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Chemical and rheological analysis of unaged and aged bio-extended binders containing lignin

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第6期10卷 947-963页

作者： Elena Gaudenzi Fabrizio Cardone Xiaohu Lu francesco Canestrari department of Civil and Building Engineering and Architecture UniversitàPolitecnica delle MarcheAncona 60131Italy Nynas AB Nynäshamn 14982Sweden

The use of alternative renewable sources to totally or partially replace bitumen is one of the most current challenges in the road pavement *** growing energy cost and environmental concerns lead to the necessity to find alternative solutions,by supporting at the same time sustainability and circular economy *** this framework,this paper presents the application of a powder lignin,a natural bio-polymer deriving from byproducts of wood pulp and paper industry,to replace part of *** bituminous blend consisting in 70%of bitumen and 30%of powder lignin(by weight)was made in laboratory through the use of a high shear stirring mixer,and a reference plain bitumen characterized by a similar consistency(i.e.,same penetration grade)was used as ***,an extensive investigation on chemical and rheological properties of the bio-binder is *** transform infrared spectroscopy(FTIR),saturates,aromatics,resins and asphaltenes(SARA),bending beam rheometer(BBR),frequency sweep tests and multiple stress creep recovery tests(MSCR)with a dynamic shear rheometer(dSR)were ***,unaged,short-and long-term aging conditions were *** indicated that powder lignin dominates the rheological behavior of the bio-binder and,from chemical analysis,it seems that it partially acts as a filler and partially as a *** would result in improved performances at both low and high temperatures,leading to a wider temperature range of performance grade(PG).Moreover,despite a stiffening effect is recognized,lignin also offers an antioxidant potentiality,reducing the aging susceptibility of the investigated bio-binder.

关键词： Bio-binders Asphalt binders Lignin Aging Sustainability

Phenotyping Key Fruit Quality Traits in Olive Using RGB Images and Back Propagation Neural Networks

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Plant Phenomics 2023年第3期5卷 484-500页

作者： Giuseppe Montanaro Angelo Petrozza Laura Rustioni francesco Cellini Vitale Nuzzo Università degli Studi della Basilicata 85100 PotenzaItaly ALSIA Agenzia Lucana Sviluppo Innovazione in AgricolturaMetapontum Agrobios Research Center75010 MetapontoItaly department of Biological and Environmental Sciences and Technologies University of SalentoLecceItaly

To predict oil and phenol concentrations in olive fruit,the combination of back propagation neural networks(BPNNs)and contact-less plant phenotyping techniques was employed to retrieve RGB image-based digital proxies of oil and phenol *** of cultivars(×3)differing in ripening time were sampled(~10-day interval,×2 years),pictured and analyzed for phenol and oil *** to this,fruit samples were pictured and images were segmented to extract the red(R),green(G),and blue(B)mean pixel values that were rearranged in 35 RGB-based colorimetric *** BPNNs were designed using as input variables(a)the original 35 RGB indexes,(b)the scores of principal components after a principal component analysis(PCA)pre-processing of those indexes,and(c)a reduced number(28)of the RGB indexes achieved after a sparse *** results show that the predictions reached the highest mean R^(2) values ranging from 0.87 to 0.95(oil)and from 0.81 to 0.90(phenols)across the *** addition to the R^(2),other performance metrics were calculated(root mean squared error and mean absolute error)and combined into a general performance indicator(GPI).The resulting rank of the GPI suggests that a BPNN with a specific topology might be designed for cultivars grouped according to their ripening *** present study documented that an RGB-based image phenotyping can effectively predict key quality traits in olive fruit supporting the developing olive sector within a digital agriculture domain.

关键词： Image image supporting

Adolescent male genitalia dissatisfaction:a surgical perspective

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Asian Journal of Andrology 2022年第2期24卷 176-179页

作者： Nicola Zampieri Ilaria dando francesco Saverio Camoglio Woman and Child Hospital Pediatric Surgical UnitUniversity of VeronaVerona 37100Italy department of Neurosciences Biomedicine and Movement SciencesBiochemistry SectionUniversity of VeronaVerona 37100Italy

Genital dissatisfaction is well known in female and *** is known about male adolescents and their genital *** aim of this study was to investigate and report the role of surgery in male adolescents to improve the evaluation of their *** considered all patients treated for external genital pathology in the period of *** and exclusion criteria were *** underwent an evaluation test before and after *** the study period,137 patients were treated,and at the end of the study,98 cases were considered for *** most frequent pathologies were webbed penis and penile curvature.A postoperative score improvement was noted and patients with concealed penis and webbed penis showed a better postoperative *** was considered an important factor associated with a worse preoperative *** of the external genitalia is important in adolescents,and it is an understudied *** may be associated with a worse evaluation of one’s genital and should be clinically considered to avoid related social problems in ***,cosmetic genital surgery should be considered even in male adolescents.

