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mRnA levels of TLR4 and TLR5 are independent of H pylori

World Journal of Gastroenterology 2008年第34期14卷 5306-5310页

作者： Elvira Garza-González Virgilio Bocanegra-garcía francisco javier Bosques-Padilla Juan Pablo Flores-Gutiérrez francisco Moreno Guillermo Ignacio Perez-Perez departmento de Microbiología Facultad de MedicinaUniversidad Autónoma de Nuevo León departmento de Biología Molecular y Bioingeniería UAM Reynosa Aztlán Universidad Autónoma de Tamaulipas Hospital Universitario "Dr. José Eleuterio González" Universidad Autónoma de Nuevo León department of Medicine and Microbiology New York University School of Medicine

AIM:To determine if the presence H pylori or its viru- lence affect toll-like receptor 4 (TLR4) and TLR5 mRnA expression levels. METHODS:For the in vivo assays, gastric biopsies were obtained from 40 patients and H pylori status was determined. For the in vitro assays, human gastric adenocarcinoma mucosal cells (AGS) were cultured in the presence or absence of twelve selected H pylori strains. H pylori strains isolated from culture-positive patients and selected strains were genotyped for cagA and vacA. The cDnA was obtained from mRnA extracted from biopsies and from infected AGS cells. TLR4 and TLR5 mRnA levels were examined by real-time PCR. RESULTS: The presence of H pylori did not affect the mRnA levels of TLR4 or TLR5 in gastric biopsies. The mRnA levels of both receptors were not influenced by the vacA status (P > 0.05 for both receptors) andthere were no differences in TLR4 or TLR5 mRnA levels among the different clinical presentations/histological fi ndings (P > 0.05). In the in vitro assay, the mRnA levels of TLR4 or TLR5 in AGS cells were not influenced by the vacAs1 status or the clinical condition as-sociated with the strains (P > 0.05 for both TLR4 and TLR5). COnCLUSIOn: The results of this study show that the mRnA levels of TLR4 and TLR5 in gastric cells, both in vivo and in vitro, are independent of H pylori colonization and suggest that vacA may not be a significant player in the first step of innate immune recognition mediated by TLR4 or TLR5.

关键词：幽门杆菌 TLR4 TLR5 胃腺癌黏膜细胞 mRnA

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Enduring association between irritable bowel syndrome and war trauma during the nicaragua civil war period:A population-based study

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World Journal of Gastroenterology 2023年第45期29卷 5953-5961页

作者： Edgar M Peña-Galo Daniel Wurzelmann javier Alcedo Rodolfo Peña Loreto Cortes Douglas Morgan department of Digestive Diseases Miguel Servet University HospitalZaragoza 50009AragonSpain javier Alcedo Aragon Health Research InstituteIIS AragonZaragoza 50009AragonSpain department of Mental Health Carolina PartnersDurhamNC 27707United States department of Data Analysis CIDE(ResearchDevelopment and Epidemiology Center)Tegucigalpa 11101Francisco MorazánHonduras School of Medicine National Autonomous University of NicaraguaLeon 21000LeonNicaragua department of Gastroenterology and Hepatology UAB University of Alabama BirminghamBirminghamAL 35233United States School of Medcine The University of North CarolinaChapel HillNC 9500United States

BACKGROUnD Psychosocial and physical trauma are known risk factors for irritable bowel syndrome(IBS),including in war veterans,whereas war exposure in civilians is *** experienced two wars,1970-1990:The Sandinistas Revolution(1970s)and The Contra War(1980s).Our aim was to investigate the role of exposure to war trauma in the subsequent development of IBS in the context of an established health surveillance system(11000 households).AIM To investigate in a civilian population the relationship between exposure to war trauma and events and the subsequent development of IBS in the context of an established public health and demographic surveillance system in western *** We conducted a nested population-based,cross-sectional study focused on functional gastrointestinal disorders based on Rome II criteria.1617 adults were randomly *** Spanish Rome II Modular Questionnaire and Harvard Trauma Questionnaire were validated in *** exposure was assessed with 10 measures of direct and indirect war trauma and post-war *** exposures were defined by≥3 *** The prevalence of IBS was 15.2%[Female(F)17.1%,Male(M)12.0%],war exposure 19.3%(F 9.3%,M 36.7%),and post-traumatic stress disorder(PTSD)5.6%(F 6.4%,M 4.3%).Significant associations with IBS in the civilian population were observed(adjusted by gender,age,socioeconomic status,education):physical and psychological abuse[adjusted odds ratio(aOR):2.25;95%confidence interval:1.1-4.5],witnessed execution(aOR:2.4;1.1-5.2),family member death(aOR:2.2;1.2-4.2),and multiple exposures(aOR:2.7;1.4-5.1).PTSD was independently associated with IBS(aOR:2.6;1.2-5.7).COnCLUSIOn An enduring association was observed in the nicaragua civilian population between specific civil war-related events and subsequent *** populations in regions with extended armed conflict may warrant provider education and targeted interventions for patients.

