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Targeting infections and inflammation through micro and nano-nutraceuticals

Food Bioscience 2022年第5期49卷 50-67页

作者： Fabiana Helen Santos Sandeep K.Panda Danielle Cristine Mota Ferreira Gargi Dey Gustavo Molina franciele maria pelissari Laboratory of Green Materials Institute of Science and TechnologyFederal University of Jequitinhonha and Mucuri ValleysCEP 39100-000DiamantinaMGBrazil Department of Food Technology School of Food EngineeringUniversity of CampinasMonteiro Lobato80CEP 13083-862CampinasSPBrazil School of Biotechnology Campus 11KIIT UniversityBhubaneswar751024India Laboratory of Food Materials Studies Department of Food TechnologyUniversity of ViçosaCEP 36570-900ViçosaMinas GeraisBrazil Laboratory of Food Biotechnology Institute of Science and TechnologyFederal University of Jequitinhonha and Mucuri ValleysCEP 39100-000DiamantinaMGBrazil

Nowadays,the pharma and food industries have been gearing up to meet the urgent need for anti-infective and anti-inflammatory nutritional *** this way,several nutraceutical compounds are being re-evaluated due to their established *** compounds have been or may be efficiently targeted against infections,inflammatory conditions and for immune ***,for successful management of these metabolic conditions,the nutraceuticals need to be designed into effective nutritional *** recent years there have been tremendous progress in the re-engineering of structurally delivery vehicles which provide stability,enhance bioaccessibility and bioavailability of these *** this perspective,this review focuses on the structural and functional aspects of several such bio-based delivery vehicles like the micro and nano particles,nano-emulsions and liposome-based *** aim is to bring forth recent information on the efficacious nutraceuticals and the suitable delivery vehicles which would be useful against infections and inflammatory conditions.

关键词： Bioactive compounds Bioavailability Probiotics Delivery systems Nanotechnology Infection diseases

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Evaluation of the Thermal Performance in External Vertical Enclosures Constituted of Metal Panels

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Journal of Civil Engineering and Architecture 2021年第10期15卷 520-528页

作者： Marcela Assunção Faria Henor Artur de Souza franciele maria Costa Ferreira Federal University of Ouro Preto(UFOP)-University Campus s/nMorro do CruzeiroOuro Preto-MG35400-000Brazil Federal Institute of Minas Gerais(IFMG)-Congonhas Campus Av.Michael Pereira de Souza3007-CampinhoCongonhas-MG36415-000Brazil

Brazil has a great climatic diversity,with different demands for the adequate thermal performance of buildings,where the variables that impact it have different influences depending on the location and the type of wrapping *** a prior study of the thermal performance of a building is not done in the design phase,the unpleasant effects for the user appear after the building is ready,and bring with them problems such as internal temperatures that are too high in the summer or too low in the ***,the objective of this study is to provide recommendations for the application of ACM(aluminum composite material)composite panels and thermoacoustic(sandwich)tiles for external enclosure in the single-family residential sector.A high standard two-story residence with approximately 162 m^(2)per floor is used as a model and through computer simulations,utilizing the Energyplus program and observing the requirements of the NBR 15.575 performance standard,the thermal performance is *** factorial experiment was applied encompassing thermal performance variables such as absorptance,natural ventilation and thermophysical properties of the wrapping for three different climatic conditions:extreme winter climate,average climate and extreme summer *** results obtained show that the thermoacoustic roof tile keeps the internal temperature more stable independent of external oscillations,while the ACM panels follow the external oscillations,not meeting the expectations of thermal performance and needing passive treatments.

关键词： Metallic(wrapping) thermal performance composite panels thermoacoustic tiles.

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A single administration of fish oil inhibits the acute inflammatory response in rats

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Asian Pacific Journal of Tropical Medicine 2017年第8期10卷 830-837页

作者： Laura Licia Milani de Arruda franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado Department of Pharmacology and Therapeutics State University of MaringaMaringa-PRBrazil Department of Chemistry State University of MaringaMaringa-PRBrazil

Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein.

