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Situations of Domestic Violence against Children and Adolescents in a Northeastern Brazilian Capital

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Open Journal of Nursing 2016年第9期6卷 633-642页

作者： Eliane Santos Cavalcante francisco arnoldo nunes de miranda Lannuzya V. e Oliveira Glauber W. dos Santos Silva Gustavo Ávila Dias Romeika C. F. de Sena Suerda Lillian da Fonseca Lins Cleonice A. A. Cavalcante Izaura Luzia Silvério Freire João E. da Costa Health School Federal University of Rio Grande do Norte Natal Brazil Nursing department Postgraduate Program in Nursing Federal University of Rio Grande do Norte Natal Brazil Natal Health City department Natal Brazil

Objective: To describe the epidemiological profile of children and adolescents who are victims of domestic violence. Method: This is a cross sectional and descriptive study, following a quantitative approach, conducted from September to december 2013, at the SOS CHILD service, in the city of Natal, Rio Grande do Norte, Brazil. The research protocol was approved by CEP/UFRN under CAAE 0166.***.051.000-11. Results: In the analysis of 69 children, the results were presented from three points of view: 1) the victim—female (56.5%), aged one to 11 years old (66.7%) and lived with one of the parents (43.5%);2) the abuser—female (60.9%) in the 14 - 23 years old and 34 - 43 years old, with the same percentage (24.6%), history of alcohol use and abuse (42.0%), the mother was the one who attacked the most (34.7%);3) types of violence, among the physical ones, the most frequent were slaps (43.2%) and punches (18.9%);the prevalence, among the psychological violence, were curses (35.4%) and abuse (27.8%);negligence, omission of care (73.5%), deprivation of care for personal appearance (18.4%);among sexual violence: sexual caresses (57.1%) and forced sex (42.9%). Conclusion: Children and adolescents placed in an unfavorable social-economic context, under the care of mothers with a history of use and abuse of alcohol and other drugs, are more vulnerable to intra-domiciliary violence.

关键词： Exposure to Violence Domestic Violence Child Health Adolescent Health

Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 139-145页

作者： Wellington Andraus francisco Tustumi Alexandre Chagas Santana Rafael Soares nunes Pinheiro Daniel Reis Waisberg Liliana Ducatti Lopes Rubens Macedo Arantes Vinicius Rocha Santos Rodrigo Bronze de Martino Luiz Augusto Carneiro D’Albuquerque department of Gastroenterology Transplantation UnitUniversidade de São PauloSão PauloBrazil

Background:Perihilar cholangiocarcinoma(phCCC)is a dismal *** is no consensus regard-ing the best treatment for patients with unresectable *** present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical *** sources:The search was conducted in PubMed,Embase,Cochrane,and *** related references were searched *** criteria were:reports in English or Portuguese literature that a)patients with confirmed diagnosis of phCCC;b)patients treated with a curative intent;c)patients with the outcomes of liver resection and liver *** reports,reviews,letters,editorials,conference abstracts and papers with full-text unavailability were excluded from the ***:Most of the current literature is based on observational retrospective studies with low grades of *** resection has better long-term outcomes than systemic chemotherapy or palliation ther-apy and liver transplantation is a good alternative for selected patients with unresectable *** candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahep-atic *** a general rule,patients presenting with a tumor having a longitudinal size>3 cm or extending below the cystic duct,lymph node disease,confirmed extrahepatic dissemination;intraoper-atively diagnosed metastatic disease;a history of other malignancies within the last five years,and did not complete chemoradiation regimen and were medically unfit should not be considered for *** of these criteria should be individually *** transplantation or resection should only be considered in highly experienced hepatobiliary centers,and any decision-making must be based on a multidisciplinary ***:phCCC is a complex condition with high *** therapies,including hepatec-tomy and liv

关键词： Liver transplantation Cholangiocarcinoma Liver neoplasms

A single session of strength training changed plasma levels of resistin,but not leptin in overweight and obese men

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Sports Medicine and Health Science 2024年第4期6卷 324-330页

