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Role of Helicobacter pylori infection and the risk of cholelithiasis

World Journal of Gastroenterology 2025年第8期31卷 152-154页

作者： Nicolò Fabbri Salvatore Greco Antonio Pesce francesco virgilio Danila Romeo Carlo V Feo Unit of General Surgery Local Health Agency of FerraraFerrara 44100Emilia-RomagnaItaly Unit of Internal Medicine Local Health Agency of FerraraFerrara 44100Emilia-RomagnaItaly Department of Morphology Surgeryand Experimental MedicineUniversity of FerraraFerrara 44100Emilia-RomagnaItaly Unit of Hepato-Biliary Surgery IRCCS San Raffaele HospitalMilan 20132LombardyItaly Local Health Agency of Ferrara Ferrara 44100Emilia-RomagnaItaly

This article aims to deepen the understanding of the role of Helicobacter pylori(***)infection in the development of cholelithiasis,initiated by the article by Yao et al,who investigated the potential link between *** infection and the development of cholelithiasis through a multicenter retrospective study on an Asian population of over 70000 *** also performed a compre-hensive analysis of previously published studies on *** and cholelithiasis,finding a positive association therein[odds ratio(OR)=1.103,P=0.049].Patients positive for *** also had lower levels of total and direct bilirubin,but higher levels of total cholesterol and low-density lipoprotein cholesterol compared to uninfected patients(P<0.05).Cohort studies have confirmed that *** is a risk factor for cholelithiasis(P<0.0001),and aggregate analyses of case-control and cross-sectional studies have shown a positive association between *** and cholelithiasis in Asia(OR=1.599,P=0.034),but not in Europe(OR=1.277,P=0.246).Moreover,*** appears to be related to a higher ratio of choledocho-lithiasis/cholecystolithiasis(OR=3.321,P=0.033).The authors conclude that *** infection is positively correlated with cholelithiasis,particularly with the choledocholithiasis phenotype,especially in Asia,and it is potentially related to bilirubin and cholesterol metabolism.

关键词： Helicobacter pylori Helicobacter pylori infection Cholelithiasis Proton pump inhibitors Choledocholithiasis

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From purines to purinergic signalling:molecular functions and human diseases

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1463-1482页

作者： Zhao Huang Na Xie Peter Illes francesco Di virgilio Henning Ulrich Alexey Semyanov Alexei Verkhratsky Beata Sperlagh Shu-Guang Yu Canhua Huang Yong Tang State Key Laboratory of Biotherapy and Cancer Center West China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengduChina International Collaborative Centre on Big Science Plan for Purinergic Signalling Chengdu University of Traditional Chinese MedicineChengduChina Rudolf-Boehm-Institut für Pharmakologie und Toxikologie Universitaet LeipzigLeipzigGermany Department of Medical Sciences University of FerraraFerraraItaly Department of Biochemistry Institute of ChemistryUniversity of São PauloSão PauloBrazil Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesMoscowRussia Sechenov First Moscow State Medical University MoscowRussia Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Department of Pharmacology Institute of Experimental MedicineHungarian Academy of SciencesBudapestHungary Acupuncture and Chronobiology Key Laboratory of Sichuan Province ChengduChina School of Basic Medical Sciences Chengdu University of Traditional Chinese MedicineChengduChina

Purines and their derivatives,most notably adenosine and ATP,are the key molecules controlling intracellular energy homoeostasis and nucleotide ***,these purines support,as chemical messengers,purinergic transmission throughout tissues and *** act as endogenous ligands that bind to and activate plasmalemmal purinoceptors,which mediate extracellular communication referred to as“purinergic signalling”.Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation,differentiation,migration,apoptosis and other physiological processes critical for the proper function of *** deregulation of purinergic signalling contributes to various diseases including neurodegeneration,rheumatic immune diseases,inflammation,and ***,gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent *** evidence indicates that purinoceptors are potential therapeutic targets,with specific purinergic agonists and antagonists demonstrating prominent therapeutic ***,dietary and herbal interventions help to restore and balance purine metabolism,thus addressing the importance of a healthy lifestyle in the prevention and relief of human *** understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases.

