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Investigation of the efficiency of intrastromal ring segments with cross-linking using different sequence and timing for keratoconus

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 703-708页

作者： Xuan-Li Liu Ping-Hua Li Pierre Fournie francois Malecaze Department of Ophthalmology of Chongqing Medical University Department of Ophtalmology CHU of ToulouseHopital Purpan

· AIM: To evaluate and compare the efficacy and stability of intrastromal corneal ring segment(ICRs)implantation with cross-linking(CXL) using different sequence and timing.· METHODS: In this single retrospective study, 86 keratoconic eyes subjected the ICRs implantation. We analyzed only 41 eyes that had complete *** were divided into three groups: ICRs implantation was applied only(group normal), ICRs first followed by CXL immediately(group CXL-S), CXL first followed by ICRs long after(group CXL-B). The visual acuity,refractive results, keratometry were compared preoperatively and 1y postoperatively. Their differences among the three groups were also analyzed.·RESULTS: Group normal comprised 25 eyes, group CXL-S 8 eyes, and group CXL-B 8 eyes. There were improvements in the mean uncorrected distance visual acuity(UDVA) and the mean corrected distance visual acuity(CDVA) compared preoperatively and 1y postoperatively [UDVA: 0.31(P =0.030) logarithmic minimum angle of resolution(log MAR) group normal, 0.4(P =0.020) group CXL-S, 0.45(P =0.001) group CXL-B;CDVA : 0. 21 log MAR( P = 0. 013) group normal, 0. 30(P =0.036) group CXL-S; 0.26(P =0.000) group CXL-B].The refractive and topographic outcomes also showed improvements. In terms of comparisons among the three groups, all the P values were above 0.05, showing no significant difference. But only group CXL-B had improvement in UDVA and CDVA for all the patients.·CONCLUSION: With safety and good visual outcomes,ICRs implantation is a viable alternative for *** significant difference was found among these three groups.

关键词： keratoconus intrastromal corneal ring segment cross-linking

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Preliminary experience of helical tomotherapy for locally advanced pancreatic cancer

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World Journal of Gastroenterology 2009年第35期15卷 4444-4445页

作者： Cyrus Chargari francois Campana Philippe Beuzeboc Sofia Zefkili Youlia M Kirova Department of Radiotherapy Institut Curie75248 ParisFrance Department of Medical Oncology Institut Curie75248 ParisFrance

Radiotherapy for locally advanced pancreatic cancer is technically difficult and frequently associated with high-grade digestive *** tomotherapy(HT)is a new irradiation modality that combines megavoltage computed tomography imaging for patient positioning with intensity-modulated fan-beam *** recent availability opens new fields of exploration for pancreatic radiotherapy as a result of its ability to tailor very well-defined dose distributions around the target ***,we report the use of HT in two patients with locally advanced pancreatic cancer. Doses to the bowel,kidneys and liver were reduced significantly,which allowed for excellent treatment tolerance without any high-grade adverse effects in either patient.

关键词： Pancreatic neoplasms Helical tomotherapy Adverse effects Treatment tolerance

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New stabilization conditions for continuous fuzzy models using their discretized forms

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International Journal of Intelligent Computing and Cybernetics 2014年第4期7卷 397-414页

作者： Ellouze Ameni Mohamed Ksantini Jimmy Lauber francois Delmotte Mohamed Chtourou Department of Electrical Engineering University of SfaxSfaxTunisia University of Valenciennes and Hainaut-Cambre´sis ValenciennesFrance University of Artois Technoparc Futura BethuneFrance

Purpose–The purpose of this paper is to deal with the stabilization of the continuous-time TakagiSugeno(TS)fuzzy models by using their discretized ***/methodology/approach–In this case,a discrete model is obtained from the discretization of the continuous TS fuzzy *** gains obtained from a non-parallel distributed compensation controller ensuring the stabilization of the discrete model are used to check if the discrete control law used in the continuous time without any zero-order hold can stabilize the continuous TS ***–This method is compared to another published ***/value–Therefore,the originality of this paper consists in the fusion of the two continuous and discrete cases to obtain new stabilization conditions in the continuous *** examples show the interest of the proposed approach.

关键词： Nonlinear control Fuzzy logic LMI Continuous-time T-S fuzzy models Discrete T-S models Discretization Nonquadratic Lyapunov functions Non-PDC control laws Stabilization

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Vineyards,but not cities,are associated with lower presence of a generalist bird,the Common Blackbird(Turdus merula),in Western France

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Avian Research 2021年第1期12卷 17-27页

作者： Bertille Mohring francois Brischoux Frédéric Angelier Centre d’Etudes Biologiques de Chizé UMR 7372CNRS–La Rochelle Université79360 Villiers en BoisFrance Environmental and Marine Biology Abo Akademi University20520 TurkuFinland.

