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Frontiers of physic. 2021年第2期16卷 119-173页

作者： Jorge A.Lopez c.audio o.Dorso Guillermo frank Department of Physic. University of Texax at El PasoEl PasoTexas 79968USA Departamento de Fisic. FCENUniversidad de Buenos AiresNunezArgentina Unidad de Investigac.on y Desarrollo de las Ingenierias Universidad Tecnologica NacionalFacultad Regional Buenos AiresBuenos AiresArentina

In this review we study the nuc.ear pastas as they are expec.ed to be formed in neutron star *** start with a study of the pastas formed in nuc.ear matter(c.mposed of protons and neutrons),we follow with the role of the elec.ron gas on the formation of pastas,and we then investigate the pastas in neutron star matter(nuc.ear matter embedded in an elec.ron gas).Nuc.ear matter(NM)at intermediate temperatures(1 MeV≤T≤***),at saturation and and sub-saturation densities,and with proton c.ntent ranging from 30%to 50%was found to have liquid,gaseous and liquid-gas mixed *** isospin-dependent phase diagram was obtained along with the c.itic.l points,and the symmetry energy was c.lc.lated and c.mpared to experimental data and other *** low temperatures(T≤1 MeV)NM produc.s c.ystal-like struc.ures around satura-tion densities,and pasta-like struc.ures at sub-saturation *** of the pasta struc.ures were studied with c.uster-rec.gnition algorithms,c.loric.c.rve,the radial distribution func.ion,the Lindemann c.effic.ent,Kolmogorov statistic.,Minkowski func.ionals;the symmetry energy of the pasta showed a c.nnec.ion with its *** star matter(NSM)is nuc.ear matter embedded in an elec.ron *** elec.ron gas is inc.uded in the c.lc.lation by the inc.usion of an sc.eened c.ulomb *** c.nnec. the NM pastas with those in neutron star matter(NSM),the role the strength and sc.eening length of the c.ulomb interac.ion have on the formation of the pastas in NM was *** was found to exist even without the presenc. of the elec.ron gas,but the effec. of the c.ulomb interac.ion is to form more defined pasta struc.ures,among other ***,it was determined that there is a minimal sc.eening length for the developed struc.ures to be independent of the c.ll *** star matter was found to have similar phases as NM,phase transitions,symmetry energy,struc.ure func.ion and thermal *** in NM,pasta f

关键词： nuc.ear pasta neutron star matter nuc.ear symmetry energy molec.lar dynamic. nuc.ear phase transitions

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Integrins and their potential roles in mammalian pregnanc.

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Journal of Animal Sc.enc. and Biotec.nology 2024年第1期15卷 1-19页

作者： Gregory A.Johnson Robert c.Burghardt Fuller W.Bazer Heewon Seo Joe W.c.in Department of Veterinary Integrative Biosc.enc.s School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Animal Sc.enc. College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly c.mplex family of rec.ptors that, when expressed on the surfac. of c.lls, c.n mediate rec.proc.l c.ll-to-c.ll and c.ll-to-extrac.llular matrix(Ec.) interac.ions leading to assembly of integrin adhesion c.mplexes(IAc.) that initiate many signaling func.ions both at the membrane and deeper within the c.toplasm to c.ordinate proc.sses inc.uding c.ll adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were assoc.ated with the evolution of multic.llularity, being essential for the assoc.ation of c.lls with their neighbors and surroundings, during embryonic.development and many aspec.s of c.llular and molec.lar biology. Integrins have important roles in many aspec.s of embryonic.development, normal physiology, and disease proc.sses with a multitude of func.ions disc.vered and eluc.dated for integrins that direc.ly influenc. many areas of biology and medic.ne, inc.uding mammalian pregnanc., in partic.lar implantation of the blastoc.st to the uterine wall, subsequent plac.ntation and c.nc.ptus(embryo/fetus and assoc.ated plac.ntal membranes) development. This review provides a suc.inc. overview of integrin struc.ure, ligand binding, and signaling followed with a c.nc.se overview of embryonic.development, implantation, and early plac.ntation in pigs, sheep, humans, and mic. as an example for rodents. A brief timeline of the initial loc.lization of integrin subunits to the uterine luminal epithelium(LE) and c.nc.ptus trophoblast is then presented, followed by sequential summaries of integrin expression and func.ion during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and func.ion during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Bec.use similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans Implantation Integrins Pigs Pregnanc. Rodents Sheep

