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Educational, psychosocial, and clinical impact of SARS-CoV-2 (COVID-19) pandemic on medical students in the United States

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World Journal of Virology 2022年第3期11卷 150-169页

作者： Veronica frank Anjali Doshi Natalie L Demirjian Brandon k k Fields Catherine Song Xiaomeng Lei Sravanthi Reddy Bhushan Desai Drayton C Harvey Steven Cen Ali Gholamrezanezhad Semmelweis University Faculty of Medicine Semmelweis University Faculty of MedicineBudapest 1085Hungary keck School of Medicine of University of Southern California Los AngelesCA 90033United States Department of Integrative Anatomical Sciences Keck School of Medicine of University of Southern CaliforniaLos AngelesCA 90033United States Department of Radiology Keck School of Medicine of University of Southern CaliforniaLos AngelesCA 90033United States

BACkGROUND The coronavirus disease 2019(COVID-19)pandemic altered education,exams,and residency applications for United States medical *** To determine the specific impact of the pandemic on US medical students and its correlation to their anxiety *** An 81-question survey was distributed via email,Facebook and social media groups using *** investigate risk factors associated with elevated anxiety level,we dichotomized the 1-10 anxiety score into low(≤5)and high(≥6).This cut point represents the 25th *** were 90(29%)shown as low anxiety and 219(71%)as high *** descriptive analyses,we used contingency tables by anxiety categories for categorical measurements with chi square test,or mean±STD for continuous measurements followed by t-test or Wilcoxson rank sum test depending on data *** Absolute Shrinkage and Selection Operator was used to select important predictors for the final multivariate *** Poisson regression model was used to fit the final multivariate model by considering the nested data structure of students clustered within *** 397 medical students from 29 states were *** half of respondents reported feeling depressed since the pandemic onset.62%of participants rated 7 or higher out of 10 when asked about anxiety *** correlated with higher anxiety scores included“concern about being unable to complete exams or rotations if contracting COVID-19”(RR 1.34;95%CI:1.05-1.72,P=0.02)and the use of mental health services such as a“psychiatrist”(RR 1.18;95%CI:1.01-1.3,P=0.04).However,those students living in cities that limited restaurant operations to exclusively takeout or delivery as the only measure of implementing social distancing(RR 0.64;95%CI:0.49-0.82,Pkely to have a high *** COVID-19 significantly

关键词： Medical student SARS-CoV-2 Anxiety Stress Psychological Impact clinical

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Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2992-3008页

作者： Shicheng Fan Yue Gao Pengfei Zhao Guomin Xie Yanying Zhou Xiao Yang Xuan Li Shuaishuai Zhang frank JGonzalez Aijuan Qu Min Huangb Huichang Bi NMPA key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial key Laboratory of New Drug Design and Evaluation School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Department of Physiology and Pathophysiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA The State key Laboratory of Chemical Oncogenomics School of Chemical Biology and BiotechnologyShenzhen Graduate School of Peking UniversityShenzhen 518055China

Fenofibrate,a peroxisome proliferator-activated receptor α(PPARα)agonist,is widely prescribed for hyperlipidemia *** studies also showed that it has therapeutic potential in various liver ***,its effects on hepatomegaly and liver regeneration and the involved mechanisms remain ***,the study showed that fenofibrate significantly promoted liver enlargement and regeneration post-partial hepatectomy in mice,which was dependent on hepatocyteexpressed PPARα.Yes-associated protein(YAP)is pivotal in manipulating liver growth and *** further identified that fenofibrate activated YAP signaling by suppressing its k48-linked ubiquitination,promoting its k63-linked ubiquitination,and enhancing the interaction and transcriptional activity of the YAP-TEAD *** inhibition of YAP-TEAD interaction using verteporfin or suppression of YAP using AAV Yap shRNA in mice significantly attenuated fenofibrate-induced *** factors,such as MYC,kRT23,RAS,and RHOA,might also participate in fenofibrate-promoted hepatomegaly and liver *** studies demonstrate that fenofibratepromoted liver enlargement and regeneration are PPARα-dependent and partially through activating the YAP signaling,with clinical implications of fenofibrate as a novel therapeutic agent for promoting liver regeneration.

