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Trends in treatment and overall survival among patients with proximal esophageal cancer

World Journal of Gastroenterology 2019年第47期25卷 6835-6846页

作者： Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad frank jp hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen Department of Internal Medicine Division of Medical OncologyGROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Department of Research Netherlands Comprehensive Cancer Organization(IKNL)Eindhoven 5612 HZNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Pathology and Data Analytics Leeds Institute of Medical Research at St James”sUniversity of LeedsLeeds LS97TFUnited Kingdom Department of Medical Oncology University Medical Center UtrechtUtrecht 3584 CXNetherlands Department of Radiation Oncology(MAASTRO clinic) GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6229 ETNetherlands Department of Internal Medicine Division of GastroenterologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Department of Radiotherapy RadiotherapiegroepDeventer 7416 SENetherlands Department of Medical Oncology Amsterdam University Medical CentersUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Radiotherapy Insituut VerbeetenTilburg 5042 SBNetherlands Department of Medical Oncology Leiden University Medical CenterLeiden 2333 ZANetherlands Department of Surgery Catharina Hospital EindhovenEindhoven 5623 EJNetherlands Department of Public Health Erasmus Medical Center RotterdamRotterdam 3015 GDNetherlands

BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital ***-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been *** trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease *** optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life *** To establish trends in treatment and OS in patients with proximal esophageal *** In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer *** proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the *** in radiotherapy,chemotherapy,and surgery,and OS were *** were stratified by presence of distant *** Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment *** In total,2783 patients were *** the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,*** metastatic disease,the use of chemotherapy and radiotherapy increased over *** OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on ***

关键词： Esophagus Esophageal cancer Proximal Cervical Upper thoracic Trends Treatment Survival Outcome

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Experimental Studies on the Irradiation of Facial Bones in Animals:A Review

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第3期3卷 113-127页

作者： Lucas Poort Bernd Lethaus Roland Bockmann Doke Buurman Jos De Jong frank hoebers Peter Kessler Department of Cranio-and Maxillofacial Surgery Maastricht University Medical CentreMaastrichtThe Netherlands GROW School for Oncology and Developmental Biology Maastricht University Medical CentreMaastrichtThe Netherlands Department of Oral-and Maxillofacial Surgery Universitatsklinikum Aachen(University Medical Centre)AachenGermany Department of Radiation Oncology(Maastro Clinic) Maastricht University Medical CentreMaastrichtThe Netherlands

Introduction: Radiotherapy is often used to treat head and neck malignancies, with inevitable effects on the surrounding healthy tissues. We have reviewed the literature concerning the experimental irradiation of facial bones in animals. Materials and Methods: A PubMed search was performed to retrieve animal experiments on the irradiation of facial bones that were published between January 1992 and January 2012. The search terms were “irradiation facial bone” and “irradiation osteoradionecrosis”. Results: Thirty-six publications were included. The irradiation sources were Cobalt60, orthovoltage, 4 - 6 megavolt photons, and brachytherapy. The total dose varied between 8 - 60 Gy in single or multiple fractions. The literature presents a broad range of animal studies that differ in terms of the in vivo model, irradiation, observation period, and evaluation of results. Discussion: The different animal models used leave many questions unanswered. A detailed and standardized description of the methodology and results would facilitate the comparability of future studies.

关键词： Irradiation Animal Experiments Facial Bones Osteoradionecrosis

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Tuberculosis in health care workers in south Australia

Tuberculosis in health care workers in south Australia

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2007年中国防痨协会全国学术会议

作者： frank T S CHIU OAM MBBS FRACP FCCP jp DEPARTMENT OF THORACIC MEDICINE ROYAL ADELAIDE HOSPITALSOUTH AUSTRALIAAUSTRALIA DEPARTMENT OF THORACIC MEDICINE ROYAL ADELAIDE HOSPITALSOUTH AUSTRALIAAUSTRALIA DEPARTMENT OF THORACIC MEDICINE ROYAL ADELAIDE HOSPITALSOUTH AUSTRALIAAUSTRALIA DEPARTMENT OF THORACIC MEDICINE ROYAL ADELAIDE HOSPITALSOUTH AUSTRALIAAUSTRALIA DEPARTMENT OF THORACIC MEDICINE ROYAL ADELAIDE HOSPITALSOUTH AUSTRALIAAUSTRALIA DEPARTMENT OF THORACIC MEDICINE ROYAL ADELAIDE HOSPITALSOUTH AUSTRALIAAUSTRALIA

＜正＞The control of the epidemic of tuberculosis in Australia over the last 50 years is one of its major population health *** incidence of tuberculosis in Australia remains at 5 to 6/100000. In South Australia,among the Australian born, the annual incidence has gradually fallen t0 0．9 ca- ses per 100000 *** majority of the no- tified cases occur in the over 65 age group and for children less than 15 years of age TB is now an un- common *** highlights the fact that

关键词： Pulmonary tuberculosis Health are Workers Pre and Post employment screening

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离子色谱电感耦合等离子体质谱联用法测定水中痕量BrO3-及Br-

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分析化学 2005年第7期33卷 993-995页

作者：沈金灿,荆淼,陈登云,沈阳,王小如,frank S. C. Lee 厦门大学化学化工学院化学系现代分析科学教育部重点实验室国家海洋局第一海洋研究所安捷伦公司中国地区厦门大学化学化工学院化学系现代分析科学教育部重点实验室厦门大学化学化工学院化学系现代分析科学教育部重点实验室国家海洋局第一海洋研究所厦门361005 青岛266061 北京100000 厦门361005 厦门361005 国家海洋局第一海洋研究所青岛266061 青岛266061

建立了离子色谱电感耦合等离子体质谱联用技术(ICICPMS)用于饮用水中的痕量BrO-3及Br-的测量。使用DIONEXCarbopacPA100(4mm×250mmi.d.)在流速1mL/min及5mmol/LNH4NO3(pH5.7)淋洗液下进行BrO-3和Br-的分离。该方法以100μL进样量对BrO-3的检出限为0.0027μmol/L(0.22μg/L);对Br-的检出限为0.0067μmol/L(0.54μg/L)。对水样的分析结果表明,所测矿泉水中的BrO-3浓度大大超出了世界卫生组织最新《饮用水水质准则》中所规定的溴酸盐的指导值,而所测量的青岛崂山区生活用水则未检出BrO-3。

关键词：溴溴酸盐离子色谱电感耦合等离子体质谱水

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