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A Fluorescent Alternative to the Synthetic Strigolactone GR24

Molecular Plant 2013年第1期6卷 100-112页

作者： Amanda Rasmussen Thomas Heugebaert Cedrick Matthys Rik Van Deun francois-didier boyer1 Sofie Goormachtig Christian Stevens Danny Geelen Plant Production Faculty of Bioscience Engineering Ghent University Coupure links 653 Ghent 9000 Belgium Research Group SynBioC Department of Sustainable Organic Chemistry and Technology Faculty of Bioscience Engineering Ghent University Coupurelinks 653 B-9000 Gent Belgium Department of Plant Systems Biology VIB Ghent 9052 Belgium Department of Plant Biotechnologyand Bioinformatics Ghent University Ghent 9052 Belgium f-element Coordination Chemistry Lab Inorganic and Physical Chemistry Department Ghent University Krijgslaan 281--$3 9000 Gent Belgium Centre de Recherche de Gif Institut de Chimie des Substances Naturelles UPR2301 CNRS INRA 1 avenue de la Terrasse F-91198 Gif-sur-Yvette Cedex France

Strigolactones have recently been implicated in both above- and below-ground developmental pathways in higher plants. To facilitate the molecular and chemical properties of strigolactones in vitro and in vivo, we have devel- oped a fluorescent strigolactone molecule, CISA-1, synthesized via a novel method which was robust, high-yielding, and used simple starting materials. We demonstrate that CISA-1 has a broad range of known strigolactone activities and further report on an adventitious rooting assay in Arabidopsis which is a highly sensitive and rapid method for testing biological activity of strigolactone analogs. In this rooting assay and the widely used Orobanche germination assay, CISA-1 showed stronger biological activity than the commonly tested GR24. CISA-1 and GR24 were equally effective at inhibiting branching in Arabidopsis inflorescence stems. In both the branching and adventitious rooting assay, we also demonstrated that CISA-1 activity is dependent on the max strigolactone signaling pathway. In water methanol solu- tions, CISA-1 was about threefold more stable than GR24, which may contribute to the increased activity observed in the various biological tests.

关键词： strigolactones adventitious rooting branching fluorescent markers parasitic weed seed germination.

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New Strigolactone Analogs as Plant Hormones with Low Activities in the Rhizosphere

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Molecular Plant 2014年第4期7卷 675-690页

作者： francois-didier boyer Alexandre de Saint Germain Jean-Bernard Pouvreau Guillaume Clave Jean-Paul Pillot Amelie Roux Amanda Rasmussen Stephen Depuydt Dominique Lauresserguesh Nicolas Frei dit Frey Thomas S.A. Heugebaert Christian V. Stevens Danny Geelen Sofie Goormachtig Catherine Rameau Institut Jean-Pierre Bourgin UMR1318 Institut National de la Recherche Agronomique (INRA)-AgroParisTech Route de Saint-Cyr (RD 10) F-78026 Versailles Cedex France Centre de Recherche de Gif Institut de Chimie des Substances Naturelles UPR2301 Centre National de la Recherche Scientifique (CNRS) 1 avenue de la Terrasse F-91198 Gif-sur-Yvette Cedex France Laboratoire de Biologie et de Pathologie Vegetales EA 1157 SFR 4207 QUASAV Universite de Nantes 44322 Nantes France Plant Production Faculty of Bioscience Engineering Ghent University Coupure links 653 Ghent 9000 Belgium Present address: School of Biosciences Division of Plant and Crop Production The University of Nottingham Sutton Bonington Leicestershire LE12 5RD UK Department of Plant Systems Biology VIB Ghent 9052 Belgium Department of Plant Biotechnology and Bioinformatics Ghent University Ghent 9052 Belgium Laboratoire de Recherche en Sciences Vegetales UMR 5546 Universite de Toulouse- Centre National de la Recherche Scientifique (CNRS) BP 42617 Auzeville F-31326 Castanet-Tolosan France Research Group SynBioC Department of Sustainable Organic Chemistry and Technology Faculty of Bioscience Engineering Ghent University Coupure links 653 B-9000 Gent Belgium

Strigolactones （SLs） are known not only as plant hormones, but also as rhizosphere signals for establishing symbiotic and parasitic interactions. The design of new specific SL analogs is a challenging goal in understanding the basic plant biology and is also useful to control plant architectures without favoring the development of parasitic plants. Two different molecules （23 （3＇-methyI-GR24）, 31 （thia-3＇-methyl-debranone-like molecule）） already described, and a new one （AR36）, for which the synthesis is presented, are biologically compared with the well-known GR24 and the recently identified CISA-1. These different structures emphasize the wide range of parts attached to the D-ring for the bioactivity as a plant hormone. These new compounds possess a common dimethylbutenolide motif but their structure varies in the ABC part of the molecules： 23 has the same ABC part as GR24, while 31 and AR36 carry, respectively, an aromatic ring and an acyclic carbon chain. Detailed information is given for the bioactivity of such derivatives in strigolactone synthesis or in perception mutant plants （pea rmsl and rms4, Arabidopsis max2 and, max4） for different hormonal functions along with their action in the rhizosphere on arbuscular mycorrhizal hyphal growth and parasitic weed germination.

