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Microbiome in the setting of burn patients:implications for infections and clinical outcomes

Burns & Trauma 2020年第1期8卷 152-159页

作者： Silvia Corcione Tommaso Lupia francesco g.de rosa on behalf of Host and Microbiota Interaction Study group(ESgHAMI)of the European Society of Clinical Microbiology and Infectious Diseases(ESCMID) department of Medical Sciences Infectious DiseasesUniversity of TurinItaly Tufts University School of Medicine BostonMAUSA 不详

Burn damage can lead to a state of immune dysregulation that facilitates the development of infections in *** most deleterious impact of this dysfunction is the loss of the skin’s natural protective ***,the risk of infection is exacerbated by protracted hospitalization,urinary catheters,endotracheal intubation,inhalation injury,arterial lines and central venous access,among other mainstays of burn ***,infections comprise the leading cause of mortality after major burn injuries,which highlights the improvements observed over the last 50 years in the care provided to burn *** need to implement the empirical selection of antibiotic therapy to treat multidrug-resistant bacteria may concomitantly lead to an overall pervasiveness of difficult-to-treat pathogens in burn centres,as well as the propagation of antimicrobial resistance and the ultimate dysregulation of a healthy *** preliminary studies are examining the variability and evolution of human and mice microbiota,both during the early and late phase burn injury,one must consider that abnormal microbiome conditions could influence the systemic inflammatory response.A better understanding of the changes in the postburn microbiome might be useful to interpret the provenance and subsequent development of infections,as well as to come up with inferences on the prognosis of burn *** review aims to summarise the current findings describing the microbiological changes in different organs and systems of burn patients and how these alterations affect the risks of infections,complications,and,ultimately,healing.

关键词： Burn Microbiome Skin microbiome gut microbiome Lung microbiome Multidrug-resistant organisms

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Uveal melanoma:Recent advances in immunotherapy

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World Journal of Clinical Oncology 2024年第1期15卷 23-31页

作者： francesco Saverio Sorrentino francesco de rosa Patrick Di Terlizzi giacomo Toneatto Andrea gabai Lucia Finocchio Carlo Salati Leopoldo Spadea Marco Zeppieri department of Surgical Sciences Unit of OphthalmologyOspedale MaggioreBologna 40100Italy department of Oncology IRCCS Istituto Romagnolo per lo Studio dei Tumori“Dino Amadori”Meldola 47014Italy department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy

Uveal melanoma(UM)is the most common primary intraocular cancer in *** incidence in Europe and the United States is 6-7 per million population per *** most primary UMs can be successfully treated and locally controlled by irradiation therapy or local tumor resection,up to 50%of UM patients develop metastases that usually involve the liver and are fatal within 1 *** date,chemotherapy and targeted treatments only obtain minimal responses in patients with metastatic UM,which is still characterized by poor *** standard therapeutic approaches for its prevention or treatment have been *** application of immunotherapy agents,such as immune checkpoint inhibitors that are effective in cutaneous melanoma,has shown limited effects in the treatment of ocular *** is due to UM’s distinct genetics,natural history,and complex interaction with the immune *** cutaneous melanomas characterized mainly by BRAF or NRAS mutations,UMs are usually triggered by a mutation in gNAQ or *** a result,more effective immunotherapeutic approaches,such as cancer vaccines,adoptive cell transfer,and other new molecules are currently being *** this review,we examine novel immunotherapeutic strategies in clinical and preclinical studies and highlight the latest insight in immunotherapy and the development of tailored treatment of UM.

