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Aortic valve stenosis provides complementary information to bleeding risk scores in non-valvular atrial fibrillation patients initiating anticoagulation

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Journal of Geriatric Cardiology 2020年第3期17卷 141-148,I0005-I0007页

作者： Gines Elvira-Ruiz Cesar Caro-Martinez Pedro JoseFlores-Blanco Juan JoseCerezo-Manchado Helena Albendin-Iglesias Alejandro Lova-Navarro Francisco Arregui-Montoya francisca maria munoz-franco Natalia Garcia-Iniesta Arcadio Garcia-Alberola JoseLuis Bailen-Lorenzo Domingo Andres Pascual-Figal Sergio Manzano-Fernández Department of Cardiology University Hospital Virgen de la ArrixacaMurciaSpain Instituto Murciano de Investigación en Biomedicina(IMIB) MurciaSpain Department of Cardiology University Hospital Morales MeseguerMurciaSpain Department of Hematology University Hospital Virgen de la ArrixacaMurciaSpain Department of Internal Medicine University Hospital Virgen de la ArrixacaMurciaSpain School of Medicine University of MurciaMurciaSpain Department of Cardiology Hospital Vega BajaAlicanteSpain

Background The identification of modifiable bleeding risk factors may be of *** aim is to evaluate if aortic stenosis(AS)provides additional information to bleeding risk scores for predicting major bleeding(MB)in non-valvular atrial fibrillation(AF).Methods We designed a retrospective multi-center study including 2880 consecutive non-valvular AF patients initiating oral anticoagulation between January 2013 and December *** was defined as moderate or severe according to European echocardiography guidelines ***,ATRIA and ORBIT scores were used to evaluate the bleeding *** was defined according to the International Society on Thrombosis and Haemostasia criteria and registered at 18 months of *** 168(5.8%)patients had *** with AS had higher risk for MB compared to those without AS(HR=2.13,95%CI:1.40-3.23,P<0.001).Patients without AS and low-intermediate bleeding risk(0 points)showed the lowest MB rate,whereas the MB rate observed among patients with AS and high bleeding risk(2 points)was the highest *** and reclassification analyses showed that AS provided additional information to bleeding risk scores for predicting MB at 18 months of *** In this population,AS was associated with an increased risk for MB at midterm *** three scoring systems showed a moderate discriminatory ability for ***,the addition of AS was associated with a significant improvement in their predictive *** suggest that the presence of this valvulopathy should be taken into account for bleeding risk assessment.

关键词： Anticoagulants Aortic stenosis Atrial fibrillation Major bleeding Valvular disease

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Abnormal ACT in a Patient with Prekallikrein Deficiency Undergoing Cardiopulmonary Bypass

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Open Journal of Anesthesiology 2024年第5期14卷 145-149页

作者： maria R. Fuertes Naila Ahmad Orlando Perez-franco Andrew Oster Marion Svendrowski Pin Yue Department of Anesthesiology and Critical Care Saint Louis University School of Medicine St. Louis MO USA

Prekallikrein deficiency is a disorder that often remains undiagnosed. Prekallikrein activates factor XII, which initiates the intrinsic coagulation pathway. Prekallikrein deficiency results in prolonged Partial Thromboplastin Time and Activated Clotting Time in absence of anticoagulants or active bleeding. This case report describes the anesthesia management of a patient with Prekallikrein deficiency who underwent cardiac surgery with Cardiopulmonary Bypass for correction of a congenital cardiac malformation. We highlight the importance of understanding the different tests available for the diagnosis of coagulation factors deficiency during administration of heparin in the setting of cardiovascular procedures under general anesthesia.

