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Nanoscale interactions between the nicotinic acetylcholine receptor and cholesterol

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BIOCELL 2021年第6期45卷 1479-1484页

作者： francisco j.BARRANTES Laboratory of Molecular Neurobiology Institute of Biomedical Research(BIOMED)UCA-CONICETFaculty of Medical SciencesBuenos AiresArgentina

Cholesterol is a major lipid in biological *** not only plays a structural role but also modulates a wide range of functional properties of neurotransmitter and hormone receptors and ion *** membraneembedded segments of the paradigm neurotransmitter receptor for acetylcholine(nAChR)contain linear sequences of amino acids with the capacity to recognize *** cholesterol consensus domains have been designated as“CARC”and its mirror sequence“CRAC”.CARC preferentially occurs in the exoplasmic-facing membrane leaflet,and CRAC,in the cytoplasmic-facing *** motifs are highly conserved among ion-channel and neurotransmitter receptor proteins in vertebrate nervous systems,where they recognize cholesterol,and in prokaryotic homologues in bacteria,where they recognize *** phylogenetically conserved trait is an indication that the hopanoids in some bacteria and cholesterol in eukaryotes subserve analogous functions,probably contributing to the stability of membrane-embedded protein *** studies from our laboratory using superresolution optical microscopy(“nanoscopy”)have disclosed other interrelated functional and structural properties exerted by cholesterol on the *** neutral lipid content at the cell surface influences both the macromolecular organization of the receptor and its translational mobility(diffusion)in the plane of the membrane.

关键词： Cholesterol Pentameric ligand-gated ion channel Nicotinic acetylcholine receptor Membrane proteins Evolution Nanoscopy Cholesterol-recognition domains

Diffusion dynamics and characterization of attogram masses in optically trapped single nanoparticles using laser-induced plasma imaging

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Nano Research 2023年第5期16卷 7470-7480页

作者： Pablo Purohit francisco j.Fortes javier Laserna UMALASERLAB Departamento de Química AnalíticaUniversidad de MálagaC/Jiménez Fraud 4Malaga 29010Spain Niels Bohr Institute University of CopenhagenBlegdamsvej 172100 CopenhagenDenmark

In the present work,a wavelength-selected plasma imaging analysis system is presented and used to track photons emitted from single-trapped nanoparticles in air at atmospheric *** isolated nanoentities were atomized and excited into plasma state using single nanosecond laser *** use of appropriate wavelength filters alongside time-optimized acquisition settings enabled the detection of molecular and atomic emissions in the *** photon detection efficiency of the imaging line resulted in a signal>400 times larger than the simultaneously-acquired dispersive spectroscopy *** increase in sensitivity outlined the evolution of diverse physicochemical processes at the single particle scale which included heat and momentum transfer from the plasma into the particle as wells as chemical *** imaging detection of excited fragments evidenced different diffusion kinetics and time frames for atoms and molecules and their influence upon both the spectroscopic emission readout and fabrication processes using the plasma as a ***,the origin of molecular species,whether naturally-occurring or derived from a chemical reaction in the plasma,could also be studied on the basis of compositional gradients found on the *** of detection for the inspected species ranged from tens to hundreds attograms,thus leading to an exceptional sensing principle for single nanoentities that may impact several areas of science and technology.

关键词： single nanoparticle inspection wavelength-selected laser-induced plasma imaging laser fabrication attogram characterization atomic/molecular diffusion

Real Renormings on Complex Banach Spaces

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Chinese Annals of Mathematics,Series B 2008年第3期29卷 239-246页

作者： francisco j GARC■A-PACHECO Alejandro MIRALLES Department of Mathematical Sciences Kent State University Departamento de Análisis Matemático Universidad de Valencia

The authors prove that every complex Banach space admits an equivalent real norm that is far away from being a complex norm. Furthermore, this real norm can be chosen to share many properties with complex norms, but i... 详细信息

关键词： Complex norms Real norms Hilbert space

A SHORT NOTE ABOUT EXPOSED POINTS IN REAL BANACH SPACES

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Acta Mathematica Scientia 2008年第4期28卷 797-800页

作者： Antonio Aizpuru francisco j Garcia-Pacheco Departamento de Matemá ticas Universidad de Cá diz Department of Mathematical Sciences Kent State University

We express the set of exposed points in terms of rotund points and non-smooth *** long as we have Banach spaces each time＂bigger＂,we consider sets of non-smooth points each time＂smaller＂.

