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Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study

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World Journal of Gastroenterology 2006年第45期12卷 7278-7284页

作者： Laurent Castéra Anne Pedeboscq Marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen Pierre-Henri Bernard Christophe Laurent Marie-Edith Lafon Maylis Capdepont Patrice Couzigou Paulette Bioulac-Sage Charles Balabaud francismégraud Armelle Ménard Service d'Hépato-Gastroentérologie H?pital St-André Bordeaux France Service d'Hépato-Gastroentérologie H?pital Haut Lévêque Pessac France INSERM ERI 10 Laboratoire deBactériologie Université Victor Segalen Bordeaux 2 BordeauxFrance INSERM E0362Groupe de Recherche pour l'étude du Foie Université VictorSegalen Bordeaux 2 Bordeaux France Service d'Anatomie Pathologique H?pital Pellegrin Bordeaux France Service de ChirurgieDigestive H?pital St-André Bordeaux France Laboratoire de Virologie Université VictorSegalen Bordeaux 2 Bordeaux France

AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species.

关键词： Hepatitis C virus Hepatitis Cirrhosis Helicobacter

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肠源弯曲菌感染的诊断方法

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国外医学（流行病学．传染病学分册） 1989年第5期16卷 227-230页

作者： Mégraud F 洪禹思

从粪便中首次分离弯曲菌至今已有15年历史。本文主要介绍在目前条件下诊断弯曲菌(不包括幽门弯曲菌)感染的一些方法。

关键词：弯曲菌感染诊断肠源弯曲菌

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Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms

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World Journal of Gastroenterology 2008年第42期14卷 6481-6487页

作者： Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud Institute of Health Research University of Costa Rica San José 2060 Costa Rica Department of Statistics University of Costa Rica San José 2060 Costa Rica Department of Pathology Calderón Guardia Hospital Costa Rica San José 2060 Costa Rica University Victor Segalen Bordeaux 2 146 rue Leo-Saignat Case 76 Bordeaux Cedex 33076 France Departments of Medicine and Microbiology New York University School of Medicine NYU. Langone Medical Center 550 First Avenue New York 10016 United States

AIM： To determine the association of Helicobacter pylori （H pylorl） CagA^＋ infection and pro-inflammatory polymorphisms of the genes interleukin （IL）-IRN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS： Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 consecutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay （ELISA）. Infection with H pylori CagA^＋ was determined by serology and polymerase chain reaction （PCR）. IL-1B and IL-1RN polymorphisms genotyping was performed by PCRrestriction fragment length polymorphism （PCR-RFIP）and PCR respectively. RESULTS： In this dyspeptic population, 86% were Hpylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis （AAG） was associated with CagA^＋ status [odd ratio （OR） = 4.1; P 〈 0.000] and fruit consumption （OR = 0.3; P 〈 0.00）. Atrophic body gastritis （ABG） was associated with pepsinogen PGI/PGII 〈 3.4 （OR = 4.9; P 〈 0.04） and alcohol consumption （OR = 7.3; P 〈 0.02）. Duodenal ulcer was associated with CagA^＋（OR = 2.9; P 〈 0.04） and smoking （OR = 2.4; P 〈 0.04）. PGI 〈 60 μg/L as well as PGI/PGII 〈 3.4 were associated with CagA^＋. CONCLUSION： In a dyspeptic population in Costa Rica, H pylori CagA^＋ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly- morphisms IL-1B ＋ 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population.

关键词： Atrophic gastritis Pepsinogen Pepticulcers Helicobacterpylori-CagA Interleukins

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耕作系统对小麦产量影响及与水保关系

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水土保持科技情报 1996年第1期14卷 14-16页

作者： francism.Epplinetal. 冯景莲

到1995年,联邦政府将要求那些因处于强烈侵蚀区而享受补助资金的农民实行水土保持耕作法。本项研究旨在确定连作小麦中各种耕作方法对产量和经济效益的影响,为此对6种耕作系统进行了10年的研究。有壁犁耕作系统的产量最高,免耕系统的产... 详细信息

到1995年,联邦政府将要求那些因处于强烈侵蚀区而享受补助资金的农民实行水土保持耕作法。本项研究旨在确定连作小麦中各种耕作方法对产量和经济效益的影响,为此对6种耕作系统进行了10年的研究。有壁犁耕作系统的产量最高,免耕系统的产量最低,有壁犁系统的效益最大,圆盘耙系统的效益次之。对于强烈侵蚀区的农民来说,圆盘耙系统是最经济又能满足水土保持要求的耕作方法,而免耕系统是最不经济的耕作方法。