关键词： Prekallikrein Deficiency Fletcher Factor Deficiency Cardiopulmonary Bypass Congenital Cardiac Malformation

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A comprehensive review of genetic causes of obesity

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World Journal of Pediatrics 2024年第1期20卷 26-39页

作者： Marcio Jose Concepcion-Zavaleta Juan Eduardo Quiroz-Aldave maria del Carmen Durand-Vasquez Elman Rolando Gamarra-Osorio Juan del Carmen Valencia de la Cruz Claudia Mercedes Barrueto-Callirgos Susan Luciana Puelles-Leon Elena de Jesus Alvarado-Leon Frans Leiva-Cabrera francisca Elena Zavaleta-Gutierrez Luis Alberto Concepcion-Urteaga Jose Paz-Ibarra Universidad Cientifica del Sur Bolivar 2150 AvenuePueblo Libre15084LimaPeru Division of Medicine Hospital de Apoyo ChepénChepenPeru Division of Family Medicine Hospital de Apoyo ChepénChepenPeru Division of Endocrinology Hospital Victor Lazarte EchegarayTrujilloPeru Division of Pediatrics Hospital de Apoyo ChepenChepenPeru Division of Internal Medicine Hospital de Apoyo ChepenChepenPeru Division of Genetics Universidad Nacional de TrujilloTrujilloPeru Division of Neonatology Hospital Belen de TrujilloTrujilloPeru Division of Internal Medicine Universidad Nacional de TrujilloTrujilloPeru Department of Medicine School of MedicineUniversidad Nacional Mayor de San MarcosLimaPeru

Background Obesity is a multifactorial chronic disease with a high,increasing worldwide *** causes account for 7%of the cases in children with extreme *** sources This narrative review was conducted by searching for papers published in the PubMed/MEDLINE,Embase and SciELO databases and included 161 *** search used the following search terms:"obesity","obesity and genetics","leptin","Prader-Willi syndrome",and"melanocortins".The types of studies included were systematic reviews,clinical trials,prospective cohort studies,cross-sectional and prospective studies,narrative reviews,and case *** The leptin-melanocortin pathway is primarily responsible for the regulation of appetite and body ***,several important aspects of the pathophysiology of obesity remain *** causes of obesity can be grouped into syndromic,monogenic,and polygenic causes and should be assessed in children with extreme obesity before the age of 5 years,hyperphagia,or a family history of extreme obesity.A microarray study,an analysis of the melanocortin type 4 receptor gene mutations and leptin levels should be performed for this *** are three therapeutic levels:lifestyle modifications,pharmacological treatment,and bariatric *** Genetic study technologies are in constant development;however,we are still far from having a personalized approach to genetic causes of obesity.A significant proportion of the affected individuals are associated with genetic causes;however,there are still barriers to its approach,as it continues to be underdiagnosed.

关键词： Leptin Melanocortin Obesity Prader-Willi syndrome Precision medicine

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Effect of asphalt thin beams mixed with three nominal maximum aggregate sizes in the bending beam rheometer on the prediction of thermal properties of bituminous material

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Frontiers of Structural and Civil Engineering 2017年第1期11卷 1-7页

作者： Chun-Hsing HO maria francisca Martinez GONZALEZ Cristina Pilar Martin LINARES Department of Civil Engineering Construction Management and Environmental Engineering Northern Arizona UniversityFlagstaff Arizona 86001 USA

The objective of this research is to evaluate an impact of asphalt mixture beams with varying sizes of aggregate in the Bending Beam Rheometer （BBR） for testing/predicting thermal cracking properties of asphalt pavements. The BBR test has following benefits： the equipment is cheaper, it uses smaller specimens, faster conditioning, easier availability for quality control, easier to manage, etc. However some concerns have been raised： some consider that the size of the aggregate may affect the test＇s results; the other concern is that such small beams cannot represent the whole properties of the asphalt pavement. To address these criticisms, imaging techniques, statistical analysis, and viscoelastic modeling are used. Asphalt thin beams prepared with three different nominal maximum aggregate size （NMAS）（12.5mm, 9.5 mm, and 4.75 mm） were tested at three different temperatures （-18℃, -24℃, and -30℃）. Based on results from statistical analyses and viscoelasticity, the ratio of asphalt binders and voids and stiffness differences among the three NMAS specimens are not significant, meaning that the impact of asphalt thin beams prepared with the three NMAS on the prediction of thermal cracking is minimal and can be neglected.