Background:Land-use change is one of the main drivers of the global erosion of *** that context,it is crucial to understand how landscape characteristics drive the presence of rare endangered ***,it is also important to study common species in multiple habitats,because they represent a large proportion of biodiversity and are essential to maintain ecological ***,some habitats,as farmlands with permanent crops(***),have been overlooked in the ***:In this study,we investigated the distribution of a widespread and common bird species,the Common Blackbird(Turdus merula),within and between the three main habitats of our study area(rural Western France).We specifically focused on(1)woodlands,(2)farmlands with a high vineyard coverage,and(3)moderately urbanized ***,we aimed to assess the beneficial and detrimental effects of these habitats and their fine-scale composition on the presence of a common bird species,relying on a survey by point counts(nearly 100 locations).We studied the effects of habitats and gradients of fine-scale habitat composition on blackbird presence using logistic regression ***:Blackbirds were present in all studied ***,their presence varied between habitats,being lower in vineyards than in woodlands and *** woodlands and cities,fine-scale analyses did not reveal any component driving the species'***,we found that shrub and tree vegetation cover had a significant positive effect on blackbird presence in ***:Our results are in agreement with the definition of a generalist ***,species distribution varied between *** high presence of blackbirds in urban areas suggests that medium-sized cities,despite their artificialization,do not constrain the settlement of this former forest specialist and that green spaces may allow blackbirds to thrive in medium-sized *** the contrar

关键词： Agriculture Biodiversity Birds Forest Turdus merula Urbanization Vineyards

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Preparation and Stability of SiO2/TiO2/Al2O3 Nanofluids Based Water/Ethylene Glycol

Preparation and Stability of SiO2/TiO2/Al2O3 Nanofluids Base...

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作者： Ninsemon Jean francois Dazihem 西南石油大学

学位级别：硕士

随着科学技术的进步,换热设备的换热强度和换热负荷急剧增加,大量数据服务器在全国范围内的普及,设备温度精确控制的需求对其传热和散热性能提出了更高的要求。在此背景下,改善换热器的工质是解决这一问题的有效途径。因此,科学家们考... 详细信息

随着科学技术的进步,换热设备的换热强度和换热负荷急剧增加,大量数据服务器在全国范围内的普及,设备温度精确控制的需求对其传热和散热性能提出了更高的要求。在此背景下,改善换热器的工质是解决这一问题的有效途径。因此,科学家们考虑利用纳米流体代替水作为热交换器的工质。纳米流体是一种革命性的传热介质,它将非金属颗粒以一定比例混合到液体中。较水而言,纳米流体在导热性上具有显著的优势。然而,纳米流体在实际运用中实现稳定是一个挑战。本研究的主要目标是提高纳米流体的稳定性。在本工作中,纳米流体的制备采用两步法,以水和乙二醇为基础液。实验研究了二氧化硅(SiO2)、二氧化钛(TiO2)和氧化铝(Al2O3)纳米流体的制备及其稳定性。考察了乙二醇体积分数、分散剂种类与浓度、纳米粒子质量分数,超声分散时间等因素的影响。通过静置沉降,粒度分析和分光光度法等方法分析纳米流体的稳定性。最后使用Haaker旋转流变仪评估温度对所制备的纳米流体粘度的影响。主要研究结果如下:在制备二氧化硅(SiO2)纳米流体时发现,聚乙烯吡络烷酮(PVP)较阿拉伯树胶(GA)更适用于SiO2-水-乙二醇基纳米流体的分散剂。对于0.2 wt%的SiO2纳米流体,当PVP质量分数为0.4 wt%;乙二醇体积分数为20%,超声时间为30 min时,为制备SiO2-水-乙二醇基纳米流体的最佳条件。在20℃～60℃加热过程中,SiO2-水-乙二醇基纳米流体的粘度最高为2.8mpa·s,最低为1.4 mpa·s。对于TiO2纳米流体,GA较PVP更为适用于TiO2-水-乙二醇基纳米流体的分散剂。对于0.08 wt%的TiO2纳米流体,当GA质量分数为0.08 wt%;乙二醇体积分数为35%,超声为60 min时,为制备TiO2-水-乙二醇基纳米流体的最佳条件。在20℃～60℃加热过程中,TiO2-水-乙二醇基纳米流体粘度最低达1.5mpa·s.对于γ-三氧化二铝(γ-Al2O3)纳米流体,乙二醇体积分数为35%时更适用于γ-A12O3-水-乙二醇基纳米流体的制备;质量分数为0.2%的阿拉伯树胶(GA)可有效提高0.1 wt%的γ-Al2O3纳米颗粒在水-乙二醇基液中的分散稳定性;超声30 min即可改善γ-A1203-水-乙二醇纳米流体的稳定性。在20℃～60℃加热过程中,Al2O3乙二醇基纳米流体粘度最低达0.97mpa·s,所制备的纳米流体可适合用于流动换热。

