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Evaluation of the Influence of Hyoscine Butylbromide on the Oral Bioavailability of Lansoprazole in Healthy Adult Volunteers

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Pharmacology & Pharmacy 2016年第7期7卷 264-271页

作者： Noemí Santos-Caballero Lina Marcela Barranco-Garduño josé Carlos Aguilar-Carrasco Miriam del Carmen Carrasco-Portugal francisco Javier Flores-Murrieta Landsteiner Scientific S.A. de C.V. Mexico City Mexico Unidad de Investigación en Farmacología Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas Mexico City Mexico Departamento de Biología Celular Instituto Nacional de Perinatología Isidro Espinosa de los Reyes Mexico City Mexico Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina Instituto Politécnico Nacional Mexico City Mexico

The gastroesophageal reflux and/or peptic ulcer diseases are clinical conditions that occur usually accompanied of symptomatic pain. Lansoprazole, a proton pump inhibitor class drug is widely used in clinical practice for treatment of these diseases. However, its efficacy can be improved by combining with spasmolytic and/or visceral analgesic such as hyoscine butylbromide. Since hyoscine butylbromide is barely absorbed and exerts some local effects at gastrointestinal tract which may modify the absorption of lansoprazole, it is important to establish if there is a pharmacokinetic interaction after the oral concomitant administration of both drugs. For this objective, twenty-five subjects received under a crossover design an oral administration of lansoprazole (15 mg) plus placebo or a fixed-dose combination with hyoscine butiylbromide (15 mg + 10 mg, respectively). Plasma samples were obtained at different times during 10 hours. Lansoprazole plasma concentrations were determined by a high performance liquid chromatography method coupled to tandem mass spectrometry. Fixed-dose combination was well tolerated. Lansoprazole pharmacokinetic parameters were: Cmax 621.81 ± 212.79 and 450.38 ± 192.14 ng/mL;AUC0-t 1941.36 ± 845.57 and 1454.66 ± 757.28 ng·h/mL;tmax 2.83 ± 0.99 and 3.40 ± 1.82h;t1/2 1.35 ± 0.39 and 1.45 ± 0.51 h, for alone and combined fixed-dose formulation, respectively. Pharmacokinetic parameters were compared by analysis of variance and ratios of AUC0-t, Cmax and 90% confidence intervals obtained. Since confidence intervals exceed the 80% - 125% limits for these parameters, we conclude that there is a significantly pharmacokinetic interaction of lansoprazole when it is administered concomitantly with hyoscine butylbromide.

关键词： Lansoprazole Hyoscine Butylbromide Fixed-Dose Formulation Pharmacokinetic Interaction

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Improving outcomes in pancreatic cancer: Key points in perioperative management

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World Journal of Gastroenterology 2014年第39期20卷 14237-14245页

作者： josé M álamo Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Lydia Barrera Miguel A Gómez Jordi Muntané francisco J Padillo Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREH o Ciberehd) Instituto de Salud Carlos Ⅲ 28029 Madrid Spain francisco J Padillo Department of General Surgery Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla 41013 Seville Spain

This review focused in the perioperative management of patients with pancreatic cancer in order to improve the outcome of the disease. We consider that the most controversial points in pancreatic cancer management are jaundice management, vascular resection and neo-adjuvant therapy. Preoperative biliary drainage is recommended only in patients with severe jaundice, as it can lead to infectious cholangitis, pancreatitis and delay in resection, which can lead to tumor progression. The development of a phase III clinical trial is mandatory to clarify the role of neo-adjuvant radiochemotherapy in pancreatic adenocarcinoma. Venous resection does not adversely affect postoperative mortality and morbidity, therefore, the need for venous resection should not be a contraindication to surgical resection in selected patients. The data on arterial resection alone, or combined with vascular resection at the time of pancreatectomy are more heterogeneous, thus, patient age and comorbidity should be evaluated before a decision on operability is made. In patients undergoing R0 resection, arterial resection can also be performed.

