检索结果-南通市图书馆

Olfactory receptors in neural regeneration in the central nervous system

neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael franco Claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Ciberned network Center for Biomedical Research in neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Magnetic mitohormesis:A non-invasive therapy for inflammatory disorders?

引用

BIOCELL 2023年第2期47卷 239-244页

作者： ALFREDO franco-OBREGÓn Department of Surgery Yong Loo Lin School of MedicineInstitute of Health Technology and InnovationiHealthtechBiolonic Currents Electromagnetic Pulsing Systems LaboratoryBICEPSHealthy Longevity Translational Research ProgrammeNUS Centre for Cancer ResearchNational University of SingaporeSingapore

An organism’s survival depends on its ability to adapt to *** are the cellular integrators of environmental stressors that ultimately translate their responses at the organismal level,and are thus central to the process whereby organisms adapt to their respective *** produce molecular energy via oxidative phosphorylation that then allows cells to biosynthetically respond and adapt to changes in their *** oxygen species(ROS)are by-products of oxidative phosphorylation that can be either beneficial or damaging,depending on the context;ROS are hence both the conveyors of environmental stress as well as cellular“adaptogens”.Mitohormesis refers to the process whereby low levels of oxidative stress spur survival adaptations,whereas excessive levels stymie *** energy and frequency pulsing electromagnetic fields have been recently shown capable of stimulating mitochondrial respiration and ROS production and instilling mitohormetic survival adaptations,similarly to,yet independently of,exercise,opening avenues for the future development of Magnetic Mitohormetic interventions for the improvement of human *** viewpoint explores the possibilities and nuances of magnetic-based therapies as a form of clinical intervention to non-invasively activate magnetic mitohormesis for the management of chronic diseases.

关键词： ROS Pulsed electromagnetic fields Mitochondria Myokines Inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The short form of the SUR1 and its functional implications in the damaged brain

引用

neural Regeneration Research 2022年第3期17卷 488-496页

作者： Iván Alquisiras-Burgos Javier franco-Pérez Moisés Rubio-Osornio Penélope Aguilera Laboratorio de Patología Vascular Cerebral Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Laboratorio de Formación Reticular Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Laboratorio Experimental de Enfermedades neurodegenerativas Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico.

Sulfonylurea receptor(SUR) belongs to the adenosine 5′-triphosphate(ATP)-binding cassette(ABC) transporter family;however,SUR is associated with ion channels and acts as a regulatory subunit determining the opening or closing of the ***8 and Abcc9 genes code for the proteins SUR1 and SUR2,*** SUR1 transcript encodes a protein of 1582 amino acids with a mass around 140–177 k Da expressed in the pancreas,brain,heart,and other *** is well known that SUR1 assembles with Kir6.2 and TRPM4 to establish K_(ATP) channels and non-selective cation channels,***8 and 9 are alternatively spliced,and the resulting transcripts encode different isoforms of SUR1 and SUR2,which have been detected by different experimental ***,the use of binding assays to sulfonylureas and Western blotting has allowed the detection of shorter forms of SUR(-65 k Da).Identity of the SUR1 variants has not been clarified,and some authors have suggested that the shorter forms are ***,immunoprecipitation assays have shown that SUR2 short forms are part of a functional channel even coexisting with the typical forms of the receptor in the *** evidence confirms that the structure of the short forms of the SURs is fully functional and does not lose the ability to interact with the *** structural changes in short forms of SUR modify its affinity to ATP,regulation of its expression might represent an advantage in pathologies where ATP concentrations decrease and a therapeutic target to induce ***,the expression of SUR1 variants might be induced by conditions associated to the decrease of energetic substrates in the brain(*** stroke and epilepsy).In this review,we want to contribute to the knowledge of SUR1 complexity by analyzing evidence that shows the existence of short SUR1 variants and its possible implications in brain function.

