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LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis

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Genes & Diseases 2024年第3期11卷 417-426页

作者： Zijian Xu Elizabeth R.Davies Liudi yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben G.Marshall David Hancock Tim Wallis Julian Downward Rob M.Ewing Donna E.Davies Mark G.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors that determine fibrosis progression or normal tissue repair are largely *** previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition(EMT)in human alveolar epithelial type Il(ATIl)cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine ***,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces EMT as a *** IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LKB1 complex.3D co-cultures of ATIl cells and MRC5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirmed that paracrine signaling between LKB1-depleted ATIl cells and fibroblasts augmented myofibroblast ***,these data suggest that reduced autophagy caused by LKB1 inhibition can induce EMT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk EMT LKB1 Pulmonary fibrosis

A conserved odorant receptor identified from antennal transcriptome of Megoura crassicauda that specifically responds to cis-jasmone

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Journal of Integrative Agriculture 2022年第7期21卷 2042-2054页

作者： WANG Bo HUANG Tian-yu yao Yuan Frederic francis YAN Chun-cai WANG Gui-rong WANG Bing Tianjin Key Laboratory of Conservation and Utilization of Animal Diversity Tianjin Normal UniversityTianjin 300387P.R.China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China Guangdong Laboratory for Lingnan Modern Agriculture(Shenzhen Branch) Genome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120P.R.China Functional and Evolutionary Entomology Gembloux Agro-Bio TechUniversity of LiegeGembloux 5030Belgium

Herbivore-induced plant volatiles(HIPVs)play a key role in the interactions between plants and herbivorous insects,as HIPVs can promote or deter herbivorous insects’*** aphids are common and serious phloem-feeding pests in farmland ecosystems,little is known about how aphids use their sensitive olfactory system to detect *** this study,the antennal transcriptomes of the aphid species Megoura crassicauda were sequenced,and expression level analyses of *** odorant receptors(ORs)were carried *** investigate the chemoreception mechanisms that *** uses to detect HIPVs,we performed in vitro functional studies of the ORs using 11 HIPVs reported to be released by aphid-infested *** total,54 candidate chemosensory genes were identified,among which 20 genes were ***20 and McraOR43 were selected for further functional characterization because their homologs in aphids were quite conserved and their expression levels in antennae of *** were relatively *** results showed that McraOR20 specifically detected cis-jasmone,as did its ortholog ApisOR20 from the pea aphid Acyrthosiphon pisum,while McraOR43 did not respond to any of the HIPV chemicals that were *** study characterized the ability of the homologous OR20 receptors in the two aphid species to detect HIPV cis-jasmone,and provides a candidate olfactory target for mediating aphid behaviors.

关键词： Megoura crassicauda transcriptome chemosensory genes odorant receptors cis-jasmone

基于冲蚀-动网格耦合的混流式水轮机泥沙磨损演化特性研究

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水动力学研究与进展（A辑） 2024年第2期39卷 234-243页

作者：黄剑峰姚激张蕾蕾北部湾大学建筑工程学院钦州535011 广西海洋工程装备与技术重点实验室钦州535011 昆明理工大学工程力学系昆明650500

含沙水流条件下,水轮机内泥沙颗粒与湍流两相介质相互作用时,泥沙冲蚀动态过程会磨损水轮机过流部件壁面,进而影响水轮机水力性能及运行安全。采用离散相模型(Discrete Phase Model,DPM)中的冲蚀-动网格耦合模型,该文数值模拟了混流式... 详细信息

含沙水流条件下,水轮机内泥沙颗粒与湍流两相介质相互作用时,泥沙冲蚀动态过程会磨损水轮机过流部件壁面,进而影响水轮机水力性能及运行安全。采用离散相模型(Discrete Phase Model,DPM)中的冲蚀-动网格耦合模型,该文数值模拟了混流式水轮机全流道泥沙颗粒冲蚀磨损演化过程,对比了单相及固液两相流工况下的湍流场特性,分析了不同泥沙质量流率与泥沙颗粒形状对于导水机构与转轮的磨损部位、冲蚀变形量以及磨损率随冲蚀时间变化的影响。结果表明:泥沙注入后,尾水管内整体流态有所改善,湍流紊乱程度被明显削弱,相比于清水工况,注入泥沙可减小84%~90%转轮湍动能;座环鼻端及临近固定导叶前缘的上下两端出现的蚀痕以变形磨损为主,活动导叶迎水面头部发生切削磨损,转轮叶片进水边靠近下环处则呈现出明显的冲蚀磨损;活动导叶冲蚀变形量大于固定导叶,转轮叶片工作面磨损率显著高于背面;泥沙质量流率增加,导叶和转轮叶片的冲蚀变形量与磨损率成倍增大,磨损率表现出脉动特性;活动导叶和转轮叶片工作面冲蚀24h后,非球形颗粒冲蚀变形量均大于球形颗粒。该研究可为多泥沙河流中水力机组的维护检修和安全稳定运行提供理论依据和参考。