关键词： Pancreatic cancer Obstructive jaundice Preoperative drainage Neo-adjuvant therapy Vascular resection

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Development and postnatal neurogenesis in the retina: a comparison between altricial and precocial bird species

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Neural Regeneration Research 2021年第1期16卷 16-20页

作者： Guadalupe Álvarez-Hernán josé Antonio de Mera-Rodríguez Yolanda Gañán Jorge Solana-Fajardo Gervasio Martín-Partido Joaquín Rodríguez-León Javier francisco-Morcillo Área de Biología Celular Departamento de AnatomíaBiología Celular y ZoologíaFacultad de CienciasUniversidad de ExtremaduraBadajozSpain Área de Anatomía Humana Departamento de AnatomíaBiología Celular y ZoologíaFacultad de MedicinaUniversidad de ExtremaduraBadajozSpain Servicio de Oftalmología Complejo Hospitalario Universitario de BadajozBadajozSpain

The visual system is affected by neurodegenerative diseases caused by the degeneration of specific retinal neurons,the leading cause of irreversible blindness in *** vertebrate phylogeny,the retina has two kinds of specialized niches of constitutive neurogenesis:the retinal progenitors located in the circumferential marginal zone and Müller *** proliferative activity in the retinal progenitors located in the circumferential marginal zone in precocial birds such as the chicken,the commonest bird model used in developmental and regenerative studies,is very *** region adds only a few retinal cells to the peripheral edge of the retina during several months after hatching,but does not seem to be involved in retinal regeneration.Müller cells in the chicken retina are not proliferative under physiological conditions,but after acute damage some of them undergo a reprogramming event,dedifferentiating into retinal stem cells and generating new retinal ***,regenerative response after injury occurs with low efficiency in the precocial avian *** contrast,it has recently been shown that neurogenesis is intense in the retina of altricial birds at *** particular,abundant proliferative activity is detected both in the circumferential marginal zone and in the outer half of the inner nuclear ***,stem cell niches are very active in the retina of altricial *** more extensive research is needed to assess the potential of proliferating cells in the adult retina of altricial birds,it emerges as an attractive model for studying different aspects of neurogenesis and neural regeneration in vertebrates.

关键词： altricial birds circumferential marginal zone Müller glia postnatal neurogenesis precocial regeneration retinogenesis

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Evaluation of Ocimum basilicum *** Different Concentrations of K^(+)as an Inhibitor of Pathogenic Bacterial Strains

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 533-541页

作者： Mercedes Georgina Ramírez-Aragón Victoria Jared Borroel-García Ramón Valenzuela-Soto Ricardo David Valdez-Cepeda francisco Javier Wong-Corral joséLuis García-Hernández Universidad Politécnica de Gómez Palacio Gómez Palacio35120México Universidad Autónoma Chapingo Centro Regional Universitario Centro-NorteZacatecasZac.Universidad Autónoma de ZacatecasFacultad de MatemáticasZacatecas98053México Departamento de Investigación y Posgrado en Alimentos Universidad de SonoraHermosillo83000México Facultad de Agricultura y Zootecnia Universidad Juárez del Estado de DurangoGómez Palacio34000México

The extraction of bioactive compounds has become one of the most interesting areas of modern *** therapeutic reasons,it´s important to obtain antimicrobial agents from natural *** objective of the present study was to determine the inhibitory effect of ethanolic extract of basil(Ocimum basilicum *** Rubin)subjected to different concentrations of potassium(K^(+))on the activity of three bacterial strains that are pathogens in *** was evaluated by inhibition surface and these results were compared to two antibiotics:Gentamicin(GE)and Ciprofloxacin(CPF)for their efficacy against each bacterial *** variables presented significant difference(p≤0.05).According to the results,basil extract evaluated showed positive antibacterial activity against the three strains of Pseudomonas aeruginosa,Listeria monocytogenes and Staphylococcus aureus on Mueller Hinton *** was observed highest inhibition areas of different diameters(15.3 mm,21.3 mm and 21.6 mm respectively)when the extract used was obtained from the plants with the highest concentration of potassium(13 mmol L-1).These values were even superior to the highest values showed on the treatments with the antibiotic gentamicin.