作者： Yago Martins Fortes Antonio Felipe Souza-Gomes Alessandro Roberto Silveira Moreira Leo Nogueira Campos Samara Silva de Moura Lucelia Scarabeli Silva Barroso Marcelo Henrique Salviano de Faria Heliana de Barros Fernandes Aline Silva de miranda Hugo Cesar Martins-Costa Ana Cristina Simoes e Silva Janaina Matos Moreira Albena nunes-Silva Laboratory of Inflammation and Exercise Immunology Department of Physical EducationSchool of Physical EducationFederal University of Ouro PretoOuro PretoMGBrazil Postgraduate Program in Health and Nutrition Nutrition SchoolFederal University of Ouro PretoOuro PretoMGBrazil Interdisciplinary Medical Research Laboratory Faculty of MedicineFederal University of Minas GeraisBelo HorizonteMGBrazil Neurobiology Laboratory Institute of Biological SciencesFederal University of Minas GeraisBelo HorizonteMGBrazil department of Physical Education Pontifical Catholic University of Minas GeraisBrazil department of Pediatrics Faculty of MedicineFederal University of Minas Gerais(UFMG)Belo HorizonteMGBrazil

Obesity has a complex multifactorial etiology and is characterized by excessive accumulation of adipose *** adipose tissue has deleterious effects on health because it secretes large amounts of inflammatory *** calorie restriction associated with strength training may be useful in managing chronic systemic *** study aimed to evaluate the acute effect of a single strength-training session on plasma adipokine levels in sedentary,overweight,and obese young *** study included twelve men(Age:[34.95±9.77]years;Height:[174.16±3.66]centimeter[cm];Weight:[97.83±12.87]kilogram(kg);body mass index[BMI]:[32.30±4.51]kg/m2),who performed a single strength training *** strength training protocol consisted of 4 sets of 12 repetitions in the following six exercises,45°leg press,bench press,leg extension,machine row,leg curl,and shoulder *** samples were collected before,immediately after,and 1-h subsequent after strength *** plasma levels of resistin and leptin were measured.A significant decrease in resistin levels were found 1 h after the strength training session if compared to levels before the training session(pre-[before][2390±1199]picograms per milliliter[pg/mL]vs post-1 h[1-h subsequent][1523±798],6 pg/mL,p=0.0028).The plasma leptin levels did not differ at any time *** conclusion,a very well controlled single session of strength training significantly decreased the plasma levels of resistin without altering the concentration of leptin in overweight and obese *** effect,at least in part,supports the benefits of exercise by reducing the low grade inflammation and insulin resistance in obesity.

关键词： Strength training Adipose tissue Obesity Chronicinflammation Resistin Leptin

Sarcopenia and Anemia Are Predictors of Poor Prognostic in Cervical Cancer Patients

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 693-704页

作者： Leandro Santos de Araujo Resende Francine Vilela de Amorim Miguel Soares Conceição Rodrigo Menezes Jales Patrick nunes Pereira Luis Otávio Sarian Glauco Baiocchi Sophie derchain Agnaldo Lopes da Silva Filho department of Gynecology and Obstetrics Botucatu Medical School S&#227o Paulo State University UNESP S&#227o Paulo Brazil department of Health Sciences University of Sao Francisco S&#227o Paulo Brazil department of Obstetrics and Gynecology School of Medical Science State University of Campinas (UNICAMP) Campinas Brazil department of Gynecologic Oncology AC Camargo Cancer Center Sao Paulo Brazil department of Gynecology and Obstetrics School of Medicine of the Federal University of Minas Gerais Belo Horizonte Brazil

Objective: Evaluate pretreatment sarcopenia and anemia as prognostic factors in women undergoing treatment for cervical cancer (CC) with concurrent chemoradiotherapy (CCRT). Methods: 151 women with CC were analysed in this cohort study. Pretreatment computed tomography (CT) images were analysed to assess skeletal muscle index (SMI). Hazard ratios (HR) and multivariate Cox proportional HR were used to analyse association between low SMI, age, body mass index (BMI), haemoglobin levels, histological type, and International Federation of Gynaecology and Obstetrics (FIGO) stage with PFS and OS. Results: A total of 151 patients were included, 53 (35.1%) presented pretreatment sarcopenia;51 (34%) stage I/II and 100 (66%) stage III/IV. Among those patients in advanced stage (III/IV) 37 (70%) (p = 0.28) were sarcopenic at the beginning of treatment. Sarcopenia was associated with worse progression-free survival (PFS) and overall survival (OS) in our cohort [HR 0.97 (p = 0.01)] [HR 0.73 (p = 0.001)], as well as anemia [HR 0.73 (p = 0.001)] [HR 0.78 (p = 0.001)]. Linear regression models indicated that despite showing no association with age, neutrophil or platelet counts, sarcopenia was associated with pretreatment anemia levels (p = 0.01). After a multivariate analysis, only haemoglobin (anemia) and complete CCRT remained associated with PFS and OS. Sarcopenia and anemia were associated with worse PFS and OS in FIGO stage I/II. Conclusion: Pretreatment sarcopenia was significantly associated with low haemoglobin levels. Anemia and incomplete CCRT were independently associated with poor prognosis in women with CC. Pretreatment sarcopenia, as low SMI, was a predictor of poor prognostic in early stages of CC.