关键词：水土保持耕作小麦产量

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精密测量和基本常数

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宇航计测技术 1984年第5期 54-65页

作者： francism.Pipkin RogersC.Ritter 乔石琼

本文对精密测量技术的最新进展以及它们在确定基本常数方面的作用作了评述。特別引人注目的进展是高稳定的钟,提出用时间标准对米的重新定义和用以保持电标准的精度的提高。对精密测量与广义相对论试验的相关性作了简略的讨论。物理学... 详细信息

本文对精密测量技术的最新进展以及它们在确定基本常数方面的作用作了评述。特別引人注目的进展是高稳定的钟,提出用时间标准对米的重新定义和用以保持电标准的精度的提高。对精密测量与广义相对论试验的相关性作了简略的讨论。物理学方面一个重要的但在很大程度上未被认识的领域包括计量学、测量学和将有关测量和理论联系起来的基本常数的确定。现代的技术世界愈来愈需要精度,但对所需测量工具的起源却几乎一无所知。五十年前还没有动向要为在雾中航行时速为1000公里的飞机制造一个精度可达30米的钟系统。但是,一些寻求不断提高基本理论实验精度的科学家们已经提供了完成这一当今很平凡的工作的工具。最近的进展已使计量领域可能成为在本世纪末前取得惊人进展的新的开端。本文将对一些新的进展加以概述并讨论其前景。

关键词：常数单位制定义数学广义相对论 Einstein引力理论精密测量

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螺杆菌属与伴或不伴肝细胞癌的丙型肝炎肝硬化的关系

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 35-36页

作者： Rocha M. Avenaud P. Mé nard A. F. Mégraud 陈云茹 Univ. Victor Segalen Bordeaux 2 Laboratoire de Bactériologie Bat 2B RDC Zone Nord 33076 Bordeaux Cedex France Prof.

Background and aims: Recent studies have suggested that bacterial coinfection with Helicobacter species in patients already infected with hepatitis C virus ( HCV) could be involved in the development of cirrhosis and hepatocellular carcin oma (HCC). A retrospective cross sectional study was performed in order to explo re the association between Helicobacter species and HCV associated liver disease s. Methods: The presence of Helicobacter species was tested by polymerase chain reaction on liver samples from four groups of patients. Resutls: Helicobacter 16 S rDNA was found in only 4.2% of liver samples from control patients (n = 24) and in 3.5% of liver samples from patients with non- cirrhotic chronic hepatit is C (n = 29) while it was found in 68.0% of liver samples from patients with HCV positive cirrhosis without HCC (n = 25) as well as in 61.3% of cirrhotic l iver samples from patients with HCV positive cirrhosis and HCC (n = 31). In addi tion, when the HCC tumour tissue was tested (n = 21), 90.5% of samples were po sitive. DNA from Helicobacter pylori- and Helicobacter pullorum- like organis ms was found. Conclusions: There is an association between the presence of Helic obacter species DNA in the liver and hepatitis C cirrhosis, with or without HCC. Indeed, the presence of these bacteria could be the result of structural change s in the liver. Alternatively, Helicobacter species could be a co- risk factor in HCV chronic liver diseases. This result warrants prospective studies to deter mine the possible causal role of these bacteria in the progression of chronic he patitis C.

关键词：螺杆菌属丙型肝炎肝脏疾病肝细胞癌肝脏结构慢性肝病横断面研究 DNA

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儿童及青少年幽门螺杆菌感染无创性检查方法的比较:多中心的欧洲人群研究

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世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 31-31页

作者： Mégraud F. 冉海红 Univ.Victor Segalen Bordeaux 2 33076 Bordeaux France Dr.

Objective: To compare the current non-invasive tests for Helicobacter pylori infection in children and *** design: This multicenter, multinational study investigated the sensitivity, specificity, and positive and negative predictive values of four non-invasive tests: urea breath test (UBT), stool antigen test, and antibody detection in serum and urine, in comparison with biopsy-based ***: Of 503 patients included pre-treatment, 473 fulfilled the definition of H pylori status and among those 316 had results available for the four non-invasive tests (including 133 H pylori-positive patients).The specificity was excellent for all *** UBT had the best sensitivity in all age groups, followed by serology, stool test, and antibody detection in urine.A trend for better sensitivity with an increase in age was observed except for the stool *** receiver operating characteristics (ROC) curves showed that sensitivity of serology, stool test, and urinelisa could be improved by changing the cutoff *** inadequate storage of the specimens may explain the poor results of the stool ***: The UBT appears to be an excellent test for diagnosis of H pylori infection for children and adolescents.

关键词：幽门螺杆菌阳性血清抗体特异性预治疗吸入试验血清检测感染状态血清学无创性方法抗原检测

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