维素-艾叶粉溶液微胶囊的制备及缓释性能研究

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广东化工 2009年第5期36卷 6-8,90页

作者：张扬杨子明邓思贤杨卓鸿李鹂欧韦文汪国成华南农业大学理学院广东广州510642 香港理工大学护理学院

文章首次以乙基纤维素为壁材,采用溶剂蒸发法制得艾叶粉水溶液微胶囊。正交实验得出制备微胶囊的最佳工艺条件为:乙基纤维素︰芯材︰乙酸乙酯︰水相=1︰2.5︰13︰130(质量比),搅拌速度:1500 r/min,乳化时间:15 mim,水油两相混合搅拌时间... 详细信息

文章首次以乙基纤维素为壁材,采用溶剂蒸发法制得艾叶粉水溶液微胶囊。正交实验得出制备微胶囊的最佳工艺条件为:乙基纤维素︰芯材︰乙酸乙酯︰水相=1︰2.5︰13︰130(质量比),搅拌速度:1500 r/min,乳化时间:15 mim,水油两相混合搅拌时间:10 min。通过扫描电镜表征结果显示,所得微胶囊固体颗粒呈球形,分散性好,粒径在20～200μm范围内。实验制得微胶囊最大载药量为48.07%,具有良好的包覆效果。透析缓释实验表明,微胶囊在37.0℃恒温生理盐水浸泡60 h后,仍有艾叶药理活性成分存在,较好地延长了储藏时间和药物有效作用时限。

关键词：乙基纤维素艾叶粉溶液微胶囊缓释

化学气体污染突发事件中的人群疏散:横断面调查

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英国医学杂志中文版 2005年第5期8卷 285-288页

作者： S Kinra G Lewendon R Nelder N Herriott R mohan m Hort S Harrison V murray 陈雷（译） Department of Social medicine University of BristolBristol BS8 2PR Public Health Development Unit Plymouth Teaching Primary Care TrustPlymouth PL1 2AD Chemical Hazards Unit Health Protection AgencyGuy＇s and St Thomas＇ Hospital TrustLondon SE14 5ER met Office Exeter EX1 3PB 不详

目的比较一个塑料工厂发生化学事故后躲藏和被疏散人群的健康结局。设计横断面调查。背景英格兰西南的市区。研究对象该地区1750位曾暴露于化学烟雾的居民,其中472人被疏散,剩下的1278人被建议躲藏在室内。主要结局测定不利于健康的症... 详细信息

目的比较一个塑料工厂发生化学事故后躲藏和被疏散人群的健康结局。设计横断面调查。背景英格兰西南的市区。研究对象该地区1750位曾暴露于化学烟雾的居民,其中472人被疏散,剩下的1278人被建议躲藏在室内。主要结局测定不利于健康的症状数目。出现4个或以上症状者被确定为一个病例。主要的结果1096位居民(63%;299人被疏散,797人躲藏起来)为本分析提供了资料。被疏散人群的平均症状分值和病例的比例比躲藏人群的要高(疏散者:症状分值1.9,病例比例19.7%(n=59);躲藏者:症状分值1.0,病例比例9.5%(n=76),二者比较P<0.001)。在事故发生后两周末时二组间的差异明显变小。成为病例的两个主要可变更危险因子是疏散(比值比2.5,95%可信区间1.7～3.8)和在事故当天直接暴露于烟雾的时间超过2小时(比值比2.0,95%可信区间1.7～2.3)。住所距工厂的距离或是干预前(头6个小时)暴露的水平对于研究对象成为病例的作用不大。结论在此次化学事故中躲藏起来可能是优于疏散人群的保护措施。这与专家们普遍认为的观点一致。尽管本研究有一定的局限性,但它是基于一场真实的事件。疏散本身有一定的风险和资源上的限制,认识上的增加可能会有助于减少将来不必要的疏散。

关键词：化学事故横断面调查人群突发事件气体污染健康结局研究对象可信区间危险因子保护措施