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Treatment-Plan Comparison of Three Advanced Radiation Treatment Modalities for Fractionated Stereotactic Radiotherapy to the Head and Neck

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2019年第2期8卷 106-120页

作者： He Wang James N. Yang Xiaodong Zhang Jing Li Steven J. Frank Zhongxiang Zhao dershan Luo Xiaorong Zhu Congjun Wang Samuel Tung Adam S. Garden David I. Rosenthal Clifton David Fuller Gary Brandon Gunn Amol J. Ghia Jay P. Reddy Shaan M. Raza franco de monte Mark S. Chambers Paul D. Brown Shirley Su Jack Phan department of Radiation Physics The University of Texas MD Anderson Cancer Center Houston TX USA department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA department of Neurosurgery The University of Texas MD Anderson Cancer Center Houston TX USA department of Oncologic dentistry Prosthodontics Thoracic/Head &Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX USA department of Radiation Oncology The Mayo Clinic Rochester MN USA

Purpose: Fractionated stereotactic radiosurgery (FSRS) can be given with at least three modalities: Gamma Knife, with the noninvasive frameless extend system (GKE);linear accelerator-based volumetric modulated arc therapy (VMAT);and intensity-modulated proton therapy (IMPT). We extracted treatment plans for patients who had received FSRS with GKE for recurrent skull base or intracranial tumors, created corresponding plans for VMAT and IMPT, and compared the quality of the three sets of plans. Methods and materials: Plans were extracted for 9 patients with recurrent malignant skull-base tumors (n = 6) or large intracranial tumors (n = 3) who had received FSRS with GKE (median dose 24 Gy in 3 fractions) in 2013 through 2015. Plans for VMAT were generated with a TrueBeam STx LINAC machine using 6-MV photons, and plans for IMPT were generated with multi-field optimization. The optimized VMAT and IMPT plans were normalized to achieve the best possible target coverage while meeting the same dose-volume constraints on organs at risk (OARs) as the GKE plans. Plans were evaluated on the basis of target coverage, conformity index, homogeneity index, gradient index, and treatment efficiency. Results: The median target volume was 10.2 cm3 (range 1.9 - 33.8 cm3). The VMAT and IMPT plans met all OAR constraints, and target coverage and conformity were comparable among all plans. VMAT and IMPT plans showed significantly better target uniformity and treatment delivery efficiency (P P Conclusion: FSRS for skull base and large intracranial lesions delivered by VMAT and IMPT can achieve comparable target coverage, conformity, and sparing of critical structure as the GKE while providing superior target uniformity and treatment delivery efficiency. The GKE had superior high-dose gradients outside the target and thus better protected surrounding normal structures.

关键词： Gamma Knife Extend System Stereotactic Radiosurgery Volumetric Modulated Arc Therapy Intensity-Modulated Proton Therapy Spot Scanning Proton Therapy

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A Single JAZ Repressor Controls the Jasmonate Pathway in Marchantia polymorpha

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Molecular Plant 2019年第2期12卷 185-198页

作者： Isabel monte Jose M. franco-Zorrilla Gloria Garcia-Casado Angel M. Zamarreno Jose M. Garcia-Mina Ryuichi Nishihama Takayuki Kohchi Roberto Solano department of Plant Molecular Genetics Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientificas (CNB-CSIC) 28049 Madrid Spain Genomics Unit Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientificas (CNB-CSIC) 28049 Madrid Spain Environmental Biology department University of Navarra Navarre Spain Graduate School of Biostudies Kyoto University Kyoto 606-8502 Japan

JAZ proteins are negative regulators of jasm onate responses,acting both as repressors of transcription factors and as co-receptors of JA-lle. The high redundancy of JAZ genes in angiosperms has hindered the characterization of a complete depletion of JAZ function. Moreover, the recent discovery that dn- OPDA is the jasmonate ligand in Marchantia polymorpha demonstrates that JA-lle is not the sole COI1/ JAZ ligand in land plants and highlights the importance of studying JAZ co-receptors in bryophytes? Here, we have exploited the low gene redundancy of the liverwort M. polymorpha to characterize the single MpJ4Z in this early diverging plant lineage. We clarify the phylogenetic history of the TIFY family, demonstrate that MpJAZ is the ortholog of AtJAZ with a conserved function, and characterize its repressor activity of dn-OPDA resp on ses. Our results show that, con sistent with previous findings in Arabidopsis, MpJAZ represses jasmonates biosynthesis, senescence, and plant defenses, and promotes cell growth and reproductive fitness, highlighting the power of studies in Marchantia.