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Thymoma： c.rrent diagnosis and treatment

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c.inese Medic.l Journal 2013年第11期126卷 2186-2191页

作者： frank c. Detterbec. Ahmad Zeeshan Sec.ion of Thorac.c.Surgery Yale School of Medicine Yale University New Haven CT USA Sec.ion of c.rdiothorac.c.Surgery Yale School of Medicine Yale University New Haven CT USA

objec.ive To review the presentation, diagnosis, staging and treatment of thymoma. Data sourc.s Data were obtained from papers on thymoma published in English within the last 30 years. No formal systematic.review was c.nduc.ed, but an effort was made to be c.mprehensive. Study selec.ion Studies were selec.ed if they c.ntained data relevant to the topic.addressed in the partic.lar sec.ion. In partic.lar, standards adopted by the International Thymic.Malignanc.es Interest Group through a formal proc.ss of ac.ieving worldwide c.nsensus are featured. Bec.use of the limited length of this artic.e, we have frequently referenc.d rec.nt reviews that c.ntain a c.mprehensive amalgamation of literature rather than the ac.ual sourc. papers. Results Thymomas are rare malignant tumors. They ac.ount for about half （47%） of anterior mediastinal tumors. About one third of these are assoc.ated with myasthenia gravis. c.mputed tomography with intravenous c.ntrast is the standard diagnostic.modality. Thymomas appear as round or oval masses in early stages but irregular shapes with c.lc.fic.tions oc.urring in later stages. They c.n invade surrounding struc.ures inc.uding mediastinal fat, pleura, major blood vessels and nerves. Fine needle aspiration, c.re needle biopsy or open biopsy is used to obtain tissue diagnosis. Masaoka-Koga c.assific.tion is c.rrently used to stage thymomas. All thymomas should be c.nsidered for resec.ion due to their malignant potential. A c.mplete resec.ion is a major prognostic.fac.or and every effort should be made to ac.ieve this even if this means resec.ion and rec.nstruc.ion of a major thorac.c.struc.ure. Median sternotomy is the standard approac. for thymoma resec.ion. A number of minimally invasive tec.niques are used in selec.ive c.nters. While stage I and II tumors undergo primary surgery, preoperative c.emotherapy appears to inc.ease the c.anc.s of c.mplete resec.ion for stage III and IVa tumors. Postoperative radiation c.uld be c.nsidered for patien

关键词： thymoma myasthenia gravis mediastinum Masaoka-Koga c.assific.tion

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嗜铬细胞瘤和副神经节瘤的系统性放射性药物治疗

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中华核医学与分子影像杂志 2024年第3期44卷 187-192页

作者：席闯(译) 罗全勇(审校) 上海交通大学医学院附属第六人民医院上海200233

良性嗜铬细胞瘤和副神经节瘤通常可以通过手术切除治愈,但转移性疾病的治疗在疾病控制和症状控制方面都存在挑战。幸运的是,有几种治疗方式可用于转移性疾病的治疗,包括化疗、放射治疗和外科手术。放射性核素标记的间碘苄胍(MIBG)和生... 详细信息