关键词： Omega-3 fatty acid Polyunsaturated fatty acid Pleurisy Leukocyte migration EPA DHA

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Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y strain

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 838-843页

作者： áurea Regina Telles Pupulin Lívia Bracht Márcia Machado de Oliveira Dalalio Francielli maria de Souza Silva-Comar Bruno Ambrósio da Rocha franciele Queiroz Ames Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado Laboratory of Parasitology Department of Basic Sciences of HealthState University of Maringá-PR Laboratory of Hepatic Metabolism Department of BiochemistryState University of Maringá-PR Laboratory of Immunology Department of Basic Sciences of HealthState University of Maringá-PR Laboratory of Inflammation Department of Pharmacology and TherapeuticState University of Maringá-PR

Objective:To identify whether Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y ***:Animals were divided into five groups:non-treated infected animals(I); benznidazole-treated infected animals(Bz; 100 mg/kg body weight,single daily dose by gavage); Canova medication(CM) treated infected animals(CM;0.2 mL/animal,single daily dose by gavage); benznidazole- and Canova medication–treated infected animals with the above-mentioned dose(Bz+CM);and non-infected animals(C).TNF-α and IL-10 levels were determined in serum aliquots after 4,7,10,13,and 29 days of *** ELISA technique was employed with R&D System *** ***:A high increase in TNF-α and IL-10 levels occurred in the infected and CM-treated groups within the treatment employed on the 10 th day after infection,coupled with a IL-10 decrease on the 13 th day after infection when compared with the other experimental ***:CM may change the balance between plasma cytokine levels(TNF-α and IL-10) in mice infected with Y strain ***,with important consequences leading towards a more severe infection.

关键词： Trypanosoma cruzi Canova medication Cytokines

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Correlation of Disgust and Contempt Expressions with Conjugal Dissatisfaction

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Journal of Behavioral and Brain Science 2018年第10期8卷 562-573页

作者： Rui Mateus Joaquim Tariane franciele Bastos Pereira Laiza de Oliveira Vilela Tayná Maiara Pilla Rodrigues Angela maria da Silva Muniz Brandino Sandro Caramaschi Faculty of Human Sciences Federal University of Grande Dourados-UFGD Dourados Mato Grosso do Sul Brazil Postgraduate Program in Developmental and Learning Psychology S&#227 o Paulo State University-UNESP/Bauru S&#227 o Paulo Brazil Faculdade Anhanguera Educacional de Bauru Bauru S&#227 o Paulo Brazil

Research has shown that dissatisfied couples in the relationship commonly exhibit facial expressions of contempt in interactions. At this point, based on the study of cognition and physiology, researchers were able to predict by longitudinal studies the probability of divorce in a marriage, with accuracy of up to 94%. Our objective was to investigate whether the occurrence of facial expressions of disgust and contempt in married women is associated with marital dissatisfaction. This is an experimental study that correlated, through filmed interviews, the frequency of facial expressions of disgust and disgust (Facial Action Coding System) to the Marital State’s Golombok Rust Inventory, in a sample composed of 20 women. Data analysis based on the Spearman Correlation Test showed a positive correlation between facial expressions of disgust and disdain and conjugal dissatisfaction (rs = 0.2198, p = 0.0280), corroborating the data in the literature.

关键词： Facial Expressions Disgust Contempt Nonverbal Communication Marital Dissatisfaction

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Microencapsulated oregano and cinnamon essential oils as a natural alternative to reduce Listeria monocytogenes in Italian salami

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Food Bioscience 2022年第6期50卷 1766-1773页

作者： franciele maria Gottardo Bárbara Biduski Lára Franco dos Santos Jucilene Sena dos Santos Laura Beatriz Rodrigues Luciana Ruschel dos Santos Graduate Program in Food Science and Technology University of Passo FundoBR 28599052-900Passo FundoRSBrazil Food Quality and Sensory Science Department Teagasc Food Research CentreAshtownDublinD15 KN3KIreland Graduate Program in Bioexperimentation University of Passo FundoBR 28599052-900Passo FundoRSBrazil College of Agronomy and Veterinary Science University of Passo FundoBR 28599052-900Passo FundoRSBrazil

Meat products are classified as perishable foods and have favourable conditions for the multiplication of microorganisms such as Listeria monocytogenes,an important pathogen associated with ready-to-eat *** compounds are used for food preservation combined with encapsulation techniques to improve *** study evaluated the anti-Listeria potential of isolated and combined microencapsulated oregano(OEO)and cinnamon(CEO)essential oils in Italian *** combination ratios of OEO and CEO were tested and 50:50 ratio(OEO:CEO)was encapsulated using sodium *** microcapsules were evaluated for encapsulation efficiency(EE),morphology and action against *** in a meat *** microcapsules and 50/50 combined EO were incorporated into the Italian salami to evaluate the physicochemical,microbiological and sensory *** combinations of EO showed *** inhibition zone and CIM with 1:16 *** microencapsulated EO had 98.36%encapsulation *** 2%microcapsule had a significant reduction of *** from the *** though the panellists mentioned the sandy attribute in the CATA,the salami with EO microcapsules texture did not differ from the *** the essential oils had high encapsulation efficiency,the smell and flavour of cinnamon and oregano interfered negatively with the sensory ***,the encapsulation of the combined essential oils(50/50)significantly reduced *** in Italian salami.