关键词： brain edema epilepsy Parkinson's disease stroke sulfonylurea receptor 1 SUR1 traumatic brain injury TRPM4

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Streamwise Vortex Interaction with a Horseshoe Vortex

引用

Journal of Thermal Science 2003年第4期12卷 304-309页

作者： Piotr Doerffer Pawel Flaszynski franco Magagnato IMP PAn Fiszera 14 PL-80 952 Gdansk PolandIMP PAN Fiszera 14 PL-80 952 Gdansk PolandFGS Karlsruhe University Kaiserstr.12 D-76 128 Karlsruhe Germany

How control in turbomachinery is very difficult because of the complexity of its fully 3-D flow structure. The authors propose to introduce streamwise vortices into the control of internal flows. A simple configuration of vortices was investigated in order to better understand the flow control methods by means of streamwise vortices. The research presented here concerns streamwise vortex interaction with a horseshoe vortex. The effects of such an interaction are significantly dependent on the relative location of the streamwise vortex in respect to the leading edge of the profile. The streamwise vortex is induced by an air jet. The horseshoe vortex is generated by the leading edge of a symmetric profile. Such a configuration gives possibility to investigate the interaction of these two vortices alone. The presented analysis is based on numerical simulations by means of n-S compressible solver with a two-equation turbulence model.

关键词： flow control horseshoe vortex streamwise vortex.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of oxygen partial pressure on properties of n-doped ZnO films deposited by magnetron sputtering

引用

Transactions of nonferrous Metals Society of China 2010年第12期20卷 2326-2330页

作者：王金忠 E.ElAnGOVAn n.franco A.ALVESE A.REGO R.MARTInS E.FORTUnATO School of Materials Science and Engineering Harbin Institute of Technology Material Science Department CENIMAT/I3N and CEMOP/UNINOVAFCT-UNLCampus de Caparica2829-516 CaparicaPortugal Ion Beam Laboratory Physics DepartmentInstitute of Technology and Nuclear EN.102686-953 SacavemPortugal Center of Molecular Chemistry-Physics Institute of Nanoscience and NanotechnologyComplexo InterdisciplinarIST 1049-001 LisboaPortugal

n-doped ZnO films were radio frequency(RF)sputtered on glass substrates and studied as a function of oxygen partial pressure(OPP)ranging from 3.0×10-4 to 9.5×10-3 Pa.X-ray diffraction patters confirmed the polycrystalline nature of the deposited *** crystalline structure is influenced by the variation of *** force microscopy analysis confirmed the agglomeration of the neighboring spherical grains with a sharp increase of root mean square(RMS)roughness when the OPP is increased above 1.4×10-3 Pa.X-ray photoelectron spectroscopy analysis revealed that the incorporation of n content into the film is decreased with the increase of OPP,noticeably n 1s XPS peaks are hardly identified at 9.5×10-3 *** average visible transmittance(380-700 nm) is increased with the increase of OPP(from～17%to 70%),and the optical absorption edge shifts towards the shorter *** films deposited with low OPP(≤3.0×10-4 Pa)show n-type conductivity and those deposited with high OPP(≥9.0×10-4 Pa)are highly resistive(>105Ω·cm)

关键词： ZnO oxygen partial pressure magnetron sputtering transmittance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kinetics and mechanisms of the catalytic thermal cracking of asphaltenes adsorbed on supported nanoparticles

引用

Petroleum Science 2016年第3期13卷 561-571页

作者： Tatiana Montoya Blanca L.Argel nashaat n.nassar Camilo A.franco Farid B.Cortés Department of Chemical and Petroleum Engineering University of Calgary 2500 University Drive NW CalgaryAB Canada Grupo de Investigacion Fenomenos de Superficie-Michael Polanyi Facultad de Minas Universidad Nacional de Colombia Sede Medellin Medellin Colombia Grupo de Investigacion en Yacimientos de Hidrocarburos Facultad de Minas Universidad Nacional de Colombia Sede Medellfn Kra 80 No. 65-223 Medellfn Colombia

