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Mortality and Associated Risk Factors among In-Patients with Covid-19 in Douala, Cameroon: A Retrospective Cross-Sectional Study

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Advances in Infectious Diseases 2022年第1期12卷 1-19页

作者： francois adrien bokalli Fru McWright Chi Ephesians Anutebeh Caven Ngoe Mbachan Takere Edwin Ewane Dieudonne Akanji Conrald Ekukole Marie-Solange Ndom Mireille-Laurent Endale David Mekolo Henry Luma Jacqueline Ze Minkande Marcelin Ngowe Ngowe Specialised COVID-19 Treatment Centre Yassa Douala Cameroon Department of Medicine Faculty of Health Sciences University of Buea Buea Cameroon Department of Medicine Laquintinie Hospital Douala Cameroon Intensive Care and Emergency Department Laquintinie Hospital Douala Cameroon Department of Internal Medicine Douala General Hospital Douala Cameroon Department of Surgery and Specialties Faculty of Medicine and Biomedical Sciences University of Yaounde Yaounde Cameroon Department of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon

Background: In March 2020, the World Health Organization declared the coronavirus disease 2019 a pandemic, this was caused by the Severe Acute Respiratory Syndrome Coronavirus 2. The overall mortality from this remains high, yet there are limited studies assessing the associated factors in Africa. Objective: To identify the factors associated with mortality in hospitalized COVID-19 patients in Douala, Cameroon. Method: We conducted a single-centre retrospective cross-sectional study by reviewing records of patients managed for COVID-19 between March and June 2020. Diagnosis was confirmed by real-time RT-PCR. Outcome of interest was mortality during hospitalization. We inputted and analyzed data using SPSS version 25.0, compared mortality between groups using the Chi’s squared test and the Fisher’s exact test where appropriately investigated for associations using the Logistic regression in a stepwise approach and alpha-value set at P = 0.05. Results: We analyzed 282 case files, 68% were males (M:F = 2:1) and a mean age of 52 (±15) years. We had an overall mortality of 31.5% (89/282 patients) and 54% (50/92 patients) admitted in the ICU died. Patients aged 0 - 39 years had a significantly lesser odds of mortality compared to those > 70 years (OR: 0.2 (0.1 - 0.5) P Conclusion: The in-hospital mortality in COVID-19 patients is very high and hospitalisation into the ICU is associated with even higher mortality. Advanced age, diffused lung involvement (particularly with alveolar consolidation), hemodynamic instability at presentation and altered level of consciousness favoured hospitalisation in the ICU. Once in the ICU, placement on mechanical ventilation did not reduce death discernibly.

关键词： COVID-19 Risk Factors Mortality Cameroon

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Helicobacter Pylori Infections in Peptic Ulcer Perforations: A Retrospective Analysis in Two Referral Hospitals in Douala, Cameroon

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Surgical Science 2020年第10期11卷 298-311页

作者： francois adrien Morel bokalli Chi Fru McWright Jerry Brown Njoh Aseneh Takere Maseoli Mbachan Ngomba Divine Mokake Jules Clément Assob Nguedia Marcelin Ngowe Ngowe Department of Medicine Faculty of Health Sciences University of Buea Buea Cameroon Laquintinie Hospital Douala Cameroon Department of Surgery Faculty of Health Sciences University of Buea Buea Cameroon Department of Biomedical Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Surgery Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon

Background: Perforations are major complications of peptic ulcer disease and surgical emergencies with important mortality and morbidity. Helicobacter pylori (H. pylori) has been identified as one of the commonest factors associated with peptic ulcer disease. However, little is known about its implication in cases of perforations in Cameroon. We aimed to determine the frequency of Helicobacter pylori infections in cases of perforated peptic ulcers, describe clinical features and outcomes of these cases in Cameroon. Method: A hospital-based retrospective cross-sectional study was conducted through the review of patients’ records admitted for peptic ulcer perforations in Laquintinie and Douala General Hospitals over a period of 5 years (January 2014 - December 2018). We defined H. pylori infection as;positive result on tissue biopsy at time of surgery. We used SPSS version 23.0 to analyse data and set an alpha value at P = 0.05. Results: We reviewed 115 cases of peptic ulcer perforation, with a mean age of 40 years and sex ratio (M:F) of 5:1. All patients underwent emergency laparotomy, 48 (41%) cases had a biopsy report and the prevalence of H. pylori infection in these cases was 47.9 %. Smoking, alcohol consumption and Non-Steroidal Anti-inflammatory Drugs (NSAIDs) use, were not associated with peptic ulcer perforation. The morbidity was at 43.7% and mortality at 14%. Mortality was increasing with a higher Mannheim Peritonitis Index score (OR: 23.51, 95% CI: 4.197 - 143.003, P-value: 0.000). Conclusion: We observed a high prevalence of H. pylori infection in patients with peptic ulcer perforations. We recommend systematic H. pylori screening in cases of perforations and that larger studies should be carried out to evaluate the association of H. pylori infection with peptic ulcer perforation in Sub-Saharan Africa.