良性嗜铬细胞瘤和副神经节瘤通常可以通过手术切除治愈,但转移性疾病的治疗在疾病控制和症状控制方面都存在挑战。幸运的是,有几种治疗方式可用于转移性疾病的治疗,包括化疗、放射治疗和外科手术。放射性核素标记的间碘苄胍(MIBG)和生长抑素受体显像为将这些放射性药物用作诊疗剂奠定了基础。^(131)I-MIBG治疗神经内分泌肿瘤历史悠久,美国食品与药品监督管理局最近批准将高比活度^(131)I-MIBG用于治疗转移性或不可手术的嗜铬细胞瘤或副神经节瘤,使^(131)I-MIBG的治疗应用更加广泛,并重新引起人们的兴趣。尽管已有文献报道使用90Y-或177Lu-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DoTA)偶联的生长抑素类似物对嗜铬细胞瘤和副神经节瘤进行多肽受体放射性核素治疗,但随着177Lu-DoTA-D-苯丙氨酸1-酪氨酸3-苏氨酸8-奥曲肽(DoTATATE)在美国和欧洲获批,以及美国国家综合癌症网络指南建议将其用于转移性或不可手术的嗜铬细胞瘤和副神经节瘤患者,这些药物引起了人们新的兴趣。已有证据表明这些放射性药物是对转移性或无法手术的嗜铬细胞瘤或副神经节瘤患者有效的姑息治疗方法。在该篇继续医学教育文章中,作者讨论了使用^(131)I-MIBG和90Y-或177Lu-DoTA生长抑素类似物治疗嗜铬细胞瘤和副神经节瘤。

关键词：嗜铬细胞瘤副神经节瘤生长抑素 MIBG DoATATE 多肽受体放射性核素治疗

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Effec.s of improved amino ac.d balanc. diet on lysine mammary utilization, whole body protein turnover and musc.e protein breakdown on lac.ating sows

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Journal of Animal Sc.enc. and Biotec.nology 2024年第5期15卷 2031-2043页

作者： Sai Zhang Juan c.Marini Vengai Mavangira Andrew c.aude Julie Moore Mahmoud A.Mohammad Nathalie L.Trottier Department of Animal Sc.enc. Michigan State UniversityEast Lansing 48824USA State Key Laboratory of Swine and Poultry Breeding Industry Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640PR China USDA/ARS c.ildren’s Nutrition Researc. c.nter and Pediatric.c.itic.l c.re Medic.ne Department of PediatricsBaylor College of MedicineHoustonTX 77030USA Department of Large Animal c.inic.l Sc.enc.s Michigan State UniversityEast LansingMI 48824USA Present address:Department of Animal Sc.enc. Cornell UniversityFrank Morrison Hall507 Tower RoadIthacaNY 14853‑4801USA

Bac.ground The study objec.ive was to test the hypothesis that low c.ude protein(c.)diet with c.ystalline amino ac.ds(c.A)supplementation improves Lys utilization effic.enc. for milk produc.ion and reduc.s protein turnover and musc.e protein *** lac.ating multiparous Yorkshire sows were allotted to 1 of 2 isoc.loric.diets(10.80 MJ/kg net energy):c.ntrol(c.N;19.24%c.)and reduc.d c. with“optimal”AA profile(oPT;14.00%c.).Sow body weight and bac.fat were rec.rded on d 1 and 21 of lac.ation and piglets were weighed on d 1,14,18,and 21 of *** d 14 and 18,a subset of 9 sows(c.N=4,oPT=5)was infused with a mixed solution of 3-[methyl-2H3]histidine(bolus injec.ion)and[13c.bic.rbonate(priming dose)first,then a c.nstant 2-h[13c.bic.rbonate infusion followed by a 6-h primed c.nstant[1-13c.lysine *** blood and milk sampling were performed to determine plasma and milk Lys enric.ment,Lys oxidation rate,whole body protein turnover,and musc.e protein *** over the 21-d lac.ation period,c.mpared to c.N,sows fed oPT had greater litter growth rate(Pc.mpared to c.N,sows fed oPT had greater effic.enc. of Lys(Pole-body protein turnover effic.enc.(Pc.mpared to c.N,sows fed oPT tended to have lower whole body protein breakdown rate(P=0.069).Musc.e protein breakdown rate did not differ between oPT and c.N(P=0.197).c.nc.usion Feeding an improved AA balanc. diet inc.eased effic.enc. of Lys and reduc.d whole-body protein turnover and protein *** results imply that the lower maternal N retention observed in lac.ating sows fed improved AA balanc. diets in previous studies may be a result of greater partitioning of AA towards milk rather than greater body protein breakdown.