The production of heavy and extra-heavy oil is challenging because of the rheological properties that crude oil presents due to its high asphaltene *** upgrading and recovery processes of these unconventional oils are typically water and energy intensive,which makes such processes costly and environmentally *** catalysts could be used to enhance the upgrading and recovery of heavy oil under both in situ and ex situ *** this study,the effect of the ni-Pd nanocatalysts supported on fumed silica nanoparticles on post-adsorption catalytic thermal cracking of n-C_7 asphaltenes was investigated using a thermogravimetric analyzer coupled with *** performance of catalytic thermal cracking of n-C_7asphaltenes in the presence of niO and PdO supported on fumed silica nanoparticles was better than on the fumed silica support *** a fixed amount of adsorbed n-C_7asphaltenes（0.2 mg/m～2）,bimetallic nanoparticles showed better catalytic behavior than monometallic nanoparticles,confirming their synergistic *** corrected OzawaFlynn-Wall equation（OFW） was used to estimate the effective activation energies of the catalytic *** mechanism function,kinetic parameters,and transition state thermodynamic functions for the thermal cracking process of n-C_7 asphaltenes in the presence and absence of nanoparticles are investigated.

关键词： Catalytic thermal cracking Adsorption nanoparticles SHS n-C7 asphaltene

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of successive sprays on liquid distribution in fluidized beds

引用

Particuology 2021年第1期19卷 17-24页

作者： Cedric Briens Liliana Pardo Reyes franco Berruti Jennifer McMillan Institute for Chemicals and Fuels from Alternative Resources Western University22312 Wonderland Rd.IldertonONN0M 2A0Canada Edmonton Research Centre Syncrude Canada Ltd942117th AveEdmontonABT6N 1H4 Canada

In processes such as Fluid Coking^(™),agglomerate formation should be minimized since it reduces the yield of valuable products,and degrades operability because of the fouling of *** experimental model,consisting of an aqueous solution of gum arabic with a dye,has been successfully developed to simulate the formation of agglomerates in the Fluid Coking^(™)process,where bitumen is sprayed into a fluidized bed of coke particles The particles wetted by a spray could be predicted by assuming that all the particles in the wake of bubbles formed from the tip of the spray jet have been wetted by the injected *** transfer of liquid from particles wetted with the spray to dry bed particles was relatively ineffective,as the number of wet particles increased by only 50%.With successive liquid injections,the proportion of the liquid trapped in agglomerates increases in latter injections:large agglomerates from earlier injections accumulate above the grid and are carried by gas bubbles into the spray jet cavity,where they seed fresh agglomerates.

关键词： Fluidized bed Liquid injection Agglomerate formation Fluid Coker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CLUE-S model based on GIS applied to management strategies of territory with oil wells—Case study:Santa Elena,Ecuador

引用

Geography and Sustainability 2022年第4期3卷 366-378页

作者： Gricelda Herrera-franco Paulo Escandón-Panchana F.J.Montalván Andrés Velastegui-Montoya Faculty of Engineering Sciences Santa Elena Peninsula State UniversityAvda.principal La Libertad240204La LibertadEcuador Geo-Recursos y Aplicaciones GIGA ESPOL Polytechnic UniversityP.O.Box 09-01-5863GuayaquilEcuador Geology area ESCETRey Juan Carlos Universityc/Tulipán s/n28933 MadridSpain Facultad de Ingeniería en Ciencias de la Tierra ESPOL Polytechnic UniversityP.O.Box 09-01-5863GuayaquilEcuador Centro de Investigación y Proyectos Aplicados a las Ciencias de la Tierra(CIPAT) ESPOL Polytechnic UniversityP.O.Box 09-01-5863GuayaquilEcuador Geoscience Institute Federal University of Pará66075-110 BelémBrazil