关键词： Fenofibrate PPARa Hepatomegaly Partial hepatectomy Liver regeneration YAP TEAD Ubiquitination

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CHC-TSCM:A Trustworthy Service Composition Method Based on an Improved CHC Genetic Algorithm

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China Communications 2013年第12期10卷 77-91页

作者：曹步清刘建勋 Xiaoqing(frank) LIU 李兵周栋康国胜 key Laboratory of knowledge Processing and Networked Manufacture School of Computer Science and EngineeringHunan University of Science and Technology Department of Computer Science Missouri University of Science and Technology State key Laboratory of Software Engineering School of ComputerWuhan University

Trustworthy service composition is an extremely important task when service composition becomes infeasible or even fails in an environment which is open,autonomic,uncertain and *** paper presents a trustworthy service composition method based on an improved Cross generation elitist selection,Heterogeneous recombination,Catacly-smic mutation(CHC) Trustworthy Service Composition Method(CHC-TSCM) genetic *** firstly obtains the total trust degree of the individual service using a trust degree measurement and evaluation model proposed in previous *** combination and computation then are performed according to the structural relation of the composite ***,the optimal trustworthy service composition is acquired by the improved CHC genetic *** results show that CHC-TSCM can effectively solve the trustworthy service composition *** with GODSS and TOCSS,this new method has several advantages:1) a higher service composition successrate;2) a smaller decline trend of the service composition success-rate,and 3) enhanced stability.

关键词： QoS service trust model CHC gen-etic algorithm trustworthy service composition

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Targeting the PI3k/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?

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World Journal of Gastroenterology 2015年第43期21卷 12261-12273页

作者： Shikha Satendra Singh Wei Ney Yap frank Arfuso Shreya kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem kumar Cancer Science Institute of Singapore National University of Singapore Department of Pharmacology Yong Loo Lin School of MedicineNational University of Singapore Davos Life Science Pte Ltd School of Biomedical Sciences Curtin Health Innovation Research InstituteCurtin University National University Cancer Institute Department of Biological Sciences University of North Texas

Frequent activation of phosphatidylinositol-3 kinases(PI3k)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIk3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3k/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3k/Akt/m TOR pathway inhibition.

关键词： Epidemiology Gastric cancer PI3k/Akt/ m TOR pathwa

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北京大气PM_(2.5)中铅的同位素测定和来源研究

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环境科学 2006年第3期27卷 401-407页

作者：李显芳刘咸德李冰董树屏刘锋 Veerle VanLierde frank Vanhaecke 中国环境科学研究院国家地质实验测试中心北京100037 国家环境分析测试中心北京100029 根特大学核科学研究所

用石英滤膜连续采集北京2003—02～2003—03的12个PM2．5样品，进行无机多元素、OC、EC和铅同位素丰度比的分析测定．对样品进行聚类分析，结合气象信息讨论了分组结果，描述了2003年春北京市的2个大气铅污染过程．2个污染过程均表现出... 详细信息

用石英滤膜连续采集北京2003—02～2003—03的12个PM2．5样品，进行无机多元素、OC、EC和铅同位素丰度比的分析测定．对样品进行聚类分析，结合气象信息讨论了分组结果，描述了2003年春北京市的2个大气铅污染过程．2个污染过程均表现出铅含量高，^206Pb／^207Pb丰度比低的特点．Al、Ca、k等地壳元素的含量与Pb的含量负相关，表明土壤尘对铅的贡献不大．比较Pb、A5、Zn、Se和Al、Ca等地壳元素含量的相关性，2个铅污染过程是由有色冶金排放和燃煤排放共同主导的．而02—28～03-02的铅污染过程中，燃煤排放贡献增大，有色冶金排放贡献下降．结果表明，汽油无铅化以后，北京市春季大气颗粒物中的铅主要来源于有色冶金排放与燃煤排放。

