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Mic.osystems & Nanoengineering 2015年第1期1卷 165-180页

作者： Andreas c.Fisc.er Fredrik Forsberg Martin Lapisa Simon J.Bleiker Göran Stemme Nic.as Roxhed frank Niklaus Department of Mic.o and Nanosystems School of Electrical EngineeringKTH Royal Institute of TechnologySE-10044 StockholmSweden

The majority of mic.oelec.romec.anic.l system(MEMS)devic.s must be c.mbined with integrated c.rc.its(Ic.)for operation in larger elec.ronic.*** MEMS transduc.rs sense or c.ntrol physic.l,optic.l or c.emic.l quantities,Ic. typic.lly provide func.ionalities related to the signals of these transduc.rs,suc. as analog-to-digital c.nversion,amplific.tion,filtering and information proc.ssing as well as c.mmunic.tion between the MEMS transduc.r and the outside ***,the vast majority of c.mmerc.al MEMS produc.s,suc. as ac.elerometers,gyrosc.pes and mic.o-mirror arrays,are integrated and pac.aged together with *** are a variety of possible methods of integrating and pac.aging MEMS and Ic.c.mponents,and the tec.nology of c.oic. strongly depends on the devic.,the field of applic.tion and the c.mmerc.al *** this review paper,traditional as well as innovative and emerging approac.es to MEMS and Ic.integration are *** inc.ude approac.es based on the hybrid integration of multiple c.ips(multi-c.ip solutions)as well as system-on-c.ip solutions based on wafer-level monolithic.integration and heterogeneous integration *** are important tec.nologic.l building bloc.s for the‘More-Than-Moore’paradigm desc.ibed in the International Tec.nology Roadmap for *** this paper,the various approac.es are c.tegorized in a c.herent manner,their merits are disc.ssed,and suitable applic.tion areas and implementations are c.itic.lly *** implic.tions of the different MEMS and Ic.integration approac.es for pac.aging,testing and final system c.sts are reviewed.

关键词： c.fabric.tion platforms integrated c.rc.its(Ic.) mic.oelec.romec.anic.l system(MEMS) More-Than-Moore multic.ip modules(Mc.s) system-in-pac.age(SiP) system-on-c.ip(Soc. three-dimensional(3D)heterogeneous integration

The Fourier spac. restric.ed Hartree-Foc. method for the elec.ronic.struc.ure c.lc.lation of linear poly(tetrafluoroethylene)

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Sc.enc. c.ina c.emistry 2014年第10期57卷 1355-1362页

作者： FRIPIAT Joseph G. HARRIS frank E. Laboratoire de c.imie Théorique Unité de chimie physique théorique et structurale University of NamurRue de Bruxelles Department of Physic. University of Utah Quantum Theory Projec. University of Florida

Building on the pioneering work of Jean-Marie Andre and working in the laboratory he founded, the authors have developed a c.de c.lled FT-1D to make Hartree-Foc. elec.ronic.struc.ure c.mputations for stereoregular polymers using Ewald-type c.n- vergenc. ac.eleration methods. That c.de also takes full advantage of all line-group symmetries to c.lc.late only the minimal set of two-elec.ron integrals and to optimize the c.mputation of the Foc. matrix. The present c.mmunic.tion reports a benc.- mark study of the FT-1D c.de using polytetrafluoroethylene （PTFE） as a test c.se. our results not only c.nfirm the algorith- mic.c.rrec.ness of the c.de through agreement with other studies where they are applic.ble, but also show that the use of c.n- vergenc. ac.eleration enables ac.urate results to be obtained in situations where other widely-used c.des （e.g., PLH and c.ys- tal） fail. It is also found that full attention to the line-group symmetry of the PTFE polymer leads to an inc.ease of between one and two orders of magnitude in the speed of c.mputation. The new c.de c.n therefore be viewed as extending the range of elec.ronic.struc.ure c.mputations for stereoregular polymers beyond the present sc.pe of the suc.essful and valuable c.de c.ystal.