关键词： strigolactones synthetic analogs Pisum sativum Arabidopsis root parasitic plants Gigaspora rosea plant growth regulator.

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Sex Pheromone System of Vesperus xatarti (Dufour) (Coleoptera:Cerambycidae)

Sex Pheromone System of Vesperus xatarti (Dufour) (Coleopter...

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The First Asia—Pacific Conference on Chemical Ecology

作者： Pierre Zagatti francois-didier boyer Marc Guisset Isabelle de Cruz-Malosse Christian Malosse Charles Descoins INRA Unite de Phytopharmacie et Mediateurs Chimiques 78026 Versailles Cedex FRANCE

Longhorn beetles belonging to the genus Vespenis show a remarkable sexual dimorphism,with winged males and totally apterous *** beetles are normally hidden in the soil,burrowing their way to the surface only to mate and lay eggs(Mayet,1890). The nocturnal behavior of the adults and the weak mobility of the females strongly suggested a female-

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Solitary pulmonary metastasis arising thirteen years after liver transplantation for HBV-related hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第30期12卷 4911-4913页

作者： Chiara Viola Tarik Asselah didier Samuel francois Durand Hamza Boudjema Dominique Valla Patrick Marcellin Service d'Hépatologie INSERM CRB3 University of Paris VII Hpital Beaujon Clichy 92 110 France Centre Hepatobiliary UPRES 3541 Formation de recherche Claude Bernard Virus et Transplantation Universite Paris-Sud Hpital Paul Brousse Villejuif 94800 France

We described a 59-year-old male patient who underwent liver transplantation in 1989 for hepatocellular carcinoma （HCC） complicating hepatitis B virus （HBV） cirrhosis. In 2001 （12 years after liver transplantation）, he developed a lung metastasis of HCC without intrahepatic recurrence and the resection was done. In July 2003, he was symptom free without any recurrence. HCC metastasis can develop even after a very long time of liver transplantation. Many HCCs grow slowly, and the growth rate of recurrent tumors in patients receiving immunosuppressive therapy is significantly greater than that of those who do not receive immunosuppressive therapy.

关键词： Hepatitis B virus Liver transplantation Hepatocellular carcinoma Metastasis Immuno-suppression

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Nanoparticles with high payloads of pipemidic acid, a poorly soluble crystalline drug: drug-initiated polymerization and self-assembly approach

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Acta Pharmaceutica Sinica B 2018年第3期8卷 420-431页

作者： Elisabetta Pancani Mario Menendez-Miranda Alexandra Pastor francois Brisset Marie-francoise Bernet-Camard didier Desmaele Ruxandra Gref Institut de Sciences Moléculaires d'Orsay(ISMO) Univ.of Paris-SudUniversitéParis-Saclay Institut Galien UMR8612 Univ.of Paris-SudUniversitéParis-Saclay Institut de Chimie Moléculaire et des Matériaux d'Orsay(ICMMO) Univ.of Paris-SudUniversitéParis-Saclay EA4043" UnitéBactéries Pathogènes et Santé"(UBaPS) Univ.of Paris-SudUniversitéParis-Saclay

Nowadays, biodegradable polymers such as poly(lactic acid)(PLA), poly(D,L-lactic-coglycolic acid)(PLGA) and poly(ε-caprolactone)(PCL) remain the most common biomaterials to produce drug-loaded nanoparticles(NPs). Pipemidic acid(PIP) is a poorly soluble antibiotic with a strong tendency to crystallize. PIP incorporation in PLA/PLGA NPs was challenging because of PIP crystals formation and burst release. As PIP had a poor affinity for the NPs, an alternative approach to encapsulation was used, consisting in coupling PIP to PCL. Thus, a PCL–PIP conjugate was successfully synthesized by an original drug-initiated polymerization in a single step without the need of ***–PIP was characterized by NMR, IR, SEC and mass spectrometry. PCL–PIP was used to prepare selfassembled NPs with PIP contents as high as 27%(w/w). The NPs were characterized by microscopy,DLS, NTA and TRPS. This study paves the way towards the production of NPs with high antibiotic payloads by drug-initiated polymerization. Further studies will deal with the synthesis of novel polymer–PIP conjugates with ester bonds between the drug and PCL. PIP can be considered as a model drug and the strategy developed here could be extended to other challenging antibiotics or anticancer drugs and employed to efficiently incorporate them in NPs.

