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Effect of nocturia in patients with different severity of obstructive sleep apnea on polysomnography: A retrospective observational study

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Asian journal of Urology 2024年第3期11卷 486-496页

作者： Chin-Heng Lu Hung-Min Chang Kuang-Hsi Chang Yen-Chuan Ou Chao-Yu Hsu Min-Che Tung frank Cheau-Feng Lin Stella Chin-Shaw Tsai Division of Urology Department of SurgeryTungs’Taichung Metroharbor HospitalTaichungTaiwanChina Rong Hsing Research Center for Translational Medicine Chung Hsing UniversityTaichungTaiwanChina College of Life Sciences Chung Hsing UniversityTaichungTaiwanChina Department of Otolaryngology Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina Department of Medical Research Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina General Education Center Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Department of Post-Baccalaureate Medicine College of MedicineChung Hsing UniversityTaichungTaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Department of Surgery Chung Shan Medical UniversityTaichungTaiwanChina College of Medicine Chung Shan Medical UniversityTaichungTaiwanChina

Patients with suspected OSA were examined using *** were divided into two groups based on the presence of *** was defined as a patient who needed to void at least *** index(AHI)was employed to classify patients according to degrees of severity:AHI<5 events/h,5 events/hAHI<15 events/h,15 events/hAHI<30 events/h,and AHI30 events/h,defined as normal,mild OSA,moderate OSA,and severe OSA,*** variables,PSG parameters,International Prostate Symptom Scores(IPSSs),and quality of life scores due to urinary symptoms were ***:In total 140 patients,114 patients had OSA(48 had mild OSA;34 had moderate OSA;and 32 had severe OSA)and 107 patients had *** total IPSS was significantly higher in nocturia patients in all groups except the group of severe OSA *** the increasing severity of OSA,more correlated factors related to nocturia were *** mild OSA patients,nocturia related to increased age(p=0.025),minimum arterial blood oxygenation saturation(p=0.046),and decreased AHI of non-rapid eye movement(p=0.047),AHI of total sleep time(p=0.010),and desaturation index(p=0.012).In moderate OSA patients,nocturia related to increased age(p<0.001),awake time(p=0.025),stage 1 sleep(p=0.033),and sleep latency(p=0.033),and decreased height(p=0.044),weight(p=0.025),and sleep efficiency(p=0.003).In severe OSA patients,nocturia related to increased weight(p=0.011),body mass index(p=0.009),awake time(p=0.008),stage 1 sleep(p=0.040),arousal number(p=0.030),arousal index(p=0.013),periodic limb movement number(p=0.013),and periodic limb movement index(p=0.004),and decreased baseline arterial blood oxygenation saturation(p=0.046).Conclusion:Our study revealed that there were more correlated factors related to nocturia with increasing severity of *** study helps in clinical education and treatment for OSA patients with different severity.

关键词： Nocturia Obstructive sleep apnea Polysomnography Apneaehypopnea index International Prostate Symptom Score

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Diagnostic delay in inflammatory bowel diseases in a German population

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World journal of Gastroenterology 2024年第29期30卷 3465-3478页

作者： Elisabeth Blüthner Annalena Dehe Carsten Büning Britta Siegmund Matthias Prager jochen Maul Alexander Krannich jan Preiß Bertram Wiedenmann Florian Rieder Raneem Khedraki frank Tacke Andreas Sturm Anja Schirbel Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Vivantes Klinikum im FriedrichshainBerlin 10249Germany Department of Internal Medicine Krankenhaus WaldfriedeBerlin 14163Germany Department of Gastroenterology Infectious Diseases and RheumatologyCharité-Universitätsmedizin BerlinBerlin 12203Germany Praxis für Gastroenterologie Berlin Zehlendorf Berlin 14195Germany Gastroenterologie am Bayrischen Platz Berlin 10825Germany Clinical Trial Office Charité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Diabetology and HepatologyVivantes Klinikum NeuköllnBerlin 10117Germany Department of Gastroenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine DRK Kliniken Berlin WestendBerlin 14050Germany Gastroenterologie im Havelland Straße der EinheitFalkensee 14612Germany

