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Hematological parameters of a neotropical wild frog population,with a phylogenetic perspective on blood cell composition in Anura

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Current Zoology 2022年第3期68卷 361-369页

作者： Lilian franco-BELUSSI Diogo B.PROVETE Taynara R.F.LEÃO Mayara S.SIQUEIRA Bruno S.L.VALVERDE Brenda O.MARTInS Classius DE OLIVEIRA Carlos Eurico FERnAnDES Instituto de Biociências Universidade Federal de Mato Grosso do SulCampo GrandeMato Grosso do Sul 79002970Brazil Gothenburg Global Biodiversity Centre GöteborgBox 100S 40530Sweden Graduate Program in Biodiversity.Instituto de Biociências Letras e Ciências ExatasUniversidade Estadual PaulistaSão Josédo Rio PretoSão PauloBrazil Graduate Program in Animal Biology.Instituto de Biociências Universidade Federal de Mato Grosso do SulCampo GrandeMato Grosso do SulBrazil Departamento de Biologia.Instituto de Biociências Letras e Ciências ExatasSão Josédo Rio PretoUniversidade Estadual PaulistaBrazil

Hematological parameters can provide key information to an animal health ***,this information is usually hard to ***,we described the hematological parameters of Leptodactylus podicipinus in the Brazilian *** measured red blood cell morphometrics,erythrogram,and *** also tested for phylogenetic signal in the erythrogram and leukogram of 48 frog species from 15 families,testing if body size explains their *** were the most abundant leukocytes(>60%)in ***,followed by neutrophils(∼10%).Given that *** is an abundant and widely distributed species in central Brazil,knowing its hematological pattern can help establish a baseline and improve its use as a bioindicator of environmental *** corpuscular hemoglobin and value contributed more to the phylomorphospace of erythrogram,in which Leptodactylus *** Hypsiboas raniceps had lower values of these variables,whereas Bufotes viridis and Hyla arborea had high *** phylogenetic signal was spread throughout the dimensions of the leukogram *** variables that most contributed to it were total leukocytes counts,lymphocytes,and *** also found a moderate phylogenetic signal for both the erythrogram and ***,body size accounted for a low proportion of variation in both the leukogram(4.7%)and erythrogram(0.57%).By applying phylogenetic comparative methods to hematological parameters,our results add a new perspective on the evolution of blood cell physiology in frogs.

关键词： erythrogram leukogram conservation physiology macroevolution population monitoring programs

TheI550Vpolymorphism in the renal human sodium/dicarboxylate cotransporter 1 (hnaDC-1) gene is associated with the risk for urolithiasis in adults from Southeastern, Mexico

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Open Journal of Genetics 2013年第2期3卷 59-66页

作者： Martha Medina-Escobedo Diana franco-Bocanegra Salha Villanueva-Jorge Lizbeth González-Herrera Departamento de Investigación en Enfermedades Renales Hospital General O’Horán Secretaria de Salud de Yucatán Mérida México Laboratorio de Genética Centro de Investigaciones Regionales Universidad Autónoma de Yucatán Mérida México

Urolithiasis (UL) is an endemic disease in Southeastern, Mexico. In order to evaluate the association of I550V polymorphism in the hnaDC-1 gene with risk for hypocitraturia and/or for UL;139 adults with UL and 132 adults without UL, were included under a case-control association study. Citrate levels in 24-h urine were quantified (citraturia). The polymorphism I550V-hnaDC-1 was determined by PCR-RFLP. Statistical analysis was performed using the STATA10.2 software. Comparison of genotype and allele frequencies between subjects with and without UL showed significant differences for genotype bb (OR = 2.34, CI: 1.19-4.59, p = 0.01) and for allele b (OR = 1.62, CI: 1.15-2.28, p = 0.005), suggesting an association with the risk for UL. Comparison of genotype and allele frequencies between subjects with hypocitraturia and subjects with normocitraturia, did not show any significant difference (p > 0.05), suggesting that this polymorphism is not associated with the risk of hypocitraturia. Interestingly, the risk for UL was increased due to an additive effect of hypocitraturia with the genotype bb (OR = 6.6, CI: 2.38-18.28, p = 0.0002) or with the allele b (OR: 4.2, CI = 2.52-6.97,

关键词： Hypocitraturia hnaDC-1 Urolithiasis Mexico Yucatan

Seasonal Variability in the Distribution of Phytoplankton in Paracas Bay/Peru, as a Response to Environmental Conditions

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Journal of Environmental Science and Engineering(B) 2019年第1期8卷 7-16页

