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Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis

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Neural Regeneration Research 2021年第2期16卷 242-246页

作者： francisco j.Barrantes Biomedical Research Institute(BIOMED)UCA-CONICET Buenos AiresArgentina

Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular j.nction of voluntary *** classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the neuromuscular j.nction,the nicotinic acetylcholine *** variants of the disease involve autoimmune attack of non-receptor scaffolding proteins or enzymes essential for building or maintaining the integrity of this peripheral *** review summarizes the participation of the above proteins in building the neuromuscular j.nction and the destruction of this cholinergic synapse by autoimmune aggression in myasthenia *** review also covers the application of a powerful biophysical technique,superresolution optical microscopy,to image the nicotinic receptor in live cells and follow its motional *** hypothesis is entertained that anomalous nanocluster formation by antibody crosslinking may lead to accelerated endocytic internalization and elevated turnover of the receptor,as observed in myasthenia gravis.

关键词： agrin autoimmune diseases muscle end-plate muscle specific kinase MuSK myasthenia gravis nanoscopy neuromuscular j.nction nicotinic acetylcholine receptor rapsyn superresolution microscopy

Age structure of a lizard along an elevational gradient reveals nonlinear lifespan patterns with altitude

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Current Zoology 2020年第4期66卷 373-382页

作者： Mar Comas Senda Reguera francisco j.amora-Camacho Gregorio moreno-Rueda Departamento de Zoologia Facultad de CienciasUniversidad de GranadaGranadaE-18071Spain Estacion Biologica de Donana(EBD-CSIC) Americo Vespucio 26SevillaE-41092Spain Department of Biological Sciences Dartmouth CollegeHanoverNHUSA

Lifespan is one of the main components of life *** lifespans can be expected in marginal ***,in the case of ectotherms,lifespan typically increases with altitude,even though temperature-one of the main factors to determine ectotherms'life history-declines with *** pattern can be explained by the fact that a shorter activity time favors *** this study,we analyzed how lifespan and other life-history traits of the lizard Psammodromus algirus vary along a 2,200 m elevational gradient in Sierra Nevada(SE Spain).Populations at inter-mediate altitudes(1,200-1,700 m),corresponding to the optimal habitat for this species,had the shortest lifespans,whereas populations inhabiting marginal habitats(at both low and at high altitudes)lived ***,this lizard did not follow the typical pattern of ectotherms,as it also lived longer at the lower limit of its distribution,nor did it show a longer lifespan in areas with optimal *** results might be explained by a complex combination of different gradients along the mountain,namely that activity time decreases with altitude whereas food availability *** could explain why lifespan was maximum at both high(limited activity time)and low(limited food availability)altitudes,resulting in similar lifespans in areas with contrasting environmental *** findings also indicated that reproductive investment and body condition increase with elevation,suggesting that alpine populations are locally adapted.

关键词： age structure elevation lite history longevity marginal habitats relative clutch mass

Opposed elevational variation in prevalence and intensity of endoparasites and their vectors in a lizard

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Current Zoology 2018年第2期64卷 197-204页

作者： Lola ALVAREZ-RUIZ Rodrigo MEGIA-PALMA Senda REGUERA Santiago Rulz francisco j. ZAMORA-CAMACHO j.rdi FIGUEROLA Gregorio moreno-RUEDA Centro de Investigaciones sobre Desertificacion-CSIC Ctra. Naquera Kin. 4.5 Moncada Valencia E-46113 Spain Departarnento de Ecologia Evolutiva Museo Nacional de Ciencias Naturales-CSIC c/Jose Gutierrez Abascal Madrid E-28006 Spain Unit of Ethology and Animal Welfare Faculty of Veterinary University CEU Cardenal Herrera Alfara del Patriarca (Valencia) E-46113 Spain Servicio de Control de Mosquitos DiputaciGn Provincial de Huelva Centro de InvestigaciGn Biornedica en Red Epidemiologia y Salud Publica (CIBERESP) Huelva Spain CIBER de Epidemiologia y Salud Peblica (CIBERESP) Spain Departamento de Biogeografia y Carnbio Global Museo Nacional de Ciencias Naturales-CSIC C/Jose Gutierrez Abascal 2 Madrid E-28006 Spain Departarnento de Ecologia de Hurnedales Estacion Biologica de Dofiana-CSIC c/Americo Vespucio s/n Sevilla E-41092 Spain Departamento de Zoologia Facultad de Ciencias Universidad de Granada Granada E-18071 Spain