关键词： Basil inhibition potassium secondary metabolites antibiotics

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Laparoscopic approach in gastrointestinal emergencies

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World Journal of Gastroenterology 2016年第9期22卷 2701-2710页

作者： Rosa M Jimenez Rodriguez Juan josé Segura-Sampedro Mercedes Flores-Cortés francisco López-Bernal Cristobalina Martín Verónica Pino Diaz Felipe Pareja Ciuro Javier Padillo Ruiz Department of Surgery Hospital Universitario Virgen del Rocio 41013 Sevilla Spain Hospital Universitario Son Espases 07010 Palma de Mallorca Spain

This review focuses on the laparoscopic approach to gastrointestinal emergencies and its more recent indications. Laparoscopic surgery has a specific place in elective procedures, but that does not apply in emergency situations. In specific emergencies, there is a huge range of indications and different techniques to apply, and not all of them are equally settle. We consider that the most controversial points in minimally invasive procedures are indications in emergency situations due to technical difficulties. Some pathologies, such as oesophageal emergencies, obstruction due to colon cancer, abdominal hernias or incarcerated postsurgical hernias, are nearly always resolved by conventional surgery, that is, an open approach due to limited intraabdominal cavity space or due to the vulnerability of the bowel. These technical problems have been solved in many diseases, such as for perforated peptic ulcer or acute appendectomy for which a laparoscopic approach has become a wellknown and globally supported procedure. On the other hand, endoscopic procedures have acquired further indications, relegating surgical solutions to a second place; this happens in cholangitis or pancreatic abscess drainage. This endoluminal approach avoids the need for laparoscopic development in these diseases. Nevertheless, new instruments and new technologies could extend the laparoscopic approach to a broader array of potentials procedures. There remains, however, a long way to go.

关键词： Minimally invasive surgery Gastrointestinal surgery Emergency surgery Digestive emergencies Abdominal emergencies

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Technical aspects of uniportal VATS lung major resections with bronchovascular reconstruction

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中华胸部外科电子杂志 2021年第4期8卷 209-217页

作者： Julio Sesma Sergio Bolufer Carlos Galvez francisco Lirio Juan joséMafé Jone Miren del campo Sergio Maroto Leyre Sebastian Marta Ortega Luis Jorge Cerezal Department of Thoracic Surgery Hospital General Universitario AlicanteAlicanteSpain

Lung major resections involving bronchovascular reconstruction pose a surgical challenge due to their technical complexity and *** traditional techniques to perform vascular or bronchial reconstructions through multiportal video-assisted thoracoscopic surgery(VATS)approach can be applied also by uniportal VATS ***,specific tools have already been developed in order to facilitate these procedures through uniportal VATS approach increasing comfort and workspace through the single port *** procedures must be performed just in very highly uniportal VATS trained teams and it is recommended that teams who perform these techniques previously have completed the advanced learning curve for lung major resections through uniportal VATS *** aim of this paper is to describe the major key points for performing most frequent bronchovascular reconstructions through uniportal VATS approach in a safe and feasible *** technique is step by step described in order to safely perform most common uniportal VATS left/right side lung major bronchovascular resections and *** tip and tricks are detailed in order to facilitate vascular control,bronchovascular reconstructions and unexpected bleeding control through uniportal VATS approach.

关键词： Video-assisted thoracoscopic surgery(VATS) uniportal angioplasty bronchoplasty lung cancer sleeve bronchovascular reconstruction

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旧金山国际机场,旧金山,加利福尼亚,美国

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世界建筑 2002年第11期 52-54页

作者： DESIGN: SKIDMORE, OWINGS & MERRILL LLP, del campo & MARU, MICHAEL WILLIS ARCHITECTS SOM建筑师事务所 del campo & MARU建筑师事务所 MICHA

旧金山国际机场新国际航站楼成为机场26亿美元扩建改造工程的核心建筑.新楼的建成,增加了26个登机口,大大提高了国际入港和离港的效率和能力,保持了旧金山是太平洋沿岸进入美洲大陆大门的地位.