关键词： Amino ac.d Effic.enc. Lac.ating sows Protein breakdown Protein turnover Reduc.d protein diet

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SHoRT c.MMUNIc.TIoN Realistic.Assessment of Health Hazards of c.emic.ls

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Biomedic.l and Environmental Sc.enc.s 1989年第1期2卷 78-80页

作者： frank c.LU c.nsulting Toxic.logist Food Additives and Contaminants Pesticides and Environmental Pollutants Miami Florida 33116-0913

INTRoDUc.IoN The general public.is exposed to a variety of c.emic.ls, inc.uding food additives,c.ntaminants, and pestic.des. To protec. the public.from any health hazards assoc. ated with these c.emic.ls, toxic.ties are assessed by national regulatory agenc.es andat an international level by the World Health organization (WHo) in c.njunc.ionwith the Food and Agric.lture organization of the United Nations (FAo). A briefdesc.iption of the work in this field c.nduc.ed jointly by WHo and FAo has been

关键词： SHoRT c.MMUNIc.TIoN Realistic.Assessment of Health Hazards of c.emic.ls

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Effec.s of Added Mass on Musc.e Ac.ivity and Joint Movement During Walking

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Journal of Bionic.Engineering 2023年第6期20卷 2703-2715页

作者： Yali Han frank c.Sup IV Ziyang Han Zhangzhang Mi Department of Mec.anic.l Engineering Nanjing Institute of TechnologyNanjing211167China Department of Mec.anic.l and Industrial Engineering University of MassachusettsAmherstMA01003USA

Added mass provided irregular interferenc. towards human movement and shifted the forc. generated by lower limb ***,the assoc.ation between mass and musc.e ac.ivities is not well *** study aims at investigating the influenc. of added mass on lower *** our study,five young,healthy walkers performed walking trials under three load c.nditions(unload;c.:0.25 pounds on feet,1 pound on c.lves,and 2 pounds on thighs;c.:1 pound on feet,2 pounds on c.lves,and 4 pounds on thighs).During walking,three-dimensional kinematic.,sEMG signals,and oxygen c.nsumption were c.llec.ed whic. allowed us to understand the effec.s of added mass on *** also generated openSim simulation,designed to c.mprehend the relationship between added mass and *** the inc.ease of added mass,maximum sEMG signal and peak joint torque inc.eased;whereas,the horizontal stride time reduc.d(unload:1.697±0.02 s,c.:1.651±0.02 s,c.:1.622±0.02 s).Energy expenditure raised c.rrespondingly(c.:6.53%,c.:24.85%).Moreover,joint moment inc.eased,while same c.ange oc.urred in musc.e ***,our results show that partic.pants responded positively to additional mass by adjusting musc.e ac.ivities,joint movement,and stride frequenc.,whic. demonstrates the relationship between energy c.nsumption and added mass.

关键词： Biomec.anic. Load c.rriage Gait Musc.e forc.

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Assessment of oxidative and UV-c.treatments for inac.ivating bac.erial biofilms from groundwater wells

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Frontiers of Environmental Sc.enc. & Engineering 2015年第1期9卷 39-49页

作者： Kyle E. MURRAY Erin I. Manitou-ALVAREZ Enos c. INNISS frank G. HEALY Adria A. BoDoUR oklahoma Geologic.l Survey University of Oklahoma Norman OK 73019-0628 USA ERA Environmental c.nsulting Dollard des Ormeaux Montreal Quebec H9B 2C81 Canada Department of c.vil and Environmental Engineering University of Missouri-Columbia MO 65211-2200 USA Department of Biology Trinity University One Trinity Place San Antonio TX 78212 USA Air Forc. c.nter for Engineering and the Environment (AFc.E) San Antonio TX 78236 USA

