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New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target?

Neural Regeneration Research 2020年第9期15卷 1580-1589页

作者： Carlos González-Fernández Pau González francisco javier rodríguez Laboratory of Molecular Neurology Hospital Nacional de Parapléjicos (HNP)

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degeneration, which leads to progressive paralysis of skeletal muscles and, ultimately, respiratory failure between 2–5 years after symptom onset. Unfortunately, currently accepted treatments for amyotrophic lateral sclerosis are extremely scarce and only provide modest benefit. As a consequence, a great effort is being done by the scientific community in order to achieve a better understanding of the different molecular and cellular processes that influence the progression and/or outcome of this neuropathological condition and, therefore, unravel new potential targets for therapeutic intervention. Interestingly, a growing number of experimental evidences have recently shown that, besides its well-known physiological roles in the developing and adult central nervous system, the Wnt family of proteins is involved in different neuropathologica conditions, including amyotrophic lateral sclerosis. These proteins are able to modulate, at least, three different signaling pathways, usually known as canonical(β-catenin dependent) and non-canonical(β-catenin independent) signaling pathways. In the present review, we aim to provide a general overview of the current knowledge that supports the relationship between the Wnt family of proteins and its associated signaling pathways and amyotrophic lateral sclerosis pathology, as well as their possible mechanisms of action. Altogether, the currently available knowledge suggests that Wnt signaling modulation might be a promising therapeutic approach to ameliorate the histopathological and functional deficits associated to amyotrophic lateral sclerosis, and thus improve the progression and outcome of this neuropathology.

关键词： ALS astrocytes Frizzled human microglia motor neuron neurodegeneration neuroinflammation spinal cord Wnt

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Study of an Ionic Fluid on the Electrochemical Test of A36 Carbon Steel Ingot

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Journal of Materials Science and Chemical Engineering 2022年第2期10卷 29-43页

作者： Socorro Valdez rodriguez Martin Ignacio Pech-Canul Hugo Rojas Oscar Sotelo francisco javier rodríguez Araceli Espinoza-Vazquez Ociel rodríguez Instituto de Ciencias Físicas-UNAM Cuernavaca Morelos México Centro de investigación y de Estudios Avanzadas del Instituto Politécnico Nacional Civestav-Saltillo Coahuila México Facultad de Ciencias Químicas e Ingeniería-UAEM Morelos México Departamento de Ingeniería Metalúrgica Facultad de Química-UNAM Ciudad de México México

An ionic fluid based on aromatic heterocyclic family constituted by 1,3-diazole groups was investigated. The purpose is to describe their electrochemical characteristics in order to identify the strategy to avoid the A36 carbon steel surface degradation by using electrochemical measurements. We found that the linear polarization resistance reveals an increasing value when the organic unsaturated cyclic ionic fluid was added to the corrosive electrolyte. The polarization curves and Tafel Extrapolation obtained to know the slopes tafel and the inhibitor efficiency from current density (icorr) shows a high efficiency inhibition value.

关键词： A36-Steel Ionic Fluid Electrochemical Degradation Tafel Extrapolation Linear Polarization Resistance Diazole Group Organic Inhibitor

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A Tutorial on Federated Learning from Theory to Practice:Foundations,Software Frameworks,Exemplary Use Cases,and Selected Trends

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 824-850页

作者： M.Victoria Luzón Nuria rodríguez-Barroso Alberto Argente-Garrido Daniel Jiménez-López Jose M.Moyano javier Del Ser Weiping Ding francisco Herrera Department of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School of Information Science and Technology Nantong UniversityNantong 226019China

When data privacy is imposed as a necessity,Federated learning(FL)emerges as a relevant artificial intelligence field for developing machine learning(ML)models in a distributed and decentralized *** allows ML models to be trained on local devices without any need for centralized data transfer,thereby reducing both the exposure of sensitive data and the possibility of data interception by malicious third *** paradigm has gained momentum in the last few years,spurred by the plethora of real-world applications that have leveraged its ability to improve the efficiency of distributed learning and to accommodate numerous participants with their data *** virtue of FL,models can be learned from all such distributed data sources while preserving data *** aim of this paper is to provide a practical tutorial on FL,including a short methodology and a systematic analysis of existing software ***,our tutorial provides exemplary cases of study from three complementary perspectives:i)Foundations of FL,describing the main components of FL,from key elements to FL categories;ii)Implementation guidelines and exemplary cases of study,by systematically examining the functionalities provided by existing software frameworks for FL deployment,devising a methodology to design a FL scenario,and providing exemplary cases of study with source code for different ML approaches;and iii)Trends,shortly reviewing a non-exhaustive list of research directions that are under active investigation in the current FL *** ultimate purpose of this work is to establish itself as a referential work for researchers,developers,and data scientists willing to explore the capabilities of FL in practical applications.

