检索结果-南通市图书馆

Chromium Differentially Affects Hydrogen Peroxide Distribution in Primary and Adventitious Roots of Arabidopsis thaliana L.

引用

Phyton-International Journal of Experimental Botany 2020年第1期89卷 35-43页

作者： Aaron Giovanni Munguia-Rodriguez Jose Lopez-Bucio Gerardo Rangel Sanchez Leon francisco Ruiz-herrera Yazmin Carreon-Abud Miguel Martinez-Trujillo Instituto de Investigaciones Quimico-Biológicas Universidad Michoacana de San Nicolas de HidalgoEdificio B3Ciudad UniversitariaC.P58030MoreliaMichoacanMexico Facultad de Biologia Universidad Michoacana de San Nicolas de Hidalgo.Edificio RCiudad UniversitariaC.P58030 MoreliaMichoacanMexico

The post-embryonic growth of the Arabidopsis thaliana root system can be modified by different types of stress,such as sublethal concentrations of metals,which may induce the production of reactive oxygen species(ROS).In this study,the effects of different concentrations of potassium chromate(K_(2)CrO_(4))on the distribution and relative quantity of hydrogen peroxide(H_(2)O_(2))were determined in primary and adventitious roots in *** HyPer line *** line has a biosensor that specifically reports H_(2)O_(2) levels within tissues as *** root growth was inhibited at 100μM Cr(VI);in contrast,adventitious root formation was induced over the main root growth *** structures proliferated from 100-160μM Cr(VI),and much higher concentrations(180-200μM)of K_(2)CrO_(4) were required to affect their *** H_(2)O_(2) distributions were observed in the columella and lateral root cap of primary roots of plants grown in medium lacking dichromate,but following the development of toxicity symptoms,H_(2)O_(2) changed its distribution to the meristem and differentiation ***,adventitious roots had comparable H_(2)O_(2) distribution patterns in untreated plants and those exposed to Cr(VI)***,differential H_(2)O_(2) distribution correlates with the resistance of adventitious roots,but not primary roots,to dichromate and underlies cell reorganization at the apex to support growth.

关键词： Chromate hydrogen peroxide root growth meristem ion toxicity adaptation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Tutorial on Federated Learning from Theory to Practice:Foundations,Software Frameworks,Exemplary Use Cases,and Selected Trends

引用

IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 824-850页

作者： M.Victoria Luzón Nuria Rodríguez-Barroso Alberto Argente-Garrido Daniel Jiménez-López Jose M.Moyano Javier Del Ser Weiping Ding francisco herrera Department of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School of Information Science and Technology Nantong UniversityNantong 226019China

When data privacy is imposed as a necessity,Federated learning(FL)emerges as a relevant artificial intelligence field for developing machine learning(ML)models in a distributed and decentralized *** allows ML models to be trained on local devices without any need for centralized data transfer,thereby reducing both the exposure of sensitive data and the possibility of data interception by malicious third *** paradigm has gained momentum in the last few years,spurred by the plethora of real-world applications that have leveraged its ability to improve the efficiency of distributed learning and to accommodate numerous participants with their data *** virtue of FL,models can be learned from all such distributed data sources while preserving data *** aim of this paper is to provide a practical tutorial on FL,including a short methodology and a systematic analysis of existing software ***,our tutorial provides exemplary cases of study from three complementary perspectives:i)Foundations of FL,describing the main components of FL,from key elements to FL categories;ii)Implementation guidelines and exemplary cases of study,by systematically examining the functionalities provided by existing software frameworks for FL deployment,devising a methodology to design a FL scenario,and providing exemplary cases of study with source code for different ML approaches;and iii)Trends,shortly reviewing a non-exhaustive list of research directions that are under active investigation in the current FL *** ultimate purpose of this work is to establish itself as a referential work for researchers,developers,and data scientists willing to explore the capabilities of FL in practical applications.

关键词： Data privacy distributed machine learning federated learning software frameworks

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Local Changes in Chromatin Accessibility and Transcriptional Networks Underlying the Nitrate Response in Arabidopsis Roots

引用

Molecular Plant 2019年第12期12卷 1545-1560页

作者： Jose M.Alvarez Tomas C.Moyano Tao Zhang Diana E.Gras francisco J.herrera Viviana Araus Jose AQ'Brien Laura Carrillo Joaquin Medina Jesus Vicente-Carbajosa Jiming Jiang Rodrigo A.Gutierrez Pontificia Universidad Catolica de Chile SantiagoChile Yangzhou University YangzhouChina Instituto de Agrobiotecnologia del Litoral CONICETSanta FeArgentina University of California BerkeleyCAUSA Trancura Biosciences Inc.San FranciscoCA 94158USA Centro de Biotecnología y Genómica de Plantas(CBGP UPM-INIA)Universidad Politecnica de Madrid(UPM)Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA)Campus de Montegancedo28223-Pozuelo de AlarcóMadridSpain Department of Horticulture University of Wisconsin-MadisonMadisonWI 53706USA Department of Plant Biology and Horticulture Michigan State UniversityMI 48824USA

Transcriptional regulation,determined by the chromatin structure and regulatory elements interacting at pro-moter regions,is a key step in plant responses to environmental ***(NO3-)is a nutrient signal that regulates the expression of hundreds of genes in Arabidopsis ***,we integrate mRNA sequencing,genome-wide RNA polymeraseⅡ(RNPⅡ),chromatin immunoprecipitation sequencing,and DNase Sequencing datasets to establish the relationship between RNPⅡoccupancy and chromatin accessibility in response to NO3-treatments in Arabidopsis *** footprinting allowed us to identify in vivo regula-tory elements controlling gene expression in response to ***3--modulated transcription factor(TF)footprints are important for a rapid increase in RNPⅡoccupancy and transcript accumulation over *** mapped key TF regulatory interactions and functionally validated the role of NAP,an NAC-domain containing TF,as a new regulatory factor in *** together,our study provides a comprehensive view of transcriptional networks in response to a nutrient signal in Arabidopsis roots.

