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Malbec，涅槃重生

美食与美酒 2013年第9期 32-41页

作者： pierre 小黑(摄影)

曾经的贵族身份沿着波尔多南下，就来到了法国西南方的Cahors地区，在这里，Malbec象征了高端的品质。相传，今天的东欧国家所用的“卡奥尔”发音的词正是来源于这个地区，追溯其源头，早在13世纪，包括法国在内的欧洲各国皇室都熟知Cah... 详细信息

曾经的贵族身份沿着波尔多南下，就来到了法国西南方的Cahors地区，在这里，Malbec象征了高端的品质。相传，今天的东欧国家所用的“卡奥尔”发音的词正是来源于这个地区，追溯其源头，早在13世纪，包括法国在内的欧洲各国皇室都熟知Cahors地区，因为这里可以提供他们所青睐的葡萄酒，它的颜色极其深，以致从杯口都看不清隔着盛满着酒的杯子后轻轻翘起的手指，它的单宁强劲，清爽的口味让人心生愉悦。在文艺复兴时期，它甚至是francois I的专享。而今天，它则深受美洲人的爱戴，尤其是美国的上流阶层，几乎成为“CahorsMalbec”最忠实的拥捧者之一。1971年，只有440公顷葡萄种植面积的Cahors获得“法国原产地”的命名。短暂的四十几年时光，看起来实在无法与闻名遐迩的波尔多、勃艮第相比。

关键词：文艺复兴时期葡萄酒东欧国家种植面积波尔多法国美洲人原产地

神经重症监护患者的液体治疗:ESICM专家共识及临床实践推荐

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国际脑血管病杂志 2019年第2期27卷 84-97页

作者： Mauro Oddo Daniele Poole Raimund Helbok Geert Meyfroidt Nino Stocchetti pierre Bouzat Maurizio Cecconi Thomas Geeraerts Ignacio-martin Loeches Herve Quintard Fabio Silvio Taccone Romergryko G. Geocadin Claude Hemphill Carole Ichai David Menon Jean-francois Payen Anders Perner martin Smith Jose Suarez Walter Videtta Elisa R. Zanier Giuseppe Citerio 何毅华(译) 常远(译) 王晓蔷(译) 潘速跃(译) Department of Medic al-Surgical Intensive Care Medicine Faculty of Biology and Medicine Centre Hospitalier Universitaire VauDOIs (CHUV) Lhiversity of Lausanne Rue du Bugnon 46 B4 08.623 1011 Lausanne Switzerland Department of Intensive Care Medicine St James's Lhiversity Hospital James's St Ushers P.O. Box 580 Dublin & Ireland Service de Reanimation Medic o-chirurgic ale Hopital Pasteur 2 UniversiteCote d'Azur CHU de Nice 06000 Nice France Unite CNRS 7275 Sophia-Antipolis France Department of Intensive Care Erasme Hospital University Libre de Bruxelles Brussels Belgium Neurosciences Critical Care Departments of Anesthesiology and Critical Care Medicine Neurology and Neurosurgery Johns Hopkins Lhiversity Baltimore MD USA Department of Neurology University of California San Francisco San Francisco CA LKA Service de Reanimation Polyvalente Hopital Pasteur 2 CHU de Nice 30 Voie Romaine CS 51069 06001 Nice Cedex 1 France Division of Anaesthesia University of Cambridge Addenbrooke's Ffospital Box 93 Hfills Road Cambridge Cambridgeshire CB2 2QQ UK Department of Intensive Care 4131 Copenhagen University Hospital- Rigshospitalet Copenhagen Denmark Department of Neuroanesthesia and Neurocritic al Care The National Ffospital for Neurosurgery and Neurology Lhiversity College London Hospitals London UK Anesthesia and Intensive Care Operative th it S. Martino Hospital Belluno Italy Hospital Nacional Professor Alejandro Posadas Buenos Aires Argentina Department of Neurosciences IRCCS-Istituto di Ricerche Farmacotogiche Mario Negri Milan Italy School of Medicine and Surgery University of Milan-Bicocca Milan Italy Neurointensive Care San Gerardo Hospital ASST-Monza 20900 Monza Italy 南方医科大学南方医院神经内科广州510515 Neurological Intensive Care Lhit Department of Neurology Medical University of Innsbruck Innsbruck Austria Department of Intensive Care Medicine University Hospitals Leuven Louvain Belgium Neuroscience Intensive Care Unit Department of Anesthesia and C