BACKGROUND Early diagnosis is key to prevent bowel damage in inflammatory bowel disease(IBD).Risk factor analyses linked with delayed diagnosis in European IBD patients are scarce and no data in German IBD patients *** To identify risk factors leading to prolonged diagnostic time in a German IBD *** Between 2012 and 2022,430 IBD patients from four Berlin hospitals were enrolled in a prospective study and asked to complete a 16-item questionnaire to determine features of the path leading to IBD *** diagnostic time was defined as the time from symptom onset to consulting a physician(patient waiting time)and from first consultation to IBD diagnosis(physician diagnostic time).Univariate and multivariate analyses were performed to identify risk factors for each time *** The total diagnostic time was significantly longer in Crohn’s disease(CD)compared to ulcerative colitis(UC)patients(12.0 vs 4.0 mo;P<0.001),mainly due to increased physician diagnostic time(5.5 vs 1.0 mo;P<0.001).In a multivariate analysis,the predominant symptoms diarrhea(P=0.012)and skin lesions(P=0.028)as well as performed gastroscopy(P=0.042)were associated with longer physician diagnostic time in CD *** UC,fever was correlated(P=0.020)with shorter physician diagnostic time,while fatigue(P=0.011)and positive family history(P=0.046)were correlated with longer physician diagnostic *** We demonstrated that CD patients compared to UC are at risk of long diagnostic *** efforts should focus on shortening the diagnostic delay for a better outcome in these patients.

关键词： Diagnostic time Diagnostic delay Crohn’s disease Ulcerative colitis Germany

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天下武功,唯快不破

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问天少年 2024年第9期 30-33页

作者： frank 不详

1947年,查克·耶格尔驾驶X-1飞机率先突破声速,打开了超声速飞行的大门。自此,人类就一直在追求更高的飞行速度。科学家与工程师们共同努力,打造出一款又一款尖端技术的结晶,只为突破速度极限。今天,让我们来认识一下这些飞行器,和它们... 详细信息

1947年,查克·耶格尔驾驶X-1飞机率先突破声速,打开了超声速飞行的大门。自此,人类就一直在追求更高的飞行速度。科学家与工程师们共同努力,打造出一款又一款尖端技术的结晶,只为突破速度极限。今天,让我们来认识一下这些飞行器,和它们超“快”的武功秘籍。

关键词：速度极限耶格尔超声速飞行飞行速度率先突破科学家与工程师武功尖端技术

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Assessment of laryngologists'ratings on physician review websites

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World journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 1-6页

作者： Meleeka Akbarpour Karen Tawk Madelyn frank Alizah S.Gomez Navid Mostaghni Mehdi Abouzari Department of Otolaryngology-Head and Neck Surgery University of CaliforniaIrvineUSA

Objective:To assess and characterize online ratings and comments on laryngologists and determine factors that correlate with higher ***:All the American Laryngological Association(ALA)members were queried across several online *** were normalized for comparison on a five-point Likert *** were categorized based on context and for positive/negative ***:Of the 331 ALA members,256(77%)were rated on at least one online *** all platforms,the average overall rating was 4.39±0.61(range:1.00-5.00).Specific positive ratings including“bedside manners,”“diagnostic accuracy,”“adequate time spent with patient,”“appropriate follow-up,”and“physician timeliness”had significant positive correlations to overall ratings,by Pearson's correlation(P<0.001).Long wait times had significant negative correlations to overall ratings(P<0.001).Conclusion:Online ratings and comments for laryngologists are significantly influenced by patient perceptions of bedside manner,physician competence,and time spent with the patient.

关键词： laryngologist online rating patient rating physician review website

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Learning the continuous-time optimal decision law from discrete-time rewards

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National Science Open 2024年第5期3卷 130-147页

作者： Ci Chen Lihua Xie Kan Xie frank Leroy Lewis Yilu Liu Shengli Xie School of Automation Guangdong University of TechnologyGuangdong Key Laboratory of IoT Information TechnologyGuangzhou 510006China Key Laboratory of Intelligent Information Processing and System Integration of IoT Ministry of EducationGuangzhou 510006China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore 111 Center for Intelligent Batch Manufacturing Based on IoT Technology Guangzhou 510006China UTA Research Institute the University of Texas at ArlingtonFort Worth 76118USA Department of Electrical Engineering and Computer Science University of TennesseeKnoxville 37996USA Oak Ridge National Laboratory Oak Ridge 37830USA Guangdong-HongKong-Macao joint Laboratory for Smart Discrete Manufacturing Guangzhou 510006China

The concept of reward is fundamental in reinforcement learning with a wide range of applications in natural and social *** an interpretable reward for decision-making that largely shapes the system's behavior has always been a challenge in reinforcement *** this work,we explore a discrete-time reward for reinforcement learning in continuous time and action spaces that represent many phenomena captured by applying physical *** find that the discrete-time reward leads to the extraction of the unique continuous-time decision law and improved computational efficiency by dropping the integrator operator that appears in classical results with integral *** apply this finding to solve output-feedback design problems in power *** results reveal that our approach removes an intermediate stage of identifying dynamical *** work suggests that the discrete-time reward is efficient in search of the desired decision law,which provides a computational tool to understand and modify the behavior of large-scale engineering systems using the optimal learned decision.