关键词： Pipemidic acid Nanoparticle Antibiotic Nanoprecipitation Crystalline drug Drug-initiated polymerization

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Antioxidant and antiglycation properties of two mango(Mangifera indica L.) cultivars from Senegal

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Asian Pacific Journal of Tropical Biomedicine 2018年第3期8卷 137-141页

作者： Samba Fama Ndoye didier Fraisse Blandine Akendengue Mbaye Diaw Dioum Rokhaya Sylla Gueye Cheikh Sall Insa Seck Catherine Felgines Matar Seck francois Senejoux Laboratory of Organic and Therapeutic Chemistry Faculty of Medicine Pharmacy and Odontology Cheikh Anta Diop University Universite Clermont Auvergne INRAUNH Department of Pharmacology and Toxicology Faculty of Medicine and Health Sciences (USS) Laboratory of Chemistry Training and Research Unit of Health Thies University

Objective: To evaluate the total phenolic contents, antioxidant and antiglycation activities of leaves, barks, roots and kernels from two cultivars of Mangifera indica(Anacardiaceae). Methods: Total phenolic contents were determined by using Folin-Ciocalteu's method. The antioxidant activities were assessed by three different protocols including DPPH, oxygen radical absorbance capacity and iron(Ⅱ) chelation assays. In addition, in vitro bovine serum albumin/D-ribose assay was chosen to evaluate the antiglycation properties of the extracts. Results: All the investigated extracts were found to contain high level of total phenols as well as potent antioxidant activities. Kernel extracts showed the highest total phenol contents and DPPH radical scavenging activities whereas higher oxygen radical absorbance capacity values were observed for leave, root and bark extracts. Besides, extracts from leaves, roots and barks from both cultivars exhibited potent inhibitory effects against the formation of advanced glycation end products, with IC_(50) values lower than the standard positive control aminoguanidine. Conclusions: The potent antiglycation and antioxidative activities of these two Mangifera indica cultivars suggest a possible role in targeting aging, diabetic complications and oxidative stress related diseases.

关键词： Mangifera indica Cultivars Polyphenols Antioxidant Antiglycation

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Validation of an In Vitro Model to Study Human Cartilage Responses to Compression

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Engineering（科研） 2012年第10期4卷 61-64页

作者： Natalia de Isla Céline Huselstein didier Mainard Jean-francois Stoltz CNRS UMR 7561 BiopoleFaculte de MédecineUniversite de LorraineVandoeuvreFrance UTCT CHU de NancyVandoeuvreFrance COT CHU de NancyVandoeuvreFrance

The aim of this work was to develop an in vitro model to study mechanical compression effects on cartilage. A pressure-controlled compression device was used in this study. Cartilage explants obtained from human knee were compressed at 1MPa/1Hz for 7 hours (30 min ON, 30 min OFF) under normoxia (5% CO2, 21% O2) or hypoxia (5% CO2, 5% O2). Cell viability was analyzed while nitric oxide (NO) and glycosaminoglycans (GAG) release was assayed in culture media. Mechanical stimulation increased NO production and GAG release by human cartilage explants under normoxia and hypoxia culture. In normoxia and hypoxia conditions, mechanical stimulation alters human OA cartilage metabolism. There is also, an increase in matrix degradation after compression, as shown by levels of GAG found in culture media. This study put in evidence the importance of mechanical compression in the progression of the osteoarthritis and present and in vitro model for mechanobiological and pharmacological studies.

关键词： Cartilage Compression In Vitro Model Nitric Oxide GAG

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Realization of Unbiased Ferrite Cobalt Nano-Composite for Non-Reciprocal Microwave Components

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材料科学与工程（中英文A版） 2013年第11期3卷 751-756页

作者： Ardaches Tchangoulian Elie Abou Diwan didier Vincent Sophie Neveu francois Royer Jean Pierre Chatelon Chadi Nader Roland Habchy LT2C Laboratory Jean-Monnet University 25 Rue Dr. R~my Annino F-42000 Saint-Etienne France Research Platform in Nano Sciences and Nanotechnologies Campus Fanar Lebanese University Jdeidet 90239 Lebanon PECSA Laboratory University of Pierre and Marie Curie Paris F-75005 France

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Biogeochemical Dynamics of Molybdenum in a Crater Lake:Seasonal Impact and Long-Term Removal

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Journal of Water Resource and Protection 2014年第4期6卷 256-271页