关键词： Data privacy distributed machine learning federated learning software frameworks

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Kfz.385油罐车

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模型世界 2018年第2期 79-81页

作者： francisco javier Martínez rodríguez

这款模型的板件是一款意大利(ITALERI)的老产品了(货号6467.1/35比例),但是适当的进行改造并添加细节后的效果依然非常不错。1我选用了Hauler出品的蚀刻片改件(货号HLU35038)来搭配这套板件。在组装前我先在蚀刻片表面上涂抹了一层AK15... 详细信息

这款模型的板件是一款意大利(ITALERI)的老产品了(货号6467.1/35比例),但是适当的进行改造并添加细节后的效果依然非常不错。1我选用了Hauler出品的蚀刻片改件(货号HLU35038)来搭配这套板件。在组装前我先在蚀刻片表面上涂抹了一层AK159金属锈蚀液,从而可以让蚀刻片表面变暗,并且让质感更像是真实的暗色钢制表面。我非常建议在使用任何蚀刻片时候都配合这款溶媒液,因为他同时还可以让漆在蚀刻片表面上有更好的附着力,同时粘贴起来也更方便。

关键词：油罐车油画颜料 Kfz.385 库尔斯克 AK

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The challenging management of malignant ureteral obstruction:Analysis of a series of 188 cases

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Current Urology 2024年第1期18卷 34-42页

作者： Alberto Artiles Medina Inés Laso García Fernando González Tello Sara Álvarez rodríguez Manuel Hevia Palacios Marina Mata Alcaraz César Mínguez Ojeda Fernando Arias Funez Victoria Gómez Dos Santos francisco javier Burgos Revilla Department of Urology Hospital Universitario Ramón y CajalMadridSpain Department of Radiology Hospital Universitario Ramón y CajalMadridSpain

Background:Malignant ureteral obstruction(MUO)is a common condition that complicates the course of advanced *** aims of this study are to analyze the causes,management,and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic ***,we studied the complications and outcomes in patients who underwent urinary *** and methods:A retrospective study was conducted on patients with computed tomography-confirmed MUO between January 2016 and November ***,clinical,radiological,laboratory,and management data were *** curves were estimated using the Kaplan-Meier method,and univariate and multivariate Cox proportional hazards models were used to test the association between parameters and ***:A total of 188 patients were *** mean age was 69.01 years(SD,14.95 years),and the majority(54.8%)were *** most common mechanism leading to MUO was compression by a pelvic mass(36.9%),and the 3 most frequent tumors causing MUO were prostate(17.6%),bladder(16.5%),and rectal cancer(11.7%).Forty-seven patients(25%)underwent urinary diversion:23(48.9%)underwent double-J stenting and 21(44.7%)underwent percutaneous *** most common reason for urinary diversion was acute kidney injury(53.3%).Recovery of renal function was observed in 55.8%of the patients after urinary *** most frequently identified complications after urinary diversion were urinary tract infection(24.4%),hematuria(17.0%),and urinary sepsis(14.9%).The median survival after hydronephrosis diagnosis was 6.43 months(interquartile range,1.91-14.81 months).In patients who underwent urinary decompression,the median survival after urinary diversion was 8.67 months(interquartile range,2.99-17.28 months).In the multivariate analysis,a lower grade of hydronephrosis and cancer cachexia negatively impacted ***:Cancer patients with MUO have a poor pro

关键词： Hydronephrosis Ureteral obstruction Neoplasms Urinary diversion Survival Prognosis

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Vertical Displacement Measurement in a Slow-Moving Sinkhole Using BOTDA

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Photonic Sensors 2024年第1期14卷 23-39页

作者： Pascual SEVILLANO javier PRECIADO-GARBAYO Jorge SEVIL francisco GUTIERREZ Juan JMARTiNEZ Sonia MARTiN-LOPEZ Miguel GONZALEZ-HERRAEZ Aragon Institute of Engineering Research(I3A) Universidad de ZaragozaZaragoza 50018Spain Electronic Enginering and Communicaton Dpartment EINAUniversidad de ZaragzaZaragza 50018Spain Aragon Photonics Labs. Zaragoza 50009Spain Department of Earth Sciences Universidad de ZaragozaZaragoza 50009Spain Department of Electronics Escuela Politecnica SuperiorUniversidad de AlcalaMadrid 28805Spain