关键词： Natural antimicrobial Sodium alginate Ready-to-eat Encapsulation

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Risk Factors Associated with Acinetobacter baumannii Infections in Patients in an Intensive Care Unit of a Public Hospital in Paraná

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Advances in Infectious Diseases 2022年第1期12卷 90-105页

作者： Mirian Carla Bortolamedi da Silva maria Helena Brandeleiro Werlang Valdir Spada Júnior Guilherme Welter Wendt Ana Paula Vieira franciele Ani Caovilla Follador Léia Carolina Lucio Cleide Viviane Busanello Martins Kérley Braga Pereira Bento Casaril Paulo Cezar Nunes Fortes Lirane Elize Defante Ferreto Post-Graduante Program Health Sciences University of Wester Paraná (UNIOESTE) Francisco Beltr&#227 o Brazil State of the Health of Paraná (SESA-PR) Francisco Beltr&#227 o Brazil

To identify risk factors for A. baumannii infection in patients hospitalized in an Intensive Care Unit (ICU) of a tertiary public hospital in Paraná, Brazil, a retrospective paired case-control study (ratio 1:2) was conducted from January 2018 to December 2020. Patients in the case group were hospitalized in the ICU with A. baumanni (n = 68 cases) and were compared with patients in the control group, without infection by A. baumannii (n = 136). Both were matched by age (±10 years), sex, and ICU stay (±5 days). Conditional multiple logistic regression was used to determine statistically significant risk factors based on the results of bivariate analyses. Mortality was higher in infected (cases) than in non-infected patients (51.5% vs. 39.7%). The incidence and bacterial resistance increased annually. At bivariate analysis, cases had longer hospital stays (median 35 vs. 22 days, p A. baumannii and antimicrobial resistance. There is need for surveillance, and constant evaluation of control actions. Risk factors were colonization, previous hospitalization, and hospitalization time. This is essential for the decision-making of professionals and optimization of prevention, control, and therapeutic management actions.

关键词： Acinetobacter baumannii Risk-Factors Infection Intensive Care

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Sward Structural Characteristics and Performance of Beef Heifers Reared under Rotational Grazing Management on Campos Grassland

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American Journal of Plant Sciences 2014年第7期5卷 1020-1029页

作者： Cezar Wancura Barbieri Fernando Luiz F. de Quadros Felipe Jochims émerson Mendes Soares Leandro Bittencourt de Oliveira Régis Maximiliano R. Carvalho Gabriela Machado Dutra Felipe Xavier de Lima franciele Gusatto Natural Grassland Ecology Research Group (LEPAN-UFSM) Universidade Federal de Santa Maria Animal Science Department Santa Maria Brazil

This study aimed to evaluate the effect of two rest intervals on structural sward characteristics and productive performance of beef heifers reared on Campos grassland managed on rotational grazing. The treatments were two intervals between grazing of 375 and 750 DD (degree days), based on thermal cumulative sum for leaf expansion of native grasses belonging to two functional groups. The experimental design was a randomized complete block design with two treatments and three replications. The tested animals were beef heifers with initial age of 12 months and average weight of 185.2 ± 17.4 kg. Measures in the pasture were: herbage mass, mass of green leaf blades, stem mass, dead material mass and green leaf allowance. The 750 DD rest interval presented higher herbage mass (24%), higher green herbage mass and 19% more leaves in the canopy. This rest interval also presents a high proportion of dead material and stems in the sward structure. In the other way, the 375 DD rest interval presents better chemical characteristics, with 20% more crude protein in the hand plucking samples. Heifers’ dry matter intake was similar between the rest intervals (2.04% of live weight) and the bite mass was also similar (0.22 g DM per bite) but the animal performance was higher in the 375 DD rest interval. The stocking density showed similarity between treatments with an average of 875 kg/LW/ha. The live weight gain per area was higher in 40 kg/LW/ha (P = 0.117) for 375 DD rest interval, reaching 251 kg/LW/ha produced over the 149 experimental days. Based on these results, we can conclude that the treatment of shortest interval between defoliation gave the highest gain individual animals in warm seasons.

关键词： Average Daily Gain Duration of Leaf Expansion Herbage Mass Rotational Grazing Stocking Rate

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