Studying the causes of parasite geographic distribution is relevant to understand ecological and evolutionary processes that affect host populations as well as for species conservation. Temperature is one of the most important environmental variables affecting parasite distribution, as raising temperatures positively affect development, reproduction, and rate of transmission of both endo- and ectoparasites. In this context, it is generally accepted that, in mountains, parasite abundance decreases with elevation. However, empirical evidence on this topic is limited. In the present study, we analyzed the elevational variation of hemoparasites and ectoparasites of a lizard, Psammodromus algirus, along a 2,200-m elevational gradient in Sierra Nevada （SE Spain）. As pre- dicted, ectoparasite （mites, ticks, mosquitoes, and sandflies） abundance decreased with elevation. However, hemoparasite prevalence and intensity in the lizard augmented with altitude, showing a pattern contrary to their vectors （mites）. We suggest that tolerance to hemoparasites may increase with elevation as a consequence of lizards at high altitudes taking advantage of increased body condition and food availability, and reduced oxidative stress. Moreover, lizards could have been selected for higher resistance against hemoparasites at lowlands （where higher rates of replication are expected）, thus reducing hemoparasite prevalence and load. Our findings imply that, in a scen- ario of climate warming, populations of lizards at high elevation may face increased abundance of ectoparasites, accompanied with strong negative effects.

关键词： elevation immune system parasite distribution Psammodromus algirus reptile

Prey availability, prey selection, and trophic niche width in the lizard Psammodromus algirus along an elevational gradient

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Current Zoology 2018年第5期64卷 603-613页

作者： Gregorio moreno-RUEDA Elena MELERO Senda REGUERA francisco j. ZAMORA-CAMACHO Ines ALVAREZ-BENITO Departamento de Zoologla Facultad de Ciencias Universidad de Granada Granada E-18071 Spain Departamento de Biogeografia y Carnbio Global Museo Nacional de Ciencias Naturales-CSIC C/Jose Gutierrez Abascal 2 E-28006 Madrid Spain

Mountains imply enormous environmental variation, with alpine habitats entailing harsh environ- ments, especially for ectotherms such as lizards. This environmental variability also may imply variation in prey availability. However, little is known about how lizard trophic ecology varies with elevation. In this study, we analyze diet, prey availability, prey selection, and trophic niche width in the lacertid lizard Psammodromus algirus along a 2,200-m elevational gradient in the Sierra Nevada （SE Spain）. The analysis of fecal samples has shown that Orthoptera, Formicidae, Hemiptera, Coleoptera, and Araneae are the main prey, although, according to their abundance in pitfall traps, Formicidae and Coleoptera are rej.cted by the lizard whereas Orthoptera, Hemiptera, and Araneae are preferred. Prey abundance and diversity increase with elevation and diet subtly varies along with the elevational gradient. The consumption of Coleoptera increases with elevation probably as a consequence of the lizard foraging more in open areas while basking. The electivity for Araneae increases with elevation. Araneae are rej.cted in the lowlands--where they are rela- tively abundant--whereas, at high elevation, this lizard positively selects them, despite they being less abundant. The lizard trophic niche width expands with elevation due to concomitant greater prey diversity and hence this lizard feeds on more prey types in highlands. Although no sex difference in diet has been found, the trophic niche is broader in females than males. As a whole, alpine lizards show a trophic niche simitar to that found at lower elevat（ons, suggesting that P. algirus is well adapted to the harsh environment found in alpine areas.

关键词： alpine habitats arthropods mountain ecology niche variation hypothesis trophic ecology

Morphological determinants of j.mping performance in the Iberian green frog

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Current Zoology 2020年第4期66卷 417-424页

作者： Gregorio moreno-Rueda Abelardo Requeinia-Blaimco francisco j.Zamora-Camacho Mar Comas Guillem Pascual Departamento de Zoologia Facultad de CienciasUniversidad de GranadaGranadaE-18071Spain Department of Biological Sciences Dartmouth CollegeHanoverNH03055USA Galanthus/Ctra.de j.ia 46.17460 CelraSpain

Predation is one of the main selective forces in nature, frequently selecting potential prey for developing escape strategies. Escape ability is typically influenced by several morphological parameters, such as morphology of the locomotor appendices, muscular capacity, body mass, or fluctuating asymmetry, and may differ between sexes and age classes. In this study, we tested the relationship among these variables and j.mping performance in 712 Iberian green frogs Pelophylax perezi from an urban population. The results suggest that the main determinant of j.mping capacity was body size (explaining 48% of variance). Larger frogs j.mped farther, but j.mping performance reached an asymptote for the largest frogs. Once controlled by structural body size, the heaviest frogs j.mped shorter distances, suggesting a trade-off between fat storage and j.mping performance. Relative hind limb length also determined a small but significant percentage of variance (2.4%) in j.mping performance-that is, the longer the hind limbs, the greater the j.mping capacity. j.veniles had relatively shorter and less muscular hind limbs than adults (for a given body size), and their j.mping performance was poorer. In our study population, the hind limbs of the frogs were very symmetrical, and we found no effect of fluctuating asymmetry on j.mping performance. Therefore, our study provides evidence that j.mping performance in frogs is not only affected by body size, but also by body mass and hind limb length, and differ between age classes.