关键词： continuous-time state and action decision law learning discrete-time reward dynamical systems reinforcement learning

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The Burden of Undiagnosed Hypertension and Associated Risk Factors among Adults in a Rural Community in Imo Sate, South-East Nigeria

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International journal of Clinical Medicine 2024年第2期15卷 101-122页

作者： Iwunze Anuli Egwim jideuma Onuoha frank Olekanma Chinonye Ndukwu Chiagozie Igbonagwam Hope Dike Victor Department of Family Medicine Federal University Teaching Hospital Owerri Nigeria Department of Public Health Central Michigan University Mount Pleasant Michigan USA

Background: Cardiovascular diseases are the leading cause of death globally and hypertension is a major contributor to this burden. Many people with hypertension have poorly controlled blood pressure and up to half of the adults with hypertension are unaware of their hypertensive status due to factors that bother on poor management and poor screening approaches. The implication is that people who have poor access to healthcare especially those in the rural communities are at increased risk of cardiovascular complications and all-cause mortality. Unfortunately, not much has been done to ascertain the burden of undiagnosed hypertension and associated risk factors in rural communities in Nigeria. Methods: We conducted a community-based cross-sectional study in a rural community in Imo State, Nigeria, on burden of undiagnosed hypertension with participants recruited via a multi-stage sampling method. An interviewer-administered questionnaire was used, and standardized instruments were applied to obtain, process and analyze the data. Tests of association between the independent variables and outcome were conducted using logistic regression. P-value of Results: A total of 380 adults participated in the study. The mean age was 44.2 years. The prevalence of undiagnosed hypertension was 35.8%. Logistic regression revealed that age, with the respondents in the age groups 26 - 35 years (OR = 10.647, 1.910 - 59.345, p-value = 0.007), 36 - 45 (OR = 3.680, 1.263 - 10.723, p-value = 0.017), 46 - 55 years (OR = 2.737, 1.114 - 6.727, p-value = 0.039), 56 - 65 years old (OR = 3.384, 1.610 - 7.115, p-value = 0.001);and being married (OR = 3.846, 1.118 - 13.233, p-value = 0.033), were independent risk factors for undiagnosed hypertension. Conclusion: The prevalence of undiagnosed hypertension in the rural population of South-East Nigeria is high. Younger age (26 - 35 years) had the highest odds of risk for occurrence of hypertension. Also being married was identified as a risk factor f

关键词： Hypertension Undiagnosed Hypertension Risk Factors Rural Community

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Soil Organic Carbon Stock Variation under Different Soil Types and Land Uses in the Sub-Humid Noun Plain, Western Cameroon

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Open journal of Soil Science 2024年第4期14卷 191-209页

作者： frank Abigail Sobze Kenfack Georges Kogge Kome Achille Bienvenue Ibrahim Viviane Pauline Mandah Dieudonne Bitondo Department of Soil Science Faculty of Agronomy and Agricultural Sciences (FASA) University of Dschang Dschang Cameroon Department of Land Surveying National Advanced School of Public Works Yaound&#233 Cameroon International Institute of Tropical Agriculture Cameroon Eco-Regional Center HFS Yaound&#233 Cameroon Department of Earth Science Faculty of Science University of Dschang Dschang Cameroon

This study was conducted to assess the current stock of soil organic carbon under different agricultural land uses, soil types and soil depths in the Noun plain in western Cameroon. Three sites were selected for the study, namely Mangoum, Makeka and Fossang, representative of the three dominant soil types of the noun plain (Andosols, Acrisols and Ferralsols). Three land uses were selected per site including natural vegetation, agroforest and crop field. Soil was sampled at three depths;0 - 20 cm, 20 - 40 cm, and 40 - 60 cm. Analysis of variance showed that soil type did not significantly influence carbon storage, but rather land uses and soil depth. SOCS decreased significantly with depth in all the sites, with an average stock of 66.3 ± 15.8 tC/ha at 0 - 20 cm, compared to an average stock of 33.3 ± 7.4 tC/ha at 40 - 60 cm. SOCS was significantly highest in the natural formation with 57.2 ± 19.7 tC/ha, and lowest in cultivated fields, at 37.7 ± 10.6 tC/ha. Andosols, with their high content of coarse fragments, stored less organic carbon than Ferralsols and Acrisols.