关键词： Cervical Cancer Sarcopenia Anemia Chemoradiotherapy

Multiple Redox and Non-Redox Interactions define 2-Cys Peroxiredoxin as a Regulatory Hub in the Chloroplast

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Molecular Plant 2009年第6期2卷 1273-1288页

作者： Meenakumari Muthuramalingam Thorsten Seidel Miriam Laxa Susana M. nunes de miranda Florian Gartner Elke Stroher Andrea Kandlbinder Karl-Josef Dietz Biochemistry and Physiology of Plants W5-134 Bielefeld University 33501 Bielefeld Germany

In plants, the highly abundant 2-cysteine peroxiredoxin （2-CysPrx） is associated with the chloroplast and involved in protecting photosynthesis. This work addresses the multiple interactions of the 2-CysPrx in the chloroplast, which depend on its redox state. Transcript co-regulation analysis showed a strong linkage to the peptidyl-prolyl-cis/trans isomerase Cyclophilin 20-3 （Cyp20-3） and other components of the photosynthetic apparatus. Co-expression in protoplasts and quantification of fluorescence resonance energy transfer （FRET） efficiency in vivo confirmed protein interactions of 2-CysPrx with Cyp20-3 as well as NADPH-dependent thioredoxin reductase C （NTRC）, while thioredoxin x （Trx-x） did not form complexes that could enable FRET. Likewise, changes in FRET of fluorescently labeled 2-CysPrx in vitro and in vivo proved redox dependent dynamics of 2-CysPrx. Addition of Cyp20-3 to an in vitro peroxidase assay with 2-CysPrx had no significant effect on peroxide reduction. Also, in the presence of NTRC, addition of Cyp20-3 did not further enhance peroxide reduction. In addition, 2-CysPrx functioned as chaperone and inhibited aggregation of citrate synthase during heat treatment. This activity was partly inhibited by Cyp20-3. As a new interaction partner of decameric 2-CysPrx, photosystem Ⅱ could be identified after chloroplast fractionation and in pull-down assays after reconstitution. In summary, the data indicate a dynamic function of plant 2-CysPrx as redox sensor, chaperone, and regulator in the chloroplast with diverse functions beyond its role as thiol peroxidase.

关键词： Oxidative and photo-oxidative stress photosynthesis chloroplast biology Arabidopsis cyclophilin peroxiredoxin thioredoxin.

Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model

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World Journal of Hepatology 2019年第4期11卷 359-369页

作者： Francielle Graus-nunes Felipe de Oliveira Santos Thatiany de Souza Marinho Carolline Santos miranda Sandra Barbosa-da-Silva Vanessa Souza-Mello Laboratorio de Morfometria Metabolismo e Doencas Cardiovasculares Departamento de Anatomia Instituto de Biologia Roberto Alcantara Gomes

BACKGROUND Obesity has been associated with hepatic overexpression of the renin-angiotensin system(RAS).AIM To evaluate the action of two angiotensin II(ANGII) receptor blockers(losartan or telmisartan) on the modulation of local hepatic RAS and the resulting metabolic effects in a diet-induced obesity murine *** Twenty C57 BL/6 mice were randomly divided into two nutritional groups for 10 wk: control group(C, n = 5, 10% of energy as fat) or high-fat group(HF, n = 15,50% of energy as fat). After treatment started, the HF group was randomly divided into three groups: untreated HF group(n = 5), HF treated with losartan(HFL, n = 5) and HF treated with telmisartan(HFT, n = 5). The treatments lasted for 5 wk, and the dose was 10 mg/kg body *** HF diet induced body mass gain(+28%, P demonstrated by reduced hepatic triacylglycerol levels coupled with reduced PLIN 2 expression and improved glycemic control.