关键词： Jasmonate repressors Marchantia Hormone signaling evolution gene redundancy

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Exploring DFT+U parameter space with a Bayesian calibration assisted by Markov chain monte Carlo sampling

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npj Computational Materials 2021年第1期7卷 1661-1669页

作者： Pedram Tavadze Reese Boucher Guillermo Avendaño-franco Keenan X.Kocan Sobhit Singh Viviana Dovale-Farelo Wilfredo Ibarra-Hernández Matthew B.Johnson David S.Mebane Aldo H.Romero department of Physics and Astronomy West Virginia UniversityMorgantownWVUSA department of Mechanical and Aerospace Engineering West Virginia UniversityMorgantownWVUSA department of Physics and Astronomy Rutgers UniversityPiscatawayNJUSA Facultad de Ingeniería Benemérita Universidad Autónoma de PueblaApdo.Postal J-39PueblaPue.72570México

The density-functional theory is widely used to predict the physical properties of ***,it usually fails for strongly correlated materials.A popular solution is to use the Hubbard correction to treat strongly correlated electronic ***,the values of the Hubbard U and J parameters are initially unknown,and they can vary from one material to *** this semi-empirical study,we explore the U and J parameter space of a group of iron-based compounds to simultaneously improve the prediction of physical properties(volume,magnetic moment,and bandgap).We used a Bayesian calibration assisted by Markov chain monte Carlo sampling for three different exchange-correlation functionals(LDA,PBE,and PBEsol).We found that LDA requires the largest U *** has the smallest standard deviation and its U and J parameters are the most transferable to other iron-based ***,PBE predicts lattice parameters reasonably well without the Hubbard correction.

关键词： materials Hubbard parameter

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An improved evaluation of the neutron background in the PandaX-Ⅱ experiment

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Science China(Physics,Mechanics & Astronomy) 2020年第3期63卷 54-63页

作者： QiuHong Wang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui YingJie Fan deQing Fang ChangBo Fu LiSheng Geng Karl Giboni franco Giuliani LinHui Gu XuYuan Guo Ke Han ChangDa He Di Huang Yan Huang YanLin Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju YiHui Lai Kun Liang HuaXuan Liu JiangLai Liu WenBo Ma YuGang Ma YaJun Mao Yue Meng Parinya Namwongsa KaiXiang Ni JinHua Ning XuYang Ning XiangXiang Ren ChangSong Shang Lin Si AnDi Tan AnQing Wang HongWei Wang Meng Wang SiGuang Wang XiuLi Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu Jumin Yuan Dan Zhang HongGuang Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China INPAC and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai Laboratory for Particle Physics and CosmologyShanghai 200240China Yalong River Hydropower development Company Ltd.Chengdu 610051China School of Physics Nankai UniversityTianjin 300071China School of Physics&International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Tsung-Dao Lee Institute Shanghai 200240China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physics Peking UniversityBeijing 100871China department of Physics University of MarylandCollege ParkMaryland 20742USA School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityJinan 250100China Center of High Energy Physics Peking UniversityBeijing 100871China University of Chinese Academy of Sciences Beijing 100049China

In dark matter direct detection experiments,neutron is a serious source of background,which can mimic the dark matter-nucleus scattering *** this paper,we present an improved evaluation of the neutron background in the PandaX-II dark matter experiment by a novel *** of fully relying on the monte Carlo simulation,the overall neutron background is determined from the neutron-induced high energy signals in the *** addition,the probability of producing a dark-matter-like background per neutron is evaluated with a complete monte Carlo generator,where the correlated emission of neutron(s)andγ(s)in the(α,n)reactions and spontaneous fissions is taken into *** this method,the neutron backgrounds in the Run 9(26-ton-day)and Run 10(28-ton-day)data sets of PandaX-II are estimated to be(0.66±0.24)and(0.47±0.25)events,respectively.

关键词： dark matter direct detection xenon neutron background high energy gamma neutron generator

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