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Pharmaceutical compounds in aquatic environment in China： locally screening and environmental risk assessment

Frontiers of Environmental Science & Engineering 2015年第3期9卷 394-401页

作者： Yongshan CHEN Xiuping XI Gang YU Qiming CAO Bin WANG franfois vince Youwei HONG Key Laboratory of Urban Environment and Health Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China School of Environment THU-VEOLIA Joint Research Center for Advanced Environmental Technology Tsinghua University Beijing 100084 China

An environmental risk assessment was performed for pharmaceutical compounds present in the aquatic environment of China. Predicted environmental concentration （PEC） of the compounds were calculated according to European Medicines Evaluation Agency （EMEA） guidelines. Available ecotoxicological data compromised by applying a very conservative assessment factor （AF） were employed to calculate the predicted noeffect concentration （PNEC）. The screening principle and the risk assessment were based on risk quotient （RQ）, which derived from the PEC and related PNEC values. PEC results indicated that all the compounds except sulfadimethoxine and levocamitine, should carry out phase II risk assessment in EMEA guideline. RQ values suggested that more than 36 pharmaceuticals may be imposed health threats to the aquatic environment; especially the antibiotic therapeutic class including amoxicillin, sulfasalazine, trimethoprim, oxytetracycline and erythromycin showed high RQ values. These substances with high RQ value （RQ≥ 1） were regarded as top- priority pharmaceuticals for control in the aquatic environment of China. However, the antibiotic substances which had low risk quotient （RQ 〈 1）, should be reassessed by its potentially induced resistance under low concentration in future.

关键词： pharmaceuticals aquatic environment risk assessment aquatic toxicity risk quotient

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