关键词： metabolism diseases urine

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Single-cell pan-omics, environmental neurology, and artificial intelligence:the time for holistic brain health research

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Neural Regeneration Research 2025年第6期20卷 1703-1704页

作者： Paolo Abondio francesco Bruno IRCCS Istituto delle Scienze Neurologiche di Bologna BolognaItaly Association for Neurogenetic Research(ARN) Lamezia TermeCatanzaroItaly

The brain,with its trillions of neural connections,different cellular types,and molecular complexities,presents a formidable challenge for researchers aiming to comprehend the multifaceted nature of neural *** traditional methods have provided valuable insights,emerging technologies offer unprecedented opportunities to delve deeper into the underpinnings of brain *** the everevolving landscape of neuroscience,the quest to unravel the mysteries of the human brain is bound to take a leap forward thanks to new technological improvements and bold interpretative frameworks.

关键词： function artificial landscape

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Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration

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Neural Regeneration Research 2025年第8期20卷 2317-2318页

作者： francesco Angelucci Jakub Hort Memory Clinic Department of NeurologySecond Faculty of MedicineCharles University and Motol University HospitalPragueCzech Republic International Clinical Research Centre St.Anne’s University HospitalBrnoCzech Republic

Frontotemporal lobar degeneration(FTLD)is a form of progressive dementia characterized by degeneration of the frontal and temporal lobes of the *** pathology involves a series of cognitive,behavioral,and neurological ... 详细信息

关键词： degeneration elevated pathology

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Magneto-Electro-Elastic Analysis of Doubly-Curved Shells: Higher-Order Equivalent Layer-Wise Formulation

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1767-1838页

作者： francesco Tornabene Matteo Viscoti Rossana Dimitri Department of Innovation Engineering University of SalentoLecce73100Italy

Recent engineering applications increasingly adopt smart materials,whose mechanical responses are sensitive to magnetic and electric *** this context,new and computationally efficient modeling strategies are essential to predict the multiphysic behavior of advanced structures ***,the manuscript presents a higher-order formulation for the static analysis of laminated anisotropic magneto-electro-elastic doubly-curved shell *** fundamental relations account for the full coupling between the electric field,magnetic field,and mechanical *** configuration variables are expanded along the thickness direction using a generalized formulation based on the Equivalent Layer-Wise ***-order polynomials are selected,allowing for the assessment of prescribed values of the configuration variables at the top and bottom sides of *** addition,an effective strategy is provided for modeling general surface distributions of mechanical pressures and electromagnetic external *** model is based on a continuum-based formulation which employs an analytical homogenization of the multifield material properties,based on Mori&Tanaka approach,of a magneto-electro-elastic composite material obtained from a piezoelectric and a piezomagnetic phase,with coupled magneto-electro-elastic effects.A semi-analytical Navier solution is applied to the fundamental equations,and an efficient post-processing equilibrium-based procedure is here used,based on the numerical assessment with the Generalized Differential Quadrature(GDQ)method,to recover the response of three-dimensional *** formulation is validated through various examples,investigating the multifield response of panels of different curvatures and lamination *** efficient homogenization procedure,based on the Mori&Tanaka approach,is employed to obtain the three-dimensional constitutive relation of magneto-electro-elastic *** model is validated against three-d

关键词： Magneto-electro-elastic materials equivalent layer-wise generalized differential quadrature higher-order theories navier solution recovery procedure smart structures

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Hygro-Thermo-Mechanical Equivalent Layer-Wise Theory of Laminated Shell Structures

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1697-1765页

作者： francesco Tornabene Matteo Viscoti Rossana Dimitri Department of Innovation Engineering University of SalentoLecce73100Italy

