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CONSTANS alters the circadian clock in Arabidopsis thaliana

Molecular Plant 2024年第8期17卷 1204-1220页

作者： Pedro de los Reyes Gloria Serrano-Bueno francisco j.romero-campero He Gao jose M.romero Federico Valverde Plant Development Group-Institute for Plant Biochemistry and Photosynthesis Consejo Superior de Investigaciones CientificasUniversidad de SevillaSevilleSpain Department of Computer Science and Artificial Intelligence Universidad de SevillaSevilleSpain Department of Plant Developmental Biology Max Planck Institute for Plant Breeding ResearchCologneGermany Department of Plant Biochemistry and Molecular Biology Universidad de SevillaSevilleSpain

Plants are sessile organisms that have acquired highly plastic developmental strategies to adapt to the *** these processes,the floral transition is essential to ensure reproductive success and is finelyregulated by several internal andexternal genetic *** photoperiodic pathway,which controls plant response to day length,is one of the most important pathways controlling *** Arabidopsis photoperiodic flowering,CONSTANS(CO)is the central gene activating the expression of the florigen FLOWERING LOCUS T(FT)in the leaves at the end of a long *** circadian clock strongly regulates Co ***,to date,no evidence has been reported regarding a feedbackloop from the photoperiod pathway back to the circadian *** transcriptional networks,we have identified relevant network motifs regulating the interplay between the circadian clock and the photoperiod *** expression,chromatin immunoprecipitation experiments,and phenotypic analysis allowed us to elucidate the role of Co over the circadian *** with altered cO expression showed a different internal clock period,measured by daily leaf rhythmic *** showed that co upregulates the expression of key genes related to the circadian clock,such as CCA1,LHY,PRR5,and Gl,at the end of a long day by bindingto specific sites on their ***,a high numberof PRR5-repressed target genes are upregulated by CO,and this could explain the phase transition promoted by *** CO-PRR5 complex interacts with the bZiP transcriptionfactor HY5andhelps to localize the complex in the promoters of clock *** together,our results indicate that there may be a feedback loop in which co communicates back to the circadian clock,providing seasonal information to the circadian system.

关键词： CONSTANS circadian clock photoperiod

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Cellular modelling using P systems and process algebra

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Progress in Natural Science:Materials International 2007年第4期17卷 375-383页

作者： francisco j. romero-campero Marian Gheorghe Gabriel Ciobanu john M. Auld Mario j. Pérez-jiménez Research Group on Natural Computing Department of Computer Science and Artificial IntelligenceUniversity of SevilleAvda.Reina Mercedes41012 SevillaSpain Department of Computer Science The University of Sheffield Regent CourtPortobello StreetSheffield S1 4DPUK Romanian Academy Institute of Computer ScienceBlvd. Carol I nr. 11700505IasiRomania

In this paper various molecular chemical interactions are modelled under different computational paradigms. P systems andπ-calculus are used to describe intra-cellular reactions like protein-protein interactions and ... 详细信息

关键词： cellular modelling P systems process algebra.

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How to express tumours using membrane systems

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Progress in Natural Science:Materials International 2007年第4期17卷 449-457页

作者： Miguel A. Gutiérrez-Naranjo Mario j. Pérez-jiménez Agustín Riscos-Núez francisco j. romero-campero Department of Computer Science and Artificial Intelligence University of Seville Avda. Reina Mercedes s/n41012SevillaSpain

In this paper we discuss the potential usefulness of membrane systems as tools for modelling tumours. The approach is followed both from a macroscopic and a microscopic point of view. In the first case, one considers the tumour as a growing mass of cells, focusing on its external shape. In the second case, one descends to the microscopic level, studying molecular signalling pathways that are crucial to determine if a cell is cancerous or not. In each of these approaches we work with appropriate variants of membrane systems.

关键词： tumour membrane system modeling.