作者： Sonia Sánchez nelly Jacobo Avy Bernales Augusto franco Jorge Quispe Georgina Flores Laboratory of Phytoplankton and Primary Production Instituto del Mar del Peru Chucuito Callao 07001 Peru Functional Area of Research in Physical Oceanography Instituto del Mar del Peru Chucuito Callao 07001 Peru Functional Area of Research in Chemical Oceanography Instituto del Mar del Peru Chucuito Callao 07001 Peru

During 2013-2015, a series of bio-oceanographic surveys was carried out in Paracas bay (13°50′ S). This coastal habitat represents a transition between open ocean and continent. Changes in distribution and structure of phytoplankton community and presence of noxious algal blooms were evaluated. The vertical stability of water column was analyzed on transects of temperature, salinity and potential density. Stratification of the water column as well as other variables presented a seasonal behavior. The maximum values were recorded in summer and were directly related to the seasonal heat flux in surface layers of the bay, while in winter this stratification index was minimum. n/P ratios showed a seasonal variation with highest values in winter and lowest ones in summer. Silicate concentrations were minimum mainly during in spring due to high biological fixation. The dominance of diatoms was evident in winter and spring, with maximum abundances of r strategists. The diversity and equitability indexes were low (nd 0.31, respectively). During summer, there was a greater contribution of oceanic species, with high concentrations of the dinoflagellate Prorocentrum cordatum;and a higher frequency of algal blooms (Akashiwo sanguinea, Heterosigma akashiwo, Eutreptiella gymnastica and Gonyaulax polygramma) in the coastal zone. Silicates and pH presented a significant correlation with diatom abundances in spring, whilst dinoflagellates were associated to warm and salinity conditions in summer. Weak correlations were found for potentially toxic dinoflagellates with temperature and for Pseudo-nitzschia group with silicates and phosphates.

关键词： HAB transition zones inshore ecosystem Paracas bay-Peru phytoplankton

健康生活方式和社会经济状况与死亡和心血管疾病发病风险的关系:基于两项前瞻性队列研究

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英国医学杂志中文版 2021年第12期24卷 695-705页

作者：张言博陈晨潘雄飞郭婧妤李艳平 Oscar H franco 刘刚潘安华中科技大学同济医学院公共卫生学院流行病与卫生统计学系武汉密歇根大学公共卫生学院流行病学系安娜堡市密歇根州美国范德堡大学医学中心纳什维尔市田纳西州美国华中科技大学同济医学院公共卫生学院卫生毒理学系武汉哈佛大学陈曾熙公共卫生学院营养学系波士顿马萨诸塞州美国伯尔尼大学社会医学和预防医学研究所伯尔尼市瑞士华中科技大学同济医学院公共卫生学院营养与食品卫生学系武汉

目的探究整体生活方式是否可以中介社会经济学地位与死亡和心血管疾病风险的关系,以及生活方式与社会经济学地位的交互作用和联合作用。研究设计来自一般人群的队列研究。参与者来自美国国家健康与营养调查(1988—1994年和1999—2014年)... 详细信息

目的探究整体生活方式是否可以中介社会经济学地位与死亡和心血管疾病风险的关系,以及生活方式与社会经济学地位的交互作用和联合作用。研究设计来自一般人群的队列研究。参与者来自美国国家健康与营养调查(1988—1994年和1999—2014年)的44462名20岁以上的成年人和来自英国生物银行研究的399537名37~73岁成年人。暴露因素基于家庭收入、职业或就业情况、受教育程度和健康保险(仅美国国家健康与营养调查),利用潜类别分析衡量参与者的社会经济学地位,根据后验概率确定低、中、高水平社会经济学地位。利用吸烟、饮酒、体力活动和膳食质量的信息构建一个健康生活方式评分。主要结局两项研究均关注了全因死亡,而英国生物银行研究还关注了心血管疾病死亡和发病。疾病结局均来自登记系统。结果美国国家健康与营养调查在平均11.2年的随访时间中记录了8906例死亡事件,英国生物银行研究在平均8.8~11.0年的随访时间中记录了22309例死亡事件和6903例心血管疾病病例。与来自高社会经济学地位的成年人相比,来自低社会经济学地位的成年人全因死亡(美国国家健康与营养调查的风险比=2.13,95%可信区间1.90~2.38;英国生物银行研究的风险比=1.96,95%可信区间1.87~2.06)、心血管疾病死亡(风险比=2.25,95%可信区间2.00~2.53)和心血管疾病发病(风险比=1.65,95%可信区间1.52~1.79)风险较高,而生活方式在上述关系中的中介比例分别为12.3%(10.7%~13.9%)、4.0%(3.5%~4.4%)、3.0%(2.5%~3.6%)和3.7%(3.1%~4.5%)。美国国家健康与营养调查中未发现生活方式与社会经济学地位间的交互作用,而在英国生物银行研究,生活方式与结局间的关系在低社会经济学地位的人群中更强。相较于同时拥有高社会经济学地位和3或4个健康生活方式因素的成年人,同时拥有低社会经济学地位和0或1个健康生活方式因素的成年人全因死亡(美国国家健康与营养调查的风险比=3.53,95%可信区间3.01~4.14;英国生物银行研究的风险比=2.65,95%可信区间2.39~2.94)、心血管疾病死亡(风险比=2.65,95%可信区间2.09~3.38)和心血管疾病发病(风险比=2.09,95%可信区间1.78~2.46)风险均更高。结论在美国和英国的成年人中,不健康的生活方式在健康不平等现象中仅起了很小的作用,故单一地促进健康生活方式可能不会大幅减少健康不平等现象,还应同时处理其他决定健康的社会因素。然而,健康生活方式与死亡和心血管疾病风险的保护关联在不同社会经济学地位的人群中稳定存在,这强调了健康生活方式在减轻疾病负担中仍具有重要作用。