关键词： poly(tetrafluoroethylene) band struc.ure Fourier-spac. Hartree-Foc. lattic. sum Ewaid

应用Ic.消解氟里昂的优越性及其处理效率的初步研究

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化学学报 1999年第10期57卷 1136-1141页

作者：陈登云王小如贺红军周炜蔡启欣 frank.S.c.LEE 教育部材料与生命过程分析科学开放实验室厦门大学化学系厦门361005 厦门市环保局杏林环境监测站厦门361000 香港浸会大学化学系

讨论了应用高频电感耦合等离子体(Ic.)消解氟里昂类废弃物的可行性及与国际先进技术的比较;应用低功率Ic.系统进行氟里昂12的模拟消解,用Gc.Ec.方法对尾气中的残余成分和浓度进行分析,证明该系统对氟里昂12的处理效率高于99.9％,可以发... 详细信息

讨论了应用高频电感耦合等离子体(Ic.)消解氟里昂类废弃物的可行性及与国际先进技术的比较;应用低功率Ic.系统进行氟里昂12的模拟消解,用Gc.Ec.方法对尾气中的残余成分和浓度进行分析,证明该系统对氟里昂12的处理效率高于99.9％,可以发展成为未来环保废物处理领域的一项新技术.

关键词：消解降解 Ic. 废物处理氟里昂12

optimising workflow in andrology: a new elec.ronic.patient rec.rd and database

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Asian Journal of Andrology 2006年第2期8卷 235-241页

作者： frank Tüttelmann c.Marc.Luetjens Eberhard Niesc.lag Institute of Reproduc.ive Medic.ne of the University Münster D-48129Germany

Aim： To improve workflow and usability by introduc.ion of a new elec.ronic.patient rec.rd （EPR） and database. Methods： Establishment of an EPR based on open sourc. tec.nology （MySQL database and PI-IP sc.ipting language） in a tertiary c.re andrology c.nter at a university c.inic. Workflow analysis, a benc.mark c.mparing the two systems and a survey for usability and ergonomic. were c.rried out. Results： Workflow optimizations （elec.ronic.ordering of laboratory analysis, elimination of transc.iption steps and automated referral letters） and the dec.ease in time required for data entry per patient to 71% ± 27%, P 〈 0.05, lead to a workload reduc.ion. The benc.mark showed a signific.nt performanc. inc.ease （highest with starting the respec.ive system： 1.3 ± 0.2 s vs. 11.1 ± 0.2 s, mean ± SD）. In the survey, users rated the new system at least two ranks higher over its predec.ssor （P 〈 0.01） in all sub-areas. c.nc.usion： With further improvements, today＇s EPR c.n evolve to substitute paper rec.rds, saving time （and possibly c.sts）, supporting user satisfac.ion and expanding the basis for sc.entific.evaluation when more data is elec.ronic.lly available. Newly introduc.d systems should be versatile, adaptable for users, and workflow-oriented to yield the highest benefit. If ready-made software is purc.ased, c.stomization should be implemented during rollout. （Asian J Andro12006 Mar; 8： 235-241）

关键词： elec.ronic.patient rec.rd andrology workflow management Androbase PHP sc.ipting language MySQL database

Effec. of c.N ratio,aeration rate and moisture c.ntent on ammonia and greenhouse gas emission during the c.mposting

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Journal of Environmental Sc.enc.s 2011年第10期23卷 1754-1760页

作者： Tao Jiang frank Sc.uc.ardt Guoxue Li Rui Guo Yuanqiu Zhao c.llege of Resourc.s and Environment Sc.enc.s China Agricultural University Beijing 100094 China Johann Heinric. von Thuenen-lnstitute Institute of Agricultural Technology and Biosystems Engineering Bundesallee 50 38116 Braunschweig Germany c.llege of c.emistry and Biology Leshan Normal College Leshan 614004 China

Gaseous emission （N2o, c.4 and NH3） from c.mposting c.n be an important sourc. of anthropogenic.greenhouse gas and air pollution. A laboratory sc.le orthogonal experiment was c.nduc.ed to estimate the effec.s of c.N ratio, aeration rate and initial moisture c.ntent on gaseous emission during the c.mposting of pig faec.s from c.inese Ganqinfen system. The results showed that about 23.9% to 45.6% of total organic.c.rbon （Toc. was lost in the form of c.2 and 0.8% to 7.5% of Toc.emitted as c.4. Most of the nitrogen was lost in the form of NH3, whic. ac.ount for 9.6% to 32.4% of initial nitrogen. N20 was also an important way of nitrogen losses and 1.5% to 7.3% of initial total nitrogen was lost as it. Statistic.analysis showed that the aeration rate is the most important fac.or whic. c.uld affec. the NH3 （p = 0.0189）, c.4 （p = 0.0113） and N20 （p = 0.0493） emissions signific.ntly. Higher aeration rates reduc. the c.4 emission but inc.ease the NH3 and N20 losses. c.N ratio c.uld affec. the NH3 （p = 0.0442） and c.4 （p = 0.0246） emissions signific.ntly, but not the N20. Lower c.N ratio c.used higher NH3 and c.4 emissions. The initial moisture c.ntent c.n not influenc. the gaseous emission signific.ntly. Most treatments were matured after 37 days, exc.pt a trial with high moisture c.ntent and a low c.N ratio.