关键词：铅大气颗粒物同位素丰度比

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Magnetic nanoparticles and concentrated magnetic nanofluids:Synthesis,properties and some applications

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China Particuology 2007年第1期5卷 43-49页

作者： Ladislau Vks Doina Bica Mikhail V. Avdeev Lab Magnetic Fluids CFATR Romanian Academy-Timisoara Division Timisoara Romania National Center for Engineering of Systems with Complex Fluids Univ. Politehnica Timisoara Timisoara Romania Lab Magnetic Fluids CFATR Romanian Academy-Timisoara Division Timisoara Romania frank Laboratory of Neutron Physics Joint Institute for Nuclear Research Dubna Russia

This paper reviews some recent results concerning chemical synthesis of magnetic nanoparticles and preparation of various types of magnetic nanofluids. Structural properties and behaviour in external magnetic field of magnetic nanofluids will be emphasized with relation to their use in leakage-free rotating seals and in biomedical applications.

关键词： Magnetic nanoparticle Magnetic nanofluid Rotating seal Biomedical application Chemical co-precipitation Structural characterization

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The all-diode-pumped laser system POLARIS——an experimentalist's tool generating ultra-high contrast pulses with high energy

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High Power Laser Science and Engineering 2014年第3期2卷 5-11页

作者： Marco Hornung Hartmut Liebetrau Andreas Seidel Sebastian keppler Alexander kessler Jrg krner Marco Hellwing frank Schorcht Diethard klpfel Ajay k.Arunachalam Georg A.Becker Alexander Svert Jens Polz Joachim Hein Malte C.kaluza Helmholtz-Institute Jena Germany Institute of Optics and Quantum Electronics JenaGermany

The development,the underlying technology and the current status of the fully diode-pumped solid-state laser system POLARIS is ***,the POLARIS system delivers 4 J energy,144 fs long laser pulses with an ultra-high temporal contrast of 5 × 1012 for the ASE,which is achieved using a so-called double chirped-pulse amplification scheme and cross-polarized wave generation pulse *** tightly focusing,the peak intensity exceeds 3.5 × 1020 W *** parameters predestine POLARIS as a scientific tool well suited for sophisticated experiments,as exemplified by presenting measurements of accelerated proton ***,an additional amplifier has been added to the laser *** the ramp-up phase,pulses from this amplifier are not yet compressed and have not yet reached the anticipated ***,an output energy of 16.6 J has been achieved so far.

关键词： design high power laser laser amplifiers laser plasmas interaction laser systems modelling optimization ultra-intense ultrashort pulse laser interaction with matter

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按照具有大地测量精度的传播时间测量法进行距离测量

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测绘科学 1988年第1期 30-36页

作者： k.Grimm P.frank k.Giger 方佩竹

本文详细介绍采用传播时间测量法、具有大地测量精度的Wild DI3000测距仪及不用反射器测量型的Wild DIOR3002测距仪。传播时间测量法既有在特定的使用中无需反射器的可能性,还有与相位测量法相比较的其它优点。

关键词：测量精度 DI 传播时间距离改正测量法距离测量

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Observations from the Working Group Peritoneal Carcinosis

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Journal of Cancer Therapy 2022年第8期13卷 507-524页

作者： Manju Domnick Martin Domnick Iris Ernst frank P. Müller Viktor Rempel Norman Bitterlich Hüseyin Sahinbas Stefan könemann Stathis Philippou Praxis and Praxisklinik Domnick Herten Germany German Centre for Stereotaxy and Precision Radiation (DZSP) Soest Germany Catholic karl Leisner Clinic gGmbH Kleve Germany St. Anna Hospital Herne Herne Germany Medizin & Service GmbH Chemnitz Germany Praxis für Hyperthermie Düsseldorf Germany Radiotherapy Centre Bochum Bochum Germany Institute of Pathology of the Augusta Hospital Bochun Germany