关键词： Irritable bowel syndrome Functional gastrointestinal disorders War trauma Civil war Post-traumatic stress disorder Central America

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Role of microRnAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2018年第36期24卷 4104-4118页

作者： Jorge-Luis Torres Ignacio novo-Veleiro Laura Manzanedo Lucía Alvela-Suárez Ronald Macías francisco-javier Laso Miguel Marcos department of Internal Medicine University Hospital of SalamancaInstitute of Biomedical Research of Salamanca-IBSAL Spanish Working Group on Alcohol and Alcoholism Spanish Society of Internal Medicine department of Internal Medicine University Hospital of Santiago de Compostela department of Internal Medicine HM Rosaleda HospitalSantiago de Compostela department of Medicine Faculty of MedicineUniversity of Salamanca

MicroRnAs(miRnAs) are small non-coding RnAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRnAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRnAsin alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(nAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRnAs in liver disease. In addition, the potential use of miRnAs as biomarkers and/or therapeutic targets is discussed. Among all miRnAs analyzed, miR-34 a, miR-122 and miR-155 are most involved in the pathogenesis of nAFLD. Of note, these three miRnAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRnAs. Currently, no single miRnA or panel of miRnAs has been identified for the detection of, or staging of ALD or nAFLD. While promising results have been shown in murine models, no therapeutic based-miRnA agents have been developed for use in humans with liver disease.

关键词： Alcohol use disorder Alcoholic liver disease non-alcoholic fatty liver disease Steatosis Obesity miRnA Biomarkers

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Promising diagnostic biomarkers of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: From clinical proteomics to microbiome

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World Journal of Hepatology 2021年第11期13卷 1494-1511页

作者： Carolina Castillo-Castro Alexandro JoséMartagón-Rosado Rocio Ortiz-Lopez Luis Felipe Garrido-Treviño Melissa Villegas-Albo francisco javier Bosques-Padilla Tecnológico de Monterrey Escuela de Medicina y Ciencias de la SaludMonterrey 64710Mexico Unidad de Investigación de Enfermedades Metabólicas Instituto Nacional de Ciencias Médicas y NutriciónCiudad de México 14080Mexico Centro Regional para el Estudio de las Enfermedades Digestivas Servicio de GastroenterologíaFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezUniversidad Autónoma de Nuevo LeónMonterrey 64460Mexico

Fatty liver has been present in the lives of patients and physicians for almost two *** knowledge has been generated regarding its etiology and consequences,although a long path seeking novel and innovative diagnostic biomarkers for nonalcoholic fatty liver disease(nAFLD)and nonalcoholic steatohepatitis(nASH)is still *** the one hand,proteomics and lipidomics have emerged as potential noninvasive resources for nAFLD *** contrast,metabolomics has been able to distinguish between nAFLD and nASH,even detecting degrees of *** the other hand,genetic and epigenetic markers have been useful in monitoring disease progression,eventually functioning as target *** markers involved in immune dysregulation,oxidative stress,and inflammation are involved in the instauration and evolution of the ***,the fascinating gut microbiome is significantly involved in nAFLD and *** review presents state-of-the-art biomarkers related to nAFLD and nASH and new promises that could eventually be positioned as diagnostic resources for this *** is evident,despite great advances in studying these biomarkers,there is still a long path before they translate into clinical benefits.

关键词： Fatty liver Biomarkers nonalcoholic fatty liver disease nonalcoholic steatohepatitis

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SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2322-2331页

