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Immediate and late effects of chronic stress in the testes of prepubertal and adult rats

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Asian journal of Andrology 2018年第4期20卷 385-390页

作者： Carina T Ribeiro Diogo B De Souza Waldemar S Costa francisco j B Sampaio Marco A Pereira-Sampaio Urogenital Research Unit State University of Rio de Janeiro Rio de Janeiro RJ 20551-030 Brazil Department of Morphology Fluminense Federal University Niteroi RJ 24210-150 Brazil

The objective of this study was to investigate the effects of chronic stress on the testes of prepubertal and adult rats and to evaluate whether any alterations could be reversed when stress induction is ended. Seventy-six male rats were assigned to eight groups depending on the type of treatment （control or stressed）, the age at which stress was initiated （prepubertal or adult）, and the time of evaluation （immediate or late）. Stress stimuli were applied for 6 weeks. Stressed prepubertal and adult rats evaluated immediately after the last stress stimulus were included in SP-I and SA-I groups, respectively. The late prepubertal （SP-L） and adult （SA-L） groups of stressed rats were evaluated 6 weeks after the last stress stimulus. Age-matched rats were used as controls （CP-I, CA-I, CP-L, and CA-L groups）. Application of stress stimuli to rats in the SP-I group resulted in body weight and seminiferous tubule diameter reduction. The rats in the SA-I group also showed several functional （testosterone level and sperm parameter） and morphological （testicular weight and seminiferous tubule diameter） reductions. The rats in the SP-L group showed increased body weight and intertubular compartment volumetric and absolute densities and reduced tubular compartment volumetric density. The rats in the SA-L group presented only reduced sperm viability. Stress stimuli promoted changes in the rats in all the study groups. The testes of the adult rats were the most affected by chronic stress. However, the stressed adult rats recovered well from the testicular alterations.

关键词： chronic stress morphometry rat testis

How to express tumours using membrane systems

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Progress in Natural Science:Materials International 2007年第4期17卷 449-457页

作者： Miguel A. Gutiérrez-Naranjo Mario j. Pérez-jiménez Agustín Riscos-Núez francisco j. Romero-Campero Department of Computer Science and Artificial Intelligence University of Seville Avda. Reina Mercedes s/n41012SevillaSpain

In this paper we discuss the potential usefulness of membrane systems as tools for modelling tumours. The approach is followed both from a macroscopic and a microscopic point of view. In the first case, one considers the tumour as a growing mass of cells, focusing on its external shape. In the second case, one descends to the microscopic level, studying molecular signalling pathways that are crucial to determine if a cell is cancerous or not. In each of these approaches we work with appropriate variants of membrane systems.

关键词： tumour membrane system modeling.

Hydrogen sulfide:A novel component in Arabidopsis peroxisomes which triggers catalase inhibition

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journal of Integrative Plant Biology 2019年第7期61卷 871-883页

作者： francisco j.Corpas juan B.Barroso Salvador Gonzalez-Gordo Maria A.Munoz-Vargas jose M.Palma Group of Antioxidants Free Radicals and Nitric Oxide in BiotechnologyFood and AgricultureDepartment of BiochemistryCell and Molecular Biology of PlantsEstacion Experimental del ZaidfnCSICC/Profesor Albareda 1E-18008 GranadaSpain Group of Biochemistry and Cell Signaling in Nitric oxide Department of Biochemistry and Molecular BiologyCampus"Las Lagunillas"E-23071University of JaenJaenSpain

Plant peroxisomes have the capacity to gen erate different reactive oxygen and nitrogen species(ROS and RNS),such as H2O2,superoxide radical(O2^·-),nitric oxide and peroxynitrite(ONOO^-).These organelles have an active nitrooxidative metabolism which can be exacerbated by adverse stress *** sulfide(H2S)is a new signaling gasotransmitter which can mediate the posttranslational modification(PTM)*** used Arabidopsis thaliana transgenic seedlings expressing cyan fluorescent protein(CFP)fused to a canonical peroxisome targeting signal 1(PTS1)to visualize peroxisomes in living cells,as well as a specific fluorescent probe which showed that peroxisomes contain H2S.H2S was also detected in chloroplasts under glyphosate-induced oxidative stress *** enzyme activities,including catalase,photorespiratory H2O2-generating glycolate oxidase(GOX)and hydroxypyruvate reductase(HPR),were assayed in vitro with a H2S *** line with the persulfidation of this enzyme,catalase activity declined significantly in the presence of the H2S *** corroborate the inhibitory effect of H2S on catalase activity,we also assayed pure catalase from bovine liver and pepper fruit-enriched samples,in which catalase activity was *** together,these data provide evidenee of the presence of H2S in plant peroxisomes which appears to regulate catalase activity and,consequently,the peroxisomal H2O2 metabolism.