关键词： Uveal melanoma Immunotherapy Ocular oncology Tumor Metastatic disease genetic mutations

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Chestnut tannin:New use,research and bioeconomy

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Journal of Bioresources and Bioproducts 2024年第3期9卷 246-252页

作者： rosaria Ciriminna francesco Meneguzzo giovanna Li Petri Cosimo Meneguzzo giuseppe Angellotti Mario Pagliaro Istituto per lo Studio dei Materiali Nanostrutturati CNRvia U.La Malfa 15390146 PalermoItaly Istituto per la Bioeconomia CNRvia Madonna del Piano 1050019 Sesto Fiorentino(FI)Italy HyRes Srl via Salvator Rosa 1882100 BeneventoItaly

Chestnut tannin,extracted from the bark or wood of chestnut trees,possesses unique properties that make it valuable in various *** serves as a natural source of tannins,which are widely used in the production of leather,textiles,and wood *** research continues to explore its potential applications,chestnut tannin remains a promising resource with diverse industrial *** new use,research and bioeconomy aspects,this study provides a unified perspective on chestnut *** advanced applications will likely emerge shortly.

关键词： Tannin Chestnut Bioeconomy Tannin market Hydrolysable tannin

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Applications of artificial intelligence in lung ultrasound:Review of deep learning methods for COVID-19 fighting

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Artificial Intelligence in Medical Imaging 2022年第2期3卷 42-54页

作者： Laura de rosa Serena L'Abbate Claudia Kusmic francesco Faita Institute of Clinical Physiology Consiglio Nazionale delle RicerchePisa 56124Italy

BACKgROUND The pandemic outbreak of the novel coronavirus disease(COVID-19)has highlighted the need to combine rapid,non-invasive and widely accessible techniques with the least risk of patient’s cross-infection to achieve a successful early detection and surveillance of the *** this regard,the lung ultrasound(LUS)technique has been proved invaluable in both the differential diagnosis and the follow-up of COVID-19 patients,and its potential may be destined to ***,indeed,LUS has been empowered through the development of automated image processing *** To provide a systematic review of the application of artificial intelligence(AI)technology in medical LUS analysis of COVID-19 patients using the preferred reporting items of systematic reviews and meta-analysis(PRISMA)*** A literature search was performed for relevant studies published from March 2020-outbreak of the pandemic-to 30 September *** articles were included in the result synthesis of this *** As part of the review,we presented the main characteristics related to AI techniques,in particular deep learning(DL),adopted in the selected articles.A survey was carried out on the type of architectures used,availability of the source code,network weights and open access datasets,use of data augmentation,use of the transfer learning strategy,type of input data and training/test datasets,and *** Finally,this review highlighted the existing challenges,including the lack of large datasets of reliable COVID-19-based LUS images to test the effectiveness of DL methods and the ethical/regulatory issues associated with the adoption of automated systems in real clinical scenarios.

关键词： Lung ultrasound deep learning Neural network COVID-19 pneumonia Medical imaging

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Ventilator-associated pneumonia(VAP)and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient:A case report

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Infectious Medicine 2023年第2期2卷 143-147页

作者： rosa Anna Passerotto francesco Lamanna Damiano Farinacci Alex Dusina Simona Di giambenedetto Arturo Ciccullo Alberto Borghetti Dipartimento di Sicurezza e Bioetica-Sezione di Malattie Infettive UniversitàCattolica del Sacro Cuore00168 RomeItaly Dipartimento di Scienze di Laboratorio e Infettivologiche Fondazione Policlinico Universitario Agostino Gemelli IRCCS00168 RomeItaly Infectious Diseases Unit San Salvatore Hospital67100 L’AquilaItaly

We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation,not vaccinated for SARS-COV-2,hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit(ICU).The hospitalization was complicated by bacteraemic ventilator-associated pneumonia(VAP)caused by multidrug-resistant Acinetobacter baumannii(MDR-AB)isolated on pleural fluid culture,treated with colistin and cefiderocol for about 3 *** molecular research of MDR-AB on transtracheal aspirate was negative following this *** aim is to show the safety,efficacy and tolerability of colistin-based combination therapy with cefiderocol for Acinetobacter baumannii infection in HIV-infected patient.