关键词：建筑设计旧金山国际机场美国

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Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis

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Cellular & Molecular Immunology 2018年第10期15卷 898-906页

作者： Marta Consuegra-Fernández Marc Julià Mario Martínez-Florensa Fernando Aranda Cristina Català Noelia Armiger-Borràs María-Teresa Arias Francisca Santiago Antonio Guilabert Anna Esteve Carlos Muñoz Carlos Ferrándiz josé-Manuel Carrascosa Edurne Pedrosa Jorge Romaní MercèAlsina josé-Manuel Mascaró-Galy francisco Lozano Immunoreceptores del Sistema Innat i Adaptatiu Institut d'Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)Barcelona 08036Spain Servicio de Dermatologia Hospital Universitario de BasurtoBilbao 48013Spain Servei d’Immunologia Centre de Diagnòstic BiomèdicHospital Clínic de BarcelonaBarcelona 08036Spain Servei de Dermatologia Hospital General de GranollersBarcelona 08402Spain Centre d’Estudis Epidemiològics sobre les ITS i Sida de Catalunya(CEEISCAT) ASPCCIBER Epidemiologia y Salud PúblicaBadalona 08916Spain Servei de Dermatologia Hospital Universitari Germans Trias i PujolBadalona 08916Spain Laboratori d’Immunobiologia per Investigaciói Aplicacions al Diagnòstic Banc de Sang i Teixits(BST)Institut d’Investigacióen Ciències de la Salut Germans Trias i PujolDepartament de Biologia Cel·lularFisiologia i ImmunologiaUniversitat Autònoma de BarcelonaBellaterra 08193Spain Servei de Dermatologia Consorci Sanitari Parc Taulí08208 Sabadell.Universitat Autónoma de BarcelonaBellaterra 08193Spain Servei de Dermatologia Hospital Clínic de BarcelonaBarcelona 08036Spain Departament de Biomedicina Universitat de BarcelonaBarcelona 08036Spain

Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental *** evidence supports CD6,a lymphocyte surface receptor mostly expressed by T cells,as a putative target in ***,a humanized anti-CD6 antibody has been assayed for the treatment of certain autoimmune disorders,including ***,we present novel evidence in mice and humans for a direct involvement of CD6 in psoriasis ***,an attenuated form of imiquimod-induced psoriasis-like skin inflammation was demonstrated in CD6-deficient mice,as deduced from lower epidermal thickness and local reduced production of pro-inflammatory cytokines,namely,***,isolated CD4+CD62L+T cells from CD6-deficient mice displayed decreased in vitro T-helper type 17 ***,a statistically significant association between CD6 single-nucleotide polymorphisms(rs17824933,rs11230563 and rs12360861)and more severe forms of psoriasis was demonstrated in a cohort of 304 patients at three public hospitals from the metropolitan area of *** together,these results provide new supportive evidence of the contribution of the CD6 lymphocyte receptor in psoriasis at both experimental and clinical levels.

关键词： ALCAM CD5 CD6 lymphocyte psoriasis

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Cardiometabolic risk through an integrative classification combining physical activity and sedentary behavior in European adolescents:HELENA study

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Journal of Sport and Health Science 2019年第1期8卷 55-62页

作者： Carlos Cristi-Montero Palma Chillón Idoia Labayen josé A.Casajus Marcela Gonzalez-Gross Jérémy Vanhelst Yannis Manios Luis A.Moreno francisco B.Ortega Jonatan R.Ruiz IRyS Group Physical Education School Pontificia Universidad Cato?lica de Valparai?o PROmoting FITness and Health through physical activity research group (PROFITH) Department of Physical Education and SportsFaculty of Sport Sciences University of Granada Department of Nutrition and Food Science University of the Basque Country Department of Health and Human Performance School of Health Sciences University of Zaragoza ImFine Research Group Facultad de Ciencias de la Actividad Física y del Deporte-INEF Universidad Politcnica de Madrid Lille Inflammation Research International Center University of Lille Department of Nutrition and Dietetics Harokopio University

