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Efficacy of a Strategy for Implementing Guidelines for the Control of Cardiovascular Risk in Primary Healthcare

World Journal of Cardiovascular Diseases 2020年第3期10卷 117-130页

作者： Maria Jesús Fernández-Luque Luis María Sánchez-Gómez Vicente Pastor y Aldeguer Carmen Suárez-Fernández Belén Sierra-garcía Soledad Mayayo-Vicente Marta Ruiz-López ángela Gallego-Arenas Rosa Sánchez Alcalde Pilar Loeches-Belinchón javier López-González francisco Rodríguez-Salvanés Blanca Novella-Arribas Dirección General de Investigación Docencia y Documentación Consejería de Sanidad Comunidad de Madrid Madrid Spain Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa (IP) Madrid Spain Universidad Autónoma de Madrid Facultad de Medicina Madrid Spain Hospital Universitario de la Princesa SERMAS Consejería de Sanidad Comunidad de Madrid Madrid Spain Gerencia Asistencial de Atención Primaria D.G. de Coordinación de Asistencia Sanitaria SERMAS Consejería de Sanidad Comunidad de Madrid Madrid Spain Unidad de Evaluación de Tecnologías Sanitarias de Madrid Procesos Integrados de Salud Consejería de Sanidad Madrid Spain

Background: A number of strategies exist for the implementation of clinical practice guides (CPGs). Aim: To assess the efficacy of implementing a cardiovascular risk CPG based on an educational method involving opinion leaders, and the habitual method of dissemination among primary healthcare teams. Design and Setting: Controlled, blinded, community intervention trial randomised by clusters. Methods: 21 primary healthcare centres were randomly assigned to either the intervention arm (n = 11) or the control arm (n = 10). The study subjects were patients aged ≥45 years assigned to the centres. The overall impact of the intervention was measured as the difference between the increase in the proportion of patients whose medical records showed the recording of all the variables necessary to calculate cardiovascular risk in both arms. Analyses were performed with Generalized Lineal Model on an intention-to-treat basis. Results: 917 subjects were included at the beginning of the trial (437 in the intervention arm and 480 in the control arm). 826 subjects were included in the final evaluation (436 in the intervention group and 390 in the control arm). At the end of the trial, the recording of the variables necessary for the calculation of the cardiovascular risk in the intervention group had increased more than in the control group (difference between increases 7.49% (95% CI 4.62 - 10.35)) after adjusting for confounding variables. Conclusions: Compared to the habitual method of dissemination, the implementation of this CPG using an educational method involving opinion leaders, improved the recording of the variables needed to calculate patients’ cardiovascular risk.

关键词： Randomized Controlled Trial Cluster Analysis Clinical Practice Guidelines Primary Healthcare Risk Factors Cardiovascular Diseases

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Boron nitride nanoresonators for phonon-enhanced molecular vibrational spectroscopy at the strong coupling limit

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Light(Science & Applications) 2017年第1期6卷 55-62页

作者： Marta Autore Peining Li Irene Dolado francisco J Alfaro-Mozaz Ruben Esteban Ainhoa Atxabal Fèlix Casanova Luis E Hueso Pablo Alonso-González javier Aizpurua Alexey Y Nikitin Saül Vélez Rainer Hillenbrand CIC nanoGUNE Donostia-San Sebastián 20018Spain Donostia International Physics Center(DIPC) Donostia-San Sebastián 20018Spain IKERBASQUE Basque Foundation for ScienceBilbao 48013Spain Departamento de Física Universidad de OviedoOviedo 33007Spain Centro de Física de Materiales(MPC CSIC-UPV/EHU)Donostia-San Sebastián 20018Spain Current address:Department of Materials ETH ZürichZürich 8093Switzerland CIC nanoGUNE and UPV/EHU Donostia-San Sebastián 20018Spain

Enhanced light-matter interactions are the basis of surface-enhanced infrared absorption(SEIRA)spectroscopy,and conventionally rely on plasmonic materials and their capability to focus light to nanoscale spot *** polariton nanoresonators made of polar crystals could represent an interesting alternative,since they exhibit large quality factors,which go far beyond those of their plasmonic *** recent emergence of van der Waals crystals enables the fabrication of highquality nanophotonic resonators based on phonon polaritons,as reported for the prototypical infrared-phononic material hexagonal boron nitride(h-BN).In this work we use,for the first time,phonon-polariton-resonant h-BN ribbons for SEIRA spectroscopy of small amounts of organic molecules in Fourier transform infrared ***,the interaction between phonon polaritons and molecular vibrations reaches experimentally the onset of the strong coupling regime,while numerical simulations predict that vibrational strong coupling can be fully *** polariton nanoresonators thus could become a viable platform for sensing,local control of chemical reactivity and infrared quantum cavity optics experiments.