The effectiveness of monitoring and early-warning systems for ground deformation phenomena,such as sinkholes,depends on their ability to accurately resolve the ongoing ground displacement and detect the subtle deformation preceding catastrophic *** sinkholes with a slow subsidence rate and diffuse edges pose a significant challenge for subsidence monitoring due to the low deformation rates and limited lateral strain *** this work,we satisfactorily illustrate the practicality of the Brillouin optical time domain analysis(BOTDA)to measure the spatial-temporal patterns of the vertical displacement in such challenging slow-moving sagging *** assess the performance of the approach,we compare the strain recorded by the distributed optical fiber sensor with the vertical displacement measured by high-precision *** results show a good spatial correlation with the ability to identify the maximum subsidence *** is also a good temporal correlation with the detection of an acceleration phase in the subsidence associated with a flood event.

关键词： Distributed fiber optic sensing(DFOS) vertical displacement measurement slow subsidence rate sinkhole hazard early-warning system

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The 2<sup>nd</sup>Step by Step International Spinal Cord Repair—Combining research Step by Step into multi-pronged approaches for spinal cord repair

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Journal of Biomedical Science and Engineering 2013年第7期6卷 21-32页

作者： Maria Teresa Moreno-Flores Francois Ferón Victor Arvanian Armin Blesch Armin Curt David J. Fink Marina Mata Kinichi Nakashima Xavier Navarro francisco javier rodríguez Michal Schwartz Mikael Svensson Erik Sundstrom Joan Romero Filip Lim Department of Biotechnology University Francisco de Vitoria Pozuelo de Alarcón Spain Department of Cell Biology Physiology and Immunology University Autonoma de Barcelona Barcelona Spain Department of Medicine University Hospital Balgrist Zurich Switzerland Department of Molecular Biology University Autónoma de Madrid Madrid Spain Department of Neurobiology Care Sciences and Society Karolinska Institute Stockholm Sweden Department of Neurobiology Weizmann Institute of Science Rehovot Israel Department of Neurology University of Michigan Ann Arbor USA Department of Stem Cell Biology and Medicine Kyushu University Fukuoka Japan Faculty of Medicine Aix Marseille University Marseille France National Paraplegics Hospital Toledo Spain Northport Veterans Affairs Medical Center Northport USA Spinal Cord Injury Center University Hospital Heidelberg Germany Step by Step Foundation Barcelona Spain

On April 26-27, 2013, the Step by Step Foundation hosted the Second International Spinal Cord Repair Meeting at the Fira Barcelona Convention Center in Hospitalet de Llobregat, Spain, highlighting some of the exciting research including clinical trials which show promise for treatments for this devastating disorder. This meeting brought together clinicians, clinical scientists and molecular biologists from more than 10 countries to evaluate current knowledge on clinical, cellular, and biomolecular aspects of spinal cord injury. A major goal of the conference in advancing the translation of research data to the clinic was to promote multi-pronged approaches for therapy of this complex problem.

关键词： Spinal Cord Injury Immunomodulation Glial Scar Nerve Grafts Neurotrophins Neural Stem Cells Electromagnetic Stimulation HSV-1 Vectors Cholecalciferol Vitamin D3 Wnt Proteins Neuroregeneration

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Microfluidic bubble-generator enables digital light processing 3D printing of porous structures

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Aggregate 2024年第1期5卷 280-291页

作者： Philipp Weber Ling Cai francisco javier Aguilar Rojas Carlos Ezio Garciamendez-Mijares Maria Celeste Tirelli Francesco Nalin Jakub Jaroszewicz Wojciech Swi eszkowski Marco Costantini Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMassachusettsUSA Institute of Physical Chemistry—Polish Academy of Sciences KasprzakaPoland Biomaterials Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWoloskaPoland

Three-dimensional(3D)printing is an emerging technique that has shown promising success in engineering human tissues in recent *** development of vatphotopolymerization printing modalities has significantly enhanced the complexity level for 3D printing of various functional structures and ***,the development of microfluidic chip systems is an emerging research sector with promising medical *** work demonstrates the coupling of a digital light processing(DLP)printing procedure with a microfluidic chip system to produce size-tunable,3D-printable porosities with narrow pore size distributions within a gelatin methacryloyl(GelMA)hydrogel *** is found that the generation of size-tunable gas bubbles trapped within an aqueous GelMA hydrogel-precursor can be controlled with high ***,the porosities are printed in two-dimensional(2D)as well as in 3D using the DLP *** addition,the cytocompatibility of the printed porous scaffolds is investigated using fibroblasts,where high cell viabilities as well as cell proliferation,spreading,and migration are *** is anticipated that the strategy is widely applicable in a range of application areas such as tissue engineering and regenerative medicine,among others.