关键词： Acinetobacter baumannii colistin cefiderocol SARS-CoV-2 HIV

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grain free diets for utility dogs during training work: Evaluation of the nutrient digestibility and faecal characteristics

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Animal Nutrition 2019年第3期5卷 297-306页

作者： Biagina Chiofalo giulia de Vita Vittorio Lo Presti Salvatore Cucinotta gabriella gaglio francesco Leone Ambra R.Di rosa department of Veterinary Sciences University of Messina Polo Universitario Annunziata

Two different diets characterized by the absence of cereals or by the presence of conventional cereals were evaluated on the nutrient digestibility and faecal characteristics and faecal fermentative endproduct concentrations of 8 neutered adult Labrador retrievers housed at the Regional Centre Helen Keller(Messina,Italy)during the training work for the service guide for the ***(age = 17 ± 1 months,initial body weight [BW]= 26.3 ± 1 *** body condition score [BCS]= 4.5 ± 0.11)were divided into 2 homogeneous groups for sex(half males and half females).Dogs in the grain free(gF)group were fed a commercial diet characterized by the absence of grain cereals,and dogs in the control(CTR)group were fed a super-premium pet food characterized by conventional grains as the carbohydrate *** trial lasted 84 *** by a 7-d of adaption *** examination,*** faecal characteristics were *** statistical model included the effects of diet(gF ***),time(from d 0 to *** of the trial)and the interaction(diet x time).The high-protein,lowcarbohydrate dry diet(gF)offered higher apparent nutrient digestibility of protein(+10%;P =0.002)and fat(+7%;Pge intestinal fermentation of carbohydrate compared to the commercial high-carbohydrate dry diet,enabling dogs to use nutrients from the diet more efficiently and thus requiring less food(-13%)to satisfy their nutrient requirements,producing less excrement(-33%;P= 0.033).and reaching a higher final BW(+8%;Pgher final BCS(+15%;P= 0.003).Therefore,the gF diet appears the nutritional plan most suitable for these animals taking due account not only of the training work done by animals with their increased nutrient and energy needs,but also of the gastrointestinal disorders consequent to stress coming from work and life in kennels,which cause in the Labrador retrievers an unusual weight loss.

关键词： Utility dog grain free diet Nutrient digestibility Faecal quality Training work

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Diffusion-weighted imaging and fluid-attenuated inversion recovery sequence in sporadic Creutzfeldt-Jakob disease:One-case report

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Neural Regeneration Research 2011年第29期6卷 2295-2297页

作者： rosa Morabito Annalisa Baglieri Rosella Ciurleo francesco Corallo rosaria de Luca Simona de Salvo Silvia guerrera Francesca Timpano Maria Adele Marino Placido Bramanti Silvia Marino Neurobioimaging Laboratory IRCCS Centro Neurolesi "Bonino Pulejo"MessinaItaly

The diagnosis of sporadic Creutzfeldt-Jakob disease （sCJD） is extremely difficult. Diffusion-weighted imaging has been shown to be the most sensitive technique for the detection of signal alterations in sCJD patients. The present study analyzed the diagnostic value of diffusion-weighted imaging and fluid-attenuated inversion recovery sequence in the early stage of sCJD in one female patient and correlated the clinical symptoms during disease course and magnetic resonance manifestations. Thalamic and basal ganglia hyperintensities were observed on magnetic resonance images in a very early stage, i.e., when the clinical typical manifestations of the disease were not present. With the progression of the disease, cortical and basal ganglia hyperintensities were observed on magnetic resonance images, showing an obvious cerebral atrophy. These findings suggest that diffusion-weighted imaging and fluid-attenuated inversion recovery sequence are helpful in diagnosing sCJD.