关键词： boron nitride phonon polaritons strong coupling surface-enhanced infrared absorption spectroscopy SEIRA

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羽蛇神峡谷中的民居墨西哥瑙卡尔潘州

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世界建筑导报 2021年第5期36卷 20-23页

作者：路易斯·劳尔·恩里克斯·蒙蒂尔 javier Senosiain(摄影) francisco Lubbert(摄影) Mario Mutschlechner(摄影) 塞诺西安禓建筑师事务所不详

该项目位于一块6.2英亩的不规则地块上。地块呈不规则状态。一沟壑横贯首尾,两边夹以橡木丛林。仅有5%的土质表面,有一个小缓坡,其一边背靠斜坡,一边沿着街道。该房产上有几个坍塌的洞穴,这是由于洞穴的砖是由一种粘土轻质砖构成的,这... 详细信息

该项目位于一块6.2英亩的不规则地块上。地块呈不规则状态。一沟壑横贯首尾,两边夹以橡木丛林。仅有5%的土质表面,有一个小缓坡,其一边背靠斜坡,一边沿着街道。该房产上有几个坍塌的洞穴,这是由于洞穴的砖是由一种粘土轻质砖构成的,这种砖在20世纪中叶的建筑业中广泛使用。不规则的表面是该项目的一个挑战,更是对羽蛇神位置的挑战。周围绿化,不能为人而动。

关键词：羽蛇神轻质砖洞穴 20世纪中叶墨西哥

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Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells

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World Journal of Stem Cells 2017年第2期9卷 26-36页

作者： Estefania Caballano-Infantes José Terron-Bautista Amparo Beltrán-Povea Gladys M Cahuana Bernat Soria Hajji Nabil francisco J Bedoya Juan R Tejedo Andalusian Center for Molecular Biology and Regenerative Medicine-University Pablo de Olavide 41092 SevilleSpain Biomedical Research Network on Diabetes and Related Metabolic Diseases(CIBERDEM) Instituto de Salud CarlosⅢ28029 MadridSpain Andalusian Center for Molecular Biology and Regenerative Medicine(CABIMER) 41092 SevilleSpain Andalusian Center for Molecular Biology and Regenerative Medicine Fundación Progreso y Salud41092 SevilleSpain Centre for Pharmacology and Therapeutics Division of Experimental MedicineImperial College LondonHammersmith Hospital CampusLondon W12 0NNUnited Kingdom

Mitochondrial dysfunction and endoplasmic reticulum stress(ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide(NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca^(2+) flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstratedthe need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies.

关键词： Endoplasmic reticulum stress Mitochondrial function Nitric oxide Pluripotency Cell differentiation Mitochondrial biogenesis

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The 2<sup>nd</sup>Step by Step International Spinal Cord Repair—Combining research Step by Step into multi-pronged approaches for spinal cord repair

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Journal of Biomedical Science and Engineering 2013年第7期6卷 21-32页

作者： Maria Teresa Moreno-Flores Francois Ferón Victor Arvanian Armin Blesch Armin Curt David J. Fink Marina Mata Kinichi Nakashima Xavier Navarro francisco javier Rodríguez Michal Schwartz Mikael Svensson Erik Sundstrom Joan Romero Filip Lim Department of Biotechnology University Francisco de Vitoria Pozuelo de Alarcón Spain Department of Cell Biology Physiology and Immunology University Autonoma de Barcelona Barcelona Spain Department of Medicine University Hospital Balgrist Zurich Switzerland Department of Molecular Biology University Autónoma de Madrid Madrid Spain Department of Neurobiology Care Sciences and Society Karolinska Institute Stockholm Sweden Department of Neurobiology Weizmann Institute of Science Rehovot Israel Department of Neurology University of Michigan Ann Arbor USA Department of Stem Cell Biology and Medicine Kyushu University Fukuoka Japan Faculty of Medicine Aix Marseille University Marseille France National Paraplegics Hospital Toledo Spain Northport Veterans Affairs Medical Center Northport USA Spinal Cord Injury Center University Hospital Heidelberg Germany Step by Step Foundation Barcelona Spain