关键词： Liver Telmisartan Losartan Obesity Angiotensin Ⅱ type 1 receptor C57BL/6 mouse

Agave sisalana extract induces cell death in Aedes aegypti hemocytes increasing nitric oxide production

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 396-399页

作者： Louise Helena Guimaraes de Oliveira Patricia Alexandria Paiva Silva de Sousa Fabrine Felipe Hilario Gabriel Joventino Nascimento Joao Paulo Saraiva Morais Everaldo Paulo de Medeiros Manoel francisco de Sousa Fabiola da Cruz nunes Biotechnology Center Federal University of Paraiba Embrapa Algodao Brazilian Agricultural Research Corporation

Objective: To investigate the effects of Agave sisalana(A. sisalana) extract on Aedes aegypti(Ae. aegypti) primary cell ***: Cells of Ae. aegypti were exposed to different concentrations of A. sisalana crude extract(0.18–6.00 mg/m L) for 24 h. Then, the cells were labeled with propidium iodide and subjected to fluorescence microscopy to verify cell viability. In addition, nitric oxide production was ***: Results showed that cells exposed to 6 mg/m L of the crude extract presented a greater percentage of death when compared to control(73.8% ± 9.6% vs. 34.6% ± 9.6%).Furthermore, there was an increase in the nitric oxide production in cells exposed to 6 mg/m L of A. sisalana crude extract [(0.81 ± 0.08) mmol/L] compared to control group[(0.41 ± 0.18) mmol/L].Conclusions: The results show that A. sisalana is cytotoxic to Ae. aegypti and may be used as raw material for new eco-friendly and inexpensive insecticides, since sisal industry discards the liquid waste for the extraction of plant fiber.

关键词： Sisal Cell culture Mosquito Insecticide

Agronomic evaluation of eight 41 B×110 richter grapevine genotypes as rootstock candidates for mediterranean viticulture

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Horticultural Plant Journal 2023年第4期9卷 720-728页

作者： Diana Marín Carlos miranda francisco Javier Abad Jorge Urrestarazu Blanca Mayor Ana Villa-Llop Luis Gonzaga Santesteban department of Agronomy Biotechnology and Food SciencePublic University of NavarreCampus ArrosadiaPamplona 31006NavarraSpain Institute for Multidisciplinary Research in Applied Biology(IMAB-UPNA) Public University of NavarreCampus ArrosadiaPamplona 31006NavarraSpain Institute for Agri-food Technology and Infrastructure of Navarre(INTIA) Edificio de PeritosAvda.Serapio Huici 22Villava 31610NavarraSpain

Choosing the most appropriate rootstock(s)is a key decision for the profitability of vineyards;therefore,there must be a sufficient range of rootstocks in the market adapted to different environmental conditions and production ***,rootstock-breeding programs have been scarce in recent decades,and most of the rootstocks used today were bred a century ago,when the needs of the sector were very different from *** this work,we aimed to evaluate new rootstock candidates before their introduction in the *** agronomic evaluation was conducted on eight novel rootstock genotypes obtained from the first generation of the cross-pollination of 41 B Millardet et de Grasset(41 B)and 110 Richter(110 R)grafted with‘Syrah’and‘Tempranillo’and planted in a typical vineyard of the Ebro Valley in *** the four consecutive growing seasons(2016–2019),growth,yield and berry composition parameters at harvest were collected.A linear mixed-effects model was constructed,considering year and block as random *** factor analysis and hierarchical clustering on principal components were performed to establish clusters of genotypes with similar *** rootstock candidates showed a very wide performance range compared to their *** trial allowed us to identify two very promising candidates(RG8 and RG10),whose registration as commercial rootstocks is already in progress.

关键词： Vitis vinifera Graft Phenolic quality Vigour Yield

Measuring External debt in a Context of Macroeconomic Imbalances

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Journal of Mathematics and System Science 2014年第3期4卷 202-207页

作者： Joao Cadete de Matos Ana Margarida de Almeida Ligia Maria nunes Daniela Black miranda Director Banco de Portugal Statistics Department Lisboa Portugal deputy-Director Banco de Portugal Statistics Department Lisboa Portugal Banco de Portugal Statistics Department Lisboa Portugal

The exploitation of new methodologies and indicators is considered valuable in measuring a key macroeconomic indicator like the external debt. The recent Portuguese economic developments illustrate the need and usefulness of having a multidimensional approach of this indicator, with several balance of payment items, such as the current and the capital account balances, the foreign direct investment or the reserves assets being carefully analysed when reading the external conditions faced by the economy. Only such an approach can provide with a comprehensive measure of external debt consistent across the range of debt instruments, institutional sectors and valuation methods used. This paper develops an assessment of external debt measures and concludes about their potential advantages and disadvantages. Comparisons are made by focusing on alternatives like gross external debt against net external debt, external debt vis-h-vis international investment position, and external debt at nominal value against external debt at market value.

关键词： External debt valuation debt instruments institutional sectors.