关键词： Perforated Peptic Ulcers Helicobacter pylori Infections Clinical Features Outcome

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Capturing Auxin Response Factors Syntax Using DNA Binding Models

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Molecular Plant 2019年第6期12卷 822-832页

作者： Amaud Stigliani Raquel Martin-Arevalillo Jeremy Lucas adrien Bessy Thomas Vinos-Poyo Victoria Mironova Teva Vernoux Renaud Dumas francois Parcy Univ. Grenoble Alpes CNRS CEA INRA BIG-LPCV 38000 Grenoble France Laboratoire de Reproduction et Developpement des Plantes Univ. Lyon ENS de Lyon UCB Lyonl CNRS INRA 46 allee dMtalie 69364 Lyon France Novosibirsk State University Pirogova Street 2 Novosibirsk Russia Institute of Cytology and Genetics SB RAS Lavrentyeva Avenue 10 Novosibirsk Russia

Auxin is a key hormone performing a wealth of functions throughout the life cycle of plants. It acts largely by regulating genes at the transcriptional level through a family of transcription factors called auxin response factors (ARFs). Even though all ARF monomers analyzed so far bind a similar DNA sequence, there is evidence that ARFs differ in their target genomic regions and regulated genes. Here, we report the use of position weight matrices (PWMs) to model ARF DNA binding specificity based on published DNA affinity purification sequencing (DAP-seq) data. We found that the genome binding of two ARFs (ARF2 and ARF5/ Monopteros [MP]) differ largely because these two factors have different preferred ARF binding site (ARFbs) arrangements (orientation and spacing). We illustrated why PWMs are more versatile to reliably identify ARFbs than the widely used consensus sequences and demonstrated their power with biochemical experiments in the identification of the regulatory regions o1IAA19, an well-characterized auxin-responsive gene. Finally, we combined gene regulation by auxin with ARF-bound regions and identified specific ARFbs configurations that are over-represented in auxin-upregulated genes, thus deciphering the ARFbs syntax functional for regulation. Our study provides a general method to exploit the potential of genome-wide DNA binding assays and to decode gene regulation.

关键词： Auxin Auxin Response Factor DAP-seq DNA binding model

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Inhibition of elastin and collagen networks degradation in human skin by gingival fibroblast. In vitro, ex vivo and in vivo studies.

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Journal of Cosmetics, Dermatological Sciences and Applications 2011年第1期1卷 4-14页

作者： Bruno Gogly francois Come Ferré Hafida Cherifi adrien Naveau Benjamin Philippe Fournier 不详

Skin aging shows an imbalance between synthesis and degradation of the extracellular matrix. The overproduction of degradative enzymes (MMPs) during the chronology- and photo-induced aging leads to a degradation of the elastic and collagen networks. In a model of collagen and elastin destruction, we showed that the gingival fibroblast was able to preserve these macromolecules by inhibiting the overproduction of metalloproteinases by overproduction of TIMP-1 and modulation of the inflammatory cytokines activity. The objective of this study is to evaluate the effect of the gingival fibroblasts on human skin. The results in vitro and ex vivo show that the gingival fibroblast protects the skin collagen and elastic network by the inhibition of MMPs which leads to an overproduction of the TIMP-1. Moreover, the gingival fibroblast modulates the activity of some enzymes responsible for the inflammation;they inhibit the IL-1β and stimulate the production of TGF-β1. In vivo studies with a duration of six months and 50 women with pronounced wrinkles show that the culture supernatant of gingival fibroblasts diluted to 5% leads to a statistically significant decrease in the number and length of wrinkles.

关键词： elastin collagen skin Matrix Metalloproteinases gingival fibroblast

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Towards thin film complete characterization using picosecond ultrasonics

Towards thin film complete characterization using picosecond...

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2008 IEEE International Ultrasonics Symposium

作者： Pierre-adrien Mante Amaud Devos Jean-francois Robillard IEMN-CNRS

＜正＞Background,Motivation and Objective Mechanical characterization of thin films is a main issue in the microelectronic *** knowledge of these properties is necessary in many fields such as copper line interconnect...

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双组分信号转导系统SrrAB对表皮葡萄球菌生长和生物膜形成的调控作用

双组分信号转导系统SrrAB对表皮葡萄球菌生长和生物膜形成的调控...

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中华医学会2014全国微生物学与免疫学学术年会

作者：吴旸武有聪朱涛韩海燕刘华勇许涛 Patrice francois adrien Fischer Friedrich Gotz 白丽瞿涤复旦大学上海医学院基础医学院医学分子病毒学教育部/卫计委重点实验室大理学院瑞士日内瓦大学医院德国图宾根大学微生物遗传学系

目的表皮葡萄球菌是人体正常菌群,其致病性与在医疗植入材料表面形成生物膜的能力密切相关。双组分信号转导系统SrrAB调控着金黄色葡萄球菌在有氧及厌氧条件下的生长代谢与毒力,然而在表皮葡萄球菌生长以及生物膜的形成中发挥何种调控...