On April 26-27, 2013, the Step by Step Foundation hosted the Second International Spinal Cord Repair Meeting at the Fira Barcelona Convention Center in Hospitalet de Llobregat, Spain, highlighting some of the exciting research including clinical trials which show promise for treatments for this devastating disorder. This meeting brought together clinicians, clinical scientists and molecular biologists from more than 10 countries to evaluate current knowledge on clinical, cellular, and biomolecular aspects of spinal cord injury. A major goal of the conference in advancing the translation of research data to the clinic was to promote multi-pronged approaches for therapy of this complex problem.

关键词： Spinal Cord Injury Immunomodulation Glial Scar Nerve Grafts Neurotrophins Neural Stem Cells Electromagnetic Stimulation HSV-1 Vectors Cholecalciferol Vitamin D3 Wnt Proteins Neuroregeneration

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Post-transplant plasma cell hepatitis in a liver transplant patient treated with pegylated interferon plus ribavirin

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Open Journal of Gastroenterology 2013年第7期3卷 307-310页

作者： Miguel Jiménez-Pérez francisco javier Rando-Munoz Rocío González-Grande Fernando González-Panizo Tamargo Jesús de la Cruz Lombardo Juan Miguel Rodrigo López Román Manteca González Department of Gastroenterology and Hepatology Liver Transplantation Unit University Hospital Carlos Haya Málaga Spain

The recurrence of hepatitis C after a liver transplant remains an important cause of graft loss and retransplant. Antiviral therapy with peginterferon plus ribavirin (PEG-INF/RBV) can achieve a sustained viral response and histological improvement in a high percentage of cases. However, this treatment is not exempt from important side effects or from the possibility of precipitating rejection, with the resulting graft loss. We report the case of a liver transplant patient who received treatment with PEG-INF/RBV and developed plasma cell hepatitis as the presenting form of rejection.

关键词： Liver Transplantation C Hepatitis Treatment Plasmatic Cells Allograft Rejection Autoinmune Response

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Functional N-Representability in 2-Matrix,1-Matrix,and Density Functional Theories

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Journal of Modern Physics 2013年第3期4卷 391-400页

作者： Eduardo V.Ludena F.javier Torres Cesar Costa Prometheus Program SenescytQuitocuador Grupo Ecuatoriano para el Estudio Experimental y Teorico de Nanosistemas(GETNano) Universidad San Francisco de Quito(USFQ)Edificion NewtonOficina N102C Diego de Robles y Via InteroceanicaQuitoEcuador Grupo de Quimica Computacional y Teorica(QCT-USFQ) Universidad San Francisco de Quito(USFQ)Diego de Robles y Via InteroceanicaC.P.17-1200-841QuitoEcuador Departamento de Fisica Escuela Politecnica Nacional(EPN)Ladron de Guevara E11-256QuitoEcuador

The N-representability conditions on the reduced second-order reduced density matrix (2-RDM), impose restrictions not only in the context of reduced density matrix theory (RDMT), but also on functionals advanced in one-matrix theory such as natural orbital functional theory (NOFT), and on functionals depending on the one-electron density such as those of density functional theory (DFT). We review some aspects of the applications of these N-representability conditions in these theories and present some conclusions.