关键词： body mass fluctuating asymmetry hind limb length hind limb width locomotor performance morphometry

Ferrofluid moving thin films for active flow control

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Chinese j.urnal of Aeronautics 2021年第5期34卷 115-119页

作者： francisco j.ARIAS Department of Fluid Mechanics Polytechnic University of CataloniaESEIAATC/Colom 1108222 BarcelonaSpain

Ferrofluid moving thin films and their possible significance with regard to active flow control for lift and attack angle enhancement are *** this strategy,a very thin film of ferrofluid is strongly attached at the wall of the wing by a normal magnetic field from below and pumped tangentially along the *** a simplified physical model and from the available experimental data on moving walls,the expected lift enhancement and effect on the attack angle were *** research and design is required in order to explore the possibilities in the use of ferrofluid moving thin films.

关键词： Active flow control Boundary layer separation Ferrofluid

Compost Input Effect on Dryland Wheat and Forage Yields and Soil Quality

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Pedosphere 2018年第3期28卷 451-462页

作者： francisco j. CALDERON Merle F. VIGIL j.seph BENj.MIN United States Department of Agriculture-Agricultural Research Service (USDA-ARS) Central Great Plains Research Station Akron80720 CO( USA)

Organic agricultural systems rely on organic amendments to achieve crop fertility requirements, and weed control must be achieved without synthetic herbicides. Our obj.ctive was to determine the crop yield and soil quality as affected by a transition from grass to dryland organic agriculture in the Central Great Plains of North America. This study evaluated three beef feedlot compost(BFC)treatments in 2010–2015 following biennial application rates: 0(control), 22.9, and 108.7 t ha^(-1) on two dryland organic cropping systems: a wheat(Triticum aestivum)-fallow(WF) rotation harvested for grain and a triticale(Triticosecale)/pea(Pisum sativum)-fallow(T/P-F) rotation harvested for forage. The triticale + pea biomass responded positively to the 108.7-t ha^(-1) BFC treatment,but not the 22.9-t ha^(-1) BFC treatment. The wheat biomass was not affected by BFC addition, but biomass N content *** feedlot compost input did not increase wheat grain yields, but had a positive effect on wheat grain Zn content. Soil total C and N contents increased with the rate of 108.7 t ha^(-1) BFC after three applications, but not with 22.9 t ha^(-1) BFC. Soil enzyme activities associated with N and C cycling responded positively to the 108.7-t ha^(-1) BFC treatment. Saturated salts were high in the soil receiving 108.7 t ha^(-1) of BFC, but did not affect crop yields. These results showed that BFC was effective in enhancing forage yields, wheat grain quality, and soil C and N, as well as specific microbial enzymes important for nutrient cycling. However, the large rates of BFC necessary to elicit these positive responses did not increase grain yields, and resulted in an excessive buildup of soil P.

关键词： organic agriculture soil C soil enzyme activity soil N pea triticale

Local Fourier Analysis for Edge-Based Discretizations on Triangular Grids

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Numerical Mathematics(Theory,Methods and Applications) 2015年第1期8卷 78-96页

作者： Carmen Rodrigo francisco Sanz francisco j.Gaspar francisco j.Lisbona Department of Applied Mathematics University of ZaragozaC/Maria de Luna 350018ZaragozaSpain BIFI University of Zaragoza C/Pedro Cerbuna 1250009ZaragozaSpain Department of Applied Mathematics University of ZaragozaC/Pedro Cerbuna 1250009ZaragozaSpain

In this paper,we present a local Fourier analysis framework for analyzing the different components within multigrid solvers for edge-based discretizations on triangular *** different stencils associated with edges of different orientation in a triangular mesh make this analysis *** resulting tool is demonstrated for the vector Laplace problem discretized by mimetic finite difference *** from the local Fourier analysis,as well as experimentally obtained results,are presented to validate the proposed analysis.

关键词： Multigrid local Fourier analysis edge-based discretizations mimetic finite differences

Macular atrophy after combined intravitreal triamcinolone and photodynamic therapy to treat choroidal neovascularization

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International j.urnal of Ophthalmology(English edition) 2010年第2期3卷 161-163页

作者： j.se M Ruiz-moreno j.vier A Montero Pedro Amat francisco Lugo Department of Ophthalmology Albacete Medical SchoolUniversity of Castilla La ManchaSpain Alicante Institute of Ophthalmology Vitreo-Retinal Unit.Spain Pio del Rio Hortega University Hospital Ophthalmology UnitValladolidSpain

AIMTo report the appearance of choriocapillaris atrophy after combined high dose intravitreal triamcinolone acetonide (TA) and photodynamic therapy (PDT) to treat choroidal neovascularization (CNV) associated with age... 详细信息

关键词： age related macular degeneration choriocapillaris atrophy intravitreous triamcinolone photodynamic therapy retinal pigment epithelium atrophy