关键词：混流式水轮机离散相冲蚀-动网格耦合泥沙磨损数值模拟

Population genetic structure of Sitobion miscanthi in China

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Journal of Integrative Agriculture 2022年第1期21卷 178-187页

作者： SUN Jing-xuan LI Qian TAN Xiao-ling FAN Jia ZHANG Yong QIN yao-guo Frédéric francis CHEN Ju-lian State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China Department of Functional and Evolutionary Entomology Gembloux Agro-Bio TechUniversity of LiègeGembloux 5030Belgium Mudanjiang Branch of Heilongjiang Academy of Agricultural Sciences Mudanjiang 157000P.R.China

The wheat aphid, Sitobion miscanthi, is one of the most destructive pests of wheat plants in the temperate regions of China. Little is known about the genetic structure evolution of the different geographic populations of S. miscanthi with its migration. In this study, we investigated the population genetic structure and demographic history of S. miscanthi by analysing 18 geographical populations across China using one mitochondrial gene, COI;one nuclear gene, EF-1α;and two endosymbiont Buchnera genes, gnd and trpA. Analysis of data from the various groups showed high haplotype diversity and low nucleotide variation. SAMOVA analysis did not find a correlation between genetic distance and geographic distance. However, areas with high population diversity exhibited high haplotype diversity. Therefore, we speculate that there are two main natural migration pathways of S. miscanthi in China. One is from Yunnan to the Sichuan Basin, and the other is from Wuhan, Xinyang and Jiaodong Peninsula areas to the northwest. Based on this hypothesis, we inferred that these aphid populations appear first in the southwestern and southern regions and spread to the north with the help of the southeastern and southwestern monsoons, which occur in spring and summer. In autumn, the aphids spread southward with the northeastern and northwestern monsoons.

关键词： Sitobion miscanthi molecular marker COI symbiotic bacteria phylogenetic tree

某水电厂1号混流式水轮机尾水管压力脉动试验研究

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广东水利水电 2024年第5期 74-78页

作者：曹斌姚泽李玺广东云舜综合能源科技有限公司广州分公司广州510540 南方电网电力科技股份有限公司广州510080

尾水管压力脉动是混流式水轮机运行稳定性的重要评价指标,研究尾水管压力脉动和机组振动稳定性对指导机组的安全运行、技术改造及科学调度具有十分重要的意义。对某水电厂1号机组进行了变负荷稳定性试验,分析了各工况下尾水管压力脉动... 详细信息

尾水管压力脉动是混流式水轮机运行稳定性的重要评价指标,研究尾水管压力脉动和机组振动稳定性对指导机组的安全运行、技术改造及科学调度具有十分重要的意义。对某水电厂1号机组进行了变负荷稳定性试验,分析了各工况下尾水管压力脉动、顶盖振动和水导轴承摆度信号之间的相关性。试验结果表明在部分负荷区域,尾水管压力脉动与顶盖振动及水导摆度信号高度相干,尾水管内低频涡带是引起机组振动的关键因素,对顶盖振动和水导摆度都有重要影响。

关键词：混流式水轮机尾水管压力脉动顶盖振动水导摆度相干分析

Improving the Quality of Rubber Plants in Bagged Nurseries by the Use of Compost-Based Culture Substrates

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Open Journal of Soil Science 2021年第11期11卷 567-585页

作者： Jean Lopez Essehi Eric francis Soumahin Guy Fernand yao Samuel Obouayeba Albert yao-Kouamé National Agricultural of Research Centre Food Crop Research Station Soil Water and Plant Central Laboratory Bouaké C&#244 te d’Ivoire University Jean Lorougnon Guédé Training and Research Unit of Agroforestry Laboratory of Physiology and Plant Pathology Daloa C&#244 te d’Ivoire National Agricultural of Research Centre Research Station of Bimbresso Hevea Program Bimbresso C&#244 te d’Ivoire University Félix Houphouë t-Boigny Training and Research Unit of Earth Sciences and Mineral Resources Department of Soil Sciences Abidjan C&#244 te d’Ivoire

The decrease of fertility soils, the rarity of quality potting soil used to fill nursery bags, the high cost of chemical fertilisers and the problems associated with their use are leading planters and rubber nurserymen in developing and/or expanding areas to look for alternative and sustainable fertilization. In this perspective, a trial was carried out at Research Station of CNRA-Bimbresso and in a farmer’s environment in order to evaluate the agronomic quality of compost made from chicken droppings and dry Panicum maximum straw to improve the growth of rubber plants in bagged nurseries. Mixtures based on potting soil and/or compost in different proportions were prepared. The follow-up of the trial focused on determination of the physico-chemical characteristics of the soils, measurement of the parameters of vegetative growth and the grafting success rate evaluation of rubber plants in nursery. The results obtained show that compost-based crop substrates increase soil organic matter, nitrogen, exchangeable bases, etc., in proportion to the doses applied. For the pH, the application of compost resulted in a reduction in soil acidity of about 1.3 unit compared to the initial values at the two study sites. The vegetative behaviour of the rubber plants also shows that qualitative (height and collar diameter) and quantitative (grafting success rate) improvements were recorded in the plants raised in compost-based substrates. The production of rubber plants in bagged nurseries was optimal with compost doses of 27 t⋅ha−1 (at Bimbresso, in the southeast) and 27 t⋅ha−1 combined with fractionated application of urea (at Kimoukro, in the centre), which under the conditions of the present study may be the recommended doses on rubber plants in bagged nurseries at C