关键词： 3D printing biofabrication bubble digital light processing microfluidics porous

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Highly graphitized carbon nanosheets with embedded Ni nanocrystals as anode for Li-ion batteries

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Nano Research 2020年第1期13卷 86-94页

作者： francisco javier Soler-Piña Celia Hernández-Rentero Alvaro Caballero Julián Morales Enrique rodríguez-Castellón Jesús Canales-Vázquez Dpto.Química Inorgánica e Ingeniería Química Instituto de Química Fina y NanoquímicaUniversidad de Córdoba14071CórdobaSpain Dpto.Química Inorgánica Cristalografía y MineralogíaFacultad de CienciasUniversidad de Málaga29071MálagaSpain Instituto de Energías Renovables Universidad de Castilla-La ManchaPaseo de La Investigación 102071AlbaceteSpain

A C/Ni composite was prepared via thermal decomposition of a nickel oleate complex at 700℃,yielding disperse Ni nanocrystals with an average size of 20 nm,encapsulated by carbon nanosheets as deduced from transmission electron microscopy(TEM)images and confirmed from X-ray photoelectron spectroscopy(XPS).Furthermore,the X-ray diffraction pattern revealed a good ordering of the carbon layers,forced by the Ni encapsulation to adopt a bending *** the close interaction between the graphitized framework and the metallic nanoparticles we have studied the properties of the composite as an anode for Li-ion *** with other nanostructured synthetic carbons,this carbon composite has a low voltage hysteresis and a modest irreversible capacity value,properties that play a significant role in its behaviour as electrodes in full cell *** moderate rate values,0.25 C,the electrode delivers an average capacity value around 723 mAh·g^−1 on cycling,among the highest values so far reported for this carbon *** higher rate values,1 C,the average capacity values delivered by the cell on cycling decrease,around 205 mAh·g^−1,but it maintains good capacity retention,a coulombic efficiency close to 100%after the first cycles and recovery of the capacity values when the rate is restored from 3 to 0.1 C.

关键词： carbon nanosheets nickel nanoparticles anode lithium batteries

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Development and postnatal neurogenesis in the retina: a comparison between altricial and precocial bird species

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Neural Regeneration Research 2021年第1期16卷 16-20页

作者： Guadalupe Álvarez-Hernán José Antonio de Mera-rodríguez Yolanda Gañán Jorge Solana-Fajardo Gervasio Martín-Partido Joaquín rodríguez-León javier francisco-Morcillo Área de Biología Celular Departamento de AnatomíaBiología Celular y ZoologíaFacultad de CienciasUniversidad de ExtremaduraBadajozSpain Área de Anatomía Humana Departamento de AnatomíaBiología Celular y ZoologíaFacultad de MedicinaUniversidad de ExtremaduraBadajozSpain Servicio de Oftalmología Complejo Hospitalario Universitario de BadajozBadajozSpain

The visual system is affected by neurodegenerative diseases caused by the degeneration of specific retinal neurons,the leading cause of irreversible blindness in *** vertebrate phylogeny,the retina has two kinds of specialized niches of constitutive neurogenesis:the retinal progenitors located in the circumferential marginal zone and Müller *** proliferative activity in the retinal progenitors located in the circumferential marginal zone in precocial birds such as the chicken,the commonest bird model used in developmental and regenerative studies,is very *** region adds only a few retinal cells to the peripheral edge of the retina during several months after hatching,but does not seem to be involved in retinal regeneration.Müller cells in the chicken retina are not proliferative under physiological conditions,but after acute damage some of them undergo a reprogramming event,dedifferentiating into retinal stem cells and generating new retinal ***,regenerative response after injury occurs with low efficiency in the precocial avian *** contrast,it has recently been shown that neurogenesis is intense in the retina of altricial birds at *** particular,abundant proliferative activity is detected both in the circumferential marginal zone and in the outer half of the inner nuclear ***,stem cell niches are very active in the retina of altricial *** more extensive research is needed to assess the potential of proliferating cells in the adult retina of altricial birds,it emerges as an attractive model for studying different aspects of neurogenesis and neural regeneration in vertebrates.

关键词： altricial birds circumferential marginal zone Müller glia postnatal neurogenesis precocial regeneration retinogenesis

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