目的表皮葡萄球菌是人体正常菌群,其致病性与在医疗植入材料表面形成生物膜的能力密切相关。双组分信号转导系统SrrAB调控着金黄色葡萄球菌在有氧及厌氧条件下的生长代谢与毒力,然而在表皮葡萄球菌生长以及生物膜的形成中发挥何种调控作用仍不清楚,因此本研究予以探讨。方法通过基因敲除技术构建了表皮葡萄球菌1457株的srrA基因敲除突变株,对其在有氧、低氧条件下的生长曲线、细胞间多糖黏附素PIA以及生物膜形成能力等表型进行了检测;并通过基因芯片

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Lipid Profile and Antioxidant Activity of Macadamia Nuts (<i>Macadamia integrifolia</i>) Cultivated in Venezuela

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Natural Science 2015年第12期7卷 535-547页

作者： Alejandra Rengel Elevina Pérez George Piombo Julien Ricci adrien Servent María Soledad Tapia Olivier Gibert Didier Montet Instituto de Ciencia y Tecnología de Alimentos Facultad de Ciencias Universidad Central de Venezuela Caracas Venezuela Cirad UMR Iate Campus de la Gaillarde 2 place Pierre Viala Montpellier France Cirad UMR 95 Qualisud TA B-95/16 73 rue Jean-Francois Breton Montpellier France

Macadamia nuts (Macadamia integrifolia) grown in Venezuela have showed an average total fat content of 70%. Oleic acid (18:1) was the main monounsaturated fatty acid (MUFA) (51.3%), followed by palmitoleic acid (16:1, 22.6%). The content of polyunsaturated fatty acids (PUFAs), C18:2 and C18:3 represented 5.4%. Thus, MUFAs and PUFAs together constituted more than 80% of the total fatty acids present. Trans-vaccenic acid was also present (3%). As regards to other phytochemical compounds, tocopherols and tocotrienols were not found in the sample, but the presence of squalene was *** antioxidant activity (44.2%) of the extract was produced by the phytochemicals present.

关键词： Lipids Antioxidant Activity Fatty Acids Macadamia Nut Phytochemical Compounds

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Usefulness of a Clinico-Biological francois’Score in the Diagnosis of Acute Appendicitis:Experience of the University Hospital Center of Parakou,Benin

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Surgical Science 2018年第3期9卷 91-96页

作者： Montcho adrien Hodonou Bio Tamou-Sambo Salako Alexandre Allode Roméo Romaric Gbédolo Djifid Morel Séto Selome Romaric Tobome Moise Francis Dossou Dodji Emile Mensah Department of Surgery and Specialties Teaching HospitalMedicine SchoolUniversity of ParakouParakouBenin Saint John of God Hospital Center of Tanguieta TanguietaBenin Teaching Hospital of Porto-Novo Faculty of Health ScienceUniversity of Abomey CalaviCotonouBenin

Introduction: Diagnostic wanderings of acute appendicitis are responsible for serious complications or abusive appendectomies. Existing Clinico-biological scores are efficient. Objective: To determine the diagnostic efficiency of Fran?ois’ score in acute appendicitis. Methodology: over 10 months, all the patients admitted in the CHUD-Parakou Emergency Department for pain in the right iliac fossa had been examined by resident students who calculated Fran?ois’ score. After verification by the surgeon, patients were put into three categories: category 1 score ≥ 2;category 2, score between -6 and 2;category 3, score below -6. Sensitivity and specificity were calculated. Results: out of 54 patients selected (29 men and 25 women), 29 were classified as group 1;19 as group 2 and 6 as group 3. An ultrasound was performed in all patients in group 2, and signs in favor of appendicitis were found in 12 patients. Of the 41 appendicectomies performed, the histologic analysis of 33 operative specimens found a pathological appendix. Sensitivity, specificity and negative predictive value per group were 100%. It has prevented almost in one every four patients (24.07%) an abusive appendectomy. Conclusion: This score would reduce diagnostic wanderings and target patient groups for imaging studies.

关键词： Acute Appendicitis francois Score Sensitivity Specificity Resource-Limited Countries

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生活倒映

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现代装饰（家居） 2014年第7期 86-93页

作者： francois Champsaur 范嘉苑法国Agence francois Champsaur

法国室内设计师francois Champsaur近来完成了位于法国马赛La Joliette地区一套150平米公寓的翻新和改造。这是一套顶楼公寓,它所在的大楼近日已由adrien Champsaur建筑公司重新整修（这幢建筑的前身是一个旧仓库,而如今已改造成一座公... 详细信息

法国室内设计师francois Champsaur近来完成了位于法国马赛La Joliette地区一套150平米公寓的翻新和改造。这是一套顶楼公寓,它所在的大楼近日已由adrien Champsaur建筑公司重新整修（这幢建筑的前身是一个旧仓库,而如今已改造成一座公寓楼）。这套公寓包含了一间客厅、两间带浴室的套房、一间餐厅、一间厨房以及一个露台。

关键词：生活建筑公司室内设计师公寓楼法国改造大楼仓库

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