目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会... 详细信息

目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会,随后委员会成员通过电话会议和在线讨论制定本专家共识。方法回顾人群、干预、对比和结局(population, intervention,comparison, and outcomes, PICO)问题,根据需要进行更新并得到证据概要。本共识关注3个主要议题:(1)神经重症监护患者的液体复苏和维持;(2)高渗液体在颅内压控制中的应用;(3)蛛网膜下腔出血后迟发性脑缺血的液体管理。经过广泛的文献检索,应用推荐分级的评估、制订与评价(Gradingof Recommendations Assessment, Development and Evaluation, GRADE)系统原则评估证据质量(从高到极低),制定治疗推荐(强或弱),并在适用时发布最佳实践声明。基于文献和专家意见提供的综合证据,应用改良德尔菲方法(使用序贯方法以避免偏倚和误解)产生最终共识声明。结果最终共识包含总共32条声明,其中13条为强推荐,17条为弱推荐,另外2条声明未提供推荐意见。结论我们发布了一份关于神经重症监护患者液体治疗的共识声明和临床实践推荐。

关键词：循证医学指南液体治疗创伤性脑损伤蛛网膜下腔出血脑出血卒中甘露醇高渗神经重症监护

Clinico-Pathological Profile of Malignant Abdominal Tumors in Children: Experience of the Pediatric Oncology Unit in Bamako

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Open Journal of Pediatrics 2021年第4期11卷 608-617页

作者： Abdoul Karim Doumbia Adama Dembele pierre Togo Oumar Coulibaly Arsene Dackono Mohamed Elmouloud Cissé Fousseyni Traoré Hawa Diall Boubacar Togo Abdoul Aziz Diakité Yakaria Coulibaly Cheick Bougadary Traore Lala N’drainy Sidibe Belco Maiga Diakite Fatoumata Léonie francois Karamoko Sacko Djeneba Konaté Guediouma Dembele Hacimi Poma Adama Bah Djibril Kassogue Oumar Keita Ibrahim Ahamadou Department of Pediatrics at CHU Gabriel Touré Bamako Mali Pediatric Surgery Department of the Gabriel Touré CHU Bamako Mali Pathological Anatomy and Cytology Department of the “Point G” CHU Bamako Mali

Introduction: the objective was to describe the epidemiological and histological aspects of malignant abdominal tumors in children. Methodology: This was a descriptive, cross-sectional study conducted from January 1, 2017 to December 31, 2018. We included all patients aged 0 to 15 years with histologically confirmed abdominal malignancies. Results: We collected 46 files of malignant tumors of the abdomen (35% of pediatric cancers). The majority of patients were under 5 years old (65%). The sex ratio was 1.7. They were generally from disadvantaged socio-economic backgrounds (67%). The average consultation time was 50 days. The main reasons for consultation were abdominal mass (48%), pain (17%) or distension (9%). The mass was large, hard (89%), immobile (71%) and painful (46%). Malnutrition was found in 80% of patients. The mass was retro-peritoneal in 63% of cases and renal in 54%. It was solid in 94% of cases and heterogeneous in 76% of cases. The assay for tumor markers was not performed. Anemia was present in all patients. Fine needle aspiration was performed in 43%, biopsy in 37% and myelogram in 15% of cases. spinal cord involvement was observed in 28% of Burkitt’s cases. The main cancers diagnosed were nephroblastoma (52%), Burkitt’s lymphoma (26%) and neuroblastoma (13%). Stage 1 and stage 2 were frequent in 20% and 22% of cases, respectively;36% of cases were not staged. The average duration of chemotherapy was 11 weeks. Total resection was performed in 30% of cases. The outcome of the patients was marked by total remission in 65%. Conclusion: Abdominal malignancies are very common in children. The diagnosis of certainty is late in our context.

关键词： Cancer Abdomen Child Sub-Saharan Africa

一种诊断肝纤维化的有效方法——评Wáng等IVIM诊断肝纤维化的论文

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新发传染病电子杂志 2017年第4期2卷 196-197页

作者： Jean-pierre Cercueil Department of Vascular and Interventional Radiology Francois-Mitterrand Teaching Hospital University of Burgundy

自从Le Bihan等作者于1986年描述体素内不相干运动(intravoxel incoherent motion,IVIM)磁共振弥散成像以来,这项技术取得了很大进展[1-4]。特别是在肝硬化和纤维化的情况下,许多研究显示了各种病理对弥散参数的影响。然而由于IVIM弥散... 详细信息

自从Le Bihan等作者于1986年描述体素内不相干运动(intravoxel incoherent motion,IVIM)磁共振弥散成像以来,这项技术取得了很大进展[1-4]。特别是在肝硬化和纤维化的情况下,许多研究显示了各种病理对弥散参数的影响。然而由于IVIM弥散参数值扫描的不稳定性,这些参数在个体患者诊断方面临床意义不大[5]。精确测量PF(f)和Dfast(D*)非常困难[6,7]。许多研究者试图提高测量精度、更好地理解扩弥散模式、改进图像采集序列或图像后处理。但是直到今天,肝脏IVIM参数测量的稳定性仍然不足,并难以满足日常的临床应用[5]。