关键词： adolescent esthetic genital dissatisfaction surgery

The critical role of apoptosis in mesenchymal stromal cell therapeutics and implications in homeostasis and normal tissue repair

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Cellular & Molecular Immunology 2023年第6期20卷 570-582页

作者： Chiara Giacomini Ceilia Graneli Ryan Hicks francesco dazzi School of Cardiovascular and Metabolic Medicine&Sciences King's College LondonLondonUK BioPharmaceuticals R&d Cell Therapy department Research and Early DevelopmentCardiovascularRenaland Metabolism(CVRM)BioPharmaceuticals R&DAstraZenecaGothenburgSweden

Mesenchymal stromal cells(MsCs)have been extensively tested for the treatment of numerous clinical conditions and have demonstrated good safety but mixed *** this outcome can be attributed in part to the heterogeneity of cell preparations,the lack of mechanistic understanding and tools to establish cell pharmacokinetics and pharmacodynamics,as well as the poorly defined criteria for patient stratification,have hampered the design of informative clinical *** and others have demonstrated that MsCs can rapidly undergo apoptosis after their *** MSCs are phagocytosed by monocytes/macrophages that are then reprogrammed to become anti-inflammatory *** apoptosis occurs when the cells are injected into patients who harbor activated cytotoxic T or NK ***,the activation state of cytotoxic T or NK cells can be used as a biomarker to predict clinical responses to MsC *** on a large body of preexisting data,an alternative view on the mechanism of MSCs is that an inflammation-dependent MSC secretome is largely responsible for their immunomodulatory *** will discuss how these different mechanisms can coexist and are instructed by two different types of Msc"licensing":one that is cell-contact dependent and the second that is mediated by inflammatory *** varied and complex mechanisms by which MsCs can orchestrate inflammatory responses and how this function is specifically driven by inflammation support a physiological role for tissue stroma in tissue homeostasis,and it acts as a sensor of damage and initiator of tissue repair by reprogramming the inflammatory environment.

关键词： Mesenchymal stromal cells Cell death immunosuppression

Passive Intermodulation Measurement:Challenges and Solutions

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Engineering 2022年第7期8卷 181-191页

作者： Zhanghua Cai Lie Liu francesco de Paulis Yihong Qi General Test Systems Inc. Shenzhen 518000China College of Electrical and Information Engineering Hunan UniversityChangsha 410082China UAq EMC Laboratory Department of Industrial and Information Engineering and EconomicsUniversity of L’AquilaL’Aquila 64100Italy

In modern wireless communication systems,the signal-to-noise ratio(SNR)is one of the most important performance *** the other radio frequency(RF)performance of the components is well designed,passive intermodulation(PIM)interference may become an important factor limiting the system’s *** it is a base station,an indoor distributed antenna system,or a satellite system,there are stringent PIM level requirements to minimize interference and enhance network capacity in multicarrier *** for systems of high power and wide bandwidth such as 5G wireless communication,PIM interference is even more *** to the complexity and uncertainty of PIM,measurement is the most important means to study and evaluate the PIM performance of wireless communication *** this review,the current main PIM measurement methods recommended by International Electrotechnical Commission(IEC)and other standard organizations are introduced,and several key challenges in PIM measurement and their solutions(including the design of PIM tester,the location of the PIM sources,the design of compact PIM anechoic chambers,and the evaluation methods of PIM anechoic chambers)are *** challenges are of great significance to solve PIM problems that may arise during device characterization and verification in real wireless communication systems.

关键词： Passive intermodulation(PIM) PIM source location Anechoic chamber

design of hybrid-electric aircraft with fault-tolerance considerations

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Chinese Journal of Aeronautics 2023年第2期36卷 160-178页

作者： Valerio MARCIELLO francesco OREFICE Fabrizio NICOLOSI danilo CILIBERTI Pierluigi dELLA VECCHIA department of Industrial Engineering University of Naples"FedericoⅡ"Naples 80125Italy

The potential benefits of hybrid-electric or all-electric propulsion have led to a growing interest in this topic over the past *** design of propulsion systems and innovative configurations has been extensively discussed in literature,but steps towards higher levels of technological readiness,optimisation algorithms based on reliable weight estimation and simulationbased mission analysis are *** paper focuses on the integration of a method for evaluating the lateral-directional controllability of an aircraft within a design chain that integrates aero-propulsive interactions,accurate modelling of the fuel system,and mid-fidelity estimation of the structural ***,the present work proposes a strategy for powerplant management in scenarios with an inoperative chain *** of hybrid-electric propulsion on the design of the vertical tail plane are evaluated involving the analysis of multiple failure scenarios and certification *** proposed application concerns a commuter aircraft.