关键词：纳米流体制备稳定性 SiO2/TiO2/Al2O3纳米流体水/乙二醇

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High Field Environment for EPM at the LNCMI

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Journal of Iron and Steel Research International 2012年第S2期19卷 1072-1075页

作者： BEAUGNON Eric DEBRAY francois LNCMI CNRS/UJF/INSA UPS

The Laboratoire National des Champs Magn(?)tiques Intenses(LNCMI) is the CNRS French National High Magnetic Field Facility associated with three universities:Joseph Fourier in Grenoble,Paul Sabatier and INSA in *** delivers to researchers direct current high magnetic field up to 35 teslas in 34 mm in Grenoble and pulsed field up to 80 T in *** of new high field magnets and associated instrumentations are user oriented. These developments(highly homogeneous magnets,magnets for diffraction studies,high field gradient magnet...) are impulsed by different user *** a few years,magneto-science is attracting new users for the study of high field effects on physical,chemical and biological processes such as electrochemistry,metallurgy,nanostructuration, implying new methodologies and new experimental developments such as high temperature environment up to 1600 K.A survey of these developments is *** laboratory is supported by the European Commission which contributes for the 'Transnational Access' to the facility.

关键词： high magnetic fields instrumentation levitation

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Lifting the veil on the keratinocyte contribution to cutaneous nociception

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Protein & Cell 2020年第4期11卷 239-250页

作者： Matthieu Talagas Nicolas Lebonvallet francois Berthod Laurent Misery Univ Brest LIEN29200 BrestFrance Laboratoire d'Organogenese Experimentale(LOEX) University of LavalQuebecCanada Department of Dermatology Brest University HospitalBrestFrance Univ Brest BSAM(Institut Brestois de Sante Agro matiere)29200 BrestFrance

Cutaneous nociception is essential to prevent individuals from sustaining *** to the conventional point of view,the responses to noxious stimuli are thought to be exclusively initiated by sensory neurons,whose activity would be at most modulated by *** recent studies have demonstrated that epidermal keratinocytes can also act as primary nociceptive transducers as a supplement to sensory *** enlighten our understanding of cutaneous nociception,this review highlights recent and relevant findings on the cellular and molecular elements that underlie the contribution of epidermal keratinocytes as nociceptive modulators and noxious sensors,both under healthy and pathological conditions.

关键词： keratinocyte nociception skin TRP pain inflammation

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VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues

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World Journal of Gastroenterology 2006年第5期12卷 830-831页

作者： Muriel Mathonnet Bernard Descottes Denis Valleix francois Labrousse Yves Denizot Service de Chimrgie DigestiveEndocrinienne et GénéraleCHU DupuytrenLimogesFrance Service de Chirurgie Viscérale et TransplantationCHU DupuytrenLimogesFrance Service d'Anatomo-Pathologie CHU DupuytrenLimogesFrance UMR CNRS 6101Faculté de MédecineLimogesFrance

We read with a great interest the recent work of Deli and colleagues. in the World Journal of Gastroenterology reporting vascular endothelial growth factor （VEGF） expression in hepatocellular carcinoma （HCC） and cirrhotic liver tissues. This well-documented work shows that VEGF was significantly higher in surrounding cirrhotic liver tissues than in HCC. Authors assessed VEGF expression using immunohistochemistry. The immunohistochemical staining is an efficient tool to assess the percentage of cells stained positively for VEGF but is not really efficient to estimate their true VEGF content. Evaluation of the VEGF protein by an enzyme-linked immunosorbent assay 0ELISA） has been reported, by us and others, to be an efficient tool in order to assess tissue VEGF expression. We have, thus, tested whether the ELISA method might be an efficient tool in order to confirm data reporting higher amounts of VEGF in surrounding cirrhotic liver tissues than in HCC. Deli and colleagues. also correctly pointed out that basic fibroblast growth factor （bFGF） has been reported to act cooperatively on VEGF expression. We have, thus, also assessed bFGF tissue levels in order to search for a putative link between VEGF and bFGF levels in cirrhotic tissues.