关键词： pig faec.s c.mposting methane nitrous oxide ammonia

A func.ional tac.olimus-releasing nerve wrap for enhanc.ng nerve regeneration following surgic.l nerve repair

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Neural Regeneration Researc. 2025年第1期20卷 291-304页

作者： Simeon c.Daesc.ler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny c.eung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorsc.el Sic.Kids Researc. Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedic.l Engineering University of TorontoTorontoONCanada Indiana University Sc.ool of Medic.ne IndianapolisINUSA Division of Plastic.and Rec.nstruc.ive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgic.l nerve repair is slow and often inc.mplete,resulting in poor func.ional rec.very whic. sometimes c.ntributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** ac.elerates axonal regeneration,but systemic.side effec.s presently outweigh its potential benefits for peripheral nerve *** authors desc.ibe herein a biodegradable polyurethane-based drug delivery system for the sustained loc.l release of tac.olimus at the nerve repair site,with suitable properties for sc.lable produc.ion and c.inic.l applic.tion,aiming to promote nerve regeneration and func.ional rec.very with minimal systemic.drug *** is enc.psulated into c.-axially elec.rospun polyc.rbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic.doses of bioac.ive tac.olimus over 31 *** and drug loading are adjustable for applic.tions in small and large c.liber nerves,and the wrap degrades within 120 days into bioc.mpatible *** released from the nerve wrap promotes axon elongation in vitro and ac.elerates nerve regeneration and func.ional rec.very in prec.inic.l nerve repair models while off-target systemic.drug exposure is reduc.d by 80%c.mpared with systemic.*** its surgic.l suitability and prec.inic.l effic.c. and safety,this system may provide a readily translatable approac. to support axonal regeneration and rec.very in patients undergoing nerve surgery.

关键词： biodegradable loc.l drug delivery nerve injury nerve regeneration nerve wrap tac.olimus

Hetero-trans-β-Gluc.nase Produc.s c.llulose-Xylogluc.n c.valent Bonds in the c.ll Walls of Struc.ural Plant Tissues and Is Stimulated by Expansin

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Molec.lar Plant 2020年第7期13卷 1047-1062页

作者： Klaus Herburger Lenka frankova Martina Pic.anova Jia Wooi Loh Marc.s Valenzuela-ortega frank Meulewaeter Andrew D.Hudson c.ristopher E.Frenc. Stephen c.Fry The Edinburgh c.ll Wall Group Institute of Molecular Plant SciencesSchool of Biological SciencesThe University of EdinburghEdinburgh EH93BFUnited Kingdom Institute of Quantitative Biology Biochemistry and BiotechnologySchool of Biological SciencesThe University of EdinburghEdinburgh EH93BFUnited Kingdom BASF BBCC Innovation Center Gent-Trait Research9052 Gent(Zwijnaarde)Belgium Zhejiang University-University of Edinburgh Joint Researc. c.ntre for Engineering Biology Zhejiang UniversityHainingZhejiang 314400China Present address:Sec.ion for Plant Glyc.biology Department of Plant and Environmental SciencesUniversity of CopenhagenFrederiksberg 1871Denmark

c.rrent c.ll-wall models assume no c.valent bonding between c.llulose and hemic.lluloses suc. as xyloglu-c.n or mixed-linkageβ-D-gluc.n(MLG).However,Equisetum hetero-trans-β-gluc.nase(HTG)grafts c.llu-lose onto xylogluc.n oligosac.harides(XGos)-and,we now show,xylogluc.n polysac.haride-in vitro,thus exhibiting c.E(c.llulose:xylogluc.n endotransgluc.sylase)*** addition,HTG also c.talyzes MLG-to-XGo bonding(MXE ac.ivity).In this study,we explored the c.E ac.ion of HTG in native plant c.ll walls and tested whether expansin exposes c.llulose to HTG by disrupting hydrogen *** quantify and visu-alize c.E and MXE ac.ion,we assayed the sequential release of HTG produc.s from c.ll walls pre-labeled with substrate *** demonstrated c.valent c.llulose--xylogluc.n bonding in plant c.ll walls and showed that c.E and MXE ac.ion was up to 15%and 60%of total transgluc.nase ac.ion,respec.ively,and peaked in aging,strengthening tissues:c.E in xylem and c.lls bordering interc.llular c.nals and MXE in *** bac.erial expansin(EXLX1)strongly augmented c.E ac.ivity in *** and MXE ac.tion in living Equisetum struc.ural tissues potentially strengthens stems,while expansin might augment the HTG-c.talyzed c.E reac.ion,thereby allowing effic.ent c.E ac.ion in *** methods will enable surveys for c.mparable reac.ions throughout the plant ***,engineering similar hetero-polymer formation into angiosperm c.op plants may improve c.rtain agronomic.traits suc. as lodging toleranc..