关键词： distributed electric propulsion Failure management Fault-tolerance analysis Hybrid-electric aircraft Lateral-directional controllability

漫游感的倡导者:意大利科幻作家弗朗西斯科·沃尔索专访

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探索与批评 2024年第1期 41-53页

作者：李雅婷弗朗西斯科·沃尔索重庆移通学院外交学院不详

意大利科幻作家与出版人弗朗西斯科·沃尔索致力传播未得到充分认识的非英语国家科幻作品,推动科幻文学的多元化发展。为此,他首次提出了科幻“漫游感”这一概念,意指科幻的“惊奇感”正以多样化的表现方式在世界各地传播。本次访谈通... 详细信息

意大利科幻作家与出版人弗朗西斯科·沃尔索致力传播未得到充分认识的非英语国家科幻作品,推动科幻文学的多元化发展。为此,他首次提出了科幻“漫游感”这一概念,意指科幻的“惊奇感”正以多样化的表现方式在世界各地传播。本次访谈通过讨论科幻作家对未来的影响、非英语科幻小说的贡献、各文化的本土创新、科幻故事筛选、跨媒体叙事和多元世界构建等话题,进一步探索这位“漫游感”倡导者的前沿观念。

关键词：世界科幻小说弗朗西斯科·沃尔索 “漫游感” 非英语科幻小说

Is precision medicine for colorectal liver metastases still a utopia?New perspectives by modern biomarkers,radiomics,and artificial intelligence

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World Journal of Gastroenterology 2022年第6期28卷 608-623页

作者： Luca Viganò Visala S Jayakody Arachchige francesco Fiz department of Hepatobiliary and General Surgery IRCCS Humanitas Research HospitalRozzano 20089MIItaly department of Biomedical Sciences Humanitas UniversityPieve Emanuele 20072MIItaly Nuclear Medicine IRCCS Humanitas Research HospitalRozzano 20089MIItaly

The management of patients with liver metastases from colorectal cancer is still *** therapeutic options and treatment strategies are available for an extremely heterogeneous clinical *** prediction of patients’outcomes and of the effectiveness of chemotherapy and loco-regional treatments are crucial to reach a precision medicine *** has been an unmet need for a long time,but recent studies have opened new *** morphological biomarkers have been *** dynamic evaluation of the metastases across a time interval,with or without chemotherapy,provided a reliable assessment of the tumor *** have been explored and,thanks to their strong association with prognosis,have the potential to drive treatment *** liver-tumor interface has been identified as one of the main determinants of tumor progression,and its components,in particular the immune infiltrate,are the focus of major *** mining and analyses provided new insights on tumor biology and are expected to have a relevant impact on clinical *** intelligence is a further step *** present paper depicts the evolution of clinical decision-making for patients affected by colorectal liver metastases,facing modern biomarkers and innovative opportunities that will characterize the evolution of clinical research and practice in the next few years.

关键词： Colorectal liver metastases Biomarkers Genetics Immune infiltrate Radiomics Artificial Intelligence

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中性悬浮粒子流在奇异角附近的重构

Acta Mechanica Sinica 2022年第8期38卷 41-48页

作者： francesco Romanò Univ.Lille CNRSONERAArts et Métiers Institute of TechnologyCentrale LilleUMR 9014-LMFL-Laboratoire de Mécanique des Fluides de Lille-Kampéde FérietUniv.LilleCNRSONERAF-59000LilleFrance

在蠕动流动条件下,针对靠近奇异角移动的颗粒进行悬浮效应修正.一些密度不匹配的粒子轨迹被用来重建整个目标区域的中性悬浮粒子的动力学.我们建议利用密度不匹配粒子的耗散动力学来探测目标区域.然后,通过重建密度不匹配颗粒流的相空间... 详细信息

在蠕动流动条件下,针对靠近奇异角移动的颗粒进行悬浮效应修正.一些密度不匹配的粒子轨迹被用来重建整个目标区域的中性悬浮粒子的动力学.我们建议利用密度不匹配粒子的耗散动力学来探测目标区域.然后,通过重建密度不匹配颗粒流的相空间,并将颗粒与流体密度比的极限值取为1,检索整个区域的中性浮力颗粒流.这种方法的鲁棒性通过对重建算子的目标函数实行有目的抖动(ill-conditioning)来证明.事实上,我们证明即使是依赖于质量不同、密度不匹配的轨道拓扑,或者依赖于密集的轨道束,而不是均匀分布的轨道,我们的算法也能很好地执行.最后讨论了该算法在微流体领域的潜在应用和改进.

关键词：悬浮粒子中性浮力微流体极限值颗粒流粒子轨迹相空间流动条件