Purpose: This study aims to compare adolescents' cardiometabolic risk score through an integrative classification of physical activity(PA),which involves the combination of moderate-to-vigorous physical activity(MVPA) and sedentary behavior(SB).Methods: A cross-sectional study derived from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study database(2006-2008) was conducted in adolescents(n = 548; boys, 47.3%; 14.7 ± 1.2 years) from 10 European cities. MVPA and SB were objectively measured using accelerometry. Adolescents were divided into 4 categories according to MVPA(meeting or not meeting the international recommendations) and the median of SB time(above or below sex-and age-specific median) as follows: High-SB & Inactive, Low-SB & Inactive,High-SB & Active, and Low-SB & Active. A clustered cardiometabolic risk score was computed using the homeostatic model assessment, systolic blood pressure, triglycerides, total cholesterol/high-density lipoprotein cholesterol, sum 4 skinfolds, and cardiorespiratory fitness(CRF).Analyses of covariance were performed to discern differences on cardiometabolic risk scores among PA categories and each health ***: The cardiometabolic risk score was lower in adolescents meeting the MVPA recommendation and with less time spent in SB in comparison to the high-SB & Inactive group(p < 0.05). However, no difference in cardiometabolic risk score was established between High-SB or Low-SB groups in inactive adolescents. It is important to note that CRF was the only variable that showed a significant modification(higher)when children were compared from the category of physically inactive with "active" but not from high-to ***: Being physically active is the most significant and protective outcome in adolescents to reduce cardiometabolic risk. Lower SB does not exhibit a significant and extra beneficial difference.

关键词： Accelerometry Cardiovascular disease Exercise Metabolic disease Sedentary lifestyles

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Hydrometeorology of Anthropogenic Erosion in the Metropolitan Region of São Paulo

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Journal of Environmental Protection 2021年第12期12卷 1234-1253页

作者： Maria del Carmen Sanz Lopez Augusto josé Pereira Filho Jorge Luiz Diaz Pinaya Departamento de Ciências Atmosférica do Instituto de Astronomia Geofísica e Ciências Atmosféricas da Universidade de S&atilde o Paulo S&atilde o Paulo Brazil

Erosive processes play an important role in environmental degradation. Rain is the main erosive agent in the Metropolitan Region of Sao Paulo. This study characterized the erosion events caused by precipitation leveraging the accumulated daily precipitation estimate generated by the Climate Prediction Center Morphing Method (CMORPH) and integrating the surface telemetric network using the Statistical Objective Analysis method (SOAS). From the Civil Defense database, 400 events were identified in the Metropolitan region of Sao Paulo (MRSP) area between 2000 and 2013 and, of these, 3 were chosen to carry out meteorological and climatological analyses. In an initial observation, 58% of them were found to occur in summer. Two regions with the highest number of erosion events were observed, in the Serra do Mar and Serra da Cantareira. In the Serra do Mar core, the municipality of São Bernardo do campo was the one with the greatest amount of erosion. Precipitation volumes were estimated for accumulations of 30 minutes, 1 day, 1 month, and 1 year. The results, from the 3 events, indicate accumulated precipitation in 30 minutes from 10 mm to 19.8 mm, daily from 30.8 mm to 69.5 mm, and 1 month from 369.7 mm to 742.5 mm, and 1 year (2010) from 1712.9 mm to 1961.8 mm. In these events, it was noted that there were heavy rains in December 2009 and January 2010. It was also noted that the CMORPH and SOAS identify the rain events found by the São Paulo meteorological radar. The meteorological analyzes of the events based on images from the São Paulo meteorological radar and the Meteosat-9 satellite indicate that the active precipitation systems are associated with cold fronts, instability lines, and isolated convection.

关键词： Hydrometeorology Anthropogenic Erosion CMORPH SOAS

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