关键词：肝纤维化诊断磁共振弥散成像论文效方不稳定性测量精度图像后处理

*** mediated PEX1 gene augmentation improves visual function in a mouse model for Zellweger spectrum disorder

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Annals of Eye Science 2018年第1期 443-443页

作者： Catherine Argyriou Ji Yun Song Ania Polosa Bruno Cecyre Jean-francois Bouchard pierre Lachapelle Jean Bennett Nancy Braverman Human Genetics McGill UniversityMontrealQCCanada Perelman School of Medicine University of PennsylvaniaPhiladelphiaPAUSA Ophthalomology McGill UniversityMontrealQCCanada School of Optometry University of MontrealMontrealQCCanada

Background:Zellweger spectrum disorder(ZSD)is an autosomal recessive disease caused by mutations in any one of 13 PEX genes whose protein products are required for peroxisome *** leading to blindness is one of the major handicaps faced by affected individuals,but treatment for this is supportive *** test whether we could improve visual function in ZSD,we performed a proof-of-concept trial for PEX1 gene augmentation therapy using the Pex1-G844D mouse model,which bears the equivalent to a common human *** model exhibits a gradual decline in scotopic ffERG response,an always residual photopic ffERG response,diminished visual acuity,and cone and bipolar cell ***:We administered subretinal injections of a PEX1-containing viral vector(***)to 2 mouse cohorts of 5 or 9 weeks of age.A GFP-containing vector was used as a control in the contralateral eye of each *** expression of the virus was confirmed by retinal histology/immunohistochemistry,and its ability to recover peroxisome import was confirmed in *** ffERG and optokinetic(OKN)analyses were performed on a subset of animals at 8,16,and 20 weeks after gene *** ffERG and OKN measures were performed when each cohort reached 32 weeks of age(23 or 27 weeks post injection).Results:Preliminary ffERG and OKN analyses at 8 weeks post injection showed mildly better retinal response and visual acuity,respectively,in the PEX1-injected eyes,as did ffERG analysis when each cohort reached 25 weeks of age(16 or 20 weeks after gene delivery).This effect was more pronounced in the cohort treated at 5 weeks of age,when ffERG response is highest in Pex1-G844D *** 32 weeks of age,the ffERG response in the PEX1-injected eyes was double that of GFP-injected eyes,on average,though there was no change in ***,in PEX1-injected eyes the photopic ffERG response improved over time,and the decline in scotopic b-wave amplitude was ameliorat

关键词： Retinal gene therapy peroxisome disorder Zellweger spectrum disorder(ZSD) PEX1

Realization of Unbiased Ferrite Cobalt Nano-Composite for Non-Reciprocal Microwave Components

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材料科学与工程（中英文A版） 2013年第11期3卷 751-756页

作者： Ardaches Tchangoulian Elie Abou Diwan Didier Vincent Sophie Neveu francois Royer Jean pierre Chatelon Chadi Nader Roland Habchy LT2C Laboratory Jean-Monnet University 25 Rue Dr. R~my Annino F-42000 Saint-Etienne France Research Platform in Nano Sciences and Nanotechnologies Campus Fanar Lebanese University Jdeidet 90239 Lebanon PECSA Laboratory University of Pierre and Marie Curie Paris F-75005 France

In telecommunication systems, heavy bulky magnets are used to establish the proper functioning of a circulator by ensuring the uniform orientation of the ferrite material"s magnetic moments. Thus to develop an unbiased coplanar microwave circulator, the approach based on "ferromagnetic nano-wired composite substrates" was promising. The idea was to do a magnetophoretic deposition of nano-colloidal cobalt ferrite nanoparticles into porous alumina membranes and permanently orient them uniformly. Therefore, in order to check the orientation possibility of the nanoparticle, samples of magnetic thin films on glass substrates were synthetized from CoFe2 O 4 nanoparticles dispersed in a silica sol-gel matrix using the dip-coating technique with and without a uniformly applied magnetic field. To investigate the magnetic behavior of the prepared samples, the Faraday rotation as a function of the applied magnetic field was measured using a spectral polarimeter. The unambiguous qualitative difference between the Faraday rotation hysteresis loops shows a large variation of coercive (μ 0 H c ) and remanent field (M/M s ) values, thus proving the orientation of the nanoparticles. Such nano-composite was a promising candidate for future miniature microwave circulators fabrication.