关键词： N-Representability DFT D1-Matrix Theory D2-Matrix Theory

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海事网络

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城市环境设计 2010年第1期 75-81页

作者： Jan Willem van Kuilenburg Kristine Birch Bald Paolo Faleschini francisco javier Casas Cobo Beatriz Villanueva Cajide Ann Carolyn Wright Monolab

Monolab建于1999年,目标是高级建筑和城市规划的研究。简易和实验是Monolab的主题。Monolab致力于通过提供高效、清晰的概念和先进的分析手段,综合当代文化处理复杂的项目Monolab设计领域广泛:从家具设计到别墅,由住宅项目、城市计划从... 详细信息

Monolab建于1999年,目标是高级建筑和城市规划的研究。简易和实验是Monolab的主题。Monolab致力于通过提供高效、清晰的概念和先进的分析手段,综合当代文化处理复杂的项目Monolab设计领域广泛:从家具设计到别墅,由住宅项目、城市计划从车站和城市中心到销售中心。

关键词：城市规划城市建设当代文化住宅项目家具设计海事艾瑟尔别墅 Lake 岛屿项目带动

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阿米巴住宅圣保罗市

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世界建筑导报 2021年第5期36卷 24-25页

作者：路易斯·劳尔·恩里克斯·蒙蒂尔 javier Senosiain(摄影) francisco Lubbert(摄影) Mario Mutschlechner(摄影) 塞诺西安禓建筑师事务所不详

该住宅距离圣保罗市120公里处,位于一个有高尔夫球场的封闭式社区中,周围植被茂盛。住宅场地朝北,可以俯瞰高尔夫球场。四周都有建筑限制。该项目要求在明确划定的空间内划分三个明显不同的公共区域:厨房、电视室和游戏室。解决方案是... 详细信息

该住宅距离圣保罗市120公里处,位于一个有高尔夫球场的封闭式社区中,周围植被茂盛。住宅场地朝北,可以俯瞰高尔夫球场。四周都有建筑限制。该项目要求在明确划定的空间内划分三个明显不同的公共区域:厨房、电视室和游戏室。解决方案是一层有三个支点或“腿”,连接非常开放的区域:餐厅和客厅,两者都有不间断的交叉视野,可以看到高尔夫球场和房子周围的地面。

关键词：高尔夫球场公共区域圣保罗市阿米巴住宅

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Management of oligometastatic non-small cell lung cancer patients:Current controversies and future directions

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World Journal of Clinical Oncology 2019年第10期10卷 318-339页

作者： Felipe Counago javier Luna Luis Leonardo Guerrero Blanca Vaquero María Cecilia Guillén-Sacoto Teresa González-Merino Begona Taboada Verónica Díaz Belén Rubio-Viqueira Ana Aurora Díaz-Gavela francisco JoséMarcos Elia del Cerro Department of Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de AlarcónMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Clinical Department Faculty of BiomedicineUniversidad EuropeaMadrid 28223Spain Department of Radiation Oncology Hospital Fundación Jiménez DíazMadrid 28040Spain Department of Medical Oncology Hospital La LuzMadrid 28003Spain Department of Radiation Oncology Complexo Hospitalario Universitario Santiago de CompostelaSantiago de Compostela 15706Spain Department of Radiation Oncology Hospital Universitario Puerta del MarCádiz 11009Spain Department of Medical Oncology Hospital Universitario Quirónsalud MadridPozuelo de AlarcónMadrid 28223Spain

Oligometastatic non-small cell lung cancer(NSCLC)describes an intermediate stage of NSCLC between localized and widely-disseminated *** stage of NSCLC is characterized by a limited number of metastases and a more indolent tumor ***,the management of oligometastatic NSCLC involves radical treatment(radiotherapy or surgery)that targets the metastatic lesions and the primary tumor to achieve disease *** approach offers the potential to achieve prolonged survival in patients who,in the past,would have only received palliative *** optimal therapeutic strategies for the different scenarios of oligometastatic disease(intracranial vs extracranial disease,synchronous vs metachronous)remain *** the lack of head-to-head studies comparing radiotherapy to surgery in these patients,the decision to apply surgery or radiotherapy(with or without systemic treatment)must be based on prognostic factors that allow us to classify *** classification will allow us to select the most appropriate therapeutic strategy on an individualized *** the future,the molecular or microRNA profiles will likely improve the treatment selection *** objective of the present article is to review the most relevant scientific evidence on the management of patients with oligometastatic NSCLC,focusing on the role of radiotherapy and *** also discuss areas of controversy and future directions.

关键词： Non-small cell lung cancer Metastasectomy Oligometastases Stereotactic ablative radiotherapy Stereotactic body radiation therapy Radiosurgery

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