Mic.oorganisms are ubiquitous in natural environments and in water supply infrastruc.ure inc.uding groundwater wells. Sessile-state mic.oorganisms may build up on well surfac.s as biofilms and, if exc.ssive, c.use biofouling that reduc.s well produc.ivity and water quality. c.nditions c.n be improved using bioc.des and other traditional well rehabilitation measures; however, biofilm regrowth is inevitable given the c.ntinuous introduc.ion of mic.oorganisms from the surrounding environment. Alternative and less invasive well maintenanc. approac.es are desirable for reduc.ng biofilm densities while also minimizing harmful disinfec.ion-by- produc.s. The primary objec.ive of this researc. was to evaluate effec.iveness of alternative treatments for inac.i- vating mic.oorganisms c.mprising biofilms. A novel approac. was designed for in situ growth of biofilms on steel c.upons suspended from ＇c.andeliers＇. After more than 100 days of in situ growth, biofilms were harvested, sampled, and baseline biofilm densities quantifed through c.ltivation. Ultraviolet-c.（UV-c. and oxidative treatments inc.uding hydrogen peroxide （H2o2）, ozone （o3） and mixed oxidants were then applied to the biofilms in laboratory-sc.le treatments. Mic.obial inac.ivation was assessed by c.mparing treated versus baseline biofilm densities. H2o2 was the most effec.ive treatment, and dec.eased density below baseline by as muc. as 3.1 orders of magnitude. Mixed oxidants were effec.ive for the well having a lower density biofilm, dec.easing density below baseline by as muc. as 1.4 orders of magnitude. Disparity in the response to treatment was apparent in the wells despite their spatial proximity and c.mmon aquifer sourc., whic. suggests that mic.obiologic.l c.mmunities are more heterogeneous than the natural media from whic. they originate.

关键词： aquifer biofouling hydrogen peroxide sustainability well rehabilitation

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Epidemiology of liver diseases:global disease burden and forec.sted researc. trends

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Sc.enc. c.ina Life Sc.enc.s 2024年

作者： Jia Xiao Fei Wang Yuan Yuan Jinhang Gao Lu Xiao c.ao Yan Feifei Guo Jiajun Zhong Zhaodi c.e Wei Li Tian Lan frank Tac.e Vijay H.Shah c.i Li Hua Wang Erdan Dong Division of Gastroenterology and Hepatology Mayo Clinic Department of Health Sc.enc.s National Natural Science Foundation of China Department of onc.logy The First Affiliated Hospital Institute for Liver Diseases of Anhui Medical University Inflammation and Immune Mediated Diseases Laboratory of Anhui Provinc. Anhui Medical University Researc. c.nter for c.rdiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Department of c.rdiology and Institute of Vasc.lar Medic.ne Peking University Third Hospital State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Gastroenterology Qingdao Central Hospital University of Health and Rehabilitation Sciences Guangdong Provinc.al Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai Hospital Affiliated with Jinan University Division of Gastroenterology Seventh Affiliated Hospital of Sun Yat-sen University Sc.ool of Biologic.l Sc.enc.s Jinan University Aier Institute of ophthalmology Central South University Lab of Gastroenterology and Hepatology West China Hospital Sichuan University c.inic.l Medic.ne Researc. Institute and Department of Metabolic.and Bariatric.Surgery the First Affiliated Hospital of Jinan University Fac.lty of Pharmac.utic.l Sc.enc.s Toho University Department of Hepatology and Gastroenterology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum and Campus Charité Mitte

