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Two agronomical aspects of Tagetes terniflora HBK for essential oil production

Journal of Agricultural Chemistry and Environment 2014年第1期3卷 9-13页

作者： Miguel ángel Serrato Cruz francisco díaz cedillo daniel Hernández Medina Arturo Curiel Rodríguez departamento de Fitotecnia Universidad Autónoma de Chapingo Carretera México-Texcoco Chapingo México Laboratorio de Química Orgánica Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Prolongación de Carpio y Plan de Ayala s/n Casco de Santo Tomás México D.F. México

The genus Tagetes is a possible source of essential oils for the biorational control of pests and diseases in Mexico. The aim of the present study was to assess the distance between plants (Pd;15 × 80, 30 × 80 and 60 × 80 cm) and urea fertilization (0, 60 and 120 kg·he-1 N) for biomass production and essential oil in Tagetes terniflora HBK. Oil was obtained by the aerial part hydro-distillation and its chemical composition was analyzed by gas chromatography coupled to mass spectrometry. Factors N, Pd and their interaction did not change plant height or the number of branches per plant;however, Pd factor modified fresh tissue (FW) and dry tissue (dW) weights and the amount of oil per plant (p ≤ 0.05) which represent a good biomass production (30 to 72.5 ton·he-1 FW, 11 to 27 ton·he-1 dW) and oil producing (168 to 383 L·he-1 ) potential in the field. Urea did not have effect on both biomass and oil response per plant but interaction of 15 x 80 dP and 120 N could favor higher biomass and oil production potential (78 ton FW, 28 ton·he-1 dW and 608 L·he-1 , respectively). Essential oil yield varied from 0.3 to 2.1% according to the management conditions. A total of 11 major compounds were identified in essential oil, the relative quantity was constant in different agronomic management factors: E- tagetone (22%), cistagetenone (20.4%), transtagetenone (20.4%), dihydrotagetone (13.4%) and cis-β-ocimene (10.3%), trans-β-ocimene (5.0%), propenyl anisole (4.3%), sphatulenole (1.1%), allyl anisole (0.7%), Z-tagetone (0.5%) and limonene (0.5%).

关键词： Tagetes terniflora Biomass Essential Oil Chemical Composition distance between Plants Nitrogen

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Activity Induced by a Naphthalene-Prazosin derivative on Ischemia/Reperfusion Injury in Rats

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Pharmacology & Pharmacy 2014年第12期5卷 1130-1142页

作者： Betty Sarabia-Alcocer Lauro Figueroa-Valverde francisco díaz-cedillo Lenin Hau-Heredia Marcela Rosas-Nexticapa Elodia García-Cervera Eduardo Pool-Gómez Rolando García-Martínez Braulio Zepeda-Acosta Laboratory of Pharmaco Chemistry Faculty of Chemical and Biological Sciences University Autonomous of Campeche Campeche México Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional México D.F. México Facultad de Nutrición Universidad Veracruzana Veracruz México Laboratorio de Neurociencias del Centro de Investigaciones Biomédicas de la Universidad Autónoma de Campeche Campeche México

In this study, a new naphthalene-prazosin derivative (compound 5) was synthetized with the objective of evaluating its activity on ischemia/reperfusion injury. The Langendorff technique was used to evaluate the effect of the compound 5 on ischemia/reperfusion injury. Additionally, the mechanism of action involved in the activity exerted by the compound 5 on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in absence or presence of following compounds;prazosin, metoprolol, indomethacin and nifedipine. The results showed that the compound 5 reduced infarct size compared with the control conditions. Other results showed that the compound 5 significantly increases (p = 0.05) the perfusion pressure and coronary resistance in isolated rat heart. In addition, other data indicate that the compound 5 increases left ventricular pressure in a dose-dependent manner (0.001 to 100 nM);however, this phenomenon was significantly inhibited by nifedipine at a dose of 1 nM (p = 0.05) and this effect was independent of cAMP levels. In conclusion, these data suggest that the naphthalene-prazosin derivative exerts a cardio protective effect via the calcium channels activation and consequently induces changes in the left ventricular pressure levels. This phenomenon results in a decrease of myocardial necrosis after ischemia and reperfusion.

关键词： Prazosin Left Ventricular Pressure Nifedipine Naphthalene

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