作者： Xavier Palomer MSilvia Román-Azcona javier Pizarro-delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer Jfrancisco nistal Raquel garcía Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera department of Pharmacology Toxicology and Therapeutic ChemistryIBUB(Institut de Biomedicina de la Universitat de Barcelona)Research Institute-Pediatric Research InstituteHospital Sant Joan de Déuand CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelonaSpain department of Biochemistry and Molecular Biomedicine IBUB and CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN)Faculty of BiologyUniversity of BarcelonaBarcelonaSpain aBCnatal-Barcelona Center for Maternal–Fetal and neonatal Medicine(Hospital Clínic and Hospital Sant Joan de deu) Institut d’Investigacions Biomèdiques August Pi i SunyerUniversitat de Barcelonaand Center for Biomedical Research on Rare Diseases(CIBER-ER)BarcelonaSpain Genomic Programming of Betacells Laboratory Institut d’Investigacions August Pi i Sunyer(IDIBAPS)and CIBERDEMBarcelonaSpain Section of Epigenomics and Disease Department of Medicineand National Institute for Health Research(NIHR)Imperial Biomedical Research CentreImperial College LondonLondonUK Servicio de Cirugía Cardiovascular Hospital Universitario Marqués de ValdecillaDepartamento de Ciencias Médicas y QuirúrgicasFacultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)Centro de Investigación Biomédica en Red Cardiovascular(CIBERCV)Instituto de Salud Carlos IIISantanderSpain departamento de Fisiología y Farmacología Facultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)SantanderSpain department of Radiation Oncology Columbia UniversityNew YorkNYUSA

Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative *** of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac *** this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 ***3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of *** with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TnF-α.notably,these effects were associated with a decrease in the mRnA and protein levels of FOS and the DnA-binding activity of ***,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its *** findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 *** fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases.

关键词： SIRT3 inflammation cardiac

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COVID-19 pandemic,as experienced in the surgical service of a district hospital in Spain

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World Journal of Clinical Cases 2021年第23期9卷 6582-6590页

作者： francisco javier Pérez Lara Maria Belen Jimenez Martinez francisco Pozo Muñoz Andres Fontalba navas Rogelio garcia Cisneros Maria Jose garcia Larrosa Ignacio garcia delgado Maria del Mar Callejon Gil department of Surgery Hopital de AntequeraAntequera 29200MálagaSpain north Malaga Healthcare District Hopital de AntequeraAntequera 29200MálagaSpain

The coronavirus disease 2019,which is caused by severe acute respiratory syndrome coronavirus 2,was first identified in december 2019 in Wuhan,China,and has since spread rapidly,evolving into a full-blown *** would like to report our experience after 1 year of this pandemic in the surgical service of a district hospital in *** have been many changes(including new protocols)that our service and the hospital have undergone,to adapt to the new *** believe that this experience can be useful for other professionals who have lived and are living a similar situation.

关键词： COVID-19 Hospital Experience Surgery Service Treatment

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<i>Ab Initio</i>Molecular Orbital Calculation for Optical and Electronic Properties Evaluation of Small and Medium Size Silicon nano-Clusters Found in Silicon Rich Oxide Films

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Journal of Modern Physics 2013年第11期4卷 1-26页

作者： néstor David Espinosa Torres José francisco javier Flores Gracia José Alberto Luna López Juan Carlos Ramírez garcía Alfredo Morales Sánchez José Luis Sosa Sánchez David Hernández de la Luz francisco Morales Morales Research Center for Advanced Materials S.C. Unit Monterrey-PIIT Apodaca México Research Center for Semiconductor devices CIDS-ICUAP-BUAP Puebla México The Faculty of Chemical Sciences BUAP Puebla México

In systems in atomic and nano scales such as clusters or agglomerates constituted of particles from a few to less than one hundred of atoms, quantum confinement effects are very important. Their optical and electronic properties are often dependent on the size of the systems and the way in which the atoms in these clusters are bonded. Generally, these nano-structures display optical and electronic properties significantly different of those found in corresponding bulk materials. Silicon agglomerates found in Silicon Rich Oxide (SRO) films have optical properties, which have reported as depended directly on nano-crystal size. Furthermore, the room temperature photoluminescence (PL) of Silicon Rich Oxides (SRO) has repeatedly generated a huge interest due to their possible applications in optoelectronic devices. However, a plausible emission mechanism has not yet widespread acceptance of the scientific community. In this research, we employed the density Functional Theory with a functional B3LYP and a basis set 6 - 31G* to calculate the optical and electronic properties of small (six to ten silicon atoms) and medium size clusters of silicon (constituted of eleven to fourteen silicon atoms). With the theoretical calculation of the structural and optical properties of silicon clusters, it is possible to evaluate the contribution of silicon agglomerates in the luminescent emission mechanism experimentally found in thin SRO films.

