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Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis

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International Journal of Oral Science 2015年第1期7卷 27-41页

作者： Laura E Zweifler Mudita K Patel francisco H nociti jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institutes of Health (NIH) Department of Prosthodontics and Periodontics Division of Periodontics School of Dentistry Campinas State University Department of Vertebrate Zoology National Museum of Natural History Smithsonian Institution Sanford Children’s Health Research Center Sanford-Burnham Medical Research Institute

Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone. Biomineralization is regulated by the ratio of inorganic phosphate （Pi） to mineral inhibitor pyrophosphate （PPi）, where local Pi and PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase （TNAP） and ectonucleotide pyrophosphatase/phosphodiesterase 1 （NPP1）. The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enppl null mouse increased acellular cementum, with little effect on cellular cementum. Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enppl gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPi environment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPi have little effect on cellular cementum formation, though matrix mineralization is affected.

关键词： cementum bone ectonucleotide pyrophosphatase phosphodiesterase 1 periodontal ligament progressive ankylosis protein tissue-nonspecific aJkalJne phosphatase

Potential of polyphenols in curbing quorum sensing and biofilm formation in Gramnegative pathogens

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Asian Pacific Journal of Tropical Biomedicine 2021年第6期11卷 231-243页

作者： Arnica F Lal Shaminder Singh francisco C.Franco,jr. Sonam Bhatia Department of Pharmaceutical Science SHALOM Institute of Health and Allied SciencesSam Higginbottom University of AgricultureTechnology and SciencesNainiPrayagrajIndia Regional Centre for Biotechnology NCR Biotech Science Cluster3rd MilestoneFaridabad-Gurugram ExpresswayFaridabad-121001HaryanaIndia Chemistry Department De La Salle Univers2401 Taft Ave.Manila 0922Philippines

Polyphenols are the secondary metabolic products of plants and are considered as active constituents to possess therapeutic *** date,a vast number of scientific literature addressed the potential of polyphenols as bio-efficient compounds owing to their structural *** to the presence of several hydroxyl groups,they are metabolized quickly due to conjugation reaction and thus,readily produce toxic metabolites as a defense material against many pathogens,reflecting their safety *** review focuses on the anti-quorum sensing and biofilm inhibition activity of polyphenols,which display their potential to treat bacterial infections by combating the virulence caused by pathogenic ***,for mitigating quorum sensing-controlled pathogenesis,the use of polyphenol-based phytochemicals holds immense potential to cure *** application of polyphenol as sensitizing agent/adjuvant therapeutics which act in synergism with antibiotics is highly remarkable.

关键词： Polyphenols Quorum sensing Biofilm Recombinant polyphenolic compounds Sensitizers Antibiotic resistance

Investigation of Galactic open cluster remnants： the case of NGC 7193

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Research in Astronomy and Astrophysics 2017年第1期17卷 31-54页

作者： Mateus de Souza Angelo Joao francisco Coelho dos Santos jr Wagner Jose Barbosa Corradi francisco Ferreira de Souza Maia Andres Eduardo Piatti Departamento de Fisica ICEx Universidade Federal de Minas Gerais Av. Antonio Carlos 6627 31270-901 Belo Horizonte MG Brazil Observatorio Astronomico Universidad Nacional de Cordoba Laprida 854 5000 Cordoba Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas Av. Rivadavia 1917 C1033AAJ Buenos AiresArgentina