关键词： nitrate transcriptional regulation footprinting RNA polymeraseⅡ regulatory networks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

非住院患者手术后转归评估方法的系统回顾

引用

麻醉与镇痛 2008年第4期4卷 69-75页

作者： francisco J. herrera Jean Wong Frances Chung 韩梅(译) 高梅(译) 钱燕宁(校) Department of Anesthesia Toronto Western Hospital University Health Network University of Toronto Toronto Ontario 不详

背景鉴于非住院手术的死亡率和并发症发生率都很低，因此应该将患者的生活质量（比如出院后恢复日常活动的能力）作为非住院手术和麻醉的终极评估指标。本文对非住院患者手术后恢复质量的各种评估方法进行了系统回顾，旨在为科研和麻醉... 详细信息

背景鉴于非住院手术的死亡率和并发症发生率都很低，因此应该将患者的生活质量（比如出院后恢复日常活动的能力）作为非住院手术和麻醉的终极评估指标。本文对非住院患者手术后恢复质量的各种评估方法进行了系统回顾，旨在为科研和麻醉质量控制评估方法的恰当选择提供指导。方法由MEDLINE，EMBASE，CINAHL，HAPI，PsyclNFO，科学探索史网站，Biosys Previews Search，Health Star和ASSIA数据库中系统检索文献，筛选出有关评估非住院患者手术和麻醉后恢复情况与转归的文献。从适宜性、可靠性、有效性、应答性、准确性、可解释性、可接受性和可行性8个方面对这些文献进行评估。结果有7篇文献符合本综述的入选标准。各评估方法的质量不尽相同。结论只有一种评价方法，即40项手术后恢复质量评分表，能够完全符合8个方面的要求，但是该方法并非专门为非住院手术和麻醉所设计。

关键词：手术后转归非住院患者评估方法系统回顾非住院手术 MEDLINE 手术后恢复生活质量

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

引用

Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

引用

Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

引用

Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

WHICH IS THE USE OF SYSTEMS THEORY IN LITERATURE ANALYSIS？： THE DISCOVERY OF THE PLACE IN LA MANCHA IN DON QUIXOTE

引用

Journal of Systems Science and Systems Engineering 2017年第4期26卷 517-530页

作者： francisco Parra-Luna Complutense University of Madrid Yucatan 26 28231 Las Rozas Spain

The use of systems theory to attempt to determine which ＂place in La Mancha＂ was the one whose name Cervantes could not quite recall in his universal novel, appears to be ordained to change certain attitudes towards science held in Cervanfine literature. The reason： after four centuries of literary analysis, systemic methodology has proven able to identify the famous ＂place＂ with acceptable accuracy. Nonetheless, certain reasonable doubts persist around the suitability of a strictly scientific analysis of literature. In light of those doubts, the present article aims primarily to facilitate critique both of the systemic approach adopted and its outcome.

关键词： Don Quixote place in La Mancha systems theory epistemological totality determinantvariables

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evolution of the 3.65-2.58 Ga Mairi Gneiss Complex,Brazil:Implications for growth of the continental crust in the São francisco Craton

引用

Geoscience Frontiers 2022年第5期13卷 110-128页

作者： Igor de Camargo Moreira Elson Paiva Oliveira Daniel francisco Martins de Sousa Institute of Geosciences University of Campinas(UNICAMP)CampinasSPBrazil

The composition and formation of the Earth’s primitive continental crust and mantle differentiation are key issues to understand and reconstruct the geodynamic terrestrial evolution,especially during the ***,the scarcity of exposure to these rocks,the complexity of lithological relationships,and the high degree of superimposed deformation,especially with long-lived magmatism,make it difficult to study ancient *** this complexity,exposures of the Archean Mairi Gneiss Complex basement unit in the São francisco Craton offer important information about the evolution of South America’s primitive ***,here we present field relationships,LA-ICP-SFMS zircon U-Pb ages,and LA-ICP-MCMS Lu-Hf isotope data for the recently identified Eoarchean to Neoarchean gneisses of the Mairi *** Complex is composed of massive and banded gneisses with mafic members ranging from dioritic to tonalitic,and felsic members ranging from TTG(Tonalite-Trondhjemite-Granodiorite)to granitic *** new data point to several magmatic episodes in the formation of the Mairi Gneiss Complex:Eoarchean(ca.3.65–3.60 Ga),early Paleoarchean(ca.3.55–3.52 Ga),middle-late Paleoarchean(ca.3.49–3.33 Ga)and Neoarchean(ca.2.74–2.58 Ga),with no records of Mesoarchean ***-Hf data unveiled a progressive evolution of mantle differentiation and crustal recycling over *** the Eoarchean,rocks are probably formed by the interaction between the pre-existing crust and juvenile contribution from chondritic to weakly depleted mantle sources,whereas mantle depletion played a role in the Paleoarchean,followed by greater differentiation of the crust with thickening and recycling in the middle–late Paleoarchean.A different stage of crustal growth and recycling dominated the Neoarchean,probably owing to the thickening of the continental crust by collision,continental arc growth,and mantle differentiation.

关键词： São francisco Craton Mairi Gneiss Complex Primitive continental crust Zircon U-Pb dating Lu-Hf isotope geochemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

引用

World Journal of Clinical Cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas francisco Pozo Muñoz Rogelio Garcia Cisneros Maria Jose Garcia Larrosa Maria del Mar Callejon Gil Ignacio Garcia Delgado Maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：