关键词： Hydrogen sulfide triggers catalase inhibition

A SHORT NOTE ABOUT EXPOSED POINTS IN REAL BANACH SPACES

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Acta Mathematica Scientia 2008年第4期28卷 797-800页

作者： Antonio Aizpuru francisco j Garcia-Pacheco Departamento de Matemá ticas Universidad de Cá diz Department of Mathematical Sciences Kent State University

We express the set of exposed points in terms of rotund points and non-smooth *** long as we have Banach spaces each time＂bigger＂,we consider sets of non-smooth points each time＂smaller＂.

关键词： Exposed point exposed face rotund point smooth point

Biliary-colonic fistula caused by cholecystectomy bile duct injury

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Hepatobiliary & Pancreatic Diseases International 2013年第4期12卷 443-445页

作者： francisco Igor B Macedo Victor j Casillas james S Davis joe U Levi Danny Sleeman Dewitt Daughtry Family Department of Surgery University of Miami Miller School of Medicine and Ryder Trauma Center/Jackson Memorial HospitalMiami Florida USA Department of Radiology University of Miami Miller School of Medicine and Ryder Trauma Center/Jackson Memorial HospitalMiami Florida USA

Biliary-colonic fistula is a rare complication after laparoscopic cholecystectomy. We present a case of post-cholecystectomy iatrogenic biliary injury that resulted in a fistula between the common hepatic duct and large bowel. Magnetic resonance cholangiopancreatography provided good visualization of injury even with concurrent normal level of alkaline phosphatase. Radiologic findings and surgical management of this condition are discussed in detail.

关键词： cholecystectomy magnetic resonance imaging biliary tract disease

Post-transcriptional regulation of seed dormancy and germination: Current understanding and future directions

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Plant Communications 2021年第4期2卷 1-22页

作者： Rocío Soledad Tognacca javier francisco Botto Consejo Nacional de Investigaciones Científicas y Técnicas Universidad de Buenos AiresInstituto de FisiologíaBiología Molecular y Neurociencias(IFIBYNE)Facultad de Ciencias Exactas y NaturalesCP1428 Buenos AiresArgentina Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasInstituto de Investigaciones Fisiològicas y Ecològicas Vinculadas a la Agricultura(IFEVA)Facultad de AgronomíaCP1417 Buenos AiresArgentina

Seed dormancy is a developmental checkpoint that prevents mature seeds from germinating under conditions that are otherwise favorable for *** and light are themost relevant environmental factors that regulate seed dormancy and *** environmental cues can trigger molecular and physiological responses including hormone signaling,particularly that of abscisic acid and *** balance between the content and sensitivity of these hormones is the key to the regulation of seed *** and light tightly regulate the transcription of thousands of genes,as well as other aspects of gene expression such asmRNAsplicing,translation,and *** remodeling determines specific transcriptional outputs,and alternative splicing leads to different outcomes and produces transcripts that encode proteins with altered or lost *** regulation of chromatin remodeling and alternative splicing may be highly relevant to seed ***,microRNAs are also critical for the control of gene expression in *** review aims to discuss recent updates on post-transcriptional regulation during seed maturation,dormancy,germination,and post-germination *** propose future prospects for understanding howdifferent post-transcriptional processes in crop seeds can contribute to the design of genotypes with better performance and higher productivity.

关键词： alternative splicing chromatin remodeling dormancy germination microRNA(miRNA) seeds

Expeditious management plan towards digital earth

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International journal of Digital Earth 2014年第8期7卷 635-649页

作者： Naveen Kumar Sidda Aneta j.Florczyk francisco j.Lopez-Pellicer Dinesh Babu I.V Ruben Bejar F.javier Zarazaga-Soria Department of Computer Science and System Engineering University of ZaragozaZaragozaSpain Department of Wood Science forestry and GeomaticsUniversity LavalSainte-FoyQCCanada

The breakthrough developments in geospatial technologies and the increasing availability of spatial data make geoinformation a business and a decisional element to the ***,it is important to have a management plan to factor in practical and feasible data sources,in building geo *** authors of this paper are motivated by the fact that right data sources could outclass in-house resources in various application *** paper outlines pragmatic cases for the tangible benefits of the existing potential data and expeditious patterns for digital *** work also proposes‘good-enough’solutions based on the pragmatic cases,available literature,and the 3D city model developed that could be sufficient in contriving the objectives of the common public usage and open business *** demonstrate this approach,the paper encapsulated the low-cost development of virtual 3D city model using publicly available cadastral data and web services.