Galactic open clusters （OCs） that survive the early gas-expulsion phase are gradually de- stroyed over time by the action of disruptive dynamical processes. Their final evolutionary stages are characterized by a poorly populated concentration of stars called an open cluster remnant （OCR）. This study is devoted to assessing the real physical nature of the OCR candidate NGC 7193. GMOS/Gemini spectroscopy of 53 stars in the inner target region were obtained to derive radial velocities and at- mospheric parameters. We also employed photometric and proper motion data. The analysis method consists of the following steps：（i） analysis of the statistical resemblance between the cluster and a set of field samples with respect to the sequences defined in color-magnitude diagrams （CMDs）; （ii） a 5-dimensional iterative exclusion routine was employed to identify outliers from kinematical and posi- tional data; （iii） isochrone fitting to thes× （J - Ks） CMD of the remaining stars and the dispersion of spectral types along empirical sequences in the （J - H） × （H - Ks） diagram were checked. A group of stars was identified for which the mean heliocentric distance is compatible with that obtained via isochrone fitting and whose metallicities are compatible with each other. Fifteen of the member stars observed spectroscopically were identified together with another 19 probable members. Our results indi- cate that NGC 7193 is a genuine OCR, of a once very populous OC, for which the following parameters were derived： d = 501±46 pc, t = 2.5±1.2 Gyr, （[Fe/H]） = -0.17±0.23 and E（B-V） = 0.05±0.05. Its luminosity and mass functions show depletion of low mass stars, confirming the OCR is in a dynam- ically evolved state.

关键词： open cluster remnants - Galactic open clusters

The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

Biomarkers and a tailored approach for immune monitoring in kidney transplantation

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World Journal of Transplantation 2017年第6期7卷 276-284页

作者： francisco Salcido-Ochoa John Carson Allen jr Tregs and HLA Research Force Francisco Kidney and Medical CentreMount Elizabeth Novena Hospital Centre for Quantitative Medicine Duke-NUS Graduate Medical School

A literature review on immune monitoring in kidney transplantation produced dozens of research articles and a multitude of promising biomarkers,all in the quest for the much sought after-but perennially elusive-"holy grail" of kidney biomarkers able to unequivocally predict acute transplant rejection vs *** methodologies and study designs were many and *** the motivation for this editorial,which espouses the notion that in today's kidney transplantation milieu,the judicious use of disease classifiers tailored to specific patient immune risks may be more achievable and productive in the long run and confer a greater advantage for patient treatment than the pursuit of a single "omniscient" *** addition,we desire to direct attention toward greater scrutiny of biomarker publications and decisions to implement biomarkers in practice,standardization of methods in the development of biomarkers and consideration for adoption of "biomarker-driven" *** propose "biomarkerdriven" biopsies as an adjunctive to and/or alternative to random surveillance(protocol) biopsies or belated indication *** discovery of a single kidney transplantation biomarker would represent a major breakthrough in kidney transplantation practice,but until that occurs-if ever it does occur,other approaches offer substantial potential for unlocking prognostic,diagnostic and therapeutic *** conclude our editorial with suggestions and recommendations for productively incorporating current biomarkers into diagnostic algorithms and for testing future biomarkers of acute rejection in kidney transplantation.

关键词： Acute rejection Banff classification Biomarker Human leukocyte antigen matching Immune monitoring Immunological risk Kidney transplantation Protocol biopsy

Preoperative albumin-bilirubin score is a prognostic factor for gastric cancer patients after curative gastrectomy

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1125-1137页

作者： Daniel Jose Szor Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos francisco Tustumi Andre Roncon Dias Bruno Zilberstein Ulysses Ribeiro jr Department of Gastroenterology Instituto do CancerHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 01246000Brazil