关键词： Exposed point exposed face rotund point smooth point

Retrieval of Elastic Green’s Tensor near a Cylindrical Inhomogeneity from Vector Correlations

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Communications in Computational Physics 2008年第1期3卷 250-270页

作者： juan AP´erez-Ruiz francisco Luzon francisco j.Sanchez-Sesma Grupo de Geof´ısica Aplicada Departamento de F´ısica AplicadaUniversidad de Almer´ıaCa˜nada de San Urbano s/n04120-Almer´ıaSpain Departamento de Sismolog´ıa Instituto de IngenieriaUniversidad Nacional Aut´onoma de M´exicoCd.UniversitariaCircuito Escolar s/nCoyoac´an 04510M´exico D.F.Mexico.

Multiple scattering of elastic waves in realistic media makes that averagefield intensities or energy densities follow diffusive processes. In such regime the successiveP to S energy conversions by distributed random inhomogeneities give rise toequipartition which means that in the phase space the available elastic energy is distributedin averagewith equal amounts among the possible states of P and S waves. Insuch diffusive regime the P to S energy ratio equilibrates in an universal way independentof the particular details of the scattering. It has been demonstrated that averagingthe cross correlations at any two points of an elastic medium subjected to diffuse elasticwavefields leads to the emergence of the Green function, which is the wave fieldthat would be observed at one position if an impulsive load is applied at the other. Inthis work we study the problem of the retrieval of the 2D tensor elastodynamic Greenfunction in an infinite elastic space containing a circular cylinder inclusion. We illuminateisotropically the elastic spacewith plane waves. We assume the spectra for both Pand S waves uniform but such that the energy ratio ES/EP=(a/b)2, which is the onepredicted by equipartition theory in two-dimensions. We then show that the Fouriertransform of azimuthal average of the cross-correlation of motion between two pointswithin an elastic medium is proportional to the imaginary part of the exact Green tensorfunction between these points. The numerical results presented here point out thepossibility of detection and imaging of diffractors and resonant diffractors by crosscorrelation even in presence of attenuation exists.

关键词： Multiple scattering elastic waves elastic Green’s tensor

Dopaminergic-cholinergic imbalance in movement disorders: a role for the novel striatal dopamine D2-muscarinic acetylcholine M1 receptor heteromer

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Neural Regeneration Research 2021年第7期16卷 1406-1408页

作者： RenéA.j.Crans francisco Ciruela Laboratory of Toxicology Department of BioanalysisGhent UniversityGhentBelgium Unitat de Farmacologia Departament Patologia i Terapèutica ExperimentalFacultat de Medicina i Ciències de la SalutIDIBELLUniversitat de BarcelonaL’Hospitalet de LlobregatBarcelonaSpain Institut de Neurociències Universitat de BarcelonaBarcelonaSpain

The striatum is the primary input structure of the basal ganglia, which participates in motivational and goaldirected behaviors(Pisani et al., 2007).In physiological conditions, local cholinergic interneurons(ChIs) an... 详细信息

关键词： al. Dopamine dopamine

Pan-retinal ganglion cell markers in mice, rats, and rhesus macaques

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Zoological Research 2023年第1期44卷 226-248页

作者： francisco M.Nadal-Nicolás Caridad Galindo-romero Fernando Lucas-Ruiz Nicholas Marsh-Amstrong Wei Li Manuel Vidal-Sanz Marta Agudo-Barriuso Grupo de Oftalmología Experimental Instituto Murciano de Investigación Biosanitaria Pascual Parrilla(IMIB)Murcia 30120Spain Dpto.Oftalmología Facultad de MedicinaUniversidad de MurciaMurcia 30120Spain Retinal Neurophysiology Section National Eye InstituteNational Institutes of HealthBethesdaMaryland 20892-2510USA Department of Ophthalmology and Vision Science University of CaliforniaDavisCA 95817USA

