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3D printing of PEEK–cHAp scaffold formedical bone implant

Bio-Design and Manufacturing 2021年第1期4卷 44-59页

作者： Bankole I.Oladapo SAbolfazl Zahedi Sikiru O.Ismail francis.t.omigbodun Oluwole K.Bowoto Mattew A.Olawumi Musa A.Muhammad School of Engineering and Sustainable Development De Montfort UniversityLeicesterUK Centre for Engineering Research School of PhysicsEngineering and Computer ScienceUniversity of HertfordshireHatfieldUK Mechanical Engineering Loughborough UniversityLoughboroughUK Faculty of Engineering Computing and mediaDe Montfort UniversityLeicesterUK Faculty of Engineering Environment and ComputingCoventry UniversityCoventryUK

the major drawback associated with PEEK implants is their biologically inert surface,which caused unsatisfactory cellular response and poor adhesion between the implants and surrounding soft tissues against proper bone *** this study,polyetheretherketone(PEEK)was incorporated with calcium hydroxyapatite(cHAp)to fabricate a PEEK-cHAp biocomposite,using the fused deposition modeling(FDM)method and a surface treatment strategy to create microporous architectures onto the filaments of PEEK lattice ***,nanostructure and morphological tests of the PEEK-cHAp biocomposite were modeled and analyzed on the FDM-printed PEEK-cHAp biocomposite sample to evaluate its mechanical and thermal strengths as well as in vitro cytotoxicity via a scanning electron microscope(SEM).A technique was used innovatively to create and investigate the porous nanostructure of the PEEK with controlled pore size and distribution to promote cell penetration and biological integration of the PEEK-cHAp into the *** vivo tests demonstrated that the surface-treated micropores facilitated the adhesion of newly regenerated soft tissues to form tight implant-tissue interfacial bonding between the cHAp and *** results of the cell culture depicted that PEEK-cHAp exhibited better cell proliferation attachment spreading and higher alkaline phosphatase activity than PEEK *** islands formed on the PEEK-cHAp composite after immersion in simulated body fluid of Dulbecco’s modified Eagle medium(DMEM)for 14 days and grew continuously with more or extended *** microstructure treatment of the crystallinity of PEEK was comparatively and significantly different from the PEEK-cHAp sample,indicating a better treatment of *** in vitro results obtained from the PEEK-cHAp biocomposite material showed its biodegradability and performance suitability for bone *** study has potential applications in the field of biomedical engineering to strengthen the conceptual kn

关键词： 3D printing PEEK-cHAp biocomposite Nanostructure Bone implant Composite morphing

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Uncertainty, certainty, and relativity(Invited Paper)

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Chinese Optics Letters 2016年第1期14卷 2-6页

作者： francis t.S.Yu Department of Electrical Engineering Penn State University

One of the most fascinating principles in quantum mechanics must be Heisenberg＇s uncertainty principle, which can be briefly stated as follows： every physicM observation cannot be precisely determined without some degree of error or uncertainty. And it is by no means can one use the principle within the limit of certainty region, as will be shown in this Letter. two of the most important pillars in modern physics must be Einstein＇s relativity theory and SchrSdinger＇s contribution to quantum mechanics. Yet, there is a profound connection between these discoveries by means of the uncertainty relationship, in which we shown that the observation of a high-speed object is conceivable if the speed of the observer keeps up with object＇s speed.

关键词： and relativity certainty Uncertainty

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Mitigation of EDFA transient effects in variable duty cycle pulsed signals

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Defence technology（防务技术） 2019年第3期15卷 276-281页

作者： D. Meena K.t. Sarath Fredy francis E. Dipin t. Srinivas Electronics and Radar Development Establishment (LRDE) DRDO Bangalore Karnataka 560093 India Model Engineering College Thrikkakara Cochin Kerala 682021 India Indian Institute of technology Madras Chennai Tamil Nadu 600036 India

We report the transient effects in Erbium Doped Fiber Amplifier (EDFA) systems for pulsed signals with different duty-cycles. the work includes the analysis using three different duty-cycles, 10%, 20% and 50%. A curve fitting technique is also proposed to predict the transients of any lesser duty-cycled pulse, once the transients of a larger duty-cycled pulse is known. Mathematical evaluation confirms the double exponential shape of transient distorted signal. Further, EDFA transient effect is experimentally verified on a Wavelength Division Multiplexed (WDM) link by multiplexing high and low bitrate modulated optical signals. We conclude the paper by proposing a transient suppression technique for variable dutycycle signals and analyzing its effectiveness with different wavelength spacing.

关键词： EDFA transients WDM Variable duty cycle Suppression

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transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN t.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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Determination of contact parameters for discrete element method simulations of granular systems

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Particuology 2008年第6期6卷 521-528页

作者： Kevin francis Malone Institute of Particle Science and Engineering University of Leeds

Both linear-spring-dashpot （LSD） and non-linear Hertzian-spring-dashpot （HSD） contact models are commonly used for the calculation of contact forces in Discrete Element Method （DEM） simulations of granular systems. Despite the popularity of these models, determination of suitable values for the contact parameters of the simulated particles such as stiffness, damping coefficient, coefficient of restitution, and simulation time step, is not altogether obvious. In this work the relationships between these contact parameters for a model system where a particle impacts on a flat base are examined. Recommendations are made concerning the determination of these contact parameters for use in DEM simulations.