关键词： nano-Crystals Silicon Clusters Silicon-Rich Oxide Luminescence Magic-number

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Oral Pharmacokinetics of Mirodenafil in Mexican Healthy Volunteers

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Pharmacology & Pharmacy 2014年第1期5卷 112-116页

作者： Miriam del Carmen Carrasco-Portugal francisco javier Flores-Murrieta Juan Gerardo Reyes-garcía noemí Santos-Caballero Landsteiner Scientific S.A. de C.V. México DF México Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina Instituto Politécnico Nacional México DF México Unidad de Investigación en Farmacología Insituto Nacional de Enfermedades Respiratorias “Ismael Cosio Villegas” México DF México Unidad de Investigación en Farmacología Insituto Nacional de Enfermedades Respiratorias “Ismael Cosio Villegas” México DF México Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina Instituto Politécnico Nacional México DF México

Mirodenafil is a 5-phosphodiesterase inhibitor that is currently marketed in Korea for the treatment of erectile dysfunction;however, no information in other populations is available. It has been described that Mirodenafil is metabolized by CYP3A4, a metabolic pathway in which interethnic differences have been reported. The purpose of this study was to characterize the oral pharmacokinetics of Mirodenafil in Mexicans. Seventeen male healthy volunteers were enrolled in this study. After an overnight fast, volunteers received an oral 100 mg dose and blood samples were collected at selected times during 24 h. Plasma was stored frozen and analyzed by an HPLC method. Pharmacokinetic parameters obtained were: Cmax 331.129 ± 32.689 ng/mL, tmax 1.574 ± 0.293 h, AUC24h 883.293 ± 104.088 ng·h/mL, AUC￥ 976.477 ± 108.812 ng·h/mL and t1/2 1.807 ± 0.171 h. Parameter values observed in this study are similar to those reported in Koreans. Since efficacy and safety studies of Mirodenafil have been conducted in Koreans, it is expected that dosage regime to employ in Mexicans should be similar to the approved for Korean population.

关键词： Erectile Dysfunction Healthy Volunteers Mexican Mirodenafil Pharmacokinetic

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Minimum inhibitory but maximum non-hemolytic concentration of plasma-treated catheters coated with *** and *** extracts

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Plasma Science and Technology 2023年第12期25卷 83-96页

作者： francisco javier ALOnSO-MOnTEMAYOR Miriam desirée DÁVILA-MEDInA Alejandro ZUGASTI-CRUZ Rosa Idalia nARRO-CÉSPEdeS María Guadalupe nEIRA-VELÁZQUEZ AidéSÁEnZ-GALInDO Eduardo ALOnSO-CAMPOS Autonomous University of Coahuila Saltillo 25280Mexico Center for Research in Applied Chemistry Saltillo 25294Mexico University of Monterrey San Pedro Garza García 66238Mexico

Antibacterial extract-coated catheters are promising alternatives to their conventional counterparts,but their hemocompatibility and thermal stability must be *** bacteria have developed resistance to conventional ***,the minimum inhibitory but non-hemolytic concentration(MIC-nH)and the thermal stability of Larrea tridentata(***)and Origanum vulgare(***)extract-coated catheters were ***,plasma pretreatment was performed to enhance the extract ***,the extract-coated catheters prevent Staphylococcus aureus colonization without causing hemolysis by using *** and *** extracts at MIC-nH(5000 and 2500μg ml~(-1),respectively).Moreover,it has been discovered that the extract coating and plasma treatment improved the thermal stability and the extract adhesion,***,this study provides evidence of alternative antibacterial but non-hemolytic extract-coated catheters.

关键词： antibacterial activity biocompatibility blood-contact device cold plasma nosocomial bacteria

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Expeditious management plan towards digital earth

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International Journal of Digital Earth 2014年第8期7卷 635-649页

作者： naveen Kumar Sidda Aneta J.Florczyk francisco J.Lopez-Pellicer Dinesh Babu I.V Ruben Bejar F.javier Zarazaga-Soria department of Computer Science and System Engineering University of ZaragozaZaragozaSpain department of Wood Science forestry and GeomaticsUniversity LavalSainte-FoyQCCanada

The breakthrough developments in geospatial technologies and the increasing availability of spatial data make geoinformation a business and a decisional element to the ***,it is important to have a management plan to factor in practical and feasible data sources,in building geo *** authors of this paper are motivated by the fact that right data sources could outclass in-house resources in various application *** paper outlines pragmatic cases for the tangible benefits of the existing potential data and expeditious patterns for digital *** work also proposes‘good-enough’solutions based on the pragmatic cases,available literature,and the 3D city model developed that could be sufficient in contriving the objectives of the common public usage and open business *** demonstrate this approach,the paper encapsulated the low-cost development of virtual 3D city model using publicly available cadastral data and web services.

关键词： spatial data sources geo management web services APIs cadastral data

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