Univocal identification of retinal ganglion cells(RGCs) is an essential prerequisite for studying their degeneration and neuroprotection. Before the advent of phenotypic markers, RGCs were normally identified using retrograde tracing of retinorecipient areas. This is an invasive technique, and its use is precluded in higher mammals such as monkeys. In the past decade, several RGC markers have been described. Here, we reviewed and analyzed the specificity of nine markers used to identify all or most RGCs, i.e., pan-RGC markers, in rats, mice, and macaques. The best markers in the three species in terms of specificity, proportion of RGCs labeled, and indicators of viability were BRN3A, expressed by vision-forming RGCs, and RBPMS, expressed by vision-and non-vision-forming RGCs. NEUN, often used to identify RGCs, was expressed by non-RGCs in the ganglion cell layer, and therefore was not RGC-specific. γ-SYN, TUj1, and NF-L labeled the RGC axons, which impaired the detection of their somas in the central retina but would be good for studying RGC morphology. In rats, TUj1 and NF-L were also expressed by non-RGCs. BM88, ERRβ,and PGP9.5 are rarely used as markers, but they identified most RGCs in the rats and macaques and ERRβ in mice. However, PGP9.5 was also expressed by non-RGCs in rats and macaques and BM88 and ERRβ were not suitable markers of viability.

关键词： RGC Optic nerve crush BM88 BRN3A Estrogen-related receptorβ ERRβ NEUN Neurofilament-L PGP9.5 RBPMS γ-SYN βIII-tubulin TUj1

Bone Remodeling and Energy Metabolism:New Perspectives

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Bone Research 2013年第1期1卷 72-84页

作者： francisco j.A.de Paula Clifford j.Rosen Department of Internal Medicine School of Medicine of Ribeiro PretoUniversity of So PauloBrazil Center for Clinical and Translational Research Maine Medical Center Research InstituteUSA

Bone mineral, adipose tissue and energy metabolism are interconnected by a complex and multilevel series of networks. Calcium and phosphorus are utilized for insulin secretion and synthesis of high energy compounds. Adipose tissue store lipids and cholecalciferol, which, in turn, can influence calcium balance and energy expenditure. Hormones long-thought to solely modulate energy and mineral homeostasis may influence adipocytic function. Osteoblasts are a target of insulin action in bone. Moreover, endocrine mediators, such as osteocalcin, are synthesized in the skeleton but regulate carbohydrate disposal and insulin secretion. Finally, osteoblasts and adipocytes originate from the same mesenchymal progenitor. The mutual crosstalk between osteoblasts and adipocytes within the bone marrow microenvironment plays a crucial role in bone remodeling. In the present review we provide an overview of the reciprocal control between bone and energy metabolism and its clinical implications.

关键词： bone adipose tissue mineral metabolism energy metabolism leptin osteocalcin

Repulsion of polarised particles from anisotropic materials with a near-zero permittivity component

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Light(Science & Applications) 2016年第1期5卷 752-759页

作者： francisco j Rodríguez-Fortuño Anatoly V Zayats Department of Physics King’s College LondonStrandLondon WC2R 2LSUK

Reduction of adhesion and stiction is crucial for robust operation on nanomechanical and optofluidic devices as well as atom and molecule behaviour near *** can be achieved using electric charging,magnetic materials or light pressure and optical *** we show that a particle scattering or emitting in close proximity to an anisotropic substrate can experience a repulsive force if one of the diagonal components of the permittivity tensor is close to *** derive an analytic condition for the existence of such repulsive force depending on the optical properties of the *** also demonstrate the effect using realistic anisotropic metamaterial implementations of a *** anisotropic metamaterial approach using metal–dielectric and graphene–dielectric multilayers provides a tuneable spectral range and a very broad bandwidth of electromagnetic repulsion forces,in contrast to isotropic substrates.

关键词： anisotropy metamaterials optical force repulsion