关键词： Discrete Element Method (DEM) Linear-spring--dashpot model Non-linear Hertzian-spring-dashpot model Contact parameters

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Vickers and Knoop Micro-hardness Behavior of Coarse-and Ultrafine-grained titanium

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Journal of Materials Science & technology 2010年第10期26卷 904-907页

作者： K.P.Sanosh A.Balakrishnan L.francis t.N.Kim Department of Information and Electronic Materials Engineering College of EngineeringPaichai University Laboratoire SIMAP GPM2 Grenoble-INPUJFCNRS 101 Rue de la PhysiqueBP46 38402 Saint Martin d'He' res CedexFrance University of Genova Department of Chemistry and Industrial Chemistry

the present study focuses on the relationship of hardness with grain size for commercially pure titanium （Cpti） and ultra fine grained titanium （UFG-ti） produced by equal channel angular process （ECAP） of Cp-ti）.Vickers and Knoop indentations of UFG-ti at different loads was ～2.5 times harder than those of *** diffraction （XRD） analysis showed peak broadening in UFG-ti due to reduced grain size and micro-lattice *** electron microscopy （SEM） revealed that ECAP had reduced the grain size of Cp-ti by ～10 *** statistics showed UFG-ti with lower dispersion in hardness values compare to Cp-ti indicating a more uniform microstructure.

关键词： Vickers Knoop Hardness Ultrafine-grained titanium

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Neutrino astronomy： An update

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Frontiers of physics 2013年第6期8卷 759-770页

作者： francis Halzen Wisconsin IceCube Particle Astrophysics Center (WIPAC) and Department of Physics University of Wisconsin Madison WI 53706 USA

Detecting neutrinos associated with the still enigmatic sources of cosmic rays has reached a new watershed with the completion of IceCube, the first detector with sensitivity to the anticipated fluxes. In this review, we will briefly revisit the rationale for constructing kilometer-scale neutrino detectors and summarize the status of the field.

关键词： neutrinos cosmic rays astrophysics

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No country is an island in regulating food safety:How the WtO monitors Chinese food safety laws through the trade Policy Review Mechanism(tPRM)

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Journal of Integrative Agriculture 2015年第11期14卷 2142-2156页

作者： francis Snyder Northwest A&F University School of transnational Law Peking University Shenzhen Graduate School College of Europe

Established within the framework of the World trade Organization （WtO）, the trade Policy Review Mechanism （tPRM） reviews periodically the trade policies of all WtO Members. the review includes many aspects of food safety regulation. China＇s trade policy is reviewed every two years. this paper analyses in detail the reviews of China＇s trade policy in 2006, 2008, 2010, 2012 and 2014. It focuses in particular on food safety laws and types of standards, alignment of domestic standards with international standards, the role of different domestic institutions, transparency and notification of food safety measures under the WtO agreements on Sanitary and Phytosanitary Measures （SPS） and on technical Barriers to trade （tBtAgreement）, import and export, and geographical indications （GIs）. It concludes that the WtO tPRM can contribute, within its mandate, to reform of Chinese food safety laws and improvement of food safety in China. it notes that China has already undertaken substantial reforms of its system for regulating food safety. It recommends that China should continue to participate actively in the tPRM, follow its own path with regard to alignment and learn selectively from other WtO Members.

关键词： food safety food standards public health consumer welfare China Chinese food safety laws World trade Organization WtO law trade Policy Review Mechanism (tPRM) SPS Agreement tBt Agreement

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topological Studies of three-dimensional Flows in a High Pressure Compressor Stator Blade Row without and with Boundary Layer Aspiration

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Chinese Journal of Aeronautics 2011年第5期24卷 541-549页

作者： Ankit SACHDEVA francis LEBOEUF Laboratoire de Mécanique des Fluides et d'Acoustique Ecole Centrale de Lyon

this paper presents a numerical study of the flow topologies of three-dimensional （3D） flows in a high pressure compressor stator blade row without and with boundary layer aspiration on the hub wall. the stator blade is representative of the first stage operating under transonic inlet conditions and the blade design encourages development of highly complex 3D flows. the blade has a small tip clearance. the computational fluid dynamics （CFD） studies show progressive increase of hub corner stall with the increase in incidence. Aspiration is implemented on the hub wall via a slot in the comer between the hub wall and the suction surface. the CFD studies show aspiration to be sensitive to the suction flow rate; lower rate leads to very complex flow struc- tures and increased level of losses whereas higher rate renders aspiration effective for control of hub comer separation. the flow topologies are studied by trace of skin friction lines on the walls. the nature of flow can be explained by the topological rules of closed separation. Furthermore, a deeper analysis is done for a particular case with advanced criterion to test the non-degeneracy of critical points in the flow field.

关键词： high pressure compressor flow topologies three-dimensional flows boundary layer aspiration tip clearance

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Fecal microbiota transplantation in allergic diseases

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World Journal of Methodology 2025年第2期15卷 83-91页

作者： Ece tüsüzÖnata ÖnerÖzdemir Division of Pediatric Allergy and Immunology Medical FacultySakarya UniversityAdapazarı54100SakaryaTürkiye

Microorganisms such as bacteria,fungi,viruses,parasites living in the human intestine constitute the human intestinal *** refers to composi-tional and quantitative changes that negatively affect healthy gut *** recent years,with the demonstration that many diseases are associated with dysbiosis,treatment strategies targeting the correction of dysbiosis in the treat-ment of these diseases have begun to be *** microbiota trans-plantation(FMt)is the process of transferring faeces from a healthy donor to another recipient in order to restore the gut microbiota and provide a therapeutic *** studies have gained popularity after probiotic,prebiotic,symbiotic studies in the treatment of dysbiosis and related *** has emerged as a potential new therapy in the treatment of allergic diseases as it is associated with the maintenance of intestinal microbiota and immunological balance(t helper 1/t helper 2 cells)and thus suppression of allergic *** this article,the definition,application,safety and use of FMt in allergic diseases will be discussed with current data.

关键词： Microbiota Dysbiosis Faecal microbiota transplantation Allergic diseases

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