关键词：纳米复合材料微波器件钴铁氧体钴纳米粒子法拉第旋转互惠无偏多孔氧化铝膜

*** in a mouse model for Zellweger spectrum disorder

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Annals of Eye Science 2018年第1期 418-418页

作者： Catherine Argyriou Anna Polosa Bruno Cecyre Erminia Di Pietro Monica Hsieh Jean-francois Bouchard pierre Lachapelle Nancy Braverman Human Genetics McGill UniversityMontrealQCCanada Ophthalomology McGill UniversityMontrealQCCanada Optometry University of MontrealMontrealQCCanada

Background:Zellweger spectrum disorder(ZSD)is an autosomal recessive disease caused by mutations in any one of 13 PEX genes whose protein products are required for peroxisome *** leading to blindness is one of the major untreatable handicaps faced by patients with ZSD but is not well characterized,and the requirement for peroxisomes in retinal health is *** address this and to inform future therapeutic studies,we examined the progression of retinopathy in our murine model for the common PEX1-G843D ***:Retinal electrophysiology(ffERG)and histology were performed in a cohort of Pex1-G844D(equivalent to human G843D)mice from 2 to 32 *** acuity was assessed using *** levels of PEX1-G843D protein,its binding partner Pex6,and its putative ligand Pex5(the peroxisome enzyme receptor)in the retina were determined by *** biochemical metabolites in the whole eye and retina were measured using LC/*** immunohistochemistry was used to visualize various cell ***:Cone ffERG response in the mutants remained residual(5%that of control)regardless of *** rod-mediated responses(50-70%of control)was reached at 4-6 wks,and then progressively decreased with age.B-waves were affected more severely than a-waves,while high frequency ERG components(oscillatory potentials)are better preserved than low frequency components(a-and b-waves).Visual evoked potential was diminished at 32 *** of visual acuity using optokinetics showed low visual reflexes by 11-13 weeks of *** found normal amounts of Pex1-G844D,Pex6,and Pex5 protein in retina,suggesting that the mutated protein is not *** of peroxisome metabolites showed elevated very long chain fatty acids(VLCFA)and decreased plasmalogens in the whole eye,indicative of peroxisome *** the retina,VLCFAs were not elevated,and only C22:6(docosahexaenoic acid)was decreased of the plasmalogens *** were

关键词： Zellweger spectrum disorder(ZSD) peroxisome disorder PEX1

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氨基酸在SiO2表面的吸附选择性研究

氨基酸在SiO2表面的吸附选择性研究

中国化学会第二十五届学术年会

作者：朴玲钰 Jean-francois Lambert Lorenzo Stievano 国家纳米科学中心 Laboratoire de Réactivité de Surface Université Pierre et Marie Curie 75252 Paris France Laboratoire de Réactivité de Surface Université Pierre et Marie Curie 75252 Paris France

We have investigated the adsorption selectivity of glycine and lysine on silica by using many kinds of characterization methods, such as TGA, FT-IR, XRD, TPD-MS, 13C NMR. We have carried out molecular

关键词：氨基酸 SiO2 选择性吸附

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层状硅酸盐Magadiite的层板剥离

科学通报 2010年第4期55卷 391-395页

作者：毕云飞 BLANCHARD Juliette LAMBERT Jean-francois 曾双亲聂红李大东李明丰杨清河陈小新石油化工科学研究院北京100083 Laboratoire de Reactivite de Surface Universite Pierre et Marie Curie4Place Jussieu

以十六烷基三甲基溴化胺和四丙基氢氧化铵为膨化剂,利用超声波的空化作用将合成的层状硅酸盐Magadiite进行层板剥离,从而制备了一种新型介孔材料.采用了XRD、氮气吸附、NMR,IR,SEM和TEM等表征工具对这种材料的结构和形貌进行了详细的表... 详细信息

以十六烷基三甲基溴化胺和四丙基氢氧化铵为膨化剂,利用超声波的空化作用将合成的层状硅酸盐Magadiite进行层板剥离,从而制备了一种新型介孔材料.采用了XRD、氮气吸附、NMR,IR,SEM和TEM等表征工具对这种材料的结构和形貌进行了详细的表征.研究结果表明:这种材料在长程上是无序的而在短程上是有序的.此外,这种新型介孔材料不仅具有高的比表面,而且约有一半的部分是外表面.形貌观察进一步表明这种介孔材料的孔壁是由不规则的单个晶体片层组成.由于这些结构特点,这种新型介孔材料同时满足了孔壁晶体化,良好的大分子可接近性的要求.

关键词： Magadiite 膨化超声处理层板剥离介孔材料