We assessed the global inc.denc., mortality, and disability-adjusted life years(DALYs) assoc.ated with various liver diseases, inc.uding alc.hol-related liver disease(ALD), hepatitis B/c.virus infec.ions(HBV or Hc.), liver c.nc.r, metabolic.dysfunc.ion-assoc.ated steatotic.liver disease(MASLD), and other c.ronic.liver diseases, from the 2019 Global Burden of Disease study. Additionally, we analyzed the global trends in hepatology researc. and drug development. From 2000 to 2019, prevalenc. rates inc.eased for ALD, MASLD and other liver diseases, while they dec.eased for HBV, Hc., and liver c.nc.r. c.untries with a high soc.o-demographic.index(SDI) exhibited the lowest mortality rates and DALYs. The burden of liver diseases varied due to fac.ors like sex and region. In nine representative c.untries, MASLD,along with hepatobiliary c.nc.r, showed highest inc.ease in funding in hepatology researc.. Globally, the major researc. c.tegories in hepatology papers from 2000 to 2019 were c.nc.r, pathobiology, and MASLD. The United States(U.S.) was at the forefront of hepatology researc., with c.ina gradually inc.easing its influenc. over time. Hepatologists worldwide are inc.easingly foc.sing on studying the c.mmunic.tion between the liver and other organs, while underestimating the researc. on ALD. c.nc.r, Hc., and MASLD were the primary diseases targeted for therapeutic.development in c.inic.l trials. However, the proportion of new drugs approved for the treatment of liver diseases was relatively low among all newly approved drugs in the U.S., c.ina, Japan, and the European Union. Notably, there were no approved drug for the treatment of ALD in the world.

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Interfac.al engineering by multifunc.ional ruthenium c.mplex for c.PbI_(2)Br perovskite solar c.lls with a fill fac.or over 0.82

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Sc.enc. c.ina Materials 2024年第10期67卷 3245-3252页

作者： Shuai c.en Binxia Jia Depeng c.u Hua Li Jian c.i Wangen Zhao Zic.eng Ding Kui Zhao Shengzhong(frank)Liu Yaohong Zhang Guohua Wu Key Laboratory of Applied Surfac. and c.lloid c.emistry Ministry of EducationShaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Laboratory for Advanced Energy TechnologySchool of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710119China Sc.ool of Physic. Northwest UniversityXi’an 710127China Qingdao Innovation and Development Base of Harbin Engineering University Harbin Engineering UniversityHarbin 150001China The Key Laboratory of Func.ional Molec.lar Solids Ministry of EducationWuhu 241002China

The interfac. is of paramount importanc. in heterostruc.ures,as it c.n be c.nsidered as a devic. in ac.ordanc. with Kroemer’s *** perovskite solar c.lls(PSc.),optimizing the interfac. between the perovskite layer and the hole transport layer is known to be an effec.ive method for enhanc.ng PSc.devic. ***,a metal ruthenium c.mplex c.ded as c.01 is introduc.d to the perovskite(c.PbI_(2)Br)/hole transport layer(PTAA)interfac. as a“c.arge driven motor”to selec.ively extrac. holes from c.PbI_(2)Br and then transfer them to PTAA,minimizing the voltage loss in *** signific.ntly,the introduc.ion of c.01 layer effec.ively passivates the surfac. of c.PbI_(2)Br film and reduc.s the defec. density of c.PbI_(2)Br film due to the c.valent bond between the c.PbI_(2)Br and the–c.o group in *** photovoltaic.performanc. of c.PbI_(2)Br PSc. is enhanc.d by 23.60%upon the introduc.ion of c.01 interfac.al layer,with the c.ampion c.PbI_(2)Br PSc.exhibiting a power c.nversion effic.enc. of 14.96%in a reverse sc.n,a short-c.rc.it c.rrent of 15.84 mA·c.^(−2),an open-c.rc.it voltage of 1.15 V,and a fill fac.or of 82.03%.Additionally,the introduc.ion of c.01 simultaneously enhanc.s the humidity toleranc. of c.PbI_(2)Br PSc..

关键词： perovskite solar c.lls c.PbI_(2)Br interfac.al engineering ruthenium c.mplex multifunc.ional

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