Some cities worldwide have oil wells directly affecting the management of the *** example,La Libertad and Salinas districts contain 467 oil wells in urban areas representing a major land-use planning *** objective is to apply the CLUE-S land use model in coastal cities with oil wells(Salinas-La Libertad),using geographic information systems considering environmental and security characteristics for territorial *** stages of the study are:i)classification and categorisation of oil wells;ii)application of the GIS-CLUE-S method and visualisation of land use dynamics;iii)use the SWOT-TOWS matrix,for the analysis of the situation and the main factors affecting the *** results indicate high vulnerability in many urban sectors and those close to the ***,the CLUE-S analysis shows that the population growth in the urban sector is close to oil well areas,making it a complex pole of human-industry interaction that impacts the management of the *** study synthesises three technical aspects:some oil wells do not comply with municipal ordinance regulations;identification of vulnerable zones due to environmental and security factors,which recommends a territorial reordering policy;as well as an education plan for the application of territorial ordering policies,with awareness and sustainability projections.

关键词： Land use Vulnerability Sustainability GIS Dinamica EGO

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of the Inclusion of Chestnut in the Finishing Diet on Volatile Compounds of Dry-Cured Ham from Celta Pig Breed

引用

Journal of Integrative Agriculture 2013年第11期12卷 2002-2012页

作者： José M Lorenzo Javier Carballo Daniel franco Centro Tecnológico de la Carne de Galicia Rúa Galicia No 4Parque Tecnológico de GaliciaSan Cibrán das Vias rea de Tecnología de los Alimentos Facultad de Ciencias de OurenseUniversidad de Vigo

The effect of the inclusion of chestnut in pigs ifnishing diet on volatile compounds of dry-cured Celta ham was studied. Twelve hams of each type （from three different pigs ifnishing diets：concentrate （CO）, mixed （MI） and chestnut （CH）） were used. Volatiles were extracted using a purge-and-trap method and analyzed by gas chromatography/mass spectrometry （GC/MS）. Thirty-nine volatile compounds were identified in dry-cured Celta ham samples. Most abundant volatiles in ham samples were aldehydes, which represented respectively, 53% （CO）, 51% （MI） and 46% （CH） of the total volatile composition. With the exception of 2-butenal, 2-methyl, all aldehydes were affected by feeding system. On the other hand, hydrocarbons n-alkanes were the second major group in the volatile proifle of dry-cured Celta hams and represented 28.9, 35.7 and 32.4%of the total volatile composition for CO, MI and CH groups, respectively. Ham samples from chestnut group showed a higher content of alcohols and this result could be related with the inclusion of chestnut in the ifnishing diet of pigs. Principal component analysis showed a good separation among groups. The discriminant analysis selected eight variables （butanoic acid, hexanal, octanal, nonenal （E）, decenal （E）, tetradecane, decane trimethyl and pyridine 2-methyl） and calculated two discriminating functions to predict if chestnut has been included in the ifnishing diet. Thus, it was possible to discriminate between groups fed with ifnishing diets containing chestnuts in their composition （mixed and chestnut group）.

关键词： dry-cured ham chestnut volatile compound finishing diet discriminant analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Positive and nontrivial Solutions for the Urysohn Integral Equation

引用

Acta Mathematica Sinica,English Series 2006年第6期22卷 1745-1750页

作者： Daniel franco Gennaro InFAnTE Donal O'REGAn Departamentode Matemática Aplicada Universidad Nacional de Educación a Distancia Dipartimentodi Matematica Universitàdella Calabria Department of Mathematics National University of Ireland

We establish new criteria for the existence of either positive or nonzero solutions of the Urysohn integral equation. We also discuss the existence of an interval of positive eigenvalues and sufficient conditions for the existence of at least a positive eigenvalue with a nonzero or positive eigenfunction for the Urysohn integral operator. Among others, we employ techniques based on fixed point index theory for compact maps, which are new for this type of equation.

关键词： Urysohn integral equation positive solutions eigenvalues

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：