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Simulating FAS-induced apoptosis by using P systems

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Progress in Natural Science:Materials International 2007年第4期17卷 424-431页

作者： Smitha Cheruku Andrei Pǎun francisco j. romero-campero Mario j. Pérez-jiménez Oscar H. Ibarra Department of Computer Science/IfM Louisiana Tech UniversityP.O. Box 10348RustonLA 71272USA Department of Computer Science and Artificial Intelligence University of SevilleAvda. Reina Mercedes s/n 41012SevillaSpain Department of Computer Science University of California-Santa BarbaraSanta BarbaraCA 93106USA

In contrast to differential equations, P systems are an unconventional model of computation which takes into consideration the discrete character of the quantity of components and the inherent randomness that exists in biological phenomena. The key feature of P systems is their compartmentalised structure which represents the heterogeneity of the structural organisation of the cells, and where one can take into account the role played by membranes in the functioning of the system, for example signalling at the cell surface, selective uptake of substances from the media, diffusion across different compartments, etc. We show here that P systems can be a reliable tool for Systems Biology and could even outperform in some cases the current simulation techniques based on differential equations. We will also use a strategy based on the well known Gillespie algorithm but running on more than one compartment called Multi-compartmental Gillespie Algorithm.

关键词： FAS-induced apoptosis P systems deterministic waiting times algorithm multi-compartmental Gillespie algorithm.

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Inexpensive and flexible nanographene-based electrodes for ubiquitous electrocardiogram monitoring

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npj Flexible Electronics 2019年第1期3卷 100-105页

作者： francisco j.romero Encarnacion Castillo Almudena Rivadeneyra Alejandro Toral-Lopez Markus Becherer francisco G.Ruiz Noel Rodriguez Diego P.Morales Pervasive Electronics Advanced Research Laboratory University of Granada18071 GranadaSpain Department of Electronics and Computer Technology University of Granada18071 GranadaSpain Institute for Nanoelectronics Technische Universität München80333 MunichGermany Biochemistry and Electronics as Sensing Technologies Group University of Granada18071 GranadaSpain

Flexible electronics is one of the fundamental technologies for the development of electronic skin,implant wearables,or ubiquitous *** this context,graphene-derived materials have attracted great interest due to their unique properties to fulfill the demands of these *** we report a simple one-step method for the fabrication of electrophysical electrodes based on the photothermal production of porous nanographene structures on the surface of flexible polyimide *** approach constitutes an inexpensive alternative to the commercial medical electrodes,leading to a lower and much more stable skin–electrode contact resistance and providing comparable signal *** technology has been framed inside the IoT paradigm through the development of a denoising and signal classification clustering algorithm suitable for its implementation in wearable *** experiments have shown promising achievements regarding noise reduction,increasing the crest factor~3.7 dB,as well as for the over 90%heart rate-monitoring accuracy.

关键词： ubiquitous IoT electrodes

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Ferrofluid moving thin films for active flow control

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Chinese journal of Aeronautics 2021年第5期34卷 115-119页

作者： francisco j.ARIAS Department of Fluid Mechanics Polytechnic University of CataloniaESEIAATC/Colom 1108222 BarcelonaSpain

Ferrofluid moving thin films and their possible significance with regard to active flow control for lift and attack angle enhancement are *** this strategy,a very thin film of ferrofluid is strongly attached at the wall of the wing by a normal magnetic field from below and pumped tangentially along the *** a simplified physical model and from the available experimental data on moving walls,the expected lift enhancement and effect on the attack angle were *** research and design is required in order to explore the possibilities in the use of ferrofluid moving thin films.

关键词： Active flow control Boundary layer separation Ferrofluid

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Local Fourier Analysis for Edge-Based Discretizations on Triangular Grids

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Numerical Mathematics(Theory,Methods and Applications) 2015年第1期8卷 78-96页

作者： Carmen Rodrigo francisco Sanz francisco j.Gaspar francisco j.Lisbona Department of Applied Mathematics University of ZaragozaC/Maria de Luna 350018ZaragozaSpain BIFI University of Zaragoza C/Pedro Cerbuna 1250009ZaragozaSpain Department of Applied Mathematics University of ZaragozaC/Pedro Cerbuna 1250009ZaragozaSpain

In this paper,we present a local Fourier analysis framework for analyzing the different components within multigrid solvers for edge-based discretizations on triangular *** different stencils associated with edges of different orientation in a triangular mesh make this analysis *** resulting tool is demonstrated for the vector Laplace problem discretized by mimetic finite difference *** from the local Fourier analysis,as well as experimentally obtained results,are presented to validate the proposed analysis.