The aim of this report was to describe the feasibility, overall survival and quality of life of combining multimodal therapy with a complementary therapy concept called LOTUS Care Cure program. The peritoneal carcinomatosis (PC) working group described their observations on the combination of multimodal therapy with a complementary therapy concept based on 132 patients with different cancer entities with suspected PC. PC was not confirmed by laparoscopy in 32.5% of the patients included in the working group of patients with suspected PC. Patient compliance and the feasibility were high. For ki67, there is a cut-off at 45% with a slower progression at 45%. The higher the karnofsky index, the more improved the therapy and tolerability, with a cut-off of 80%. Overall, 72.0% of patients died. The median survival time in the overall population was 3.74 years (95% CI, 2.57 to 4.91) with a sharp decline in the first 16 weeks. The quality of life of patients can be improved with the implementation of the complementary LOTUS Care Cure Project. Overall, the therapy of PC requires a multi-professional team of therapists and a multimodal therapy concept. The multimodal concept together with the Lotus Care Cure project shows very good feasibility with high compliance and ultimately leads to better and low-risk patient care.

关键词： Multimodal and Complementary Therapy Peritoneal Carcinosis Quality of Life

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Hetero-trans-β-Glucanase Produces Cellulose-Xyloglucan Covalent Bonds in the Cell Walls of Structural Plant Tissues and Is Stimulated by Expansin

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Molecular Plant 2020年第7期13卷 1047-1062页

作者： klaus Herburger Lenka frankova Martina Picmanova Jia Wooi Loh Marcos Valenzuela-Ortega frank Meulewaeter Andrew D.Hudson Christopher E.French Stephen C.Fry The Edinburgh Cell Wall Group Institute of Molecular Plant SciencesSchool of Biological SciencesThe University of EdinburghEdinburgh EH93BFUnited Kingdom Institute of Quantitative Biology Biochemistry and BiotechnologySchool of Biological SciencesThe University of EdinburghEdinburgh EH93BFUnited Kingdom BASF BBCC Innovation Center Gent-Trait Research9052 Gent(Zwijnaarde)Belgium Zhejiang University-University of Edinburgh Joint Research Centre for Engineering Biology Zhejiang UniversityHainingZhejiang 314400China Present address:Section for Plant Glycobiology Department of Plant and Environmental SciencesUniversity of CopenhagenFrederiksberg 1871Denmark

Current cell-wall models assume no covalent bonding between cellulose and hemicelluloses such as xyloglu-can or mixed-linkageβ-D-glucan(MLG).However,Equisetum hetero-trans-β-glucanase(HTG)grafts cellu-lose onto xyloglucan oligosaccharides(XGOs)-and,we now show,xyloglucan polysaccharide-in vitro,thus exhibiting CXE(cellulose:xyloglucan endotransglucosylase)*** addition,HTG also catalyzes MLG-to-XGO bonding(MXE activity).In this study,we explored the CXE action of HTG in native plant cell walls and tested whether expansin exposes cellulose to HTG by disrupting hydrogen *** quantify and visu-alize CXE and MXE action,we assayed the sequential release of HTG products from cell walls pre-labeled with substrate *** demonstrated covalent cellulose--xyloglucan bonding in plant cell walls and showed that CXE and MXE action was up to 15%and 60%of total transglucanase action,respectively,and peaked in aging,strengthening tissues:CXE in xylem and cells bordering intercellular canals and MXE in *** bacterial expansin(EXLX1)strongly augmented CXE activity in *** and MXE ac-tion in living Equisetum structural tissues potentially strengthens stems,while expansin might augment the HTG-catalyzed CXE reaction,thereby allowing efficient CXE action in *** methods will enable surveys for comparable reactions throughout the plant ***,engineering similar hetero-polymer formation into angiosperm crop plants may improve certain agronomic traits such as lodging tolerance.

关键词： cell wall cellulose hemicelluloses hetero-trans-p-glucanase hetero-transglycosylation xyloglucan

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