关键词： Vascular endothelial growth factor Hepatocellular carcinoma, Cirrhotic liver tissues

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Impact of time to diagnosis on the occurrence of cardiogenic shock in MIS‑C post‑COVID-19 infection

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World Journal of Pediatrics 2023年第6期19卷 595-604页

作者： Said Bichali Mathilde Bonnet Marie‑Emilie Lampin Jean‑Benoit Baudelet Heloise Reumaux Olivia Domanski Thameur Rakza Alexandre Delarue Morgan Recher Jerome Soquet francois Dubos Stephane Leteurtre Ali Houeijeh francois Godart Pediatric Cardiology Univ.LilleCHU Lille2 Avenue Oscar Lambret59000 LilleFrance Pediatric Intensive Care Univ.LilleCHU Lille59000 LilleFrance ULR 2694‑Metrics:Evaluation des Technologies de Sante et des Pratiques Medicales Univ.Lille59000 LilleFrance Pediatric Rhumatology Univ.LilleCHU Lille59000 LilleFrance Cardiac Surgery Univ.LilleCHU Lille59000 LilleFrance Pediatric Emergency Univ.LilleCHU Lille59000 LilleFrance

Background In multisystem inflammatory syndrome in children(MIS-C),diagnostic delay could be associated with *** study aims to measure the time to diagnosis in MIS-C,assess its impact on the occurrence of cardiogenic shock,and specify its *** A single-center prospective cohort observational study was conducted between May 2020 and July 2022 at a tertiary care *** meeting the World Health Organization MIS-C criteria were included.A long time to diagnosis was defined as six days or *** on time to diagnosis were collected by two independent *** primary outcome was the occurrence of cardiogenic *** regression and receiver operating characteristic curve analysis were used for outcomes,and a Cox proportional hazards model was used for *** Totally 60 children were assessed for inclusion,and 31 were finally analyzed[52%males,median age 8.8(5.7-10.7)years].The median time to diagnosis was 5.3(4.2-6.2)*** univariable analysis,age above the median,time to diagnosis,high C-reactive protein,and high N-terminal pro-B-type natriuretic peptide(NT-proBNP)were associated with cardiogenic shock[odds ratio(OR)6.13(1.02-36.9),2.79(1.15-6.74),2.08(1.05-4.12),and 1.70(1.04-2.78),respectively].In multivariable analysis,time to diagnosis≥6 days was associated with cardiogenic shock[adjusted OR(aOR)21.2(1.98-227)].Time to diagnosis≥6 days had a sensitivity of 89% and a specificity of 77% in predicting cardiogenic shock;the addition of age>8 years and NT-proBNP at diagnosis≥11,254 ng/L increased the specificity to 91%.Independent determinants of short time to diagnosis were age<8.8 years[aHR 0.34(0.13-0.88)],short distance to tertiary care hospital[aHR 0.27(0.08-0.92)],and the late period of the COVID-19 pandemic[aHR 2.48(1.05-5.85)].Conclusions Time to diagnosis≥6 days was independently associated with cardiogenic shock in *** diagnosis and treatment are crucial to avoid the use of inotropes and

关键词： COVID-19 Delay in diagnosis Heart failure MIS-C SARS-CoV-2

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Lamb波压差式微流量传感器

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光学精密工程 2009年第5期17卷 1033-1038页

作者：贾宏光光玲玲 MANCEAU Jean-francois BASTIEN francois 刘波中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院研究生院北京100039 法国科学院FEMTO-ST研究所MN2S实验室法国贝桑松25044

为提高微流体系统中的流量检测灵敏度,增大动态检测范围,实现温度补偿,提出了一种基于Lamb波的压差式微流量传感系统。该传感系统主要由两个Lamb波压力传感器和微通道组成,它利用Lamb波薄膜内应力的敏感特性,以频率计量的方式间接测量... 详细信息

为提高微流体系统中的流量检测灵敏度,增大动态检测范围,实现温度补偿,提出了一种基于Lamb波的压差式微流量传感系统。该传感系统主要由两个Lamb波压力传感器和微通道组成,它利用Lamb波薄膜内应力的敏感特性,以频率计量的方式间接测量微通道两端的压力差;并采用双Lamb波压力传感器构成差动式测量结构进行温度补偿。对长20 mm,宽1 mm,高50μm的微通道进行了流量测试实验,结果表明:在流量测试范围内,微通道两端的频率差与流量基本呈线性变化,其线性相关系数为0.999 9;在微流量传感器未进行优化的前提下,最小检测量为0.627μL/s。

关键词：微流体系统微流量传感器 Lamb波

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