关键词：心血管疾病死亡事件家庭收入可信区间健康不平等健康保险膳食质量体力活动

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共振荧光

华中师范大学学报(自然科学版) 1984年第2期 19-32页

作者： franco. Persico 意大利Palermo大学

本文提出了在强驱动场作用下的n个二能级原子系的共振荧光理论。应用了以驱动场修饰(Dress)原子的规范变换,以及修饰算符的Langevin方程,从而研究了系统的时间演化。此外还证明了在一些特定情况下,系统呈现出“准超辐射”和“超黑暗”(S... 详细信息

本文提出了在强驱动场作用下的n个二能级原子系的共振荧光理论。应用了以驱动场修饰(Dress)原子的规范变换,以及修饰算符的Langevin方程,从而研究了系统的时间演化。此外还证明了在一些特定情况下,系统呈现出“准超辐射”和“超黑暗”(Superdarkening)的行为。

关键词：共振荧光常数数学算符分子原子二能级激光场

Sentinel lymph node mapping for malignant melanoma of the external auditory canal

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World Journal of Surgical Procedures 2015年第1期5卷 173-176页

作者： Joel franco Lauren A Hansen Richard T Miyamoto Mark Tann Michael G Moore St.Louis University School of Medicine Department of Otolaryngology-Head and neck Surgery Indiana University School of Medicine Indiana University School of Medicine Department of Radiology and Imaging Services

We describe a novel technique for sentinel lymph node mapping and biopsy of a primary cutaneous malignant melanoma in the medial portion of the external auditory canal. The approach is illustrated through a case report and technical description of a procedure performed under general anesthesia on a 19-year-old female patient. Due to the hidden and sensitive location of the primary tumor in the medial external auditory canal, the lymphoscintigraphy injection had to be performed by the surgeon immediately prior to the resection of her c T2 a n0M0 lesion. Final pathology revealed clear margins at the primary site resection and 2 intraparotid sentinel lymph nodes with microscopic foci of metastatic malignant melanoma, which led to further surgical management. A completion left parotidectomy and neck dissection yielded no additional metastatic disease in the fifty-five nodes that were evaluated. Using this technique, sentinel lymph node mapping and biopsy accurately predicted the highest risk lymph nodes for the primary lesion of the medial portion of the external auditory canal.

关键词： Malignant melanoma External auditory canal Head and neck Sentinel lymph node biopsy Sentinel lymph node mapping

Estimating upper stem diameters and volume of Douglas-fir and Western hemlock trees in the Pacific northwest

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Forest Ecosystems 2018年第3期5卷 199-210页

作者： Krishna P.Poudel Hailemariam Temesgen Andrew n.Gray Department of Forest Engineering Resources and Management College of Forestry Oregon State University USDA Forest Service PNW Research Station

Background: Volume and taper equations are essential for obtaining estimates of total and merchantable stem volume. Taper functions provide advantages to merchantable volume equations because they estimate diameter inside or outside bark at specific heights on the stem, enabling the estimation of total and merchantable stem volume, volume of individual logs, and a height at a given ***: Using data collected from 1218 trees(1093 Douglas-fir(Pseudotsuga menziesii(Mirbel) franco) and 125 western hemlock(Tsuga heterophylla)), we evaluated the performance of one simple polynomial function and four variable-exponent taper functions in predicting upper stem diameter. Sample trees were collected from different parts of the states of Oregon, Washington, and California. We compared inside-bark volume estimates obtained from the selected taper equation with estimates obtained from a simple logarithmic volume equation for the data obtained in this study and the equations used by the Forest Inventory and Analysis program in the Pacific northwest(FIA-PnW) in the state of California and western half of the states of Oregon and ***: Variable exponent taper equations were generally better than the simple polynomial taper *** FIA-PnW volume equations performed fairly well but volume equations with fewer parameters fitted in this study provided comparable results. The RMSE obtained from taper-based volume estimates were also comparable with the RMSE of the FIA-PnW volume equations for Douglas-fir and western hemlock trees ***: The taper equations fitted in this study provide added benefit to the users over the FIA-PnW volume equations by enabling the users to predict diameter at any height, height to a given diameter, and merchantable volume in addition to cubic volume including top and stump(CVTS) of Douglas-fir and western hemlock trees in the Pacific northwest. The findings of this study also give more confidence to the use