关键词： bending beam rheometer thin beams thermal cracking

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Comparison of PM_(10) concentrations and metal content in three different sites of the Venice Lagoon: An analysis of possible aerosol sources

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Journal of Environmental Sciences 2012年第11期24卷 1954-1965页

作者： Daniele Contini franco Belosi Andrea Gambaro Daniela Cesari Angela maria Stortini maria Chiara Bove Institute of Atmospheric Sciences and Climate ISAC-CNRLecceItaly Institute of Atmospheric Sciences and Climate ISAC-CNRBolognaItaly Department of Environmental Sciences Informatics and StatisticsUniversity Ca'Foscari of VeniceVeneziaItaly Institute of Atmospheric Sciences and Climate ISAC-CNRLecceItaly. Institute for the Dynamics of Environmental Processes IDPA-CNRVeneziaItaly

The Venice Lagoon is exposed to atmospheric pollutants from industrial activities, thermoelectric power plants, petrochemical plants, incinerator, domestic heating, ship traffic, glass factories and vehicular emissions on the mainland. In 2005, construction began on the mobile dams （MOSE）, one dam for each channel connecting the lagoon to the Adriatic Sea as a barrier against high tide. These construction works could represent an additional source of pollutants. PM10 samples were taken on random days between 2007 and 2010 at three different sites： Punta Sabbioni, Chioggia and Malamocco, located near the respective dam construction worksites. Chemical analyses of V, Cr, Fe, Co, Ni, Cu, Zn, As, Mo, Cd, Sb, T1 and Pb in PM10 samples were performed by Inductively coupled plasma- quadrupole mass spectrometry （ICP-QMS） and results were used to identify the main aerosol sources. The correlation of measured data with meteorology, and source apportionment, failed to highlight a contribution specifically associated to the emissions of the MOSE construction works. The comparison of the measurements at the three sites showed a substantial homogeneity of metal concentrations in the area. Source apportionment with principal component analysis （PCA） and positive matrix factorization （PMF） showed that a four principal factors model could describe the sources of metals in PM10. Three of them were assigned to specific sources in the area and one was characterised as a source of mixed origin （anthropogenic and crustal）. A specific anthropogenic source of PM10 rich in Ni and Cr, active at the Chioggia site, was also identified.

关键词： MOdulo Sperimentale Elettromeccanico metals Venice Lagoon PM10 principal component analysis positive matrixfactorization

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Update of the spectrum of mucopolysaccharidoses type Ⅲ in Tunisia: identification of three novel mutations and in silico structural analysis of the missense mutations

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World Journal of Pediatrics 2017年第4期13卷 374-380页

作者： Souad Ouesleti maria francisca Coutinho Isaura Ribeiro Abdehedi Miled Dalila Saidane Mosbahi Sandra Alves Biochemical Service CHU Farhat Hached4000SousseTunisia Research and Development Unit Department of Human GeneticsNational Institute of Health Dr.Ricardo JorgePortoPortugal Biochemical Genetics Unit Medical Genetics Center Dr.Jacinto de Magalh(a)esPorto Hospital CentrePortoPortugal Laboratory of Analysis Treatment and Valorization of Pollutants of the Environment and ProductsFaculty of PharmacyUniversity of Monastir5000Tunisia