关键词： spatial data sources geo management web services APIs cadastral data

Dissecting the molecular pathophysiology of drug-induced liver injury

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World journal of Gastroenterology 2018年第13期24卷 1373-1385页

作者： Hui Ye Leonard j Nelson Manuel Gómez del Moral Eduardo Martínez-Naves francisco javier Cubero Department of Immunology Ophtalmology and ORLComplutense University School of MedicineMadrid 28040Spain 12 de Octubre Health Research Institute(imas12) Madrid 28041Spain Institute for BioEngineering(Human Liver Tissue Engineering Faraday BuildingThe University of EdinburghThe King BuildingsMayfield RoadEdinburgh EH9 3 JLScotlandUnited Kingdom Department of Cell Biology Complutense University School of MedicineMadrid 28040Spain

Drug-induced liver injury(DILI) has become a major topic in the field of Hepatology and Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic, cholestatic and mixed. Although the clinical manifestations of DILI are variable and the pathogenesis complicated, recent insights using improved preclinical models, have allowed a better understanding of the mechanisms that trigger liver damage. In this review, we will discuss the pathophysiological mechanisms underlying DILI. The toxicity of the drug eventually induces hepatocellular damage through multiple molecular pathways, including direct hepatic toxicity and innate and adaptive immune responses. Drugs or their metabolites, such as the common analgesic, acetaminophen, can cause direct hepatic toxicity through accumulation of reactive oxygen species and mitochondrial dysfunction. The innate and adaptive immune responses play also a very important role in the occurrence of idiosyncratic DILI. Furthermore, we examine common forms of hepatocyte death and their association with the activation of specific signaling pathways.

关键词： signaling pathways acetaminophen Drug-induced liver injury cell death reactive oxygen species

Postural control quantification in minimally and moderately impaired persons with multiple sclerosis:The reliability of a posturographic test and its relationships with functional ability

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journal of Sport and Health Science 2020年第6期9卷 677-684页

作者： David Barbado Ramon Gomez-Illan Pedro Moreno-Navarro Gregori Valero-Conesa Raul Reina francisco j.Vera-Garcia Department of Sport Sciences Sports Research CentreMiguel Hern_andez University of ElcheElche(Alicante)03202Spain

Background:Postural control has been associated with the functional impairment in persons with multiple sclerosis(pwMS).However,there is a need for reliable methods to assess postural control in early stages of the disease,when subtle changes can be difficult to *** aims of this study were to assess the absolute and relative reliability of a standing and a sitting posturographic protocol in minimally(Expanded Disability Status Scale≤2)and moderately(2.5≤Expanded Disability Status Scale≤4)impaired pwMS,and to analyze relationships among postural control and functional mobility and gait ***:To assess postural control in an upright stance,14 minimally and 16 moderately impaired pwMS performed six 70 s trials in tandem stance,3 with their weaker leg behind(TSWL)and 3 with their stronger leg behind(TSSL).Additionally,participants completed five 70 s trials using an unstable sitting protocol(US)to assess trunk *** mean radial errors of TSWL,TSSL,and US trials were calculated as postural control ***,participants performed the Timed Up and Go test(TUG)and the Timed 25-foot Walk test(T25FW)to measure their functional mobility and gait speed,*** was evaluated using the intraclass correlation coefficient(ICC3,1)and the standard error of measurement(SEM).Analyses of variances were carried out to assess between-group ***’g index(dg)was used to estimate the effect size of *** correlation analyses(r)were performed to examine the relationships among the postural control and the functional ***:Posturographic tests showed a high reliability in both minimally(0.87≤ICC≤0.92;9.32%≤SEM≤11.76%)and moderately(0.80≤ICC≤0.92;10.33%≤SEM≤15.33%)impaired ***,T25FW and TUG displayed a high consistency in minimally(0.89≤ICC≤0.94;3.43%≤SEM≤5.17%)and moderately(0.85≤ICC≤0.93;5.57%≤SEM≤6.56%)impaired *** impaired pwMS showed a better performance on the TUG,T25FW

关键词： Balance Consistency of the assessment Core stability Functional mobility