关键词： Pacific northwest Biomass equations Utilization standards Diameter inside bark

Molecular Modeling of Quinoline-Based Compounds as Potential Dual Inhibitors of Reverse Transcriptase and Integrase of HIV

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Computational Molecular Bioscience 2018年第3期8卷 122-148页

作者： Alberto Cabrera Leonor Huerta Hernández Daniel Chávez José L. Medina-franco Departamento de Farmacia Facultad de Química Universidad Nacional Autónoma de México México City México Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México México City México Centro de Graduados e Investigación en Química del Instituto Tecnológico de Tijuana Tijuana México

As follow-up of our past publication?[1], we propose that quinolones (as part of the pyridinone family) are capable to increase the number of interactions with HIV reverse transcriptase (RT) or integrase (In) by adding a halogen in position C-8 of aromatic portion of the quinolones. This addition could help with the activity of dual inhibitors of RT and In. In this work, we add a chlorine atom with the rationale to identify in the docking simulations a halogen interaction with the oxygen in the near aminoacids in the binding pockets of RT and In enzymes. Our docking studies started with RT and 320 structures. Later, we took 73 structures with good results in docking with RT. The structures that we choose contain ester or acids groups in C-3 due the structural similarity with groups in charge to interact with the Mg++ ions in Elvitegravir. In conclusion, we obtained 14 structures that could occupy the allosteric pocket of RT and could inhibit the catalytic activity of In, for this reason could be dual inhibitors. A major perspective of this work is the synthesis and testing of the potential dual inhibitors designed.

关键词： Reverse Transcriptase Integrase Quinolone Dual Inhibitor Docking

Immunomodulatory oligonucleotide IMT504:Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy

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World Journal of Stem Cells 2017年第3期9卷 45-67页

作者： Jorge Zorzopulos Steven M Opal Andrés Hernando-Insúa Juan M Rodriguez Fernanda Elías Juan Fló Ricardo A López norma A Chasseing Victoria A Lux-Lantos Maria F Coronel Raul franco Alejandro D Montaner David L Horn Immunotech S.A. Ciudad de Buenos Aires C1440FFXArgentina Infectious Disease Division Memorial Hospital of Rhode Island and Alpert Medical SchoolProvidenceRI 02905United States Fundación Pablo Cassara Ciudad Autonoma de Buenos Aires C1440FFXArgentina Instituto de Biología y Medicina Experimental(IBYME-COnICET) Ciudad Autónoma de Buenos Aires C1428ADNArgentina Instituto de Ciencia y Tecnolog'DR.Cesar Milstein” Fundación Pablo CassaráCiudad Autonoma de Buenos Aires C1440FFXArgentina David Horn LLC DoylestownPA 18902United States

The immune responses of humans and animals to insults(i.e., infections, traumas, tumoral transformation and radiation) are based on an intricate network of cells and chemical messengers. Abnormally high inflammation immediately after insult or abnormally prolonged proinflammatory stimuli bringing about chronic inflammation can lead to life-threatening or severely debilitating diseases. Mesenchymal stem cell(MSC) transplant has proved to be an effective therapy in preclinical studies which evaluated a vast diversity of inflammatory conditions. MSCs lead to resolution of inflammation, preparation for regeneration and actual regeneration, and then ultimate return to normal baseline or homeostasis. However, in clinical trials of transplanted MSCs, the expectations of great medical benefit have not yet been fulfilled. As a practical alternative to MSC transplant, a synthetic drug with the capacity to boost endogenous MSC expansion and/or activation may also be effective. Regarding this, IMT504, the prototype of a major class of immunomodulatory oligonucleotides, induces in vivo expansion of MSCs, resulting in a marked improvement in preclinical models of neuropathic pain, osteoporosis, diabetes and sepsis. IMT504 is easily manufactured and has an excellent preclinical safety record. In the small number of patients studied thus far, IMT504 has been well-tolerated, even at very high dosage. Further clinical investigation is necessary to demonstrate the utility of IMT504 for resolution of inflammation and regeneration in a broad array of human diseases that would likely benefit from an immunoprotective/immunoregenerative therapy.

关键词： Immunohomeostasis Immunoprotection Immunoregeneration Inflammation Mesenchymal stem cells IMT504