Background:Mucopolysaccharidoses type Ⅲ (MPS Ⅲ) are a group of autosomai recessive lysosomal storage diseases,caused by mutations in genes that code for enzymes involved in the lysosomal degradation of heparan sulphate:heparan sulfate sulfamidase (SGSH),a-N-acetylglucosaminidase (NAGLU),heparan sulfate acetyl-CoA:a-glucosaminide N-acetyltransferase (HGSNAT),and N-acetylglucosamine-6-sulfatase (GNS).Methods:In this study,we have performed the molecular analysis of the SGSH,NAGLU and HGSNAT genes in 10 patients from 6 different MPS Ⅲ Tunisian ***:In the SGSH gene,two mutations were identified:one novel (p.D477N) and one already described (p.Q365X).In the NAGLU gene,two novel mutations were discovered (p.L550P and p.E153X).For the novel missense mutations found in these two genes we performed an in silico structural analysis and the results were consistent with the clinical course of the patients harboring those ***,in HGSNAT gene,we found the splicesite mutation c.234+1G>A that had already been reported as relatively frequent in MPS ⅢC patients from countries surrounding the basin of the Mediterranean *** presence in two Tunisian MPS ⅢC families points to the hypothesis of its peri Mediterranean *** the exception of the c.234+1G>A mutation,that was identified in two unrelated MPS ⅢC families,the other identified mutations were family-specific and were always found in homozygosity in the patients studied,thus reflecting the existence of consanguinity in MPS Ⅲ Tunisian ***:Three novel mutations are reported here,further contributing to the knowledge of the molecular basis of these *** results of this study will allow carrier detection in affected families and prenatal molecular diagnosis,leading to an improvement in genetic counseling.

关键词： molecular characterization mucopolysaccharidosis Ⅲ mutation

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Precision medicine in gastric cancer

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 804-829页

作者： Patrizia Bonelli Antonella Borrelli Franca maria Tuccillo Lucrezia Silvestro Raffaele Palaia franco maria Buonaguro Molecular Biology and Viral Oncology Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy Abdominal Medical Oncology Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy Gastro-pancreatic Surgery Division Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy

Gastric cancer(GC)is a complex disease linked to a series of environmental factors and unhealthy lifestyle habits,and especially to genetic *** represents the second leading cause of cancer-related deaths *** onset is subtle,and the majority of patients are diagnosed once the cancer is already *** recent years,there have been innovations in the management of advanced GC including the introduction of new classifications based on its molecular *** to new technologies such as next-generation sequencing and microarray,the Cancer Genome Atlas and Asian Cancer Research Group classifications have also paved the way for precision medicine in GC,making it possible to integrate diagnostic and therapeutic *** the objectives of the subdivision of GC into subtypes is to select patients in whom molecular targeted drugs can achieve the best results;many lines of research have been initiated to this *** phase III clinical trials,trastuzumab,anti-Erb-B2 receptor tyrosine kinase 2(commonly known as ERBB2)and ramucirumab,anti-vascular endothelial growth factor receptor 2(commonly known as VEGFR2)monoclonal antibodies,were approved and introduced into first-and second-line therapies for patients with advanced/metastatic ***,the heterogeneity of this neoplasia makes the practical application of such approaches ***,scientific progress has not been matched by progress in clinical practice in terms of significant improvements in *** continues to be low in contrast to the reduction in deaths from many common cancers such as colorectal,lung,breast,and prostate *** several target molecules have been identified on which targeted drugs can act and novel products have been introduced into experimental therapeutic protocols,the overall approach to treating advanced stage GC has not substantially ***,surgical resection with adjuvant or neoadjuvant radiotherapy and ch

关键词： Gastric cancer Molecular characterization Biomarkers Precision medicine Targeted therapy

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A tree counting algorithm for precision agriculture tasks

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International Journal of Digital Earth 2013年第1期6卷 94-102页

作者： franco Santoro Eufemia Tarantino Benedetto Figorito Stefania Gualano Anna maria D’Onghia Centre International de Hautes Etudes Agronomiques Me´diterrane´ennes(CIHEAM) BariItaly School of Environmental Engineering Polytechnic University of BariBariItaly Institute of Intelligent Systems for Automation(ISSIA CNR) BariItaly

This study proposes an automatic procedure for individual fruit tree identification using GeoEye-1 sensor *** on site-specific pruning practices,the morphologic characteristics of tree crowns may generate one or more brightness peaks(tree top)on the *** optimize tree counting and to minimize typical background noises from orchards(*** soil,weeds,and man-made objects),a four-step algorithm was implemented with spatial transforms and functions suitable for spaced stands(asymmetrical smoothing filter,local minimum filter,mask layer,and spatial aggregation operator).System perfor-mance was evaluated through objective criteria,showing consistent results in fast capturing tree position for precision agriculture tasks.