关键词： Carbon Stocks Soil Type Soil Depth Agricultural Land Use Noun Plain

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多模态批评隐喻意义建构的认知视角——以“扫黑除恶”漫画为例

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巢湖学院学报 2024年第2期26卷 99-106页

作者：张鑫 frank Hang XU 云南师范大学外国语学院云南昆明650500 长春光华学院跨文化研究院吉林长春130033

文章采用多模态话语分析视角,结合Charteris-Black的批评隐喻分析方法和认知语言学的概念整合理论,建构多模态批评隐喻的认知分析框架,并以60幅“扫黑除恶”漫画为语料,从认知视角剖析漫画背后的意识形态和内在含义。研究结果表明,“扫... 详细信息

文章采用多模态话语分析视角,结合Charteris-Black的批评隐喻分析方法和认知语言学的概念整合理论,建构多模态批评隐喻的认知分析框架,并以60幅“扫黑除恶”漫画为语料,从认知视角剖析漫画背后的意识形态和内在含义。研究结果表明,“扫黑除恶”漫画中运用了方位隐喻和战斗隐喻,其目标喻围绕“执法人员”“黑恶势力”和“保护伞”这三个方面展开,结合图案模态、文字模态和多种隐喻建构了多模态“击打场景”“除虫场景”以及“拔伞场景”。多模态批评隐喻的认知分析框架可以深度解释漫画背后含义的生成机制和认知机制,对于深层次理解漫画有较好的启发和借鉴意义。

关键词： “扫黑除恶”漫画批评隐喻概念整合理论

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《绿野仙踪》(节选)

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疯狂英语（新读写） 2024年第4期 52-54,78页

作者： Lyman frank Baum 不详

1900年,莱曼·弗兰克·鲍姆完成《绿野仙踪》(即《奥兹国的魔术师》)。鲍姆写《绿野仙踪》时,并没有想到要把它写成多卷集,可是这部书获得了巨大的成功,在读者中引起越来越大的反响,人们要求把它写下去的呼声也越来越高。1900年,《绿野... 详细信息

1900年,莱曼·弗兰克·鲍姆完成《绿野仙踪》(即《奥兹国的魔术师》)。鲍姆写《绿野仙踪》时,并没有想到要把它写成多卷集,可是这部书获得了巨大的成功,在读者中引起越来越大的反响,人们要求把它写下去的呼声也越来越高。1900年,《绿野仙踪》出版后,连续两年高居童书畅销榜的首位。

关键词：《绿野仙踪》畅销榜莱曼

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Effects of unilateral superimposed high-frequency jet ventilation on porcine hemodynamics and gas exchange during one-lung flooding

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World journal of Experimental Medicine 2024年第1期14卷 88-99页

作者： Thomas Lesser frank Wolfram Conny Braun Reiner Gottschall Department of Thoracic and Vascular Surgery SRH Wald Klinikum GeraGera D-07548Germany Central Experimental Animal Facility Jena University HospitalJena 07743Germany Department of Anaesthesiology and Intensive Care Jena University HospitalJena 07747Germany

BACKGROUND Superimposed high-frequency jet ventilation(SHFjV)is suitable for respiratory motion reduction and essential for effective lung tumor *** filling of the target lung wing one-lung flooding(OLF)is necessary for therapeutic ultrasound ***,whether unilateral SHFjV allows adequate hemodynamics and gas exchange is *** To compared SHFjV with pressure-controlled ventilation(PCV)during OLF by assessing hemodynamics and gas exchange in different animal *** SHFjV or PCV was used alternatingly to ventilate the non-flooded lungs of the 12 anesthetized pigs during *** animal positions were changed from left lateral position to supine position(SP)to right lateral position(RLP)every 30 *** each position,ventilation was maintained for 15 min in both *** variables and arterial blood gas levels were repeatedly *** Unilateral SHFjV led to lower carbon dioxide removal than PCV without abnormally elevated carbon dioxide *** slightly decreased oxygenation in SP and RLP compared with PCV;the lowest values of PaO_(2) and PaO_(2)/FiO_(2) ratio were found in SP[13.0;interquartile range(IQR):12.6-5.6 and 32.5(IQR:31.5-38.9)kPa].Conversely,during SHFjV,the shunt fraction was higher in all animal positions(highest in the RLP:0.30).CONCLUSION In porcine model,unilateral SHFjV may provide adequate ventilation in different animal positions during *** oxygenation and CO_(2) removal rates compared to PCV did not lead to hypoxia or *** can be safely used for lung tumor ablation to minimize ventilation-induced lung motion.

关键词： One-lung ventilation Unilateral superimposed high-frequency jet ventilation One-lung flooding

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