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Precise role of H pylori in duodenal ulceration

World Journal of Gastroenterology 2006年第40期12卷 6413-6419页

作者： Michael Hobsley frank i tovey John Holton Department of Surgery Royal Free and University College Medical School London United Kingdom Department of Microbiology Royal Free and University College Medical School London United Kingdom

The facts that H pylori infection is commoner in duodenal ulcer (DU) patients than in the normal population, and that eradication results in most cases being cured, have led to the belief that it causes DU. However, early cases of DU are less likely than established ones to be infected. H pylori-negative cases are usually ascribed to specific associated factors such as non-steroidal anti-inflammatory drugs (NSAiDs), Crohn’s disease, and hypergastrinaemia, but even after excluding these, several H pylori-negative cases remain and are particularly common in areas of low prevalence of H pylori infection. Moreover, this incidence of H pylori negative DU is not associated with a fall in overall DU prevalence when compared with countries with a higher H pylori prevalence. in countries with a high H pylori prevalence there are regional differences in DU prevalence, but no evidence of an overall higher prevalence of DU than in countries with a low H pylori prevalence. There is no evidence that virulence factors are predictive of clinical outcome. After healing following eradication of H pylori infection DU can still recur. Medical or surgical measures to reduce acid output can lead to long-term healing despite persistence of H pylori infection. Up to half of cases of acute DU perforation are H pylori negative. These findings lead to the conclusion that H pylori infection does not itself cause DU, but leads to resistance to healing, i.e., chronicity. This conclusion is shown not to be incompatible with the universally high prevalence of DU compared with controls.

关键词： Duodenal ulceration H pylori infection Not causal Delays healing

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Role of dietary phospholipids and phytosterols in protection against peptic ulceration as shown by experiments on rats

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World Journal of Gastroenterology 2015年第5期21卷 1377-1384页

作者： frank i tovey Division of Surgery and interventional Science University College LondonLondon W1W 7EJUnited Kingdom

Geographically the prevalence of duodenal ulceration is related to the staple foods in the diet in regions of developing countries where the diet is *** is higher in regions where the diet is based on milled rice,refined wheat or maize,yams,cassava,sweet potato,or green bananas,and is lower in regions where the staple diet is based on unrefined wheat or maize,soya,certain millets or certain *** on rat gastric and duodenal ulcer models showed that it was the lipid fraction in staple foods from low prevalence areas that was protective against bothgastric and duodenal ulceration,including ulceration due to non-steroidal anti-inflammatory drugs(NSAiDs).it also promoted ulcer *** lipid from the pulse,Dolichos biflorus,horse gram which was highly protective was used to identify the fractions with protective activity in the *** protective activity lay in the phospholipid,sterol and sterol ester *** the phospholipid fraction phosphatidyl choline(lethicin) and phosphatidyl ethanolamine(cephalin) were *** the sterol fraction the sub-fractions showing protective activity contained β-sitosterol,stigmasterol,and an unidentified isomer of β-*** evidence from animal models shows that certain dietary phospholipids and phytosterols have a protective action against gastroduodenal ulceration,both singly and in *** supports the protective role of staple diets in areas of low duodenal ulcer prevalence and may prove to be of importance in the prevention and treatment of duodenal ulceration and management of recurrent ulcers.A combination of phospholipids and phytosterols could also play an important role in protection against ulceration due to NSAiDs.

关键词： Peptic ulceration Mucosal protection Nonsteroidal

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Congratulation on World Journal of Gastroenterology

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World Journal of Gastroenterology 2007年第1期13卷 158-158页

作者： frank ivor tovey Honorary Research Felllow Department of Surgery University College London London United Kingdom

Dear Professor Lian-Sheng Ma, Professor Michael Hobsley and i have greatly enjoyed reading the account of all you have done towards the development of ＂The World Journal of Gastroenterology＂, as described in the article by Zhen-Xi Li in the November 21st. issue of the Journal. it is an amazing achievement! Yours is the only international gastroenterological iournal to come out weekly! The standard of the articles is extremely high and the Journal is equal in size to ＂Gut＂（Leaderette： 2005 impact Factor-Gastroenterology ＆ Hepatology list：1 GASTROENTEROLOGY 12.386; 2 HEPATOLOGY 9.792; GUT 7.692）, which comes out only monthly. You have achieved all this in a matter of only 10 years-truly a wonderful achievement. We do congratulate you.

关键词： Gastroenterology

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Treatment of duodenal ulceration with Furazolidine in China preceded the discovery of its association with H pylori

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World Journal of Gastroenterology 2007年第22期13卷 3147-3147页

作者： frank ivor tovey Honorary Research Felllow Department of Surgery University College London London United Kingdom

it is not generally known that patients with duodenal ulceration were being treated with an antibiotic, Furazolidone, in China five or more years before Marshall and Warren published their seminal paper in 1984 about the association between duodenal ulceration and Campylobacter like organisms in the stomach, later named Hpylori. Marshall and Warren won the 2005 Nobel Prize in physiology or medicine for their work on how a bacterium can relate to gastric inflammation or peptic ulceration.

关键词：十二指肠溃疡呋喃唑酮幽门螺杆菌治疗

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