BACKGROUND Albumin-bilirubin(ALBI)score is an indicator of liver dysfunction and is useful for predicting prognosis of hepatocellular ***,this liver function index has been used to predict prognosis in other ***,the significance of ALBI score in gastric cancer(GC)after radical resection has not been *** To evaluate the prognostic value of the preoperative ALBI status in patients with GC who received curative *** Patients with GC who underwent curative intended gastrectomy were retrospectively evaluated from our prospective *** score was calculated as follows:(log10 bilirubin×0.660)+(albumin×-0.085).The receiver operating characteristic curve with area under the curve(AUC)was plotted to evaluate the ability of ALBI score in predicting recurrence or *** optimal cutoff value was determined by maximizing Youden’s index,and patients were divided into low and high-ALBI *** Kaplan-Meier curve was used to analyze the survival,and the log-rank test was used for comparison between *** A total of 361 patients(235 males)were *** median ALBI value for the entire cohort was-2.89(IQR-3.13;-2.59).The AUC for ALBI score was 0.617(95%CI:0.556-0.673,P<0.001),and the cutoff value ***,211(58.4%)patients were classified as low-ALBI group and 150(41.6%)as high-ALBI *** age(P=0.005),lower hemoglobin level(P<0.001),American Society of Anesthesiologists classification III/IV(P=0.001),and D1 lymphadenectomy P=0.003)were more frequent in the high-ALBI *** was no difference between both groups in terms of Lauren histological type,depth of tumor invasion(pT),presence of lymph node metastasis(pN),and pathologic(pTNM)*** postoperative complication,and mortality at 30 and 90 days were higher in the high-ALBI *** the survival analysis,the high-ALBI group had worse disease-free survival(DFS)and overall survival(OS)compared to those with low-ALBI(P<0.001).

关键词： Stomach neoplasms Adenocarcinoma Albumin-bilirubin Biomarker Prognosis Survival

Antioxidant,cytotoxic,and anti-venom activity of Alstonia parvifolia ***

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Asian Pacific Journal of Tropical Biomedicine 2021年第10期11卷 460-468页

作者： Maria Carmen S.Tan Mary Stephanie S.Carranza Virgilio C.Linis Raymond S.Malabed Yves Ira A.Reyes francisco C.Franco,jr. Glenn G.Oyong Chemistry Department De La Salle University2401 Taft AvenueManila 1004Philippines Biology Department De La Salle University2401 Taft AvenueManila 1004Philippines Department of Chemistry Graduate School of ScienceOsaka UniversityOsaka 563-0034Japan Molecular Science Unit Laboratory Center for Natural Sciences and Environmental ResearchDe la Salle University2401 Taft AvenueManila 1004Philippines

Objective:To evaluate antioxidant,cytotoxic,and anti-venom capacity of crude bark extracts of Alstonia parvifolia ***:Gas chromatography-mass spectrometry(GC-MS)and energy dispersive X-ray analyses were accomplished to characterize the chemical constituents of Alstonia *** characterization was evaluated using an inhibitory phospholipase A_(2)(PLA_(2))assay,DPPH,and cytotoxicity *** the constituents listed in the GC-MS analyses,molecular docking was conducted to inspect the binding energies between the chosen compounds and selected PLA_(2) ***:GC-MS analyses showed that the Alstonia parvifolia crude extract consisted predominantly of acetylmarinobufogenin(14.89%),γ-sitosterol(10.44%),3-O-methyl-D-glucose(5.88%),3,5-dimethoxy-4-hydroxyphenylacetic acid(5.30%),(2α,5α)-17-methoxyaspidofractinin-3-one(AFM)(4.08%),and 2,3,5,6,7,8,9-heptahydro-1-phenyl-5-(p-chlorophenylimino)-1H-benzo[e][1,4]thiazepine(HPT)(1.37%).The principal elemental components of Alstonia parvifolia were Ca(4.012%)and K(1.496%),as exhibited by energy dispersive X-ray *** parvifolia showed significant free radical scavenging ability(IC_(50):0.287 mg/mL)and was non-cytotoxic to normal HDFn cells(IC_(50)>100μg/mL).Moreover,Alstonia parvifolia was favorably cytotoxic to MCF-7(IC_(50):4.42µg/mL),followed by H69PR,HT-29,and THP-1,with IC_(50) values of 4.94,5.07,and 6.27µg/mL,*** parvifolia also displayed notable inhibition against PLA_(2) activity of Naja philippinensis Taylor venom with IC_(50) of(15.2±1.8)μg/*** and cluster analyses projected negative binding energies from AFM(−6.36 to−9.68 kcal/mol),HPT(−7.38 to−9.77 kcal/mol),and acetylmarinobufogenin(−7.22 to−9.59 kcal/mol).These calculations were for the particular interactions of Alstonia parvifolia constituents to PLA_(2) homologues where the utmost affinity was detected in HPT owing to the dipole interactions with amino acid ***:The bark e