关键词： Compost Soils Parameters Vegetative Growth Hevea brasiliensis Côte d’Ivoire

Lake-Based Nursery Rearing of Nile Tilapia (Oreochromis niloticus) Fingerlings in Nylon Hapas: Effects of Stocking Density on Growth, Survival and Profitability

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Agricultural Sciences 2016年第10期7卷 660-669页

作者： Amos Asase francis Kofi Ewusie Nunoo Felix yao Klenam Attipoe Department of Fisheries and Water Resources University of Energy and Natural Resources Sunyani Ghana Department of Marine and Fisheries Sciences University of Ghana Legon Ghana CSIR/Water Research Institute Aquaculture Research and Development Centre Akosombo Ghana

The inadequate supply of tilapia fingerling is a major limitation to cage culture development in Ghana. Lake-based hapa systems are very efficient in nursing fingerlings although the process can be tricky due to inherent effects of stocking densities and environmental factors. This study aimed at assessing the growth, survival and profitability of Nile tilapia (Oreochromis niloticus) fingerlings of the Akosombo strain reared in nine 1 m3 Lake-based hapas at different densities. Each hapa was stocked with 2.12 ± 0.14 g sex-reversed tilapia fingerlings at varying stocking densities of 400 fish/m3, 800 fish/m3 and 1200 fish/m3 serving as treatments T1, T2 and T3 respectively. Each treatment was replicated thrice. Bi-weekly samplings were done and water quality parameters were measured. After the experiment, analysis of variance showed significant differences (p

关键词： Hapa Fingerlings Stocking Density Tilapia

锂参与合成MOF-5用于CO2/CH4混合气体分离

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无机化学学报 2015年第3期31卷 509-513页

作者： Somboon Chaemchuen 周奎姚宸罗志雄 francis Verpoort 武汉理工大学材料复合新技术国家重点实验室武汉430070 武汉理工大学材料科学与工程学院武汉430070 武汉理工大学化学化工与生命科学学院.武汉430070

利用溶剂热法合成了不同锂含量的MOF-5(x Li-MOF-5,x=0,1,3,5)。在MOF-5结晶过程中,锂离子被合并入其骨架结构中。实验表明,合并入骨架的锂能够改变MOF-5的结构和表面化学性质。不同的x Li-MOF-5能够不同程度降低骨架相互穿插的程度从... 详细信息

利用溶剂热法合成了不同锂含量的MOF-5(x Li-MOF-5,x=0,1,3,5)。在MOF-5结晶过程中,锂离子被合并入其骨架结构中。实验表明,合并入骨架的锂能够改变MOF-5的结构和表面化学性质。不同的x Li-MOF-5能够不同程度降低骨架相互穿插的程度从而导致其吸附分离能力的大幅改变。其中,3Li-MOF-5具有最高的二氧化碳捕获能力(5.47 mmol·g-1),对40%CO2/60%CH4混合气体具有最优吸附选择性。

关键词： MOF-5 CO2/CH4分离锂掺入穿插结构

Characterization of Digestates from Anaerobic Co-Digestion of Manioc Effluent, Human Urine and Cow Dung

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Journal of Water Resource and Protection 2019年第6期11卷 777-788页

作者： Kpata-Konan Nazo Edith Kouamé yao francis Kouamé Kouamé Martin Konan Koffi Felix Department of Agroforestry/University Jean Lorougnon Gué dé Daloa C&#244 te d’Ivoire Department of Environment/University Jean Lorougnon Gué dé Daloa C&#244 te d’Ivoire

This study focused on the characterization of digestates resulting from anaerobic digestion of manioc effluents from attiéké factories. Two types of digestate were characterized, one consisting of manioc effluent + urine and another composed of manioc effluent + urine + cow dung. As a result, these residues of bio-digestion rich in nutrients (NPK) can be used as agricultural fertilizer. Moreover, the determination of some microorganisms and heavy metals digestates allowed to better appreciate its fertilizing quality. These parameters remained in accordance with the quality standards of a digestate prescribed. These results show that digestates from anaerobic co-digestion of manioc effluents, urine and cow dung can be used without fear as an agricultural biofertilizer.

关键词： Manioc Effluent Human Urine Cow Dung Anaerobic Co-Digestion Digestate