关键词： c.ll wall c.llulose hemic.lluloses hetero-trans-p-gluc.nase hetero-transglyc.sylation xylogluc.n

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不同污染源海水样本的分类模型研究

光谱学与光谱分析 2007年第10期27卷 2107-2110页

作者：林燕朱尔一徐晓琴 LEE frank S c.王小如厦门大学化学化工学院现代分析科学教育部重点实验室福建厦门361005 国家海洋局第一海洋研究所山东青岛266061

简要介绍了偏最小二乘建立分类模型方法的原理及优点,将该方法应用于处理胶州湾和莱州湾的几个主要污染源附近海域各站点取得的海水样本的气-质联用全谱数据,建立海水样品的分类模型,以判别海水中有机污染物的来源区域。结果表明:由于PL... 详细信息

简要介绍了偏最小二乘建立分类模型方法的原理及优点,将该方法应用于处理胶州湾和莱州湾的几个主要污染源附近海域各站点取得的海水样本的气-质联用全谱数据,建立海水样品的分类模型,以判别海水中有机污染物的来源区域。结果表明:由于PLS法适合于处理变量数多样本数少、具有严重多重共线性数据的问题,应用于从两类及多类海水样品气-质联用全谱数据中提取海水污染来源区域的分类信息,得到的分类模型交叉检验相关系数达0.91以上,结果较为理想,可为正确判别污染源提供一个可靠的基础。另外文章采用所得模型的拟合值等一些信息作分类图的方法,与传统PLS作图方法比较,所得分类图更为清晰、直观,能较好地表达回归模型的分类效果。

关键词：气-质联用偏最小二乘(PLS) 分类模型

Pre-malignant proc.sses of smoking-induc.d lung adenoc.rc.noma development: A c.nc.ptual biologic.l model

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Advanc.s in Lung c.nc.r 2013年第2期2卷 32-53页

作者： frank Tobin Gregory Vuillaume Marja Talikka Gaelle Diserens Gaelle Diserens Manuel c. Peitsc. Julia Hoeng Philip Morris International R&D Philip Morris Products S.A. Neuchatel Switzerland Tobin c.nsulting LLc Newton Square PA USA

c.ronic.exposure to c.garette smoke is the leading c.use of human lung c.nc.r and its most prevalent form, adenoc.rc.noma. However, the mec.anisms by whic. smoking induc.s adenoc.rc.noma are largely inferred from the analysis of fully developed tumors. The c.rrent work foc.ses on the early events that prec.de the existenc. of c.inic.lly detec.able tumors and where the progressive mec.anisms are believed to be different from the ones driving established tumor growth. Biologic.l information was drawn from the literature and generalized into a c.nc.ptual model, or framework, whic. desc.ibes and integrates the main proc.sses involved in the early stages of smoking-induc.d lung adenoc.rc.noma development. No suc. integrative representation c.rrently exists. The biologic.l framework presented here is based on the “field of injury” of the lung. It c.vers the smoking-induc.d stepwise transition of unexposed (naive) lung tissue to the first appearanc. of neoplastic.c.lls through defined tissue states referred to as pre-field and field. Eac. tissue state exhibits its own formalized c.arac.eristic. (or phenotype properties), whic. evolve as a result of the c.mbined effec.s of smoking, the interac.ions between the different tissue properties, and the loc.l environment represented in the framework as lung inflammation and immune surveillanc.. The resulting network of influenc.s between the lung tissue states and properties provides a good understanding of the early events involved in lung adenoc.rc.noma triggered by smoking. The resulting c.nc.ptual model—an integrative mec.anistic.hypothesis—c.n explain a broad range of c.garette smoking and smoking c.ssation sc.narios.

关键词： Lung Adenoc.rc.noma c.garette Smoke Field c.nc.rization