This study presents a generalized two-dimensional model for evaluating the stationary hygro-thermo-mechanical response of laminated shell structures made of advanced *** introduces a generalized kinematic model,enabling the assessment of arbitrary values of temperature variation and mass concentration variation for the unvaried configuration at the top and bottom *** is achieved through the Equivalent Layer-Wise description of the unknown field variable using higher-order polynomials and zigzag *** addition,an elastic foundation is modeled utilizing the Winkler-Pasternak *** fundamental equations,derived from the total free energy of the system,are solved analytically using Navier’s ***,the Fourier-based generalized differential quadrature numerical method is adopted to efficiently recover the through-the-thickness distribution of secondary variables in agreement with the hygro-thermal loading *** formulation is applied in some examples of investigation where the response of panels of different curvature and lamination schemes is evaluated under external hygro-thermal fluxes and prescribed values of temperature and moisture *** addition,this study investigates the effect of the hygro-thermal coupling due to Dufour and Soret *** present formulation is verified to be a valuable tool for reducing computational effort and determining the effect on the mechanical response of laminated structures in a thermal and hygrometric environment.

关键词： Dufour and Soret effects equivalent layer-wise hygro-thermal analysis generalized differential quadrature Navier solution smart structures

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Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： francesco Ferrini Esri H.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

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Rectal neuroendocrine tumors: Can we predict their behavior?

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World Journal of Gastroenterology 2025年第5期31卷 129-132页

作者： Elisabetta Dell'Unto francesco Panzuto Gianluca Esposito Department of Medical-Surgical Sciences and Translational Medicine Sapienza University of RomeRome 00189LazioItaly

Rectal neuroendocrine tumors(r-NETs)are the second most common type of neuroendocrine tumor in the gastrointestinal tract,with an increase in incidence in the last *** are low-grade tumors and,given their low risk of meta-stasis,current guidelines recommend endoscopic resection for small *** GATIS predicting score,proposed by Zeng et al,represents an innovative model designed to predict individualized survival outcomes for patients with r-NETs,analyzing the relationship between clinicopathological features and patient *** authors identified tumor grade,T stage,tumor size,age,and progno-stic nutritional index as key prognostic factors,demonstrating that the GATIS Score provides a more accurate prognosis assessment compared to the World Health Organization classification or the tumor-node-metastasis staging ***,further larger prospective studies are necessary,and the scientific community's efforts in this context should be directed toward developing interna-tional multicentric prospective studies,with the ultimate aim of accurately de-fining and understanding the behavior of these conditions.

关键词： Rectal neuroendocrine tumors Prognostic factors GATIS prognostic score Carcinoids Survival outcomes

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Pressure-Dependent Thermal Network Model for Press-Pack Power Modules with Prognostics of Mechanical Status

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CSEE Journal of Power and Energy Systems 2025年第1期11卷 424-439页

作者： Yao Chang Yu Zhou Ankang Zhu Haoze Luo Wuhua Li Chushan Li francesco Iannuzzo Xiangning He College of Electrical Engineering Zhejiang UniversityHangzhou310027China Zhejiang University–University of Illinois at Urbana-Champaign Institute Zhejiang UniversityHaining314400China Department of Energy Technology Aalborg UniversityAalborg 9220Denmark

The press-pack power module with multi-chip layout has drawn increasing attention from industry and academia with its thermal analysis becoming an essential ***,the pressure-dependent thermal variables,such as thermal contact resistance and thermal coupling resistance,are often *** this paper,a pressure-dependent thermal network model is developed to characterize the thermal performance and mechanical status of press-pack power *** including the thermal contact resistance and thermal coupling resistance as the function of pressure,the proposed model ensures a more precise thermo-mechanical evaluation inside the press-pack power *** influence of pressure on self-heating effects and thermal coupling effects of power modules is studied using the knowledge of elastic mechanics.A press-pack prototype with variable pressure loads is ***,thermal experiments under different pressures on chips are conducted and the pressure-variable temperature responses of the thermal network are ***,the feasibility of the proposed thermal network model is validated.A cost-effective prognostic method on the mechanical status of press-pack power module is also achieved.

关键词： Mechanical status press-pack power module pressure-dependent model thermal network.

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Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

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