作者： Alassane Thiam didier Jezequel Alexis Groleau francois Prevot Filipa Lopes Patrick Alberic Catherine Quiblier Elivira Bura-Nakic Irena Ciglenecki Hassiba Lazar Eric Viollier Universite de Thies UFR Sciences de l’IngenieurThiesSenegal Laboratoire de Geochimie des Eaux Universite Paris Diderot-Institut de Physique du Globe de ParisParisFrance Laboratoires Genie des Procedes et Materiaux Ecole de Chimie de ParisChatenay-MalabryFrance UMR611-CNRS/Universite d’Orleans OrleansFrance Museum National d’Histoire Naturelle Equipe“Systematique et Ecotoxicologie des Micro-Algues”ParisFrance Rudjer Boskovic Institute Center for Marine and Environmental ResearchZagrebCroatia

Despite a large variety of processes that can control Mo and its potential to become an environmental tracer of euxinic environment, this element is not often studied in lakes. The aim of this paper is to identify main seasonal biogeochemical processes that involve Mo in a well constrained freshwater system (Lake Pavin water-column) in order to evaluate their respective importance. In Lake Pavin, 4 main processes have been identified: 1) the transitional process represented by Mo assimilation of by phytoplankton in the epilimnion (nitrogen biological fixation and nitrate assimilation);2) transient process represented by dissolved Mo adsorption onto Fe and Mn metal oxides at oxic/anoxic interface (depth 50 - 60 m);3) Mo precipitation where apparent sulfide production rate is maximum, and from 80 m depths;4) release of dissolved Mo due to Mo benthic flux or input from a deep source.

关键词： Molybdenum Biogeochemical Cycles Diatoms ICP-MS Meromictic Lake

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Predictive factors for survival and score application in liver retransplantation for hepatitis C recurrence

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World Journal of Gastroenterology 2016年第18期22卷 4547-4558页

作者： Alice Tung Wan Song Rodolphe Sobesky Carmen Vinaixa Jérome Dumortier Sylvie Radenne francois Durand Yvon Calmus Géraldine Rousseau Marianne Latournerie Cyrille Feray Valérie Delvart Bruno Roche Stéphanie Haim-Boukobza Anne-Marie Roque-Afonso Denis Castaing Edson Abdala Luiz Augusto Carneiro D’Albuquerque Jean-Charles Duclos-Vallée Marina Berenguer didier Samuel INSERM Unit 785 Villejuif 94800France Liver and Digestive Organ Transplantation Division Gastroenterology DepartmentUniversity of Sao Paulo Medical SchoolSao Paulo 05403-900Brazil Universite Paris-Sud Villejuif 94800France Liver Transplantation Laboratory LIM-37 Sao Paulo 01246-903Brazil AP-HP Hopital Paul Brousse Villejuif 94800France La Fe Hospital University of Valencia and CiberehdValencia 46026Spain Hopital Edouard Herriot Lyon 69003France Hopital Croix Rousse Lyon 69004France AP-HP Hopital Beaujon Clichy 92110France AP-HP Hopital St Antoine Paris 75011France AP-HP Hopital Salpetriere Paris 75013France CHU Pontchaillou Rennes 35000France AP-HP Hopital Henri Mondor Creteil 94010France Viral Hepatitis Laboratory LIM-47 Sao Paulo 01246-903Brazil

AIM: To identify risk factors associated with survival in patients retransplanted for hepatitis C virus(HCV) recurrence and to apply a survival score to this ***: We retrospectively identified 108 patients retransplanted for HCV recurrence in eight European liver transplantation centers(seven in France, one in Spain). Data collection comprised clinical and laboratory variables, including virological and antiviral treatment data. We then analyzed the factors associated with survival in this population. A recently published score that predicts survival in retransplantation in patients with hepatitis C was applied. Because there are currently no uniform recommendations regarding selection of the best candidates for retransplantation in this setting, we also described the clinical characteristics of 164 patients not retransplanted, with F3, F4, or fibrosing cholestatic hepatitis(FCH) post-first graft presenting with hepatic decompensation. RESULTS: Overall retransplantation patient survival rates were 55%, 47%, and 43% at 3, 5, and 10 years, respectively. Patients who were retransplanted for advanced cirrhosis had survival rates of 59%, 52%, and 49% at 3, 5, and 10 years, while those retransplanted for FCH had survival rates of 34%, 29%, and 11%, respectively. Under multivariate analysis, and adjusting for the center effect and the occurrence of FCH, factors associated with better survival after retransplantation were: negative HCV viremia before retransplantation, antiviral therapy after retransplantation, non-genotype 1, a Model for End-stage Liver Disease(MELD) score < 25 when replaced on the waiting list, and a retransplantation donor age < 60 years. Although the numbers were small, in the context of the new antivirals era, we showed that outcomes in patientswho underwent retransplantation with undetectable HCV viremia did not depend on donor age and MELD score. The Andrés score was applied to 102 patients for whom all score variables were available,

关键词： Antivirals Hepatitis C Mortality Prognosis Retransplantation Risk factors

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