关键词： Multigrid local Fourier analysis edge-based discretizations mimetic finite differences

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Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis

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Neural Regeneration Research 2021年第2期16卷 242-246页

作者： francisco j.Barrantes Biomedical Research Institute(BIOMED)UCA-CONICET Buenos AiresArgentina

Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary *** classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the neuromuscular junction,the nicotinic acetylcholine *** variants of the disease involve autoimmune attack of non-receptor scaffolding proteins or enzymes essential for building or maintaining the integrity of this peripheral *** review summarizes the participation of the above proteins in building the neuromuscular junction and the destruction of this cholinergic synapse by autoimmune aggression in myasthenia *** review also covers the application of a powerful biophysical technique,superresolution optical microscopy,to image the nicotinic receptor in live cells and follow its motional *** hypothesis is entertained that anomalous nanocluster formation by antibody crosslinking may lead to accelerated endocytic internalization and elevated turnover of the receptor,as observed in myasthenia gravis.

关键词： agrin autoimmune diseases muscle end-plate muscle specific kinase MuSK myasthenia gravis nanoscopy neuromuscular junction nicotinic acetylcholine receptor rapsyn superresolution microscopy

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Controversies around the treatment of peritoneal metastases of colorectal cancer

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World journal of Gastrointestinal Oncology 2025年第1期17卷 260-264页

作者： francisco j Morera-Ocon Clara Navarro-Campoy Ticiano Guastella francisco Landete-Molina Department of General Surgery Hospital General de RequenaRequena 46340Spain Department of Gynecology and Obstetrics Hospital 9 OctubreValencia 46015Spain Department of Pathology Hospital General de RequenaRequena 46340Spain

In this editorial we examine the article by Wu et al published in the World journal of Gastrointestinal *** resection for peritoneal metastases from colorectal cancer(CRC)has been gradually accepted in the medical oncology community.A randomized trial(PRODIGE 7)on cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPEC)failed to prove any benefit of oxaliplatin in the overall survival of patients with peritoneal metastases from colorectal ***,isolated systemic chemotherapy for CRC stage IV has demonstrated a reduced response in peritoneal metastases than that obtained in other metastatic sites such as the *** tool is required in those patients to achieve more local control of the *** groups in peritoneal surgery continue to use HIPEC in their procedures,using other agents than oxaliplatin for peritoneal cavity infusion,such as mitomycin *** patients present with complex surgical issues to manage,and consequently a large burden of complications has to be ***,identifying patients who will benefit from CRS with or without HIPEC would be of great interest.

关键词： Colorectal cancer Peritoneal metastasis Hyperthermic intraoperative chemotherapy Treatment strategies Peritoneal Surface Oncology GroupInternational

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Shear velocity criterion for incipient motion of sediment

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Water Science and Engineering 2014年第2期7卷 183-193页

作者： francisco j.M.SIMOES U.S. Geological Survey Geomorphology and Sediment Transport LaboratoryGolden CO 80403 USA

The prediction of incipient motion has had great importance to the theory of sediment transport. The most commonly used methods are based on the concept of critical shear stress and employ an approach similar, or identical, to the Shields diagram. An alternative method that uses the movability number, defined as the ratio of the shear velocity to the particle＇s settling velocity, was employed in this study. A large amount of experimental data were used to develop an empirical incipient motion criterion based on the movability number. It is shown that this approach can provide a simple and accurate method of computing the threshold condition for sediment motion.

关键词： incipient motion sediment transport Shields diagram critical shear stress criticalshear velocity movability number

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