关键词： Creutzfeldt-Jacob disease fluid-attenuated inversion recovery diffusion-weighted imaging magnetic resonance imaging

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The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis:A comparison between SARS-COV-2-related sepsis and sepsis from other causes

Infectious Medicine

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Infectious Medicine 2023年第3期2卷 202-211页

作者： Andrea Piccioni Laura Franza Federico rosa Marcello Candelli Marcello Covino Michela Ferrara gianpietroVolonnino giuseppe Bertozzi Maria Vittoria Zamponi Aniello Maiese gabriele Savioli francesco Franceschi Raffaele La Russa department of Emergency Medicine Fondazione Policlinico Universitario A.Gemelli IRCCS1-00168 RomeItaly UniversitàCattolica del Sacro Cuore 1-00168 RomeItaly department of Anatomical HistologicalForensic and Orthopedic SciencesSapienza University of Rome00186 RomeItaly department of Clinical and Experimental Medicine Institute of Legal MedicineUniversity of Foggia71100 FoggiaItaly department of Surgical Medicaland Molecular Pathology and Critical Care MedicineUniversity of Pisavia Roma 5556126 PisaItaly Emergency department IRCCS Policlinico San Matteo27100 PaviaItaly department of Clinical-Surgical Diagnostic and Pediatric SciencesUniversity of Pavia27100 PaviaItaly

Background:COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement,even leading to serious disorders,such as cytokine ***:We then conducted a literature review on the topic of sepsis and covid-19,and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control ***:Sepsis associated with covid-19 infection has some similarities and differences from that from other ***:In this paper the complex interplay between the 2 disorders was discussed,focusing on the similarities and on the effect that one could have on the other.A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed.

关键词： SARS-COV-2 Cytokine storm SARS-CoV-2 Septic shock Sepsis

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Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration

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Neuroscience Bulletin 2018年第2期34卷 270-282页

作者： Maria Antonietta Panaro Alessandra Aloisi giuseppe Nicolardi Dario Domenico Lofrumento francesco de Nuccio Velia La Pesa Antonia Cianciulli rosaria Rinaldi rosa Calvello Vania Fontani Salvatore Rinaldi department of Biosciences Biotechnologies and Biophar- maceutics University of Bari Bari Italy CNR Institute for Microelectronics and Microsystems Via Monteroni (Campus Ecotekne) 73100 Lecce Italy department of Biological and Environmental Sciences and Technologies Section of Human Anatomy University of Salento Lecce Italy Neuropathology Unit Institute of Experimental Neurology Division of Neuroscience IRCCS San Raffaele Scientific Institute Via Olgettina 60 20132 Milan Italy department of Mathematics and Physics University of Salento Via Amesano 73100 Lecce Italy CNR Institute of Nanoscience NEST Piazza San Silvestro 12 56127 Pisa Italy department of Regenerative Medicine Rinaldi Fontani Institute Viale Belfiore 43 50144 Florence Italy Research department Rinaldi Fontani Foundation Viale Belfiore 43 50144 Florence Italy IRF (Shanghai) Medical Sciences 3000 Long Dong Avenue Zhangjiang High-Tech Park Shanghai China

In this study, the effects of Radio Electric Asymmetric Conveyer(REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP),were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes(REAC TO-RgN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage inmice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TORgN-N. These results indicated that REAC TO-RgN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism.

关键词： Parkinson’s disease Neurodegeneration Neuroinflammation REAC TO-RgN-N treatment

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Minimally invasive colorectal surgery learning curve

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World Journal of gastrointestinal Endoscopy 2022年第11期14卷 731-736页

作者： Serafino Vanella Enrico Coppola Bottazzi giancarlo Farese rosa Murano Adele Noviello Tommaso Palma Maria godas francesco Crafa department of general and Oncology Surgery A.O.R.N.San Giuseppe MoscatiAvellino 83100Italy

The learning curve in minimally invasive colorectal surgery is a constant subject of discussion in the *** data likely reflects the varying.degrees of each surgeon’s experience in colorectal,laparoscopic or robotic *** factors are necessary for a successful minimally invasive colorectal surgery training program,including:Compliance with oncological outcomes;dissection along the embryological planes;constant presence of an expert tutor;periodic discussion of the morbidity and mortality rate;and creation of a dedicated,expert team.

关键词： Learning curve Colorectal surgery Laparoscopy Robotic surgery Minimally invasive surgery Cusum method

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