关键词： individual tree identification image processing GeoEye-1 data precision agriculture geospatial data integration remote sensing sensor agri-culture

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Gastrointestinal involvement in paediatric COVID-19 — from pathogenesis to clinical management: A comprehensive review

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World Journal of Gastroenterology 2021年第23期27卷 3303-3316页

作者： Carmelina Calitri Ilaria Fumi maria Giovanna Ignaccolo Elena Banino Stefania Benetti maria MaddalenaLupica Francesca Fantone Mariella Pace franco Garofalo Department of Paediatrics Infermi HospitalASLTO3Rivoli 10098Italy

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),is responsible for the first pandemic of the 21st *** found in adults,signs and symptoms related to the disease mainly involve the respiratory tract in the paediatric ***,a considerable number of children present with gastrointestinal symptoms such as vomiting,abdominal pain,and *** purpose of this review is an accurate description,from pathogenesis to clinical presentation,diagnosis and treatment,of COVID-19 effects on the gastrointestinal system at a paediatric ***-CoV-2 can be identified in stool specimens of affected children by real-time polymerase chain reaction *** can last for several weeks after the end of the symptomatic *** signs and symptoms are generally self-limited,can correlate with blood tests and imaging alterations,and may require supportive treatment such as ***,they can precede severe disease manifestations such as the COVID-19-related multisystem inflammatory *** belonging to risk categories such as those affected by celiac disease,inflammatory bowel disease,and hepatic disease seem to not have a more severe course than the others,even if they are undergoing immunosuppressant *** follow-ups of patients with chronic diseases need to be revised during the pandemic period in order to postpone unnecessary tests,mainly endoscopic ones.

关键词： SARS-CoV-2 COVID-19 Paediatric Gastrointestinal Diarrhea Hydration

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HCS strategy targeting dysregulation of the VHL/HIF pathway for drug discovery

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Advances in Bioscience and Biotechnology 2013年第3期4卷 398-405页

作者： Bastien Cautain Nuria de Pedro maria munoz de Escalona Jose R.Tormo Olga Genilloud francisca Vicente Screening and Target Validation Department Fundacion MedinaGranadaSpain

One-third of top-selling drugs are derived from natural products. When only a fraction of the bioactive natural products diversity has been explored, huge opportunities still remain for discovering novel leads for the development of new drugs. Clear cell renal cell carcinoma (ccRCC) is a highly vascular tumour arising from epithelial elements. Mutations in the Von Hippel-Lindau (VHL) gene are responsible for VHL disease and arise in the majority of Renal Cell Carcinoma (RCC) as well as in other types of cancer. Renal carcinoma cell lines with naturally occurring VHL mutations (RCC4 VA) and their genetically matched wild-type VHL (RCC4 VHL) counterparts were seeded onto 96-well plates and allowed to attach overnight. Fungal extracts were tested on both cell lines. Clinically useful antitumor agents were used as positive controls and as reference points to establish the efficacy and selectivity of the new compounds. Renal cell carcinoma cell lines expressing VHL or not were treated with Carboxyfluorescein succinimidyl ester (CFSE). The day after cell inoculation, extracts were added and during the following days of incubation, fluorescence intensity was measured as a surrogate marker for cell viability. The most promising extracts selectively inhibited growth of pVHL-defi- cient cells but not of wild-type VHL cells. We used High Content Bio-imaging, a complete cellular imaging workflow that integrates instruments and software to acquire and analyze images, to evaluate their effect. Cell imaging can reveal effects that would be overlooked by other cell assay approaches. This target-based whole cell screen is a new strategy, which ensures cell permeability and target selectivity especially in natural product screening where natural product purification is a labour of extensive work. This approach permitted a dynamic study where fluorescence was measured without affecting cell viability and enabling a better detection of cytotoxic effects such as autophagy, senescence or

关键词： High Content Screening Natural Products HIF Drug Discovery

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