关键词： Alstonia parvifolia Merr. Naja philippinensis Taylor Gas chromatography-electron ionization-mass spectrometry Secretory phospholipase A_(2) Cytotoxicity assay Anti-venom

Evaluation of Pre-Cecal, Ileal Digestibility and Glycemic Response in Fistulated Horses Fed with Different Starch Sources

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Food and Nutrition Sciences 2015年第1期6卷 151-160页

作者： Alexandre Augustode Oliveira Gobesso Mariano Etchichury José Esler de Freitas jr. francisco Palma Rennó Hugo Tosi Department of Nutrition and Animal Production Faculty of Veterinary Medicine School of Veterinary Medicine and Animal Science University of Sao Paulo Pirassununga Brazil Department of Animal Science Sao Paulo State University Jaboticabal Brazil

The objective of this study was to evaluate the coefficients of pre-cecal, ileal digestibility, and glycemic response in cannulated horses fed with different starch sources. Four male horses were used in a 4 × 4 Balanced Latin Square cannulated in the cecum, with 36 months of age and average weight of 350 kg. The horses were fed with hay and the following sources of starch in concentrates: 1) corn (C);2) oats (O);3) sorghum (S);and 4) corn/oats (CO). The experiment consisted of four periods of eighteen days each, being the first twelve days of adaptation and six days to collect samples. There was no difference in cecal and ileal digestibility of starch, CP, ADF, NDF and OM among diets evaluated. However, horses fed with oats diet had higher values of pre-cecal apparent digestibility of DM in relation at the horses fed to sorghum and corn/oats diets. The values of CF digestibility were higher for equines fed with oats and sorghum diet compared to corn/oats diet. The horses fed with corn/oats diet had lower plasma glucose concentrations 30 minutes before the supply and higher insulin concentrations 210 minutes after ingestion of the foods. The digestibility of nutrients in equine diets, in pre-cecal and pre-ileal evaluation, presents significant differences, depending on the starch source provided, oat, corn or sorghum. The plasma glucose concentrations are directly correlated with the digestibility of starch.

关键词： Horses Pre-Cecal Digestibility Fistula Ileum Glucose

Idiopathic dilated cardiomyopathy in pregnancy

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Open Journal of Obstetrics and Gynecology 2013年第5期3卷 438-440页

作者： Joao Paulo Candido Barbosa Maria Regina Melo da Justa Feijao francisco Herlanio Costa Carvalho Carlos Augusto Alencar jr. francisco Edson de Lucena Feitosa Federal University of Ceara FortalezaBrazil Department of Obstetrics Federal University of CearaFortalezaBrazil

The aim of this study was to highlight the importance of knowledge of idiopathic dilated cardiomyopathy (IDC) in pregnancy and its complications, with the order to establish early diagnosis and treatment. We report the case of a primigravida aged 17, previously healthy, 18 weeks of gestation with dyspnea at rest, which started 2 weeks ago. During the investigation, the echocardiogram (ECO) showed left ventricle (LV) dilation with impaired systolic and diastolic function, LV ejection fraction of 20%. We did not identify a cause for the patient’s clinical condition, being diagnosed with IDC. The patient remained in obstetrics and cardiology monitoring for up to 23 weeks of gestation, when it was decided by the interruption of pregnancy by caesarean section due to hemodynamic instability. The newborn came to death four days after the procedure. The patient evolved to clinical improvement, 16 days after the resolution of gestation, was discharged for outpatient monitoring.

关键词： Cardiomyopathy Pregnancy Dyspnea at Rest Caesarean Section